Elaborating on efficient Anti-proliferation agents of cancer cells and Anti-inflammatory-based N-bisphosphonic acids

Archiv der Pharmazie

Volumn 345, Issue 2, 2012, Pages 123-136

  Abdou, Wafaa M ^a   Khidre, Rizk E ^a   Kamel, Azza A ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Anti inflammatory activity; Anti tumor screening; Bisphosphonates; Chalcones; Tetrazoloquinolines

Indexed keywords

1 (1H PYRROL 2 YL) 3 (TETRAZOLO[1,5 A]QUINOLIN 4 YL)PROP 2 EN 1 ONE; 1 (FURAN 2 YL) 3 (TETRAZOLO[1,5 A]QUINOLIN 4 YL)PROP 2 EN 1 ONE; 1 PHENYL 3 (TETRAZOLO[1,5 A]QUINOLIN 4 YL)PROP 2 EN 1 ONE; 2 (2 CHLOROQUINOLIN 3 YL) 4 (FURAN 2 YL) 4 OXOBUTANE 1,1 DIYL DIPHOSPHONIC ACID; 2 (2 CHLOROQUINOLIN 3 YL) 4 OXO 4 (1H PYRROL 2 YL)BUTANE 1,1 DIYL DIPHOSPHONIC ACID; 2 (2 CHLOROQUINOLIN 3 YL) 4 OXO 4 (THIOPHEN 2 YL)BUTANE 1,1 DIYL DIPHOSPHONIC ACID; 2 (2 CHLOROQUINOLIN 3 YL) 4 OXO 4 PHENYLBUTANE 1,1 DIYL DIPHOSPHONIC ACID; 2 CYANO 3 (TETRAZOLO[1,5 A]QUINOLIN 4 YLACRYLAMIDE; 3 (TETRAZOLO[1,5 A]QUINOLIN 4 YL) 1 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 4 AMINO 2 (2 CHLOROQUINOLIN 3 YL) 4 OXOBUT 2 ENE 1,1 DIYL DIPHOSPHONIC ACID; 4 AMINO 4 OXO 2 (TETRAZOLO[1,5 A]QUINOLIN 4 YL)BUT 2 ENE 1,1 DIYL DIPHOSPHONIC ACID; 4 OXO 2 (TETRAZOLO[1,5 A]QUINOLIN 4 YL) 4 (THIOPHEN 2 YL)BUTANE 1,1 DIYL DIPHOSPHONIC ACID; 4 OXO 4 PHENYL 2 (TETRAZOLO[1,5 A]QUINOLIN 4 YL)BUTANE 1,1 DIYL DIPHOSPHONIC ACID; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CARRAGEENAN; ESTER DERIVATIVE; METHYLENEBISPHOSPONIC ACID TETRAETHYL ESTER; TETRAETHYL 2 (2 CHLOROQUINOLIN 3 YL) 4 (FURAN 2 YL) 4 OXOBUTANE 1,1 DIYL DIPHOSPHONATE; TETRAETHYL 2 (2 CHLOROQUINOLIN 3 YL) 4 OXO 4 (1H PYRROL 2 YL)BUTANE 1,1 DIYL DIPHOSPHONATE; TETRAETHYL 2 (2 CHLOROQUINOLIN 3 YL) 4 OXO 4 (THIOPHEN 2 YL)BUTANE 1,1 DIYL DIPHOSPHONATE; TETRAETHYL 2 (2 CHLOROQUINOLIN 3 YL) 4 OXO 4 PHENYLBUTANE 1,1 DIYL DIPHOSPHONATE; TETRAETHYL 4 (FURAN 2 YL) 4 OXO 2 (TETRAZOLO [1,5 A]QUINOLIN 4 YL)BUTANE 1,1 DIYL DIPHOSPHONATE; TETRAETHYL 4 AMINO 2 (2 CHLOROQUINOLIN 3 YL) 4 OXOBUT 2 ENE 1,1 DIYL DIPHOSPHONATE; TETRAETHYL 4 AMINO 4 OXO 2 (TETRAZOLO[1,5 A]QUINOLIN 4 YL)BUT 2 ENE 1,1 DIYL DIPHOSPHONATE; TETRAETHYL 4 OXO 2 (TETRAZOLO[1,5 A]QUINOLIN 4 YL) 4 (THIOPHEN 2 YL)BUTANE 1,1 DIYL DIPHOSPHONATE; TETRAETHYL 4 OXO 4 (1H PYRROL 2 YL) 2 (TETRAZOLO [1,5 A]QUINOLIN 4 YL)BUTANE 1,1 DIYL DIPHOSPHONATE; TETRAETHYL 4 OXO 4 PHENYL 2 (TETRAZOLO[1,5 A] QUINOLIN 4 YL)BUTANE 1,1 DIYL DIPHOSPHONATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CENTRAL NERVOUS SYSTEM TUMOR; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG POTENCY; DRUG SCREENING; DRUG SENSITIVITY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LEUKEMIA; LUNG CANCER; MALE; MELANOMA; MICHAEL ADDITION; NONHUMAN; OVARY CANCER; PAW EDEMA; PRIORITY JOURNAL; PROSTATE CANCER;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84856351713     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201100080     Document Type: Article

References (35)

