Effects of bosentan on nondigital ulcers in patients with systemic sclerosis

British Journal of Dermatology

Volumn 166, Issue 2, 2012, Pages 417-421

  Taniguchi, T ^a   Asano, Y ^a   Hatano, M ^a   Tamaki, Z ^a   Tomita, M ^a   Kawashima, T ^a   Miyazaki, M ^a   Sumida, H ^a   Akamata, K ^a   Takahashi, T ^a   Ichimura, Y ^a   Toyama, T ^a   Sugita, M ^a   Noda, S ^a   Yao, A ^a   Kinugawa, K ^a   Sato, S ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BOSENTAN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CYANOSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; FEMALE; FOLLOW UP; FOOT ULCER; GANGRENE; HUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SKIN NECROSIS; SKIN ULCER; STENOSIS; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS; TREATMENT DURATION; WOUND HEALING;

ADULT; AGED; AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; DERMATOLOGIC AGENTS; FEMALE; FOOT ULCER; HUMANS; HYPERTENSION, PULMONARY; MIDDLE AGED; OFF-LABEL USE; SCLERODERMA, SYSTEMIC; SULFONAMIDES; TREATMENT OUTCOME; WOUND HEALING;

EID: 84856236005     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2011.10581.x     Document Type: Article

References (15)

1. Asano Y,. Future treatments in systemic sclerosis. J Dermatol 2010; 37: 54-70.
2. Steen VD, Medsger TA,. The value of the Health Assessment Questionnaire and special patient-generated scales to demonstrate change in systemic sclerosis patients over time. Arthritis Rheum 1997; 40: 1984-91.
3. Korn JH, Mayes M, Matucci-Cerinic M, et al. Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist. Arthritis Rheum 2004; 50: 3985-93.
4. Matucci-Cerinic M, Denton CP, Furst DE, et al. Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 2011; 70: 32-8.
5. Ferreira ME, Scheinberg MA,. Successful treatment with bosentan of non-digital skin ulcers in severe scleroderma. Ann Rheum Dis 2008; 67: 1784-5.
6. Ichimura Y, Asano Y, Hatano M, et al. Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene. Mod Rheumatol 2011; 21: 548-52.
7. Cambrey AD, Harrison NK, Dawes KE, et al. Increased levels of endothelin-1 in bronchoalveolar lavage fluid from patients with systemic sclerosis contribute to fibroblast mitogenic activity in vitro. Am J Respir Cell Mol Biol 1994; 11: 439-45.
8. Shi-Wen X, Chen Y, Denton CP, et al. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell 2004; 15: 2707-19.
9. Yang Z, Krasnici N, Lüscher TF,. Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade. Circulation 1999; 100: 5-8.
10. Iannone F, Riccardi MT, Guiducci S, et al. Bosentan regulates the expression of adhesion molecules on circulating T cells and serum soluble adhesion molecules in systemic sclerosis-associated pulmonary arterial hypertension. Ann Rheum Dis 2008; 67: 1121-6.
11. Fonseca C, Abraham D, Renzoni EA,. Endothelin in pulmonary fibrosis. Am J Respir Cell Mol Biol 2011; 44: 1-10.
12. Vancheeswaran R, Magoulas T, Efrat G, et al. Circulating endothelin-1 levels in systemic sclerosis subsets-a marker of fibrosis or vascular dysfunction? J Rheumatol 1994; 21: 1838-44.
13. Castañares C, Redondo-Horcajo M, Magán-Marchal N, et al. Signaling by ALK5 mediates TGF-β-induced ET-1 expression in endothelial cells: a role for migration and proliferation. J Cell Sci 2007; 120: 1256-66.
14. Oberringer M, Meins C, Bubel M, et al. In vitro wounding: effects of hypoxia and transforming growth factor β1 on proliferation, migration and myofibroblastic differentiation in an endothelial cell-fibroblast co-culture model. J Mol Histol 2008; 39: 37-47.
15. Lagares D, García-Fernández RA, Jiménez CL, et al. Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis. Arthritis Rheum 2010; 62: 878-89.