Analysis of p16 CDKN2A methylation and HPV-16 infection in oral mucosal dysplasia

Pathobiology

Volumn 79, Issue 2, 2012, Pages 94-100

  Fonseca Silva, Thiago ^a   Farias, Lucyana Conceição ^a   Cardoso, Claudio Marcelo ^a   De Souza, Ludmilla Regina ^a   De Carvalho Fraga, Carlos Alberto ^a   De Oliveira, Marcos Vinícius MacEdo ^a   Barros, Lucas Oliveira ^a   Alves, Lucas Rodrigues ^a   De Paula, Alfredo Maurício Batista ^a   Marques Silva, Luciano ^b   Gomez, Ricardo Santiago ^b   Guimarães, André Luiz Sena ^a  

^a STATE UNIVERSITY OF MONTES CLAROS   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

DNMT3B; Head and neck cancer; HPV; Methylation; Oral premalignant lesions; p16 CDKN2A; Polymorphism

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3B;

ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DNA POLYMORPHISM; EPITHELIUM DYSPLASIA; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN TISSUE; METHYLATION; ORAL MUCOSAL DISEASE; PAPILLOMAVIRUS INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; AGED; CASE-CONTROL STUDIES; DNA METHYLATION; FEMALE; GENES, P16; GENOTYPE; HUMAN PAPILLOMAVIRUS 16; HUMAN PAPILLOMAVIRUS 18; HUMANS; MALE; MIDDLE AGED; MOUTH MUCOSA; PAPILLOMAVIRUS INFECTIONS;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16;

EID: 84856164138     PISSN: 10152008     EISSN: 14230291     Source Type: Journal    
DOI: 10.1159/000334926     Document Type: Article

References (62)

