Bosentan regulates the expression of adhesion molecules on circulating T cells and serum soluble adhesion molecules in systemic sclerosis-associated pulmonary arterial hypertension

Annals of the Rheumatic Diseases

Volumn 67, Issue 8, 2008, Pages 1121-1126

  Iannone, F ^a   Riccardi, M T ^a   Guiducci, S ^b   Bizzoca, R ^a   Cinelli, M ^b   Matucci Cerinic, M ^b   Lapadula, G ^a,c  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c POLICLINICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BOSENTAN; CD31 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PADGEM PROTEIN; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4; VON WILLEBRAND FACTOR;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; DISEASE ASSOCIATION; DOPPLER ECHOCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOFLUORESCENCE; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; SYSTEMIC SCLEROSIS; T LYMPHOCYTE; TREATMENT DURATION;

ADULT; AGED; ANALYSIS OF VARIANCE; ANTIBODIES, ANTINUCLEAR; ANTIGENS, CD3; ANTIHYPERTENSIVE AGENTS; AUTOANTIBODIES; CASE-CONTROL STUDIES; CELL ADHESION MOLECULES; CENTROMERE; ENDOTHELIN-1; FEMALE; HUMANS; HYPERTENSION, PULMONARY; INTEGRIN ALPHA4BETA1; L-SELECTIN; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MALE; MIDDLE AGED; SCLERODERMA, SYSTEMIC; SULFONAMIDES; T-LYMPHOCYTES;

EID: 47949095665     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2007.080424     Document Type: Article

References (24)

1. Abraham DJ, Varga J. Scleroderma: from cell and molecular mechanisms to disease models. Trends Immunol 2005;26:587-95.
2. Springer TA. Adhesion receptors of the immune system. Nature 1990;346:425-34.
3. Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S. Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: relationship to organ systemic involvement. Clin Rheumatol 2005;24:111-6.
4. Galie N, Manes A, Branzi A. The endothelin system in pulmonary arterial hypertension. Cardiovasc Res 2004;61:227-37.
5. Davenport AP, Maguire JJ. Endothelin. Handb Exp Pharmacol 2006;295-329.
6. Runo JR, Loyd JE. Primary pulmonary hypertension. Lancet 2003;361:1533-44.
7. Rubin LJ, Badesch DB, Barst RJ, Galie N, Black CM, Keogh A, et al. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 2002;346:896-903.
8. LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA Jr, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988;15:202-5.
9. Williams MH, Das C, Handler CE, Akram MR, Davar J, Denton CP, et al. Systemic sclerosis associated pulmonary hypertension: improved survival in the current era. Heart 2006;92:926-32.
10. Jimenez SA, Derk CT. Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis. Ann Intern Med 2004;140:37-50.
11. Sackstein R. The lymphocyte homing receptors: gatekeepers of the multistep paradigm. Curr Opin Hematol 2005;12:444-50.
12. Shahin AA, Anwar S, Elawar AH, Sharaf AE, Hamid MA, Eleinin AA, et al. Circulating soluble adhesion molecules in patients with systemic sclerosis: correlation between circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) and impaired left ventricular diastolic function. Rheumatol Int 2000;20:21-4.
13. Ihn H, Sato S, Fujimoto M, Takehara K, Tamaki K. Increased serum levels of soluble vascular cell adhesion molecule-1 and E-selectin in patients with systemic sclerosis. Br J Rheumatol 1998;37:1188-92.
14. Denton CP, Bickerstaff MC, Shiwen X, Carulli MT, Haskard DO, Dubois RM, et al. Serial circulating adhesion molecule levels reflect disease severity in systemic sclerosis. Br J Rheumatol 1995;34:1048-54.
15. Kiener H, Graninger W, Machold K, Aringer M, Graninger WB. Increased levels of circulating intercellular adhesion molecule-1 in patients with systemic sclerosis. Clin Exp Rheumatol 1994;12:483-7.
16. Carson CW, Beall LD, Hunder GG, Johnson CM, Newman W. Serum ELAM-1 is increased in vasculitis, scleroderma, and systemic lupus erythematosus. J Rheumatol 1993;20:809-14.
17. Blann AD, Constans J, Carpentier P, Renard M, Satger B, Guerin V, et al. Soluble P selectin in systemic sclerosis: relationship with von Willebrand factor, autoantibodies and diffuse or localised/limited disease. Thromb Res 2003;109:203-6.
18. Scheja A, Akesson A, Geborek P, Wildt M, Wollheim CB, Wollheim FA, et al. Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma). Arthritis Res 2001;3:178-82.
19. Blann AD, Illingworth KJ, Jayson MI. Raised concentrations of von Willebrand factor antigen in systemic sclerosis. Ann Rheum Dis 1991;50:337-8.
20. Channick RN, Simonneau G, Sitbon O, Robbins IM, Frost A, Tapson VF, et al. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet 2001;358:1119-23.
21. Sfikakis PP, Papamichael C, Stamatelopoulos KS, Tousoulis D, Fragiadaki KG, Katsichti P, et al. Improvement of vascular endothelial function using the oral endothelin receptor antagonist bosentan in patients with systemic sclerosis. Arthritis Rheum 2007;56:1985-93.
22. Zouki C, Baron C, Fournier A, Filep JG. Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ET(A) receptors and platelet-activating factor. Br J Pharmacol 1999;127:969-79.
23. Xu SW, Denton CP, Dashwood MR, Abraham DJ, Black CM. Endothelin-1 regulation of intercellular adhesion molecule-1 expression in normal and sclerodermal fibroblasts. J Cardiovasc Pharmacol 1998;31(Suppl 1):S545-7.
24. Waters CE, Shi-Wen X, Denton CP, Abraham DJ, Pearson JD. Signaling pathways regulating intercellular adhesion molecule 1 expression by endothelin 1: comparison with interleukin-1β in normal and scleroderma dermal fibroblasts. Arthritis Rheum 2006;54:649-60.