CD4+ helper 1 cells facilitate regression of murine lyme carditis

Infection and Immunity

Volumn 69, Issue 9, 2001, Pages 5264-5269

  Bockenstedt, L K ^a   Kang, I ^a   Chang, C ^a   Persing, D ^a   Hayday, A ^a   Barthold, S W ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; LYMPHOCYTE ANTIGEN RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; BORRELIA BURGDORFERI; CARDITIS; CONTROLLED STUDY; DISEASE COURSE; HELPER CELL; IMMUNE RESPONSE; LYME DISEASE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MOUSE MUTANT; MYOCARDITIS; TH1 CELL;

ANIMALS; B-LYMPHOCYTES; BORRELIA BURGDORFERI GROUP; INTERFERON TYPE II; LYME DISEASE; MICE; MICE, SCID; MYOCARDITIS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TH1 CELLS;

EID: 0034741920     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.9.5264-5269.2001     Document Type: Article

References (36)

1. Effect of anti-interleukin 12 treatment on murine Lyme borreliosis
2. Carditis in Lyme disease susceptible and resistant strains of laboratory mice infected with Borrelia burgdorferi
3. Isolation and cultivation of Lyme disease spirochetes
4. Lyme borreliosis in selected strains and ages of laboratory mice
5. Passive immunizing activity of sera from mice infected with Borrelia burgdorferi
6. Chronic Lyme borreliosis in the laboratory mouse
7. Serum-mediated resolution of Lyme arthritis in mice
8. Protective and arthritis-resolving activity in serum of mice infected with Borrelia burgdorferi
9. Kinetics of Borrelia burgdorferi dissemination and evolution of disease following intradermal inoculation of mice
10. Lyme borreliosis in genetically resistant and susceptible mice with severe combined immunodeficiency
11. The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells
12. Lyme disease
13. Experimental Lyme arthritis in the absence of interleukin-4 or gamma interferon
14. Dual role of interleukin-10 in murine Lyme disease: Regulation of arthritis severity and host defense
15. Cytokines in murine Lyme carditis: Th1 cytokine expression follows expression of proinflammatory cytokines in a susceptible mouse strain
16. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
17. Early induction of gamma interferon and interleukin-10 production in draining lymph nodes from mice infected with Borrelia burgdorferi
18. Quantitative detection of Borrelia burgdorferi with a microtiter-based competitive PCR assay
19. T helper cell cytokines in the early evolution of murine Lyme arthritis
20. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
21. The T helper cell response in Lyme arthritis: Differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis
22. T helper phenotype and genetic susceptibility in experimental Lyme disease
23. T-cell-independent responses to Borrelia burgdorferi are critical for protective immunity and resolution of Lyme disease
24. T cell-mediated pathology in murine Lyme borreliosis
25. Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: Exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease
26. Murine Lyme disease: No evidence for active immune downregulation in resolving or subclinical infection
27. Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells
28. Peripheral T lymphocytes: Expansion potential and homeostatic regulation of pool sizes and CD4/8 ratios in vivo
29. + T cell interactions
30. Early murine Lyme carditis is macrophage-mediated and does not require Class II MHC antigen
31. The severe combined immunodeficiency (scid) mouse: A laboratory model for the analysis of Lyme arthritis and carditis
32. Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manisfests predominantly in the joints, heart, and liver
33. Modulation of murine Lyme borreliosis by interruption of the B7/CD28 T cell costimulatory pathway
34. Lyme disease: A review of aspects of its immunology and immunopathogenesis
35. high γδ T cells in Lyme arthritis
36. Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis