An abundant, truncated human sulfonylurea receptor 1 splice variant has prodiabetic properties and impairs sulfonylurea action

Cellular and Molecular Life Sciences

Volumn 69, Issue 1, 2012, Pages 129-148

  Schmid, Diethart ^a   Stolzlechner, Michael ^a   Sorgner, Albin ^a   Bentele, Caterina ^a   Assinger, Alice ^a   Chiba, Peter ^a   Moeslinger, Thomas ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Alterative splicing; ATP sensitive potassium channels; Glibenclamide; Glucose induced insulin release; Sulfonylurea receptor

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM; COMPLEMENTARY DNA; GLIBENCLAMIDE; GLUCOSE; INSULIN; MESSENGER RNA; SULFONYLUREA; SULFONYLUREA RECEPTOR 1;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CELL SURFACE; CONTROLLED STUDY; DIABETES MELLITUS; EXON; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; IN VITRO STUDY; INSULIN RELEASE; INSULINOMA; NONHUMAN; PATCH CLAMP; PREDICTION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RECEPTOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SULFONYLUREA RECEPTOR 1 GENE; TUMOR CELL; WESTERN BLOTTING;

ALTERNATIVE SPLICING; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CALCIUM; CERCOPITHECUS AETHIOPS; COS CELLS; DIABETES MELLITUS, TYPE 2; EXONS; GLYBURIDE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; KATP CHANNELS; MYOCARDIUM; ORGAN SPECIFICITY; PANCREAS; POLYMORPHISM, SINGLE NUCLEOTIDE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RECEPTORS, DRUG; RNA, MESSENGER; SPECIES SPECIFICITY;

RATTUS;

EID: 84856232078     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0739-x     Document Type: Article

References (49)

