Structural insight into activation mechanism of Toxoplasma gondii nucleoside triphosphate diphosphohydrolases by disulfide reduction

Journal of Biological Chemistry

Volumn 287, Issue 5, 2012, Pages 3051-3066

  Krug, Ulrike ^a   Zebisch, Matthias ^a,b   Krauss, Michel ^a   Sträter, Norbert ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; ACTIVE SITE RESIDUES; ATP ANALOGS; COFACTORS; COMPLEX STRUCTURE; CONSTITUTIVELY ACTIVES; DISULFIDE BONDS; DISULFIDE REDUCTION; INTRACELLULAR PARASITES; OPEN CONFORMATION; REDUCTIVE CLEAVAGE; SEQUENCE IDENTITY; STRUCTURAL INSIGHTS; SUBSTRATE BINDING; TETRAMERS; TOXOPLASMA GONDII; TRIPHOSPHATE;

BIOMOLECULES; COVALENT BONDS; ENZYMES; OLIGOMERS;

AMINO ACIDS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; APYRASE; ARGININE; CYSTEINE; DISULFIDE; GLUTAMINE; GLYCINE; ISOENZYME; MAGNESIUM; NUCLEOSIDE TRIPHOSPHATE; TETRAMER;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; ENZYME ACTIVATION; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; HYDROGEN BOND; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR MODEL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; TOXOPLASMA GONDII;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; APOENZYMES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DISULFIDES; ENZYME ACTIVATION; MUTATION, MISSENSE; PROTOZOAN PROTEINS; PYROPHOSPHATASES; STRUCTURE-ACTIVITY RELATIONSHIP; TOXOPLASMA;

TOXOPLASMA GONDII;

EID: 84856270496     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.294348     Document Type: Article

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