1. De Paula AM, Souza LR, Farias LC, Correa GT, Fraga CA, Eleuterio NB, Silveira AC, Santos FB, Haikal DS, Guimaraes AL, Gomez RS: Analysis of 724 cases of primary head and neck squamous cell carcinoma (HNSCC) with a focus on young patients and p53 immunolocalization. Oral Oncol 2009; 45: 777-782.
2. Rodstrom PO, Jontell M, Mattsson U, Holmberg E: Cancer and oral lichen planus in a Swedish population. Oral Oncol 2004; 40: 131-138. (Pubitemid 38030355)
3. Llewellyn CD, Johnson NW, Warnakulasuriya S: Factors associated with delay in presentation among younger patients with oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004; 97: 707-713. (Pubitemid 38747001)
4. Rhodus NL: Oral cancer: leukoplakia and squamous cell carcinoma. Dent Clin North Am 2005; 49: 143-165, ix. (Pubitemid 39563615)
5. Napier SS, Speight PM: Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med 2008; 37: 1-10. (Pubitemid 350264786)
6. Mithani SK, Mydlarz WK, Grumbine FL, Smith IM, Califano JA: Molecular genetics of premalignant oral lesions. Oral Dis 2007; 13: 126-133.
7. van der Waal I: Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management. Oral Oncol 2010; 46: 423-425.
8. Kannan K, Latha PN, Shanmugam G: Expression of bcl-2 oncoprotein in indian oral squamous cell carcinomas. Oral Oncol 1998; 34: 373-376. (Pubitemid 28440298)
9. Rosin MP, Lam WL, Poh C, Le ND, Li RJ, Zeng T, Priddy R, Zhang L: 3p14 and 9p21 loss is a simple tool for predicting second oral malignancy at previously treated oral cancer sites. Cancer Res 2002; 62: 6447-6450. (Pubitemid 35364104)
10. Scully C, Field JK, Tanzawa H: Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN). 1. Carcinogen metabolism, DNA repair and cell cycle control. Oral Oncol 2000; 36: 256-263. (Pubitemid 30227706)
11. Toruner GA, Ulger C, Alkan M, Galante AT, Rinaggio J, Wilk R, Tian B, Soteropoulos P, Hameed MR, Schwalb MN, Dermody JJ: Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. Cancer Genet Cytogenet 2004; 154: 27-35. (Pubitemid 39286169)
12. Balderas-Loaeza A, Anaya-Saavedra G, Ramirez-Amador VA, Guido-Jimenez MC, Kalantari M, Calleja-Macias IE, Bernard HU, Garcia-Carranca A: Human papillomavirus-DNA methylation patterns support a causal association of the virus with oral squamous cell carcinomas. Int J Cancer 2007; 120: 2165-2169. (Pubitemid 46555853)
13. Herman JG, Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003; 349: 2042-2054. (Pubitemid 37448928)
14. Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3: 415-428. (Pubitemid 34587077)
15. O'Regan EM, Toner ME, Finn SP, Fan CY, Ring M, Hagmar B, Timon C, Smyth P, Cahill S, Flavin R, Sheils OM, O'Leary JJ: P16(ink4a) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas. Hum Pathol 2008; 39: 452-458. (Pubitemid 351186693)
16. Youssef EM, Lotan D, Issa JP, Wakasa K, Fan YH, Mao L, Hassan K, Feng L, Lee JJ, Lippman SM, Hong WK, Lotan R: Hypermethylation of the retinoic acid receptor-beta( 2) gene in head and neck carcinogenesis. Clin Cancer Res 2004; 10: 1733-1742. (Pubitemid 38435565)
17. Hermann A, Gowher H, Jeltsch A: Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol Life Sci 2004; 61: 2571-2587. (Pubitemid 39586518)
18. Gronbaek K, Hother C, Jones PA: Epigenetic changes in cancer. APMIS 2007; 115: 1039-1059. (Pubitemid 350179474)
19. Shen H, Wang L, Spitz MR, Hong WK, Mao L, Wei Q: A novel polymorphism in human cytosine DNA-methyltransferase-3b promoter is associated with an increased risk of lung cancer. Cancer Res 2002; 62: 4992-4995. (Pubitemid 34984424)
20. Singal R, Das PM, Manoharan M, Reis IM, Schlesselman JJ: Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk. Oncol Rep 2005; 14: 569-573.
21. Wu Y, Lin JS: DNA methyltransferase 3B promoter polymorphism and its susceptibility to primary hepatocellular carcinoma in the Chinese Han nationality population: a case-control study. World J Gastroenterol 2007; 13: 6082-6086. (Pubitemid 350238280)
22. Simao Tde A, Simoes GL, Ribeiro FS, Cidade DA, Andreollo NA, Lopes LR, Macedo JM, Acatauassu R, Teixeira AM, Felzenszwalb I, Pinto LF, Albano RM: Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas. Hum Exp Toxicol 2006; 25: 515-522. (Pubitemid 44409041)
23. Wang J, Walsh G, Liu DD, Lee JJ, Mao L: Expression of delta DNMT3B variants and its association with promoter methylation of p16 and RASSF1A in primary non-small cell lung cancer. Cancer Res 2006; 66: 8361-8367.
24. Acay RR, Felizzola CR, Arajo NS, Souza SO: Evaluation of proliferative potential in oral lichen planus and oral lichenoid lesions using immunohistochemical expression of p53 and ki67. Oral Oncol 2006; 42: 475-480.
25. Oliveira MC, Soares RC, Pinto LP, Souza LB, Medeiros SR, Costa AL: High-risk human papillomavirus (HPV) is not associated with p53 and bcl-2 expression in oral squamous cell carcinomas. Auris Nasus Larynx 2009; 36: 450-456.
26. D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML: Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007; 356: 1944-1956. (Pubitemid 46740304)
27. Szalmas A, Konya J: Epigenetic alterations in cervical carcinogenesis. Semin Cancer Biol 2009; 19: 144-152.