1. A Noma 1983 ATP-regulated K+ channels in cardiac muscle Nature 305 147 148 6310409 10.1038/305147a0 1:CAS:528:DyaL3sXltlOnurk%3D
2. N Venkatesh ST Lamp JN Weiss 1991 Sulfonylureas, ATP-sensitive K+ channels, and cellular K+ loss during hypoxia, ischemia, and metabolic inhibition in mammalian ventricle Circ Res 69 3 623 637 1908355 1:CAS:528:DyaK3MXmtVCrt7o%3D
3. P Rorsman 1997 The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint Diabetologia 40 5 487 495 9165215 10.1007/s001250050706 1:CAS:528:DyaK2sXjtVOrsLc%3D (Pubitemid 27186783)
4. S Seino T Miki 2003 Physiological and pathophysiological roles of ATP-sensitive K+ channels Prog Biophys Mol Biol 81 2 133 176 12565699 10.1016/S0079-6107(02)00053-6 1:CAS:528:DC%2BD3sXotlOhsA%3D%3D (Pubitemid 36141258)
5. AP Babenko L Aguilar Bryan J Bryan 1998 A view of sur/KIR6.X, KATP channels Annu Rev Physiol 60 667 687 9558481 10.1146/annurev.physiol.60.1.667 1:CAS:528:DyaK1cXitVOhsbk%3D (Pubitemid 28157891)
6. J Bryan A Munoz X Zhang M Dufer G Drews P Krippeit-Drews L Aguilar-Bryan 2007 ABCC8 and ABCC9: ABC transporters that regulate K+ channels Pflugers Arch 453 5 703 718 16897043 10.1007/s00424-006-0116-z 1:CAS:528:DC%2BD2sXhtFWjt7w%3D (Pubitemid 46192541)
7. WA Chutkow MC Simon MM Le Beau CF Burant 1996 Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels Diabetes 45 10 1439 1445 8826984 10.2337/diabetes.45.10.1439 1:CAS:528:DyaK28XmtFCnt7s%3D (Pubitemid 26332911)
8. WA Chutkow JC Makielski DJ Nelson CF Burant Z Fan 1999 Alternative splicing of sur2 exon 17 regulates nucleotide sensitivity of the ATP-sensitive potassium channel J Biol Chem 274 19 13656 13665 10224138 10.1074/jbc.274.19. 13656 1:CAS:528:DyaK1MXjtFOksLw%3D (Pubitemid 29220508)
9. L Gros S Trapp M Dabrowski FM Ashcroft D Bataille P Blache 2002 Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31 Br J Pharmacol 137 1 98 106 12183335 10.1038/sj.bjp.0704836 1:CAS:528:DC%2BD38XmslCltLY%3D (Pubitemid 34983468)
10. A Hambrock R Preisig-Muller U Russ A Piehl PJ Hanley J Ray J Daut U Quast C Derst 2002 Four novel splice variants of sulfonylurea receptor 1 Am J Physiol Cell Physiol 283 2 C587 C598 12107069 1:CAS:528:DC%2BD38XmslSgsrw%3D
11. PA Brady A Terzic 1998 The sulfonylurea controversy: more questions from the heart J Am Coll Cardiol 31 5 950 956 9561992 10.1016/S0735-1097(98)00038-2 1:STN:280:DyaK1c3itVCmuw%3D%3D (Pubitemid 28212491)
12. R Ashfield FM Gribble SJ Ashcroft FM Ashcroft 1999 Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel Diabetes 48 6 1341 1347 10342826 10.2337/diabetes.48.6.1341 1:CAS:528: DyaK1MXjsFSgt7w%3D (Pubitemid 29241036)
13. JW Elrod M Harrell TP Flagg S Gundewar MA Magnuson CG Nichols WA Coetzee DJ Lefer 2008 Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury Circulation 117 11 1405 1413 18316485 10.1161/CIRCULATIONAHA.107.745539 1:CAS:528: DC%2BD1cXivFynsrY%3D (Pubitemid 351501493)
14. M Gopalakrishnan DE Johnson RA Janis DJ Triggle 1991 Characterization of binding of the ATP-sensitive potassium channel ligand, [3H]glyburide, to neuronal and muscle preparations J Pharmacol Exp Ther 257 3 1162 1171 1904493 1:CAS:528:DyaK3MXlsFSis7c%3D
15. K Hussain KE Cosgrove 2005 From congenital hyperinsulinism to diabetes mellitus: the role of pancreatic beta-cell KATP channels Pediatr Diabetes 6 2 103 113 15963039 10.1111/j.1399-543X.2005.00109.x (Pubitemid 40916645)
16. H Huopio F Reimann R Ashfield J Komulainen HL Lenko J Rahier I Vauhkonen J Kere M Laakso F Ashcroft T Otonkoski 2000 Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1 J Clin Invest 106 7 897 906 11018078 10.1172/JCI9804 1:CAS:528:DC%2BD3cXntVyhsrw%3D
