Expression of genes encoding smooth muscle contractile proteins in vaginal tissue of women with and without pelvic organ prolapse

Neurourology and Urodynamics

Volumn 31, Issue 1, 2012, Pages 109-114

  Bortolini, Maria A T ^a,b   Shynlova, Oksana ^c   Drutz, Harold P ^a   Castro, Rodrigo A ^b   Girão, Manoel J B C ^b   Lye, Stephen ^c   Alarab, May ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

actin; menopause; myosin; POP; smooth muscle; vagina

Indexed keywords

ACTIN GAMMA2; CALDESMON; MESSENGER RNA; MYOSIN HEAVY CHAIN; SMOOTH MUSCLE ACTIN; TROPOMYOSIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; MUTATION; NUCLEOTIDE SEQUENCE; PELVIC ORGAN PROLAPSE; POSTMENOPAUSE; PREMENOPAUSE; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE; VAGINA; VAGINA EPITHELIUM;

ACTINS; ADULT; AGED; AGING; BIOPSY; CALMODULIN-BINDING PROTEINS; CASE-CONTROL STUDIES; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE, SMOOTH; MYOSIN HEAVY CHAINS; PELVIC ORGAN PROLAPSE; POSTMENOPAUSE; RNA, MESSENGER; TROPOMYOSIN; VAGINA;

EID: 84856227284     PISSN: 07332467     EISSN: 15206777     Source Type: Journal    
DOI: 10.1002/nau.21175     Document Type: Article

References (26)

1. Mant J, Painter R, Vessey M,. Epidemiology of genital prolapse: Observations from the Oxford Family Planning Association study. Br J Obstet Gynaecol 1997; 104: 579-85.
2. Olsen AL, Smith VJ, Bergstrom JO, et al. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol 1997; 89: 501-6.
3. Delancey JO, Starr RA,. Histology of the connection between the vagina and levator ani muscle: Implications for urinary tract function. J Reprod Med 1990; 35: 765-71.
4. Weber AM, Walters MD,. Anterior vaginal prolapse: Review of anatomy and techniques of surgical repair. Obstet Gynecol 1997; 89: 311-8.
5. Schaffer JI, Wai CY, Boreham MK,. Etiology of pelvic organ prolapse. Clin Obstet Gynecol 2005; 48: 639-47.
6. Rubenstein PA,. The functional importance of multiple actin isoforms. Bioessays 1990; 12: 309-15.
7. Chacko S, Longhurst PA,. Contractile proteins and their response to bladder outlet obstruction. Adv Exp Med Biol 1995; 385: 55-63.
8. Kelley C,. Characterization of isoform diversity among smooth muscle and nonmuscle myosin heavy chains. Comp Biochem Physiol 1997; 117B: 39-49.
9. Hodgkinson JL,. Actin and the smooth muscle regulatory proteins: A structural perspective. J Muscle Res Cell Motil 2000; 21: 115-30.
10. Earley JJ, Su X, Moreland RS,. Caldesmon inhibits active crossbridges in unstimulated vascular smooth muscle: An antisense oligodeoxynucleotide approach. Circ Res 1998; 83: 661-7.
11. Boreham MK, Wai CY, Miller RT, et al. Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse. Am J Obstet Gynecol 2002; 187: 56-63.
12. Badiou W, Granier G, Bousquet PJ, et al. Comparative histological analysis of anterior vaginal wall in women with pelvic organ prolapse or control subjects. A pilot study. Int Urogynecol J 2008; 19: 723-9.
13. Boreham MK, Miller RT, Schaffer JI, et al. Smooth muscle myosin heavy chain and caldesmon expression in the anterior vaginal wall of women with and without pelvic organ prolapse. Am J Obstet Gynecol 2001; 185: 944-52.
14. Takacs P, Gualtieri M, Nassiri M, et al. Caldesmon expression is decreased in women with anterior vaginal wall prolapse: A pilot study. Int Urogynecol J 2009; 20: 985-90.
15. Da Chung J, Bai SW,. Roles of sex steroid receptors and cell cycle regulation in pathogenesis of pelvic organ prolapse. Curr Opin Obstet Gynecol 2006; 18: 551-4.
16. Lang JH, Zhu L, Sun ZJ, et al. Estrogen levels and estrogen receptors in patients with stress urinary incontinence and pelvic organ prolapse. Int J Gynaecol Obstet 2003; 80: 35-9.
17. Tinelli A, Malvasi A, Rahimi S, et al. Age-related pelvic floor modifications and prolapse risk factors in postmenopausal women. Menopause 2010; 17: 204-12.
18. Bump RC, Mattiasson A, Bo K, et al. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol 1996; 175: 10-7.
19. Bortolini MAT, Shynlova O, Drutz HP, et al. Expression of bone morphogenetic protein-1 in vaginal tissue of women with and without pelvic organ prolapse. Am J Obst Gynecol 2011; 204: 544e1-8.
20. Miller M, Vadachkoria S, Luthy DA, et al. Evaluation of housekeeping genes in placental comparative expression studies. Placenta 2005; 26: 601-7.
21. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3: 34.
22. Kerkhof MH, Hendriks L, Brölmann HA,. Changes in connective tissue in patients with pelvic organ prolapse - A review of the current literature. Int Urogynecol J Pelvic Floor Dysfunct 2009; 20: 461-74.
23. Moalli PA, Shand SH, Zyczynski HM, et al. Remodeling of vaginal connective tissue in patients with prolapse. Obstet Gynecol 2005; 106: 620-7.
24. Word RA, Li X-H, Lin VK,. Effect of stretch on expression of caldesmon mRNA and protein in myometrial cells [abstract]. J Soc Gynecol Investig 1997; 4: 160.
25. Cevallos M, Riha GM, Wang X, et al. Cyclic strain induces expression of specific smooth muscle cell markers in human endothelial cells. Differentiation 2006; 74: 552-61.
26. Perry SV,. Vertebrate tropomyosin: Distribution, properties and function. J Muscle Res Cell Motil 2001; 22: 5-49.