Effects of lipoic acid on apelin in 3T3-L1 adipocytes and in high-fat fed rats

Journal of Physiology and Biochemistry

Volumn 67, Issue 3, 2011, Pages 479-486

  Fernández Galilea, Marta ^a   Peŕez Matute, Patricia ^a,b   Prieto Hontoria, Pedro ^a   Alfredo Martinez J ^a   Moreno Aliaga, María Jesús ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b CENTER FOR BIOMEDICAL RESEARCH OF LA RIOJA CIBIR   (Spain)

Author keywords

Adipocytes; AMPK; Apelin; Insulin resistance; Lipoic acid; Obesity

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; APLN PROTEIN, RAT; CHROMONE DERIVATIVE; GLUCOSE; INSULIN; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; SIGNAL PEPTIDE; THIOCTIC ACID;

ANIMAL; ARTICLE; BLOOD; BODY WEIGHT; CELL STRAIN 3T3; DIET SUPPLEMENTATION; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GENETICS; GLUCOSE BLOOD LEVEL; LIPID DIET; MALE; METABOLISM; MOUSE; OBESITY; RAT; SECRETION; WHITE ADIPOSE TISSUE; WISTAR RAT;

3T3-L1 CELLS; ADIPOCYTES, WHITE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CHROMONES; DIET, HIGH-FAT; DIETARY SUPPLEMENTS; GENE EXPRESSION; GLUCOSE; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MORPHOLINES; OBESITY; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR; THIOCTIC ACID;

EID: 84856377231     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-011-0087-1     Document Type: Article

References (39)

