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Volumn 52, Issue 10, 2011, Pages 7455-7463

The small GTPase Rap1 is a novel regulator of RPE Cell barrier function

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; RAP1 PROTEIN; MICRORNA;

EID: 84856368264     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7295     Document Type: Article
Times cited : (29)

References (53)
  • 1
    • 33751103471 scopus 로고    scopus 로고
    • Age-related macular degeneration-emerging pathogenetic and therapeutic concepts
    • Gehrs KM, Anderson DH, Johnson LV, Hageman GS. Age-related macular degeneration-emerging pathogenetic and therapeutic concepts. Ann Med. 2006;38:450-471.
    • (2006) Ann Med , vol.38 , pp. 450-471
    • Gehrs, K.M.1    Anderson, D.H.2    Johnson, L.V.3    Hageman, G.S.4
  • 2
    • 11144354339 scopus 로고    scopus 로고
    • Prevalence of agerelated macular degeneration in the United States
    • Friedman DS, O'Colmain BJ, Munoz B, et al. Prevalence of agerelated macular degeneration in the United States. Arch Ophthalmol. 2004;122:564-572.
    • (2004) Arch Ophthalmol , vol.122 , pp. 564-572
    • Friedman, D.S.1    O'Colmain, B.J.2    Munoz, B.3
  • 3
    • 0032807809 scopus 로고    scopus 로고
    • Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation
    • Blaauwgeers HG, Holtkamp GM, Rutten H, et al. Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation. Am J Pathol. 1999;155:421-428.
    • (1999) Am J Pathol , vol.155 , pp. 421-428
    • Blaauwgeers, H.G.1    Holtkamp, G.M.2    Rutten, H.3
  • 4
    • 0347651828 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor in the monkey retinal pigment epithelium and interphotoreceptor matrix: Apical secretion and distribution
    • Becerra SP, Fariss RN, Wu YQ, Montuenga LM, Wong P, Pfeffer BA. Pigment epithelium-derived factor in the monkey retinal pigment epithelium and interphotoreceptor matrix: apical secretion and distribution. Exp Eye Res. 2004;78:223-234.
    • (2004) Exp Eye Res , vol.78 , pp. 223-234
    • Becerra, S.P.1    Fariss, R.N.2    Wu, Y.Q.3    Montuenga, L.M.4    Wong, P.5    Pfeffer, B.A.6
  • 5
    • 43549093349 scopus 로고    scopus 로고
    • Reduction of endogenous angiogenesis inhibitors in Bruch's membrane of the submacular region in eyes with age-related macular degeneration
    • Bhutto IA, Uno K, Merges C, Zhang L, McLeod DS, Lutty GA. Reduction of endogenous angiogenesis inhibitors in Bruch's membrane of the submacular region in eyes with age-related macular degeneration. Arch Ophthalmol. 2008;126:670-678.
    • (2008) Arch Ophthalmol , vol.126 , pp. 670-678
    • Bhutto, I.A.1    Uno, K.2    Merges, C.3    Zhang, L.4    McLeod, D.S.5    Lutty, G.A.6
  • 6
    • 33847260238 scopus 로고    scopus 로고
    • Development and role of tight junctions in the retinal pigment epithelium
    • Rizzolo LJ. Development and role of tight junctions in the retinal pigment epithelium. Int Rev Cytol. 2007;258:195-234.
    • (2007) Int Rev Cytol , vol.258 , pp. 195-234
    • Rizzolo, L.J.1
  • 7
    • 77953434480 scopus 로고    scopus 로고
    • Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: Relevance to age-related macular degeneration
    • Sonoda S, Sreekumar PG, Kase S, et al. Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration. Aging (Albany NY). 2009;2:28-42.
    • (2009) Aging (Albany NY) , vol.2 , pp. 28-42
    • Sonoda, S.1    Sreekumar, P.G.2    Kase, S.3
  • 9
    • 0141645207 scopus 로고    scopus 로고
    • Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism
    • Hartnett ME, Lappas A, Darland D, McColm JR, Lovejoy S, D'Amore PA. Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism. Exp Eye Res. 2003;77:593-599.
