Oxygenated compounds from the bioconversion of isostevic acid and their inhibition of TNF-α and COX-2 expressions in LPS-stimulated RAW 264.7 cells

Phytochemistry

Volumn 75, Issue , 2012, Pages 90-98

  Yang, Li Ming ^a,b   Chang, Shwu Fen ^a   Lin, Wen Kuang ^a   Chou, Bo Hon ^a   Wang, Li Hsuan ^a,c   Liu, Pan Chun ^a   Lin, Shwu Jiuan ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

COX 2; Diterpenoid; Isostevic acid; Microbial transformation; TNF

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DITERPENE; ISOSTEVIC ACID; LIPOPOLYSACCHARIDE; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; GENETICS; MACROPHAGE; METABOLISM; MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DITERPENES; DRUG EVALUATION, PRECLINICAL; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

ASPERGILLUS NIGER; BACILLUS MEGATERIUM; MORTIERELLA; UMBELOPSIS ISABELLINA;

EID: 84856210579     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2011.12.006     Document Type: Article

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