1. Attane C, Daviaud D, Dray C, Dusaulcy R, Masseboeuf M, Prevot D, Carpene C, Castan-Laurell I, Valet P (2011) Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo. J Mol Endocrinol 46:21-28
2. Boucher J, Masri B, Daviaud D, Gesta S, Guigne C, Mazzucotelli A, Castan-Laurell I, Tack I, Knibiehler B, Carpene C, Audigier Y, Saulnier-Blache JS, Valet P (2005) Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 146:1764-1771 (Pubitemid 40396885)
3. Butler JA, Hagen TM, Moreau R (2009) Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion. Arch Biochem Biophys 485:63-71
4. Carbonelli MG, Di Renzo L, Bigioni M, Di Daniele N, De Lorenzo A, Fusco MA (2010) Alpha-lipoic acid supplementation: a tool for obesity therapy? Curr Pharm Des 16:840-846
5. Carpene C, Dray C, Attane C, Valet P, Portillo MP, Churruca I, Milagro FI, Castan-Laurell I (2007) Expanding role for the apelin/APJ system in physiopathology. J Physiol Biochem 63:359-373
6. Castan-Laurell I, Boucher J, Dray C, Daviaud D, Guigne C, Valet P (2005) Apelin, a novel adipokine over-produced in obesity: friend or foe? Mol Cell Endocrinol 245:7-9 (Pubitemid 43049740)
7. Cinti S (2005) The adipose organ. Prostaglandins Leukot Essent Fatty Acids 73:9-15
8. Daviaud D, Boucher J, Gesta S, Dray C, Guigne C, Quilliot D, Ayav A, Ziegler O, Carpene C, Saulnier-Blache JS, Valet P, Castan-Laurell I (2006) TNFalpha up-regulates apelin expression in human and mouse adipose tissue. FASEB J 20:1528-1530
9. Dray C, Debard C, Jager J, Disse E, Daviaud D, Martin P, Attane C, Wanecq E, Guigne C, Bost F, Tanti JF, Laville M, Vidal H, Valet P, Castan-Laurell I (2010) Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans. Am J Physiol Endocrinol Metab 298:E1161-E1169
10. Dray C, Knauf C, Daviaud D, Waget A, Boucher J, Buleon M, Cani PD, Attane C, Guigne C, Carpene C, Burcelin R, Castan-Laurell I, Valet P (2008) Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab 8:437-445
11. Estrada DE, Ewart HS, Tsakiridis T, Volchuk A, Ramlal T, Tritschler H, Klip A (1996) Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 45:1798-1804 (Pubitemid 26398962)
12. Garcia-Diaz D, Campion J, Milagro FI, Martinez JA (2007) Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers. Mol Cell Biochem 305:87-94 (Pubitemid 47517171)
13. Huong D, Ide T (2008) Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Br J Nutr 100:79-87
14. Kapica M, Puzio I, Kato I, Kuwahara A, Zabielski R (2008) Role of feed-regulating peptides on pancreatic exocrine secretion. J Physiol Pharmacol 59(Suppl 2):145-159
15. Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Viollet B, Youn JH, Lee HK, Lee KU (2004) Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 10:727-733 (Pubitemid 38937638)
16. Koh EH, Lee WJ, Kim MS, Park JY, Lee IK, Lee KU (2005) Intracellular fatty acid metabolism in skeletal muscle and insulin resistance. Curr Diabetes Rev 1:331-336
17. Lee WJ, Lee IK, Kim HS, Kim YM, Koh EH, Won JC, Han SM, Kim MS, Jo I, Oh GT, Park IS, Youn JH, Park SW, Lee KU, Park JY (2005) Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol 25:2488-2494 (Pubitemid 43732268)
18. Lee WJ, Song KH, Koh EH, Won JC, Kim HS, Park HS, Kim MS, Kim SW, Lee KU, Park JY (2005) Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun 332:885-891
19. Li L, Yang G, Li Q, Tang Y, Yang M, Yang H, Li K (2006) Changes and relations of circulating visfatin, apelin, and resistin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects. Exp Clin Endocrinol Diabetes 114:544-548 (Pubitemid 46087259)
20. Lorente-Cebrian S, Bustos M, Marti A, Martinez JA, Moreno-Aliaga MJ (2009) Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes. Clin Sci (Lond) 117:243-249
21. Lorente-Cebrian S, Bustos M, Marti A, Martinez JA, Moreno-Aliaga MJ (2010) Eicosapentaenoic acid upregulates apelin secretion and gene expression in 3T3-L1 adipocytes. Mol Nutr Food Res 54(Suppl 1):S104 -S111
22. Moreno-Aliaga MJ, Matsumura F (2002) Effects of 1,1, 1-trichloro-2,2- bis(p-chlorophenyl)-ethane (p, p'-DDT) on 3T3-L1 and 3T3-F442A adipocyte differentiation. Biochem Pharmacol 63:997-1007 (Pubitemid 34243014)
23. Packer L, Kraemer K, Rimbach G (2001) Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 17:888-895 (Pubitemid 33001657)
24. Park KG, Min AK, Koh EH, Kim HS, Kim MO, Park HS, Kim YD, Yoon TS, Jang BK, Hwang JS, Kim JB, Choi HS, Park JY, Lee IK, Lee KU (2008) Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. Hepatology 48:1477-1486
25. Perez-Echarri N, Perez-Matute P, Marcos-Gomez B, Martinez JA, Moreno-Aliaga MJ (2009) Effects of eicosapentaenoic acid ethyl ester on visfatin and apelin in lean and overweight (cafeteria diet-fed) rats. Br J Nutr 101:1059-1067
26. Perez-Matute P, Marti A, Martinez JA, Fernandez-Otero MP, Stanhope KL, Havel PJ, Moreno-Aliaga MJ (2005) Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism. Am J Physiol Regul Integr Comp Physiol 288: R1682-R1688 (Pubitemid 40720718)
27. Prieto-Hontoria PL, Pérez-Matute P, Fernández-Galilea M, Barber A, Martinez JA, Moreno-Aliaga MJ (2009) Lipoic acid prevents body weight gain induced by a high fat diet in rats: effects on intestinal sugar transport. J Physiol Biochem 65:43-50
28. Prieto-Hontoria PL, Pérez-Matute P, Fernández-Galilea M, Martínez JA, Moreno-Aliaga MJ (2009) Effects of dietary supplementation with lipoic acid on leptin and adiponectin plasma levels in lean and obese Wistar rats. Acta Physiol 195(suppl 667):129
29. Prieto-Hontoria PL, Pérez-Matute P, Fernández-Galilea M, Martinez JA, Moreno-Aliaga MJ (2011) Lipoic acid inhibits leptin secretion and Sp1 activity in adipocytes. Mol Nutr Food Res. doi:10.1002/mnfr.201000534
30. Purnell JQ, Hirsch IB (1997) New oral therapies for type 2 diabetes. Am Fam Physician 56:1835-1842 (Pubitemid 27479485)
31. Quazi R, Palaniswamy C, Frishman WH (2009) The emerging role of apelin in cardiovascular disease and health. Cardiol Rev 17:283-286
32. Ringstrom C, Nitert MD, Bennet H, Fex M, Valet P, Rehfeld JF, Friis-Hansen L, Wierup N (2010) Apelin is a novel islet peptide. Regul Pept 162:44-51
33. Rudich A, Tirosh A, Potashnik R, Khamaisi M, Bashan N (1999) Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes. Diabetologia 42:949-957 (Pubitemid 29369603)
34. Sena CM, Nunes E, Louro T, Proenca T, Fernandes R, Boarder MR, Seica RM (2008) Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats. Br J Pharmacol 153:894-906 (Pubitemid 351328927)
35. Sena CM, Nunes E, Louro T, Proenca T, Seica RM (2007) Endothelial dysfunction in type 2 diabetes: effect of antioxidants. Rev Port Cardiol 26:609-619 (Pubitemid 47122811)
36. Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM (2004) Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem 11:1135-1146 (Pubitemid 38585058)
37. Song KH, Lee WJ, Koh JM, Kim HS, Youn JY, Park HS, Koh EH, Kim MS, Youn JH, Lee KU, Park JY (2005) Alpha-lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochem Biophys Res Commun 326:197-202 (Pubitemid 39573219)
38. Wei L, Hou X, Tatemoto K (2005) Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes. Regul Pept 132:27-32 (Pubitemid 41607499)
39. Xu DP, Wells WW (1996) Alpha-lipoic acid dependent regeneration of ascorbic acid from dehydroascorbic acid in rat liver mitochondria. J Bioenerg Biomembr 28:77-85 (Pubitemid 26070488)