1. R. Tedesco, A. N. Shaw, R. Bambal, D. Chai, N. O. Concha, M. G. Darcy, D. Dhanak, D. M. Fitch, A. Gates, W. G. Gerhardt, D. L. Halegoua, C. Han, G. A. Hofmann, V. K. Johnston, A. C. Kaura, N. Liu, R. M. Keenan, J. Lin-Goerke, R. T. Sarisky, K. J. Wiggall, M. N. Zimmerman, K. J. Duffy, J. Med. Chem. 2006, 49, 971-983.
2. T. Yoneda, A. Sasaki, C. Dustan, P. J. William, F. Bauss, Y. A. De Clerck, G. R. Mundy, J. Clin. Invest. 1997, 99, 2509-2517.
3. A. Lipton, R. L. Theriault, G. N. Hortobagyi, J. Simeone, R. D. Knight, K. Mellars, D. J. Reitsma, M. Heffernan, J. Seaman, J. Cancer 2000, 88, 1082-1090.
4. M. Busch, M. Rave-Frank, A. Hille, E. Duhmke, Eur. J. Med. Res. 1998, 3, 427-431.
5. J. E. Brown, R. E. Coleman, Breast Cancer Res. 2002, 4, 24-29
6. I. J. Diel, N. Marschner, M. Kindler, O. Lange, M. Untch, H. J. Hurtz, G. P. Breitbach, B. Richter, Proc. ASCO 1999, 18, 128.
7. L. I. Plotkin, J. I. Aguirre, S. Kousteni, S. C. Manolagas, T. Bellido, J. Biol. Chem. 2005, 280, 7317-7325
8. R. G. Russell, Bisphosphonates: From bench to bedside, Ann. NY Acad. Sci. 2006, 1068, 367-401.
9. W. M. Abdou, A. A. Kamel, A. A. Shaddy, Eur. J. Med. Chem. 2010, 45, 5217-5224.
10. W. M. Abdou, R. E. Khidre, A. A. Shaddy, J. Heterocycl. Chem. 2011, accepted for publication. ((DOI!))
11. W. M. Abdou, A. A. Shaddy, J. Med. Chem. Res. 2010, 19, 39-40.
12. W. M. Abdou, A. A. Shaddy, ARKIVOC 2009, 9, 143-182.
13. W. M. Abdou, N. A. Ganoub, A. Geronikaki, E. Sabry, Eur. J. Med. Chem. 2008, 43, 1015-1024.
14. W. M. Abdou, M. D. Khidre, A. A. Sediek, Lett. Org. Chem. 2006, 3, 634-640.
15. W. M. Abdou, N. A. Ganoub, A. F. Fahmy, A. A. Shaddy, Monatsh. Chem. 2006, 136, 105-116.
16. W. M. Abdou, Y. O. Elkhoshnieh, N. A. Ganoub, SYNLETT 2002, 785-790.
17. M. S. Shahabuddin, M. Nambiar, B. Choudhary, G. M. Advirao, S. C. Raghavan, Invest. New Drugs 2010, 28, 35-48.
18. M. Yamato, Y. Takeuchi, K. Hashigaki, Y. Ikeda, M. R. Chang, K. Takeuchi, M. Matsushima, T. Tsuruo, T. Tashiro, J. Med. Chem. 1989, 32, 1295-1300
19. Z. Ma, Y. Hano, T. Nomura, Y. Chen, Med. Chem. Lett. 2004, 14, 1193-1196.
20. N. M. Ibrahim, H. A. A. Yosef, J. Chem. Res. 2009, 220-224.
21. R. Ferrer, G. Lobo, N. Gamboq, J. Rodrigues, C. Abramjuk, K. Jung, M. Lein, J. E. Charris, Sci. Pharm. 2009, 77, 725-741.
22. A. H. Kategaonkar, S. B. Sapkal, B. R. Madje, B. B. Shingate, M. S. Shingare, Chem. Heterocycl. Compd. 2010, 46, 933-937
23. P. Cmoch, L. Stefaniak, G. A. Webb, Magn. Reson. Chem. 1997, 35, 237-242.
24. H. Fleisch, Bisphosphonates: A New Class of Drugs in Diseases of Bone and Calcium Metabolism, in Handbook of Experimental Pharmacology (Ed.:, P. F. Baker,), Vol. 83, Springer, Berlin/Heidelberg 1988, pp. 441-465.
25. F. H. M. Ebetino, D. Francis, M. J. Rogers, R. G. G. Russell, Rev. Contemp. Pharmacother. 1998, 9, 233-243.
26. T. Kitamura, M. Itoh, T. Noda, M. Matsuura, K. Wakabayashi, Int. J. Cancer 2004, 109, 576-580.
27. M. R. Boyd, K. D. Paull, Drug Dev. Res. 1995, 34, 91-109.
28. C. A. Wintar, E. A. Risley, G. W. Nuss, Proc. Soc. Exp. Biol. Med. 1962, 111, 544-547.
29. M. Di Rosa, J. P. Giroud, D. A. Willoughby, J. Pathol. 1971, 104, 15-29.
30. R. A. Nugent, S. T. Schlachter, M. Murphy, C. J. Dunn, N. D. Staite, L. A. Galinet, S. K. Shields, H. Wu, D. G. Aspar, K. A. Richard, J. Med. Chem. 1994, 37, 4449-4454.
31. R. A. Nugent, M. Murphy, S. T. Schlachter, C. J. Dunn, R. J. Smith, N. D. Staite, L. A. Galinet, S. K. Shields, D. G. Aspar, K. A. Richard, N. A. Rohloff, J. Med. Chem. 1993, 36, 134-139.
32. P. Cmoch, L. Stefaniak, G. A. Webb, Magn. Reson. Chem. 1997, 35, 237-242.
33. N. J. Datta, R. C. Khunt, A. R. Parikh, Orient. J. Chem. 2002, 18, 131-134.
34. N. M. Fathy, G. H. Elgemeie, J. Chem. Eng. Data 1988, 33, 218-219.
35. V. Tiwari, P. Ali, J. Meshram, Int. J. Chem. Tech. Res. 2010, 2, 1031-1035.