The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

European Journal of Cancer

Volumn 48, Issue 3, 2012, Pages 396-406

  Hernlund, Emma ^a   Olofsson, Maria Hägg ^a   Fayad, Walid ^a   Fryknäs, Mrten ^b   Lesiak Mieczkowska, Karolina ^a   Zhang, Xiaonan ^a   Brnjic, Slavica ^a   Schmidt, Vivien ^a   D'Arcy, Padraig ^a   Sjöblom, Tobias ^c   Milito, Angelo De ^a   Larsson, Rolf ^b   Linder, Stig ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Cancer therapy; mTOR; NVP BEZ235; PI3K; Regrowth resistance

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; BORTEZOMIB; CASPASE 3; CISPLATIN; DOXORUBICIN; ETOPOSIDE; INITIATION FACTOR 4E BINDING PROTEIN 1; K RAS PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; PROTEIN P53; UBIQUITIN; VINBLASTINE;

ALLELE; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE ARREST; CELL PROLIFERATION; COLON CARCINOMA; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MONOLAYER CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; WESTERN BLOTTING; WILD TYPE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; FLOW CYTOMETRY; HUMANS; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; PHOSPHATIDYLINOSITOL 3-KINASES; QUINOLINES; TUMOR CELLS, CULTURED;

EID: 84856235027     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2011.11.013     Document Type: Article

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