    • (2003) Exp Eye Res , vol.77 , pp. 593-599
    • Hartnett, M.E.1    Lappas, A.2    Darland, D.3    McColm, J.R.4    Lovejoy, S.5    D'Amore, P.A.6
  • 10
    • 33947189597 scopus 로고    scopus 로고
    • Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1
    • Peterson LJ, Wittchen ES, Geisen P, Burridge K, Hartnett ME. Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1. Exp Eye Res. 2007;84:737-744.
    • (2007) Exp Eye Res , vol.84 , pp. 737-744
    • Peterson, L.J.1    Wittchen, E.S.2    Geisen, P.3    Burridge, K.4    Hartnett, M.E.5
  • 11
    • 79952569659 scopus 로고    scopus 로고
    • The role of RPE cellassociated VEGF189 in choroidal endothelial cell transmigration in neovascular age-related macular degeneration
    • Wang H, Geisen P, Wittchen ES, et al. The role of RPE cellassociated VEGF189 in choroidal endothelial cell transmigration in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52:570-578.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 570-578
    • Wang, H.1    Geisen, P.2    Wittchen, E.S.3
  • 12
    • 77957370166 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization
    • Monaghan-Benson E, Hartmann J, Vendrov AE, et al. The role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization. Am J Pathol. 2010;177:2091-2102.
    • (2010) Am J Pathol , vol.177 , pp. 2091-2102
    • Monaghan-Benson, E.1    Hartmann, J.2    Vendrov, A.E.3
  • 13
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 1995;81:53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 14
    • 0042344706 scopus 로고    scopus 로고
    • Rho GTPases and the regulation of endothelial permeability
    • Wojciak-Stothard B, Ridley AJ. Rho GTPases and the regulation of endothelial permeability. Vascul Pharmacol. 2002;39:187-199.
    • (2002) Vascul Pharmacol , vol.39 , pp. 187-199
    • Wojciak-Stothard, B.1    Ridley, A.J.2
  • 15
    • 0036774217 scopus 로고    scopus 로고
    • Cell-cell adhesion and signalling
    • Braga VM. Cell-cell adhesion and signalling. Curr Opin Cell Biol. 2002;14:546-556.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 546-556
    • Braga, V.M.1
  • 16
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall A. Rho GTPases and the actin cytoskeleton. Science. 1998;279:509-514.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 17
    • 0028807377 scopus 로고
    • Ras-related proteins in signal transduction and growth control
    • McCormick F. Ras-related proteins in signal transduction and growth control. Mol Reprod Dev. 1995;42:500-506.
    • (1995) Mol Reprod Dev , vol.42 , pp. 500-506
    • McCormick, F.1
  • 18
    • 0842281652 scopus 로고    scopus 로고
    • Rho and Rac take center stage
    • Burridge K, Wennerberg K. Rho and Rac take center stage. Cell. 2004;116:167-179.
    • (2004) Cell , vol.116 , pp. 167-179
    • Burridge, K.1    Wennerberg, K.2
  • 19
    • 24144444059 scopus 로고    scopus 로고
    • Epac1 regulates integrity of endothelial cell junctions through VE-cadherin
    • Kooistra MR, Corada M, Dejana E, Bos JL. Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett. 2005;579:4966-4972.
    • (2005) FEBS Lett , vol.579 , pp. 4966-4972
    • Kooistra, M.R.1    Corada, M.2    Dejana, E.3    Bos, J.L.4
  • 20
    • 31944446602 scopus 로고    scopus 로고
    • MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion
    • Sakurai A, Fukuhara S, Yamagishi A, et al. MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol Biol Cell. 2006;17:966-976.
    • (2006) Mol Biol Cell , vol.17 , pp. 966-976
    • Sakurai, A.1    Fukuhara, S.2    Yamagishi, A.3
  • 21
    • 41649100672 scopus 로고    scopus 로고
    • Role of epac1, an exchange factor for rap GTPases, in endothelial microtubule dynamics and barrier function
    • Sehrawat S, Cullere X, Patel S, Italiano J Jr, Mayadas TN. Role of epac1, an exchange factor for rap GTPases, in endothelial microtubule dynamics and barrier function. Mol Biol Cell. 2008;19: 1261-1270.
