Expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with severe pelvic organ prolapse

American Journal of Obstetrics and Gynecology

Volumn 204, Issue 6, 2011, Pages 544.e1-544.e8

  Bortolini, Maria A T ^a,b   Shynlova, Oksana ^a   Drutz, Harold P ^a   Giro, Manoel J B C ^b   Castro, Rodrigo A ^b   Lye, Stephen ^a   Alarab, May ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bone Morphogenetic Protein 1; extracellular matrix; pelvic organ prolapse; procollagen C proteinase; vagina

Indexed keywords

ISOPROTEIN; MESSENGER RNA; PROCOLLAGEN C PROTEINASE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; FEMALE; GENE EXPRESSION PROFILING; HUMAN; MENOPAUSE; MOLECULAR WEIGHT; NUCLEOTIDE SEQUENCE; PELVIC ORGAN PROLAPSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

EID: 79958084442     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2011.01.021     Document Type: Article

References (27)

1. L.L. Subak, L.E. Waetjen, and S. Van den Eaden Cost of pelvic organ prolapse surgery in the United States Obstet Gynecol 98 2001 646 651 (Pubitemid 32907461)
2. R.C. Bump, and P.A. Norton Epidemiology and natural history of pelvic floor dysfunction Obstet Gynecol Clin North Am 25 1998 723 746 (Pubitemid 28562493)
3. P.A. Moalli, I.S. Jones, L.A. Meyn, and H.M. Zyczynski Risk factors associated with pelvic floor disorders in women undergoing surgical repair Obstet Gynecol 101 Pt 1 2003 869 874 (Pubitemid 36561246)
4. J.O.L. DeLancey Anatomy and biomechanics of genital prolapse Clin Obstet Gynecol 36 1993 897 909
5. A.M. Weber, and M.D. Walters Anterior vaginal prolapse: review of anatomy and techniques of surgical repair Obstet Gynecol 89 1997 311 318 (Pubitemid 27057227)
6. J.I. Schaffer, C.Y. Wai, and M.K. Boreham Etiology of pelvic organ prolapse Clin Obstet Gynecol 48 2005 639 647 (Pubitemid 41134118)
7. P.C. Trackman Diverse biological functions of extracellular collagen processing enzymes J Cell Biochem 96 2005 927 937 (Pubitemid 41688719)
8. G. Ge, and D.S. Greenspan Developmental roles of the BMP1/TLD metalloproteinases Birth Defects Res C Embryo Today 78 2006 47 68 (Pubitemid 43726175)
9. The National Center for Biotechnology Information Online http://www.ncbi.nlm.nih.gov/protein/P13497.2 Accessed Feb. 28, 2011
10. M.H. Kerkhof, L. Hendriks, and H.A. Brlmann Changes in connective tissue in patients with pelvic organ prolapsea review of the current literature Int Urogynecol J Pelvic Floor Dysfunct 20 2009 461 474
11. S.R. Jackson, N.C. Avery, J.F. Tarlton, S.D. Eckford, P. Abrams, and A.J. Bailey Changes in metabolism of collagen in genitourinary prolapse Lancet 347 1996 1658 1661 (Pubitemid 26177387)
12. M. Alarab, M.A. Bortolini, H. Drutz, S. Lye, and O. Shynlova LOX family enzymes expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse Int Urogynecol J Pelvic Floor Dysfunct 21 2010 1397 1404
13. S.M. Roshanravan, P.G. Drewes, and R.A. Word Estrogen regulates elastogenesis and processing of Procollagen and Lysyl Oxidases in the vaginal wall Reproductive Sciences 17 2010 3
14. J. Da Chung, and S.W. Bai Roles of sex steroid receptors and cell cycle regulation in pathogenesis of pelvic organ prolapse Curr Opin Obstet Gynecol 18 2006 551 554 (Pubitemid 44319029)
15. P.A. Moalli, S.H. Shand, H.M. Zyczynski, S.C. Gordy, and L.A. Meyn Remodeling of vaginal connective tissue in patients with prolapse Obstet Gynecol 106 2005 620 627
16. R.C. Bump, A. Mattiasson, and K. Bo The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction Am J Obstet Gynecol 175 1996 10 17 (Pubitemid 26282199)
17. J.V. Ricci, J.R. Lisa, C.H. Thom, and W.L. Kron The relationship of the vagina to adjacent organs in reconstructive surgery: a histologic study Am J Surg 74 1947 387 410
18. M.K. Boreham, C.Y. Wai, R.T. Miller, J.I. Schaffer, and R.A. Word Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse Am J Obstet Gynecol 187 2002 56 63 (Pubitemid 34800301)
19. J. Vandesompele, K. De Preter, and F. Pattyn Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome Biol 3 2002 34
20. T.D. Schmittgen, and K.J. Livak Analyzing real-time PCR data by the comparative C(T) method Nat Protoc 3 2008 1101 1108 (Pubitemid 351818697)
21. K. Takahara, G.E. Lyons, and D.S. Greenspan Bone Morphogenetic Protein-1 and Mammalian Tolloid Homologue (mTLD) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues J Biol Chem 269 1994 32572 32578
22. M. Janitz, V. Heiser, U. Bottcher, O. Landt, and R. Lauster Three alternatively spliced variants of the gene coding for the Bon Morphogenetic protein-1 J Mol Med 76 1998 141 146 (Pubitemid 28085094)
23. N. Suzuki, P.A. Labosky, and Y. Furuta Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid Development 122 1996 3587 3595 (Pubitemid 26396000)
24. R.C. Read Signs of herniosis in women with vaginal prolapse and/or stress incontinence Hernia 12 2008 449 452
25. M. Parsons, E. Kessler, G.J. Laurent, R.A. Brown, and J.E. Bishop Mechanical load enhances procollagen processing in dermal fibroblasts by regulating levels of procollagen c-proteinase Exp Cell Res 252 1999 319 331 (Pubitemid 29530262)
26. D.L. Allen, B.J. Greybeck, A.M. Hanson, A.S. Cleary, and S.F. Lindsay Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation J Physiol Sci 60 2010 343 352
27. A.M. Weber, G.M. Buchsbaum, and B. Chen Basic science and translational research in female pelvic floor disorders: proceedings of an NIH-sponsored meeting Neurourol Urodyn 23 2004 288 301 (Pubitemid 38859417)