A review of current smoke constituent measurement activities and aspects of yield variability

Regulatory Toxicology and Pharmacology

Volumn 62, Issue 1, 2012, Pages 202-213

  Purkis, Stephen W ^a   Meger, Michael ^b   Wuttke, Roland ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b JT International SA   (Switzerland)

Author keywords

Cigarettes; Regulation; Reproducibility; Smoke constituents; Testing; Tobacco

Indexed keywords

CHEMICAL COMPOUND;

ANALYTIC METHOD; ARTICLE; CHEMICAL ANALYSIS; CIGARETTE SMOKING; ENVIRONMENTAL MONITORING; EUROPEAN UNION; GOVERNMENT REGULATION; HUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; STANDARDIZATION; TOBACCO INDUSTRY;

AIR POLLUTANTS; ENVIRONMENTAL MONITORING; GOVERNMENT REGULATION; LABORATORIES; REPRODUCIBILITY OF RESULTS; TOBACCO SMOKE POLLUTION;

NICOTIANA TABACUM;

EID: 84856227767     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.10.006     Document Type: Article

References (74)

1. AOAC, 2002. Appendix D; Guidelines for collaborative study procedures to validate characteristics of a method of analysis. AOAC Official Methods Program 78 (5). (accessed May 2011). http://www.aoac.org/Official_Methods/Collaborative_Study_Validation_Guidelines.pdf.
2. Australian Government, 2001. Cigarette emissions data. Department of Health and Ageing. (accessed April 2011). http://www.health.gov.au/internet/main/publishing.nsf/Content/tobacco-emis.
3. Baker R. The development and significance of standards for smoking-machine methodology. Beiträge Tabakforsch Int. 2002, 20(1):23-41.
4. Borgerding, M.F., Bodnar, J.A., Wingate, D.E., 2000a. The 1999 Massachusetts benchmark study - Final Report: presented to the Massachusetts Department of Public Health. (accessed April 2011). http://legacy.library.ucsf.edu/tid/yek21c00.
5. Borgerding, M.F., Cohen, N., Massey, S.R., Thomas, D.R.E. in consultation with Kaiserman, M.J. and Rickert, W.S. 2000b. The 1999 Canadian Benchmark Study. Provided to Health Canada on May 24, 2000.
6. Borgerding M., Klus H. Analysis of complex mixtures - cigarette smoke. Exp. Toxicol. Pathol. 2005, 57:43-73.
7. Brazilian National Health Surveillance Agency, 2007. RDC No. 90 (2007) and its amendments.
8. Chen P.X., Moldoveanu S.C. Mainstream smoke chemical analyses for 2R4F Kentucky reference cigarette. Beiträge Tabakforsch Int. 2003, 20:448-458.
9. Chepiga T., Morton M., Murphy P., Avalos J., Bombick B., Doolittle D., Borgerding M., Swauger J. A comparison of the mainstream smoke chemistry and mutagenicity of a representative sample of the US cigarette market with two Kentucky reference cigarettes (K1R4F and K1R5F). Food Chem. Toxicol. 2000, 38:949-962.
10. Commonwealth of Massachusetts, 1997. Tobacco disclosure act. General laws of Massachusetts, Chapter 94, Section 307B 105 CMR 660.000, Cigarette and smokeless tobacco products: Reports of added constituents and nicotine ratings.
11. CORESTA, 2004. Recommended method 58. Determination of benzo[a]pyrene in cigarette mainstream smoke - gas chromatography - mass spectrometry method. (accessed April 2011). http://www.coresta.org/Recommended_Methods/CRM_58.pdf.
12. CORESTA, 2005. Recommended method 63.Determination of tobacco-specific nitrosamines in cigarette mainstream smoke - GC-TEA method. (accessed April 2011). http://www.coresta.org/Recommended_Methods/CRM_63.pdf.
13. CORESTA, 2009. CORESTA Approved Monitor No. 6 (CM6): use and conditions. (accessed May 2011). http://www.coresta.org/CM6/CM6_Use&Conditions-Oct2009.pdf.
14. CORESTA, 2010. Recommended method 70. Determination of selected volatile organic compounds in the mainstream smoke of cigarettes - gas chromatography-mass spectrometry method (accessed April 2011). http://www.coresta.org/Recommended_Methods/CRM_70.pdf.
15. Committees on toxicity, carcinogenicity, mutagenicity of chemicals in food, consumer products and the environment (COT, COC, COM), 2004. Joint statement on the re-assessment of the toxicological testing of tobacco products. p4 (accessed April 2011). http://cot.food.gov.uk/pdfs/cotstatementtobacco0409.
