Methylation-mediated repression of microRNA-143 enhances MLL-AF4 oncogene expression

Oncogene

Volumn 31, Issue 4, 2012, Pages 507-517

  Dou, L ^a   Zheng, D ^b   Li, J ^a   Li, Y ^a   Gao, L ^a   Wang, L ^a   Yu, L ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b 309TH HOSPITAL OF PLA   (China)

Author keywords

Leukemia; Methylation; MiR 143; MLL AF4

Indexed keywords

HYBRID PROTEIN; MICRORNA; MICRORNA 143; MIXED LINEAGE LEUKEMIA AF4 FUSION PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; METHYLATION; PRIORITY JOURNAL; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA METHYLATION; DOWN-REGULATION; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; LEUKEMIA, B-CELL; MICRORNAS; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENES;

EID: 84856215661     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.248     Document Type: Article

References (32)

1. Akao Y, Nakagawa Y, Hirata I, Iio A, Itoh T, Kojima K et al. (2010). Role of anti-oncomirs miR-143 and-145 in human colorectal tumors. Cancer Gene Ther 17: 398-408.
2. Akao Y, Nakagawa Y, Iio A, Naoe T. (2009). Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells. Leuk Res 33: 1530-1538.
3. Akao Y, Nakagawa Y, Kitade Y, Kinoshita T, Naoe T. (2007). Downregulation of microRNAs-143 and-145 in B-cell malignancies. Cancer Sci 98: 1914-1920. (Pubitemid 350002197)
4. Bittner S, Bobak N, Herrmann AM, Göbel K, Meuth P, Höhn KG et al. (2010). Upregulation of K2P5. 1 potassium channels in multiple sclerosis. Ann Neurol 68: 58-69.
5. Chen X, Guo X, Zhang H, Xiang Y, Chen J, Yin Y et al. (2009). Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene 28: 1385-1392.
6. Clape C, Fritz V, Henriquet C, Apparailly F, Fernandez PL, Iborra F et al. (2009). miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice. PLoS One 4: e7542.
7. Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN et al. (2009). miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 460: 705-710.
8. Erfurth FE, Popovic R, Grembecka J, Cierpicki T, Theisler C, Xia ZB et al. (2008). MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. Proc Natl Acad Sci USA 105: 7517-7522. (Pubitemid 351830050)
9. Esquela-Kerscher A, Slack FJ. (2006). Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269.
10. Fazi F, Racanicchi S, Zardo G, Starnes LM, Mancini M, Travaglini L et al. (2007). Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein. Cancer Cell 12: 457-466. (Pubitemid 350046404)
11. Gao W, Yu Y, Cao H, Shen H, Li X, Pan S et al. (2010). Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis. Biomed Pharmacother 64: 399-408.
12. Garzon R, Fabbri M, Cimmino A, Calin GA, Croce CM. (2006). MicroRNA expression and function in cancer. Trends Mol Med 12: 580-587. (Pubitemid 44780201)
13. Glas M, Rath BH, Simon M, Reinartz R, Schramme A, Trageser D et al. (2010). Residual tumor cells are unique cellular targets in glioblastoM.A. Ann Neurol 68: 264-269.
14. Langevin SM, Stone RA, Bunker CH, Lyons-Weiler MA, Laframboise WA, Kelly L et al. (2011). MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck. Cancer 117: 1454-1462.
15. Lin TC, Hou HA, Chou WC, Ou DL, Yu SL, Tien HF et al. (2011). CEBPA methylation as a prognostic biomarker in patients with de novo acute myeloid leukemia. Leukemia 25: 32-40.
16. Liu H, Cheng EH, Hsieh JJ. (2009). MLL fusions: pathways to leukemia. Cancer Biol Ther 8: 1204-1211.
17. Liu Q, Fu H, Sun F, Zhang H, Tie Y, Zhu J et al. (2008). miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res 36: 5391-5404.
18. Lowenberg B. (2008). Diagnosis and prognosis in acute myeloid leukemia-the art of distinction. N Engl J Med 358: 1960-1962. (Pubitemid 351620119)
19. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D et al. (2005). MicroRNA expression profiles classify human cancers. Nature 435: 834-838. (Pubitemid 40839735)
20. Lujambio A, Calin GA, Villanueva A, Ropero S, Sanchez-Cespedes M, Blanco D et al. (2008). A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci USA 105: 13556-13561.
21. Luty AA, Kwok JBJ, Dobson-Stone C, Loy CT, Coupland KG, Karlström H et al. (2010). Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-Cmotor neuron disease. Ann Neurol 68: 639-649.
22. Metzler M, Forster A, Pannell R, Arends MJ, Daser A, Lobato MN et al. (2006). A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology. Oncogene 25: 3093-3103. (Pubitemid 43881551)
23. Meyer B, Wurm JP, Kotter P, Leisegang MS, Schilling V, Buchhaupt M et al. (2011). The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of {Psi}1191 in yeast 18S rRNA. Nucleic Acids Res 39: 1526-1537.
24. Ronchi AE, Bottardi S, Mazzucchelli C, Ottolenghi S, Santoro C. (1995). Differential binding of the NFE3 and CP1/NFY transcription factors to the human gamma-and epsilon-globin CCAAT boxes. J Biol Chem 270: 21934-21941.
25. Santoro R, Li J, Grummt I. (2002). The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet 32: 393-396. (Pubitemid 35266113)
26. Slaby O, Svoboda M, Fabian P, Smerdova T, Knoflickova D, Bednarikova M et al. (2007). Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer. Oncology 72: 397-402. (Pubitemid 351238155)
27. Takagi T, Iio A, Nakagawa Y, Naoe T, Tanigawa N, Akao Y. (2009). Decreased expression of microRNA-143 and-145 in human gastric cancers. Oncology 77: 12-21.
28. Thomas M, Gessner A, Vornlocher HP, Hadwiger P, Greil J, Heidenreich O. (2005). Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells. Blood 106: 3559-3566. (Pubitemid 41609194)
29. Walker BA, Wardell CP, Chiecchio L, Smith EM, Boyd KD, Neri A et al. (2011). Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloM.A. Blood 117: 553-562.
30. Wang CJ, Zhou ZG, Wang L, Yang L, Zhou B, Gu J et al. (2009). Clinicopathological significance of microRNA-31,-143 and-145 expression in colorectal cancer. Dis Markers 26: 27-34.
31. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M et al. (2006). Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9: 189-198. (Pubitemid 43357945)
32. Yu L, Liu C, Vandeusen J, Becknell B, Dai Z, Wu YZ et al. (2005). Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. Nat Genet 37: 265-274. (Pubitemid 41716253)