17. SE Flanagan S Clauin C Bellanne-Chantelot P de Lonlay LW Harries AL Gloyn S Ellard 2009 Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism Hum Mutat 30 2 170 180 18767144 10.1002/humu.20838 1:CAS:528:DC%2BD1MXjtFKmsLw%3D
18. OP Hamill A Marty E Neher B Sakmann FJ Sigworth 1981 Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches Pflugers Arch 391 2 85 100 6270629 10.1007/BF00656997 1:STN:280:DyaL38%2FjslWrug%3D%3D (Pubitemid 11012976)
19. T Klapperstuck D Glanz M Klapperstuck J Wohlrab 2009 Methodological aspects of measuring absolute values of membrane potential in human cells by flow cytometry Cytometry A 75 7 593 608 19504578
20. S Mittman J Guo WS Agnew 1999 Structure and alternative splicing of the gene encoding alpha1G, a human brain T calcium channel alpha1 subunit Neurosci Lett 274 3 143 146 10548410 10.1016/S0304-3940(99)00716-8 1:CAS:528: DyaK1MXmsFartb4%3D (Pubitemid 29462532)
21. CM Malboeuf SJ Isaacs NH Tran B Kim 2001 Thermal effects on reverse transcription: improvement of accuracy and processivity in cDNA synthesis Biotechniques 30 5 1074 1078 11355343 1:CAS:528:DC%2BD3MXjsVeltbw%3D 1080, 1082, passim
22. DT Jones 1999 Protein secondary structure prediction based on position-specific scoring matrices J Mol Biol 292 2 195 202 10493868 10.1006/jmbi.1999.3091 1:CAS:528:DyaK1MXlvFyksb0%3D (Pubitemid 29435759)
23. C Wu C Orozco J Boyer M Leglise J Goodale S Batalov CL Hodge J Haase J Janes JW Huss 3rd AI Su 2009 BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources Genome Biol 10 11 R130 19919682 10.1186/gb-2009-10-11-r130
24. S Brunak J Engelbrecht S Knudsen 1991 Prediction of human mRNA donor and acceptor sites from the DNA sequence J Mol Biol 220 1 49 65 2067018 10.1016/0022-2836(91)90380-O 1:CAS:528:DyaK3MXlt1yqs7Y%3D (Pubitemid 121004542)
25. E Hough DJ Beech A Sivaprasadarao 2000 Identification of molecular regions responsible for the membrane trafficking of Kir6.2 Pflugers Arch 440 3 481 487 10954336 10.1007/s004240000311 1:CAS:528:DC%2BD3cXjvFCgu78%3D (Pubitemid 30445723)
26. FM Gribble R Ashfield C Ammala FM Ashcroft 1997 Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes J Physiol 498 Pt 1 87 98 9023770 1:CAS:528:DyaK2sXmslGkug%3D%3D (Pubitemid 27056881)
27. L Li A Rojas J Wu C Jiang 2004 Disruption of glucose sensing and insulin secretion by ribozyme Kir6.2-gene targeting in insulin-secreting cells Endocrinology 145 9 4408 4414 15166124 10.1210/en.2004-0285 1:CAS:528: DC%2BD2cXnt1Citbo%3D (Pubitemid 39120591)
28. M Hussain AC Wareham 1994 Rundown and reactivation of ATP-sensitive potassium channels (KATP) in mouse skeletal muscle J Membr Biol 141 3 257 265 7807525 1:CAS:528:DyaK2cXmt1Ojur0%3D (Pubitemid 24305247)
29. R Ashfield SJ Ashcroft 1998 Cloning of the promoters for the beta-cell ATP-sensitive K-channel subunits Kir6.2 and SUR1 Diabetes 47 8 1274 1280 9703328 10.2337/diabetes.47.8.1274 1:CAS:528:DyaK1cXltFyrt7o%3D (Pubitemid 28357005)
30. M Curley MT Cairns AM Friel OM McMeel JJ Morrison TJ Smith 2002 Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium Mol Hum Reprod 8 10 941 945 12356945 10.1093/molehr/8.10.941 1:CAS:528:DC%2BD38XovFWnsb4%3D (Pubitemid 35174929)
31. JM Haynes AL Cook 2006 Protein kinase G-induced activation of K(ATP) channels reduces contractility of human prostate tissue Prostate 66 4 377 385 16302263 10.1002/pros.20355 1:CAS:528:DC%2BD28XivVCktbc%3D (Pubitemid 43346948)
32. JJ Acevedo I Mendoza-Lujambio JL de la Vega-Beltran CL Trevino R Felix A Darszon 2006 KATP channels in mouse spermatogenic cells and sperm, and their role in capacitation Dev Biol 289 2 395 405 16343479 10.1016/j.ydbio.2005.11.002 1:CAS:528:DC%2BD28XksVGqtQ%3D%3D (Pubitemid 43049942)
33. Bardou O, Trinh NT, Brochiero E (2009) Molecular diversity and function of K+ channels in airway and alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 296(2):145-155
