Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

Free Radical Biology and Medicine

Volumn 52, Issue 3, 2012, Pages 699-704

  Zhu, Xiongwei ^a,h   Castellani, Rudy J ^b   Moreira, Paula I ^c   Aliev, Gjumrakch ^d   Shenk, Justin C ^d   Siedlak, Sandra L ^a   Harris, Peggy L R ^a   Fujioka, Hisashi ^e   Sayre, Lawrence M ^a   Szweda, Pamela A ^f   Szweda, Luke I ^g   Smith, Mark A ^a   Perry, George ^d,h  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^g OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^h University of San Antonio   (United States)

Author keywords

fluorophore; granulovacuolar degeneration; Hirano body; hydroxynonenal; lipid peroxidation; lipofuscin; oxidative stress; protein cross linking

Indexed keywords

LIPOFUSCIN;

ADULT; AGED; ALZHEIMER DISEASE; ANTIBODY LABELING; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOELECTRON MICROSCOPY; IMMUNOREACTIVITY; LIPID STORAGE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN CROSS LINKING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALDEHYDES; ALZHEIMER DISEASE; BRAIN; CASE-CONTROL STUDIES; CYTOPLASMIC GRANULES; HUMANS; LIPID PEROXIDATION; LIPOFUSCIN; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; NERVE TISSUE PROTEINS; NEURONS; OXIDATIVE STRESS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84856283539     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.11.004     Document Type: Article

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