    • (2008) Mol Biol Cell , vol.19 , pp. 1261-1270
    • Sehrawat, S.1    Cullere, X.2    Patel, S.3    Italiano Jr., J.4    Mayadas, T.N.5
  • 22
    • 34250177621 scopus 로고    scopus 로고
    • Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA-and Epac1/Rap1-dependent Rac activation
    • Birukova AA, Zagranichnaya T, Fu P, et al. Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA-and Epac1/Rap1-dependent Rac activation. Exp Cell Res. 2007;313: 2504-2520.
    • (2007) Exp Cell Res , vol.313 , pp. 2504-2520
    • Birukova, A.A.1    Zagranichnaya, T.2    Fu, P.3
  • 23
    • 0033603578 scopus 로고    scopus 로고
    • Rap1 GTPaseactivating protein SPA-1 negatively regulates cell adhesion
    • Tsukamoto N, Hattori M, Yang H, Bos JL, Minato N. Rap1 GTPaseactivating protein SPA-1 negatively regulates cell adhesion. J Biol Chem. 1999;274:18463-18469.
    • (1999) J Biol Chem , vol.274 , pp. 18463-18469
    • Tsukamoto, N.1    Hattori, M.2    Yang, H.3    Bos, J.L.4    Minato, N.5
  • 24
    • 0038350597 scopus 로고    scopus 로고
    • AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1
    • Su L, Hattori M, Moriyama M, et al. AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. J Biol Chem. 2003;278:15232-15238.
    • (2003) J Biol Chem , vol.278 , pp. 15232-15238
    • Su, L.1    Hattori, M.2    Moriyama, M.3
  • 26
    • 14944377651 scopus 로고    scopus 로고
    • Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase
    • Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood. 2005;105:1950-1955.
    • (2005) Blood , vol.105 , pp. 1950-1955
    • Cullere, X.1    Shaw, S.K.2    Andersson, L.3    Hirahashi, J.4    Luscinskas, F.W.5    Mayadas, T.N.6
  • 27
    • 33645298436 scopus 로고    scopus 로고
    • Vascular endothelial cadherin-mediated cell-cell adhesion regulated by a small GTPase, Rap1
    • Fukuhara S, Sakurai A, Yamagishi A, Sako K, Mochizuki N. Vascular endothelial cadherin-mediated cell-cell adhesion regulated by a small GTPase, Rap1. J Biochem Mol Biol. 2006;39:132-139.
    • (2006) J Biochem Mol Biol , vol.39 , pp. 132-139
    • Fukuhara, S.1    Sakurai, A.2    Yamagishi, A.3    Sako, K.4    Mochizuki, N.5
  • 29
    • 3242685086 scopus 로고    scopus 로고
    • Rap1 regulates the formation of E-cadherin-based cell-cell contacts
    • Hogan C, Serpente N, Cogram P, et al. Rap1 regulates the formation of E-cadherin-based cell-cell contacts. Mol Cell Biol. 2004; 6690-6700.
    • (2004) Mol Cell Biol , pp. 6690-6700
    • Hogan, C.1    Serpente, N.2    Cogram, P.3
  • 30
    • 33748544246 scopus 로고    scopus 로고
    • Characterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term culture
    • Geisen P, McColm JR, King BM, Hartnett ME. Characterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term culture. Curr Eye Res. 2006;31:739-748.
    • (2006) Curr Eye Res , vol.31 , pp. 739-748
    • Geisen, P.1    McColm, J.R.2    King, B.M.3    Hartnett, M.E.4
  • 31
    • 31044453220 scopus 로고    scopus 로고
    • Choroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factor
    • Geisen P, McColm JR, Hartnett ME. Choroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factor. Exp Eye Res. 2006;82:608-619.