34. AJ Matlin F Clark CW Smith 2005 Understanding alternative splicing: towards a cellular code Nat Rev Mol Cell Biol 6 5 386 398 15956978 10.1038/nrm1645 1:CAS:528:DC%2BD2MXjvF2jsbo%3D (Pubitemid 40637856)
35. L Cartegni J Wang Z Zhu MQ Zhang AR Krainer 2003 ESE finder: a web resource to identify exonic splicing enhancers Nucleic Acids Res 31 13 3568 3571 12824367 10.1093/nar/gkg616 1:CAS:528:DC%2BD3sXltVWisLw%3D (Pubitemid 37442199)
36. Y Sakamoto H Inoue P Keshavarz K Miyawaki Y Yamaguchi M Moritani K Kunika N Nakamura T Yoshikawa N Yasui H Shiota T Tanahashi M Itakura 2007 SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population J Hum Genet 52 10 781 793 17823772 10.1007/s10038-007-0190-x 1:CAS:528:DC%2BD2sXhtFSrsrvO (Pubitemid 47512860)
37. J Aittoniemi C Fotinou TJ Craig H de Wet P Proks FM Ashcroft 2009 Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator Philos Trans R Soc Lond B Biol Sci 364 1514 257 267 18990670 10.1098/rstb.2008.0142 1:CAS:528:DC%2BD1MXivFSltLk%3D
38. M Winkler D Stephan S Bieger P Kuhner F Wolff U Quast 2007 Testing the bipartite model of the sulfonylurea receptor binding site: binding of A-, B-, and A + B-site ligands J Pharmacol Exp Ther 322 2 701 708 17495126 10.1124/jpet.107.123224 1:CAS:528:DC%2BD2sXoslSjur8%3D (Pubitemid 47105784)
39. MV Mikhailov EA Mikhailova SJ Ashcroft 2001 Molecular structure of the glibenclamide binding site of the beta-cell K(ATP) channel FEBS Lett 499 1-2 154 160 11418131 10.1016/S0014-5793(01)02538-8 1:CAS:528:DC%2BD3MXksVGksbg%3D (Pubitemid 32539340)
40. WH Vila-Carriles G Zhao J Bryan 2007 Defining a binding pocket for sulfonylureas in ATP-sensitive potassium channels Faseb J 21 1 18 25 17110465 10.1096/fj.06-6730hyp 1:CAS:528:DC%2BD2sXmvFeqtw%3D%3D (Pubitemid 46061354)
41. N Zerangue B Schwappach YN Jan LY Jan 1999 A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels Neuron 22 3 537 548 S0896-6273(00)80708-4[pii] 10197533 10.1016/S0896-6273(00)80708-4 1:CAS:528:DyaK1MXit1emtrg%3D (Pubitemid 29159852)
42. KW Chan H Zhang DE Logothetis 2003 N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits EMBO J 22 15 3833 3843 12881418 10.1093/emboj/cdg376 1:CAS:528:DC%2BD3sXlsl2ks7o%3D (Pubitemid 36975711)
43. S Shyng T Ferrigni CG Nichols 1997 Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor J Gen Physiol 110 6 643 654 9382893 10.1085/jgp.110.6.643 1:CAS:528:DyaK2sXnvFGhs74%3D (Pubitemid 27524605)
44. NE Lepor 2004 Diabetes mellitus. The sulfonylurea controversy: friend or foe? Rev Cardiovasc Med 5 2 134 135 15184844
45. PA Brady A Jovanovic 2003 The sulfonylurea controversy: much ado about nothing or cause for concern? J Am Coll Cardiol 42 6 1022 1025 13678924 10.1016/S0735-1097(03)00897-0 (Pubitemid 37108587)
46. M Suzuki N Sasaki T Miki N Sakamoto Y Ohmoto-Sekine M Tamagawa S Seino E Marban H Nakaya 2002 Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice J Clin Invest 109 4 509 516 11854323 1:CAS:528:DC%2BD38XhsVSkt70%3D (Pubitemid 34171782)
47. A Jovanovic S Jovanovic E Lorenz A Terzic 1998 Recombinant cardiac ATP-sensitive K+ channel subunits confer resistance to chemical hypoxia-reoxygenation injury [see comments] Circulation 98 15 1548 1555 9769309 1:CAS:528:DyaK1cXntFSkt7s%3D (Pubitemid 28481672)
48. M Dufer D Haspel P Krippeit-Drews L Aguilar-Bryan J Bryan G Drews 2009 Activation of the Na+/K+ -ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells Pflugers Arch 457 6 1351 1360 18836740 10.1007/s00424-008-0592-4 1:STN:280:DC%2BD1M3gtlSqsA%3D%3D
49. DS Bell MS Mayo 1998 Improved glycemic control with use of oral hypoglycemic therapy with or without insulin Endocr Pract 4 2 82 85 15251750 1:STN:280:DC%2BD2czkvVersg%3D%3D