Targeted gene delivery to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption

Experimental Neurology

Volumn 233, Issue 1, 2012, Pages 350-356

  Huang, Qin ^a,b   Deng, Jinmu ^a   Wang, Feng ^a   Chen, Song ^a   Liu, Yingjiang ^b   Wang, Zhibiao ^b   Wang, Zhigang ^a   Cheng, Yuan ^a  

^a THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Blood brain barrier; Central nervous system; Focused ultrasound; Gene therapy; Magnetic resonance imaging; Microbubbles

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; PLASMID DNA;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CYTOPLASM; DRUG DISTRIBUTION; DRUG UPTAKE; ENDOCYTOSIS; GENE; GENE THERAPY; GENETIC TRANSFECTION; IN VIVO GENE TRANSFER; MAGNETIC RESONANCE IMAGING GUIDED FOCUSED ULTRASOUND MEDIATED GENE DELIVERY; MALE; MEMBRANE DAMAGE; MICROBUBBLE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TARGET ORGAN;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN-DERIVED NEUROTROPHIC FACTOR; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED STRAINS; MICROSCOPY, ELECTRON, TRANSMISSION; SOUND;

EID: 84856212147     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.10.027     Document Type: Article

References (27)

1. Borden M.A., Caskey C.F., Little E., Gillies R.J., Ferrara K.W. DNA and polylysine adsorption and multilayer construction onto cationic lipid-coated microbubbles. Langmuir 2007, 23:9401-9408.
2. Brunoni A.R., Lopes M., Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int. J. Neuropsychopharmacol. 2008, 11:1169-1180.
3. Chen B., Dowlatshahi D., MacQueen G.M., Wang J.F., Young L.T. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol. Psychiatry 2001, 50:260-265.
4. Huang E.J., Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu. Rev. Neurosci. 2001, 24:677-736.
5. Hynynen K. Ultrasound for drug and gene delivery to the brain. Adv. Drug Deliv. Rev. 2008, 60:1209-1217.
6. Hynynen K., Jolesz F.A. Demonstration of potential noninvasive ultrasound brain therapy through an intact skull. Ultrasound Med. Biol. 1998, 24:275-283.
7. Jordao J.F., Ayala-Grosso C.A., Markham K., Huang Y., Chopra R., McLaurin J., Hynynen K., Aubert I. Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease. PLoS One 2010, 5:e10549.
8. Kinoshita M. Targeted drug delivery to the brain using focused ultrasound. Top. Magn. Reson. Imaging 2006, 17:209-215.
9. Kinoshita M., McDannold N., Jolesz F.A., Hynynen K. Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:11719-11723.
10. Kinoshita M., McDannold N., Jolesz F.A., Hynynen K. Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. Biochem. Biophys. Res. Commun. 2006, 340:1085-1090.
11. Liang H.D., Tang J., Halliwell M. Sonoporation, drug delivery, and gene therapy. Proc. Inst. Mech. Eng. H 2010, 224:343-361.
12. Liu H.L., Hua M.Y., Chen P.Y., Chu P.C., Pan C.H., Yang H.W., Huang C.Y., Wang J.J., Yen T.C., Wei K.C. Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment. Radiology 2010, 255:415-425.
13. McDannold N., Vykhodtseva N., Raymond S., Jolesz F.A., Hynynen K. MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits. Ultrasound Med. Biol. 2005, 31:1527-1537.
14. Mehier-Humbert S., Guy R.H. Physical methods for gene transfer: improving the kinetics of gene delivery into cells. Adv. Drug Deliv. Rev. 2005, 57:733-753.
15. Mei J., Cheng Y., Song Y., Yang Y., Wang F., Liu Y., Wang Z. Experimental study on targeted methotrexate delivery to the rabbit brain via magnetic resonance imaging-guided focused ultrasound. J. Ultrasound Med. 2009, 28:871-880.
16. Meijering B.D., Juffermans L.J., van Wamel A., Henning R.H., Zuhorn I.S., Emmer M., Versteilen A.M., Paulus W.J., van Gilst W.H., Kooiman K., de Jong N., Musters R.J., Deelman L.E., Kamp O. Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation. Circ. Res. 2009, 104:679-687.
17. Pardridge W.M. Blood-brain barrier drug targeting: the future of brain drug development. Mol. Interv. 2003, 3:90-105,51.
18. Pardridge W.M. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2005, 2:3-14.
19. Ricci V., Pomponi M., Martinotti G., Bentivoglio A., Loria G., Bernardini S., Caltagirone C., Bria P., Angelucci F. Antidepressant treatment restores brain-derived neurotrophic factor serum levels and ameliorates motor function in Parkinson disease patients. J. Clin. Psychopharmacol. 2010, 30:751-753.
20. Sekiguchi K., Yasuzumi F., Morishita R. Exogenous expression of hepatocyte growth factor (HGF) in rat striatum by naked plasmid DNA. Neurosci. Res. 2003, 45:173-180.
21. Sheikov N., McDannold N., Vykhodtseva N., Jolesz F., Hynynen K. Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med. Biol. 2004, 30:979-989.
22. Treat L.H., McDannold N., Vykhodtseva N., Zhang Y., Tam K., Hynynen K. Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int. J. Cancer 2007, 121:901-907.
23. Vykhodtseva N., McDannold N., Hynynen K. Progress and problems in the application of focused ultrasound for blood-brain barrier disruption. Ultrasonics 2008, 48:279-296.
24. Yang F.Y., Lin Y.S., Kang K.H., Chao T.K. Reversible blood-brain barrier disruption by repeated transcranial focused ultrasound allows enhanced extravasation. J. Control Release 2011, 150:111-116.
25. Yin X., Hynynen K. A numerical study of transcranial focused ultrasound beam propagation at low frequency. Phys. Med. Biol. 2005, 50:1821-1836.
26. Yoon C.S., Park J.H. Ultrasound-mediated gene delivery. Expert Opin. Drug Deliv. 2010, 7:321-330.
27. Zuccato C., Cattaneo E. Brain-derived neurotrophic factor in neurodegenerative diseases. Nat. Rev. Neurol. 2009, 5:311-322.