Tocotrienols prevent hydrogen peroxide-induced axon and dendrite degeneration in cerebellar granule cells

Free Radical Research

Volumn 46, Issue 2, 2012, Pages 184-193

  Fukui, Koji ^a,d   Ushiki, Keisuke ^a   Takatsu, Hirokatsu ^b   Koike, Tatsuro ^c   Urano, Shiro ^a,d  

^a Department of Bioscience and Engineering   (Japan)

^b Japanese Associate Degree Program   (Malaysia)

^c HOKKAIDO UNIVERSITY   (Japan)

^d SHIBAURA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

autophagy; axon; dendrite; ROS; tocotrienol

Indexed keywords

ALPHA TOCOTRIENOL; COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; GAMMA TOCOTRIENOL; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SURVIVAL; CEREBELLUM; CEREBELLUM GRANULE NEURON; CONTROLLED STUDY; DENDRITE; GRANULE CELL; MALE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NERVE FIBER DEGENERATION; NEUROPROTECTION; NONHUMAN; WESTERN BLOTTING;

ANIMALS; AUTOPHAGY; AXONS; CELLS, CULTURED; CEREBELLUM; CHROMANS; DENDRITES; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPID PEROXIDATION; MICE; MICE, INBRED C57BL; MICROTUBULE-ASSOCIATED PROTEINS; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; PRIMARY CELL CULTURE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN E;

EID: 84856256430     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2011.647689     Document Type: Article

References (43)

