Caldesmon expression is decreased in women with anterior vaginal wall prolapse: A pilot study

International Urogynecology Journal

Volumn 20, Issue 8, 2009, Pages 985-990

  Takacs, Peter ^a   Gualtieri, Marc ^a   Nassiri, Mehdi ^b   Candiotti, Keith ^c   Fornoni, Alessia ^c   Medina, Carlos A ^a  

^a JACKSON MEMORIAL HOSPITAL   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Caldesmon; Prolapse; Smooth muscle cell; Vagina

Indexed keywords

CALDESMON; MESSENGER RNA; MYOSIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIGITAL IMAGING; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PELVIC ORGAN PROLAPSE; PILOT STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; STAINING;

EID: 67650630983     PISSN: 09373462     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00192-009-0876-z     Document Type: Article

References (19)

1. Olsen AL, Smith VJ, Bergstrom JO, Colling JC, Clark AL (1997) Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol 89:501-506
2. Baden WF, Walker T (1992) The anatomy of uterovaginal support. In: Baden WF, Walker T (eds) Surgical repair of vaginal defects. JB Lippincott, Philadelphia, pp 42-49
3. Norton PA, Boyd C, Deak S (1992) Collagen synthesis in women with genital prolapse or stress urinary incontinence. Neurourol Urodyn 11:300-301
4. Smith AR, Hosker GL, Warrell DW (1989) The role of partial denervation of the pelvic floor in the aetiology of genitourinary prolapse and stress incontinence of urine. A neurophysiological study. Br J Obstet Gynaecol 96:24-28
5. Boreham MK, Miller RT, Schaffer JI, Word RA (2001) Smooth muscle myosin heavy chain and caldesmon expression in the anterior vaginal wall of women with and without pelvic organ prolapse. Am J Obstet Gynecol 185:944-952
6. Boreham MK, Wai CY, Miller RT, Schaffer JI, Word RA (2002) Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse. Am J Obstet Gynecol 187:56-63
7. Boreham MK, Wai CY, Miller RT, Schaffer JI, Word RA (2002) Morphometric properties of the posterior vaginal wall in women with pelvic organ prolapse. Am J Obstet Gynecol 187:1501-1508 discussion 1508-1509
8. Gabriel B et al (2005) Uterosacral ligament in postmenopausal women with or without pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct 16:475-479
9. Ozdegirmenci O et al (2005) Smooth muscle fraction of the round ligament in women with pelvic organ prolapse: A computer-based morphometric analysis. Int Urogynecol J Pelvic Floor Dysfunct 16:39-43 discussion 43
10. Hodgkinson JL (2000) Actin and the smooth muscle regulatory proteins: A structural perspective. J Muscle Res Cell Motil 21:115-130
11. Huber PA (1997) Caldesmon. Int J Biochem Cell Biol 29:1047-1051
12. Katsuyama H, Wang CL, Morgan KG (1992) Regulation of vascular smooth muscle tone by caldesmon. J Biol Chem 267:14555-14558
13. Ansari S, Alahyan M, Marston SB, El-Mezgueldi M (2008) Role of caldesmon in the Ca2+ regulation of smooth muscle thin filaments: Evidence for a cooperative switching mechanism. J Biol Chem 283:47-56
14. Li Y, Lin JL, Reiter RS, Daniels K, Soll DR, Lin JJ (2004) Caldesmon mutant defective in Ca(2+)-calmodulin binding interferes with assembly of stress fibers and affects cell morphology, growth and motility. J Cell Sci 117:3593-3604
15. Bump RC et al (1996) The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol 175:10-17
16. Lehr HA, Mankoff DA, Corwin D, Santeusanio G, Gown AM (1997) Application of photoshop-based image analysis to quantification of hormone receptor expression in breast cancer. J Histochem Cytochem 45:1559-1565
17. Morgan KG, Gangopadhyay SS (2001) Invited review: Cross-bridge regulation by thin filament-associated proteins. J Appl Physiol 91:953-962
18. Lin AD et al (2006) Alteration of contractile and regulatory proteins in estrogen-induced hypertrophy of female rabbit bladder. Urology 68:1139-1143
19. Mannikarottu AS, Changolkar AK, Disanto ME, Wein AJ, Chacko S (2005) Over expression of smooth muscle thin filament associated proteins in the bladder wall of diabetics. J Urol 174:360-364