16. Counts M.E., Hsu F.S., Laffoon S.W., Dwyer R.W., Cox R.H. Mainstream smoke constituent yields and predicting relationships from a worldwide market sample of cigarette brands: ISO smoking conditions. Regul. Toxicol. Pharmacol. 2004, 39:111-134.
17. Counts M.E., Morton M.J., Laffoon S.W., Cox R.H., Lipowicz P.J. Smoke composition and predicting relationships for international commercial cigarettes smoked with three machine-smoking conditions. Regul. Toxicol. Pharmacol. 2005, 41:185-227.
18. Darrall K., Figgins J., Brown R., Phillips G. Determination of benzene and associated volatile compounds in mainstream cigarette smoke. Analyst 1998, 123:1095-1101.
19. European Commission Directive, 2001. On the approximation of the laws, regulations and administrative provisions of the Member States concerning the manufacture, presentation and sale of tobacco products; 2001/37/EC of the European Parliament and of the Council June 5th.
20. European Commission, 2007. Cigarette yield measurement and some basic steps for laboratory approval - practical guide September 11th. (accessed May 2011). http://ec.europa.eu/health/ph_determinants/life_style/Tobacco/Documents/best_practices_en.pdf.
21. Federal Trade Commission, 1967. Cigarettes: testing for tar and nicotine content. 32 Fed. Register 11, 178.
22. Food and Drug Administration, 2009. The Family Smoking Prevention and Tobacco Control Act, HR 1256, Section 904 (e). http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/TobaccoProductsScientificAdvisoryCommittee/UCM204339.pdf.
23. Framework Convention for Tobacco Control, 2008. Elaboration of guidelines for the implementation of Articles 9 and 10 of the Framework Convention on Tobacco Control, Progress Report of the Working Group. FCTC/COP/3/6 August 21st. (accessed April 2011). http://apps.who.int/gb/fctc/PDF/cop3/FCTC_COP3_6-en.pdf.
24. Froggatt, P., 1988. Fourth Report of the Independent Scientific Committee on Smoking and Health, HMSO.
25. Gray N., Boyle P. The case of the disappearing nitrosamines: a potentially global phenomenon. Tobacco Control 2004, 13:13-16.
26. Gregg E., Hill C., Hollywood M., Kearney M., McAdam K., McLaughlin D., Purkis S.W., Williams M. The UK smoke constituents testing study. Summary of results and comparison with other studies. Beiträge zur Tabakforsch. Int. 2004, 21:117-138.
27. Hahn J., Heller W.-D. Determination of carbon monoxide in cigarette smoke - problems in evaluating results. Deutsche Lebensmittel Rundschau 2002, 98(5):165-169.
28. Health Canada, 1999a. Determination of " tar" , nicotine and carbon monoxide in mainstream tobacco smoke. (accessed May 2011). http://www.hc-sc.gc.ca/hc-ps/tobac-tabac/legislation/reg/indust/method/_main-principal/nicotine-eng.php.
29. Health Canada, 1999b, Health Canada methods. (accessed May 2011). http://www.hc-sc.gc.ca/hc-ps/tobac-tabac/legislation/reg/indust/method/index-eng.php#main.
30. Health Canada, 2005. Tobacco Reporting Regulations (TTR) (2000) and its amendments (2005). (accessed August 2011). http://www.hc-sc.gc.ca/hc-ps/tobac-tabac/legislation/reg/indust/index-eng.php.
31. Higby, R., 2010. Acceptable analytical methods for assessing the quantity of each constituent. Comments presented at the Tobacco Products Constituents Subcommittee of the Tobacco Products Scientific Advisory Committee Galthersburg, MD June 8th. (accessed April 2011). http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/TobaccoProductsScientificAdvisoryCommittee/UCM222981.pdf.
32. Hoffmann D., Hoffmann I. The changing cigarette: chemical studies and bioassays. Risks associated with smoking cigarettes with low machine-measured yield of tar and nicotine 2001, 159-191. National Institute of Health, Bethesda MD.
33. Hsu, F., Whidby, J.F., McVeety, B.D., Moore, N.H., Westerberg, R.B., Karnes, H.T., Bolton, S., 1999. Inter-laboratory analytical methods comparison. Tobacco Science Research Conference, Montreal, Paper 33. (accessed April 2011). http://legacy.library.ucsf.edu/tid/bbx55c00.
34. Hyodo, T., Inoue, O., Katagiri, H., Mikita, A., Fujiwara, M., 2006. Long term inter-laboratory comparisons of selected smoke analysis in 2R4F mainstream smoke; CORESTA Congress Paper SS7. http://www.coresta.org/Past_Abstracts/Paris2006-SmokeTech-Oct06.pdf.