    • (2006) Exp Eye Res , vol.82 , pp. 608-619
    • Geisen, P.1    McColm, J.R.2    Hartnett, M.E.3
  • 32
    • 85006314494 scopus 로고    scopus 로고
    • A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
    • Enserink JM, Christensen AE, de Rooij J, et al. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol. 2002;4:901-906.
    • (2002) Nat Cell Biol , vol.4 , pp. 901-906
    • Enserink, J.M.1    Christensen, A.E.2    de Rooij, J.3
  • 33
    • 52049118125 scopus 로고    scopus 로고
    • Analysis of low molecular weight GTPase activity in endothelial cell cultures
    • Wittchen ES, Burridge K. Analysis of low molecular weight GTPase activity in endothelial cell cultures. Methods Enzymol. 2008;443: 285-298.
    • (2008) Methods Enzymol , vol.443 , pp. 285-298
    • Wittchen, E.S.1    Burridge, K.2
  • 34
    • 0031014969 scopus 로고    scopus 로고
    • Rapid Ca2+-mediated activation of Rap1 in human platelets
    • Franke B, Akkerman JW, Bos JL. Rapid Ca2+-mediated activation of Rap1 in human platelets. Embo J. 1997;16:252-259.
    • (1997) Embo J , vol.16 , pp. 252-259
    • Franke, B.1    Akkerman, J.W.2    Bos, J.L.3
  • 35
    • 4644360563 scopus 로고    scopus 로고
    • Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays
    • Solly K, Wang X, Xu X, Strulovici B, Zheng W. Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays. Assay Drug Dev Technol. 2004;2:363-372.
    • (2004) Assay Drug Dev Technol , vol.2 , pp. 363-372
    • Solly, K.1    Wang, X.2    Xu, X.3    Strulovici, B.4    Zheng, W.5
  • 36
    • 33845914589 scopus 로고    scopus 로고
    • Dynamic and label-free cellbased assays using the real-time cell electronic sensing system
    • Atienza JM, Yu N, Kirstein SL, et al. Dynamic and label-free cellbased assays using the real-time cell electronic sensing system. Assay Drug Dev Technol. 2006;4:597-607.
    • (2006) Assay Drug Dev Technol , vol.4 , pp. 597-607
    • Atienza, J.M.1    Yu, N.2    Kirstein, S.L.3
  • 37
    • 0025897167 scopus 로고
    • Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1
    • Rubinfeld B, Munemitsu S, Clark R, et al. Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. Cell. 1991;65:1033-1042.
    • (1991) Cell , vol.65 , pp. 1033-1042
    • Rubinfeld, B.1    Munemitsu, S.2    Clark, R.3
  • 38
    • 28244447739 scopus 로고    scopus 로고
    • GTPase activating proteins: Structural and functional insights 18 years after discovery
    • Scheffzek K, Ahmadian MR. GTPase activating proteins: structural and functional insights 18 years after discovery. Cell Mol Life Sci. 2005;62:3014-3038.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 3014-3038
    • Scheffzek, K.1    Ahmadian, M.R.2
  • 39
    • 77949538387 scopus 로고    scopus 로고
    • Epac: Defining a new mechanism for cAMP action
    • Gloerich M, Bos JL. Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol. 2010;50:355-375.
    • (2010) Annu Rev Pharmacol Toxicol , vol.50 , pp. 355-375
    • Gloerich, M.1    Bos, J.L.2
  • 41
    • 77951209408 scopus 로고    scopus 로고
    • Direct activation of RhoA by reactive oxygen species requires a redoxsensitive motif
    • Aghajanian A, Wittchen ES, Campbell SL, Burridge K. Direct activation of RhoA by reactive oxygen species requires a redoxsensitive motif. PLoS One. 2009;4:e8045.
    • (2009) PLoS One , vol.4
    • Aghajanian, A.1    Wittchen, E.S.2    Campbell, S.L.3    Burridge, K.4
  • 42
    • 77955856027 scopus 로고    scopus 로고
    • Endothelial adherens junctions and the actin cytoskeleton: An 'infinity net'?
    • Lampugnani MG. Endothelial adherens junctions and the actin cytoskeleton: an 'infinity net'? J Biol. 2010;9:16.