1. Sies H. Oxidative stress: oxidants and antioxidants.Exp Physiol 1997;82:291-295. (Pubitemid 27182306)
2. Harman D. Aging; a theory based on free radical and radiation chemistry. J Gerontrol 1956;11(3):298-300.
3. Fukui K, Omoi N, Hayasaka T, Shinkai T, Suzuki S, Abe K, Urano S. Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E. Ann NY Acad Sci 2002;959:275-284. (Pubitemid 34457568)
4. Fukui K, Takatsu H, Shinkai T, Suzuki S, Abe K, Urano S. Appearance of amyloid beta-like substances and delayed-type apoptosis in rat hippocampus CA1 region through aging and oxidative stress. J Alzheimers Dis 2005;8:299-309.
5. Urano S, Sato Y, Otonari T, Makabe S, Suzuki S, Ogata M, Endo T. Aging and oxidative stress in neurodegeneration. Biofactors 1998;7:103-112. (Pubitemid 28073880)
6. Touma E, Kato S, Fukui K, Koike T. Calpain-mediated cleavage of collapsing response mediator protein (CRMP)-2 during neurite degeneration in mice. Eur J Neurosci 2007; 26:3368-3381. (Pubitemid 350243516)
7. 2+ chelators cause" dying-back" neurite degeneration associated with energy impairment. J Neurosci Res 2007;85:2844-2855. (Pubitemid 47523568)
8. Sies H, Stahl W, Sundquist AR. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Ann NY Acad Sci 1992;669:7-20. (Pubitemid 23009923)
9. Niki E, Noguchi N. Dynamics of antioxidant action of vitamin E. Acc Chem Res 2004;37(1):45-51.
10. Samhan-Arias AK, Tyurina YY, Kagan VE. Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation. J Clin Biochem Nutr 2011;48(1):91-95.
11. Sen CK, Rink C, Khanna S. Palm oil-derived natural vitamin E alpha-tocotrienol in brain health and disease. J Am Coll Nutr 2010;29(3 Suppl):314S-323S.
12. Miyazawa T, Shibata A, Sookwong P, Kawakami Y, EitsukaT, Asai A, Oikawa S, Nakagawa K. Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol). J Nutr Biochem 2009;20(2):79-86.
13. Frank J, Chin XW, Schrader C, Eckert GP, Rimbach G. Do tocotrienols have potential as neuroprotective dietary factors? Ageing Res Rev 2011; doi:10.1016/j.arr.2011.06.006.
14. Saito Y, Nishio K, Ogawa-Akazawa Y, Yamanaka K, Miyama A, Yoshida Y, Noguchi N, Niki E. Cytoplrotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function. Free Radic Biol Med 2010;49(10):1542-1549.
15. Noguchi N, Hanyu R, Nonaka A, Okimoto Y, Kodama T. Inhibition of THP-1 cell adheshion to endothelial cells by α-tocopherol and α-tocotrienol is dependent on intracellular concentration of the antioxidants. Free Radic Biol Med 2003; 34(12):1614-1620. (Pubitemid 36638721)
16. Wang LH, Strimatter SM. A family of rat CRMP genes is differentially expressed in the nervous system. J Neurosci 1996;16:6197-6207.
17. Fukata Y, Itoh T, Kimura T, Manager C, Nishimura T, Shiromizu T, et al. CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat Cell Biol 2002;4:583-591.
18. Yuasa-Kawada J, Suzuki R, Kano F, Ohkawara T, Murata M, Noda M. Axonal morphologenesis controlled by antagonistic roles of two CRMP subtypes in microtubule organization. Eur J Neurosci 2003;17:2329-2343. (Pubitemid 36793742)
19. Ikegami K, Koike T. Non-apoptotic neurite degeneration in apoptotic neuronal death: pivotal role of mitochondrial function in neurites. Neuroscience 2003;122:81-93.
20. Omoi NO, Arai M, Saito M, Takatsu H, Shibata A, Fukuzawa K, et al. Influence of oxidative stress on fusion of pre-synaptic plasma membranes of the rat brain with phosphatidyl choline liposomes, and protective effect of vitamin E. J Nutr Sci Vitaminol (Tokyo) 2006;52:248-255. (Pubitemid 44520052)
21. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem 1979;95:351-358. (Pubitemid 9194347)
22. Fukui K, Abe K, Urano S. Vitamin E improve cognitive defi-cit of rats caused by oxidative stress and aging. J Clin Biochem Nutri 2008;43(Suppl 1):47-50.
23. Niemann A, Takatsuki A, Elä s ser HP. Thelysosomotropic agent monodansylcadaverine also acts as a solvent polarity probe. J Histochem Cytochem 2000;48(2):251-258. (Pubitemid 30127062)
24. de Zwart LL, Meerman JH, Commandeur JN, Vermelen NP. Biomarkers of free radical damage: Applications in experimental animal and in humans. Free Radic Biol Med 1999; 26(1-2):202-228.
25. Serbinova E, Kagan VE, Han D, Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med 1991;10(5):263-275 (Pubitemid 121003898)
26. Arimura N, Menager C, Fukata Y, Kaibuchi K.Role of CRMP-2 in neuronal polarity. J Neurobiol 2004;58(1):34-47. (Pubitemid 37543336)
27. Jiang SX, Kappler J, Zurakowski B, DesboisA, Aylsworth A, Hou ST. Calpain cleavage of collapsin response mediator proteins in ischemic mouse brain. Eur J Neurosci 2007;26(4): 801-809. (Pubitemid 47274611)
28. Chrrrier E, Reibel S, Rogemond V, Aguera M, Thomasset N, Honnorat J. Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders. Mol Neurobiol 2003;28(1):51-64.
29. Inagaki N, Chihara K, Arimura N, Menager C, Kawano Y, Matsuo N, et al. CRMP-2 induces axons in cultured hippocampal neurons. Nature Neurosci 2001;4:781-782. (Pubitemid 32702507)
30. Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, et al. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J Neurochem 2007;103:1132-1144. (Pubitemid 47568734)
31. Yoshida H, Watanabe A, Ihara Y. Collapsin response mediator protein-2 is associated with neurofibrillary tangles in Alzheimer's disease. J Biol Chem 1998;273(16):9761-9768. (Pubitemid 28183069)
32. Petratos S, Li QX, George AJ, Hou X, Kerr ML, Unabia SE, et al. The β-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism. Brain 2008;131:90-108.
33. Vuaillat C, Varrin-Doyer M, Bernard A, Sagardoy I, Cavagna S, Chounlamountri I, Lafon M, Giraudon P. High CRMP2 expression in peripheral T lymphocytes is associated with recruitment to the brain during virus-induced neuroinflammation. J Neuroimmunol 2008;193(1-2):38-51.
34. Castegna A, Aksenov M, Thongboonkerd V, Klein JB, Pierce WM, Booze R, Markesbery WR, Butterfield DA. Proteomic identification of oxidativelymodificated proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heart shock cognate 71. J Neurochem 2002;82(6):1524-1532.
35. Yamada KM, Spooner BS, Wessells NK. Axon growth: roles of microfilaments and microtubules. Proc Natl Acad Sci USA 1970;66(4):1206-1212.
36. Gu Y, Ihara Y. Evidence that collapsing response mediator protein-2 is involved in the dynamics of microtubules. J Biol Chem 2000;275:17917-17920. (Pubitemid 30414732)
37. Chae YC, Lee S, Heo K, Ha SH, Jung Y, Kim JH, Ihara Y, Suh PG, Ryu SH. (2009). Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity, Cell Signal, 21(12), 1818-1826.
38. Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, et al. Semaphorin3A signaling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP-2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimr's disease. Gene Cell 2005;10(2): 165-179. (Pubitemid 40287519)
39. Yang Y, Fukui K, Koike T, Zheng X. Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons. Eur J Neurosci 2007;26:2979-2988. (Pubitemid 350115519)
40. Ma Q, Qiang J, Gu P, Wang Y, Geng Y, Wang M. Age-related autophagy alterations in thebrain of senescence accelerated mouse prone 8 (SAMP8) mice. Exp Gerontol 2011;46(7): 533-541.
41. Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD. Promoting basa l levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult drosophila. Autophagy 2008;4(2): 176-184. (Pubitemid 351231181)
42. Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, et al. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and Alzheimer's disease.Proc Natl Acad Sci USA 2010;107(32):14164-14169.
43. C uervo AM. Autophagy and aging: keeping that old broom working. Trends Genet 2008;24(12):604-612.