35. Hyodo T., Maruta Y., Itaya H., Mikita A., Kodera T., Meger M. Evaluation of functional relationships for predicting mainstream smoke constituent machine yields for conventional cigarettes from the Japanese market. Regul. Toxicol. Pharmacol. 2007, 48:194-224.
36. International Agency for Research on Cancer (IARC), 2004. Monographs on the Evaluation of Carcinogenic Risk to Humans (vol. 83(1), pp. 1-1546). In: Tobacco Smoke and Involuntary Smoking. World Health Organization, Geneva.
37. Intorp M., Purkis S.W., Whittaker M.W., Wright W. Determination of " Hoffmann analytes" in cigarette mainstream smoke. The CORESTA 2006 collaborative study. Beiträge Tabakforsch Int. 2009, 23:161-202.
38. ISO 3402, 1999. Tobacco and tobacco products - atmosphere for conditioning and testing, fourth ed., International Organization for Standardization, Geneva, Switzerland.
39. ISO 3308, 2009. Routine analytical cigarette-smoking machine - definitions and standard conditions, fourth ed., Amendment 1, International Organization for Standardization, Geneva, Switzerland.
40. ISO 4387, 2008. Cigarettes - determination of total and nicotine free dry particulate matter using a routine analytical smoking machine, third ed., Amendment 1, International Organization for Standardization, Geneva, Switzerland.
41. ISO 5725-2, 1994. Accuracy (trueness and precision) of measurement methods and results, Part 2. Basic methods for the determination of repeatability and reproducibility of a standard measurement method, International Organization for Standardization, Geneva, Switzerland.
42. ISO 5725-6, 2001. Accuracy (trueness and precision) of measurement methods and results. Part 6. Use in practice of accuracy values International Organization for Standardization, Geneva, Switzerland.
43. ISO 8243, 2006. Cigarettes - sampling. International Organization for Standardization, Geneva, Switzerland.
44. ISO 8454, 2009. Cigarettes - determination of carbon monoxide in the vapour phase of cigarette smoke - NDIR method. third ed., Amendment 1 International Organization for Standardization, Geneva, Switzerland.
45. ISO 10315, 2000. Cigarettes - determination of nicotine in smoke condensates - gas-chromatographic method, second ed., International Organization for Standardization, Geneva, Switzerland.
46. ISO 10362-1, 1999. Cigarettes - determination of water in smoke condensates - Part 1: gas-chromatographic method, second ed., International Organization for Standardization, Geneva, Switzerland.
47. ISO 10362-2, 1994. Cigarettes - determination of water in smoke condensates - Part 2: Karl Fischer method, first ed., International Organization for Standardization, Geneva, Switzerland.
48. ISO/IEC 17025, 2005. General requirements for the competence of testing and calibration laboratories, second ed., International Organization for Standardization, Geneva, Switzerland.
49. ISO/TR 22305, 2006. Technical Report ISO/TR 22305: Cigarettes - measurement of nicotine-free dry particulate matter, nicotine, water and carbon monoxide in cigarette smoke - analysis of data from collaborative studies reporting relationships between repeatability, reproducibility and tolerances, International Organization for Standardization, Geneva, Switzerland.
50. ISO 22634, 2007. Determination of benzo[a]pyrene in cigarette mainstream smoke - method using gas chromatography/mass spectrometry, International Organization for Standardization, Geneva.
51. Jarvis, M., 2004. Towards a science based testing of tobacco products that takes into consideration public health concerns; 25th Meeting of ISO/TC126, 22-23rd November, Geneva. (accessed April 2011). http://legacy.library.ucsf.edu/tid/kil17a00.
52. King, B., Borland, R., Fowles, J., 2007. Mainstream smoke emissions of Australian and Canadian cigarettes: Nicotine and Tobacco Research, 9 (8), 835-844.
53. Korean Ministry for Health, Welfare and Family Affairs, 2010. Tobacco Business Act No. 9932, Jan. 18.
54. Kozlowski L.T., O'Connor R.J. Official cigarette tar tests are misleading: use of a two-stage, compensating test. Lancet 2000, 355:2159-2161.