    • (2010) J Biol , vol.9 , pp. 16
    • Lampugnani, M.G.1
  • 43
    • 0022475550 scopus 로고
    • Changes in membrane-microfilament interaction in intercellular adherens junctions upon removal of extracellular Ca2+ ions
    • Volberg T, Geiger B, Kartenbeck J, Franke WW. Changes in membrane-microfilament interaction in intercellular adherens junctions upon removal of extracellular Ca2+ ions. J Cell Biol. 1986;102: 1832-1842.
    • (1986) J Cell Biol , vol.102 , pp. 1832-1842
    • Volberg, T.1    Geiger, B.2    Kartenbeck, J.3    Franke, W.W.4
  • 44
    • 0017891781 scopus 로고
    • Polarized monolayers formed by epithelial cells on a permeable and translucent support
    • Cereijido M, Robbins ES, Dolan WJ, Rotunno CA, Sabatini DD. Polarized monolayers formed by epithelial cells on a permeable and translucent support. J Cell Biol. 1978;77:853-880.
    • (1978) J Cell Biol , vol.77 , pp. 853-880
    • Cereijido, M.1    Robbins, E.S.2    Dolan, W.J.3    Rotunno, C.A.4    Sabatini, D.D.5
  • 45
    • 67650457597 scopus 로고    scopus 로고
    • CCR3 is a target for age-related macular degeneration diagnosis and therapy
    • Takeda A, Baffi JZ, Kleinman ME, et al. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature. 2009;460:225-230.
    • (2009) Nature , vol.460 , pp. 225-230
    • Takeda, A.1    Baffi, J.Z.2    Kleinman, M.E.3
  • 46
    • 0029872876 scopus 로고    scopus 로고
    • ARPE-19, a human retinal pigment epithelial cell line with differentiated properties
    • Dunn KC, Aotaki-Keen AE, Putkey FR, Hjelmeland LM. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res. 1996;62:155-169.
    • (1996) Exp Eye Res , vol.62 , pp. 155-169
    • Dunn, K.C.1    Aotaki-Keen, A.E.2    Putkey, F.R.3    Hjelmeland, L.M.4
  • 47
    • 3142750597 scopus 로고    scopus 로고
    • The expression of native and cultured RPE grown on different matrices
    • Tian J, Ishibashi K, Handa JT. The expression of native and cultured RPE grown on different matrices. Physiol Genomics. 2004;17:170-182.
    • (2004) Physiol Genomics , vol.17 , pp. 170-182
    • Tian, J.1    Ishibashi, K.2    Handa, J.T.3
  • 48
    • 79955931428 scopus 로고    scopus 로고
    • Claudin-19 and the barrier properties of the human retinal pigment epithelium
    • Peng S, Rao VS, Adelman RA, Rizzolo LJ. Claudin-19 and the barrier properties of the human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2011;52:1392-1403.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 1392-1403
    • Peng, S.1    Rao, V.S.2    Adelman, R.A.3    Rizzolo, L.J.4
  • 49
    • 33749632278 scopus 로고    scopus 로고
    • Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    • Ferrara N, Damico L, Shams N, Lowman H, Kim R. Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina. 2006;26:859-870.
    • (2006) Retina , vol.26 , pp. 859-870
    • Ferrara, N.1    Damico, L.2    Shams, N.3    Lowman, H.4    Kim, R.5
  • 50
    • 0034982543 scopus 로고    scopus 로고
    • Ethics and human fetal retinal pigment epithelium transplantation
    • Gieser JP. Ethics and human fetal retinal pigment epithelium transplantation. Arch Ophthalmol. 2001;119:899-900.
    • (2001) Arch Ophthalmol , vol.119 , pp. 899-900
    • Gieser, J.P.1
  • 52
    • 40049099471 scopus 로고    scopus 로고
    • Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins
    • Li Y, Yan J, De P, et al. Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol. 2007;179:8322-8331.
    • (2007) J Immunol , vol.179 , pp. 8322-8331
    • Li, Y.1    Yan, J.2    De, P.3


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