55. LGC, 2000a. Cigarette yields using intense smoking protocols. Comparison of benzo[a]pyrene yields from USA and UK cigarette blends. LGC Report FN40/M26/00. (accessed April 2011). http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@ab/documents/digitalasset/dh_095253.pdf.
56. LGC, 2000b. Cigarette yields using intense smoking protocols Part 2. Polycyclic aromatic hydrocarbon yields LGC Report FN40/M14/00. (accessed April 2011). http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@ab/documents/digitalasset/dh_095255.pdf.
57. LGC, 2000c. Cigarette yields using intense smoking protocols. Part 3. Nitric oxide yields LGC Report FN40/M32/00. (accessed April 2011). http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@ab/documents/digitalasset/dh_095248.pdf.
58. LGC, 2002. Cigarette yields using intense smoking protocols. Part 4. Volatile organic compounds. LGC Report FN40/M03/02. (accessed April 2011). http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@ab/documents/digitalasset/dh_095246.pdf.
59. OECD, 2005. Guiding Principles for Regulatory Quality and Performance. (accessed May 2011). http://www.oecd.org/dataoecd/24/6/34976533.pdf.
60. Phillips G., Waller R. Yields of tar and other smoke components from UK cigarettes. Food Chem. Toxicol. 1991, 29(7):469-474.
61. Pickworth, W., Houlgate, P., Schorp, M., Dixon, M., Borgerding, M.F., Zaatari, G., 2005. A review of human smoking behaviour and recommendations for a new ISO standard for machine smoking of cigarettes; Report of the Ad Hoc WG9 smoking review team to ISO TC126 WG9. (accessed April 2011). http://legacy.library.ucsf.edu/tid/mqt27a00.
62. Purkis S.W., Hill C.A., Bailey I.A. Current measurement reliability of selected smoke analytes. Beiträge Tabakforsch Int. 2003, 20(5):314-324.
63. Purkis S.W. Analysis of the data variability in the Australian benchmark study 2000-2001. Beiträge Tabakforsch Int. 2009, 23(5):334-336.
64. Purkis S.W., Drake L., Meger M., Mariner D.C. A review of the UK methodology used for monitoring cigarette smoke yields, aspects of analytical data variability and their impact on current and future regulatory compliance. Regul. Toxicol. Pharmacol. 2010, 56:365-373.
65. Purkis S.W., Cahours X., Rey M., Teillet B., Troude V., Verron T. Some consequences of using cigarette smoking regimes with different intensities on smoke yields and their variability. Regul. Toxicol. Pharmacol. 2011, 59:293-309.
66. Rickert, W., Wright, W., 2002. Stability of yields of Canadian Mandated analytes from the Kentucky Reference Cigarette 1R4F: a time series analysis; CORESTA Congress Paper ST26. (accessed April 2011). http://legacy.library.ucsf.edu/tid/xcl86a00.
67. Rodgman A., Perfetti T.A. The Chemical Components of Tobacco and Tobacco Smoke 2009, CRC Press, Boca Raton, FL.
68. Saint-Jalm, Y., Borgerding, M.F., Chapman, S.G., Morgan, W.T., 2006. Alternative smoking regimes. CORESTA Task Force Report. (accessed April 2011). http://www.coresta.org/Reports/Alternative-Smoking-Regimes-FinalReport-July2006.pdf.
69. Swauger J.E., Steichen T.J., Murphy P.A., Kinsler S. An analysis of the mainstream smoke chemistry of samples of the US cigarette market acquired between 1995 and 2000. Regul. Toxicol. Pharmacol. 2002, 35:142-156.
70. Taiwan Department of Health 2009. Regulations Governing Reporting of Tobacco Product Information under the Tobacco Hazards Prevention & Control Act (THPCA) (2007).
71. University of Kentucky, 2011. Reference cigarette program, College of Agriculture. (accessed August 2011). http://www.ca.uky.edu/refcig/.
72. Venezuela Ministry of Health & Social Development, 2004. Regulation & Control of Cigarette & other Derivative Tobacco Products for Human Consumption. No. 109.
73. WHO, World Health Organization, 2008. The Scientific Basis of Tobacco Product Regulation: Second Report of a WHO Study Group (WHO Technical Report Series 951, p. 277), WHO, Geneva.
74. Young, C., 2010. Global Collaborative Study - Method validation of TNCO in mainstream cigarette smoke, Intense Smoking Regime. ISO/TC126 Working Group 10, Document N66, May 5th.