28. Wu MF, Cheng YW, Lai JC, Hsu MC, Chen JT, Liu WS, Chiou MC, Chen CY, Lee H: Frequent p16INK4a promoter hypermethylation in human papillomavirus-infected female lung cancer in Taiwan. Int J Cancer 2005; 113: 440-445. (Pubitemid 40038712)
29. Lin TS, Lee H, Chen RA, Ho ML, Lin CY, Chen YH, Tsai YY, Chou MC, Cheng YW: An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection. Cancer Lett 2005; 226: 77-84. (Pubitemid 40943432)
30. Farias LC, Fraga CA, De Oliveira MV, Silva TF, Marques-Silva L, Moreira PR, De-Paula AM, Gomez RS, Guimaraes AL: Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival. Int J Oncol 2010; 37: 167-176.
31. Fraga CA, de Oliveira MV, de Oliveira ES, Barros LO, Santos FB, Gomez RS, De-Paula AM, Guimaraes AL: A high HIF-1alpha expression genotype is associated with poor prognosis of upper aerodigestive tract carcinoma patients. Oral Oncol 2011, E-pub ahead of print.
32. Banoczy J, Csiba A: Occurrence of epithelial dysplasia in oral leukoplakia: analysis and follow-up study of 12 cases. Oral Surg Oral Med Oral Pathol 1976; 42: 766-774.
33. Goldenberg D, Harden S, Masayesva BG, Ha P, Benoit N, Westra WH, Koch WM, Sidransky D, Califano JA: Intraoperative molecular margin analysis in head and neck cancer. Arch Otolaryngol Head Neck Surg 2004; 130: 39-44. (Pubitemid 38095427)
34. Moreira PR, Guimaraes MM, Guimaraes AL, Diniz MG, Gomes CC, Brito JA, Gomez RS: Methylation of p16, p21, p27, rb1 and p53 genes in odontogenic keratocysts. J Oral Pathol Med 2009; 38: 99-103.
35. Katiyar S, Hedau S, Jain N, Kar P, Khuroo MS, Mohanta J, Kumar S, Gopalkrishna V, Kumar N, Das BC: P53 gene mutation and human papillomavirus (HPV) infection in esophageal carcinoma from three different endemic geographic regions of India. Cancer Lett 2005; 218: 69-79. (Pubitemid 40082703)
36. Cao J, Zhou J, Gao Y, Gu L, Meng H, Liu H, Deng D: Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study. Clin Cancer Res 2009; 15: 5178-5183.
37. Schwartz SM, Daling JR, Doody DR, Wipf GC, Carter JJ, Madeleine MM, Mao EJ, Fitzgibbons ED, Huang S, Beckmann AM, McDougall JK, Galloway DA: Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst 1998; 90: 1626-1636. (Pubitemid 28523437)
38. Guimaraes AL, Gomes CC, da Silva LM, Correia-Silva Jde F, Victoria JM, Gomez RS, Bittencourt H: Association between oral HSV-1 and survival in allogeneic hematopoietic stem cell transplanted patients. Med Oral Patol Oral Cir Bucal 2009; 14:E62-E68.
39. Robertson KD, Uzvolgyi E, Liang G, Talmadge C, Sumegi J, Gonzales FA, Jones PA: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res 1999; 27: 2291-2298. (Pubitemid 29245646)
40. Wild L, Flanagan JM: Genome-wide hypomethylation in cancer may be a passive consequence of transformation. Biochim Biophys Acta 2010; 1806: 50-57.
41. Feinberg AP: The epigenetics of cancer etiology. Semin Cancer Biol 2004; 14: 427-432. (Pubitemid 39360990)
42. Momparler RL: Cancer epigenetics. Oncogene 2003; 22: 6479-6483. (Pubitemid 37372327)
43. Ducasse M, Brown MA: Epigenetic aberrations and cancer. Mol Cancer 2006; 5: 60.
44. Teodoridis JM, Strathdee G, Brown R: Epigenetic silencing mediated by CpG island methylation: potential as a therapeutic target and as a biomarker. Drug Resist Updat 2004; 7: 267-278. (Pubitemid 39469099)
45. Takeshima M, Saitoh M, Kusano K, Nagayasu H, Kurashige Y, Malsantha M, Arakawa T, Takuma T, Chiba I, Kaku T, Shibata T, Abiko Y: High frequency of hypermethylation of p14, p15 and p16 in oral pre-cancerous lesions associated with betel-quid chewing in Sri Lanka. J Oral Pathol Med 2008; 37: 475-479.
46. Sinha P, Bahadur S, Thakar A, Matta A, Macha M, Ralhan R, Gupta SD: Significance of promoter hypermethylation of p16 gene for margin assessment in carcinoma tongue. Head Neck 2009; 31: 1423-1430.
47. Zhang ZY, Sdek P, Cao J, Chen WT: Human papillomavirus type 16 and 18 DNA in oral squamous cell carcinoma and normal mucosa. Int J Oral Maxillofac Surg 2004; 33: 71-74. (Pubitemid 38035496)
48. Saini R, Tang TH, Zain RB, Cheong SC, Musa KI, Saini D, Ismail AR, Abraham MT, Mustafa WM, Santhanam J: Significant association of high-risk human papillomavirus (HPV) but not of p53 polymorphisms with oral squamous cell carcinomas in Malaysia. J Cancer Res Clin Oncol 2011; 137: 311-320.
49. Torrente MC, Rodrigo JP, Haigentz M Jr, Dikkers FG, Rinaldo A, Takes RP, Olofsson J, Ferlito A: Human papillomavirus infections in laryngeal cancer. Head Neck 2011; 33: 581-586.
50. Baumann JL, Cohen S, Evjen AN, Law JH, Vadivelu S, Attia A, Schindler JS, Chung CH, Wirth PS, Meijer CJ, Snijders PJ, Yarbrough WG, Slebos RJ: Human papillomavirus in early laryngeal carcinoma. Laryngoscope 2009; 119: 1531-1537.
51. Angiero F, Gatta LB, Seramondi R, Berenzi A, Benetti A, Magistro S, Ordesi P, Grigolato P, Dessy E: Frequency and role of HPV in the progression of epithelial dysplasia to oral cancer. Anticancer Res 2010; 30: 3435-3440.
52. Bouda M, Gorgoulis VG, Kastrinakis NG, Giannoudis A, Tsoli E, Danassi-Afentaki D, Foukas P, Kyroudi A, Laskaris G, Herrington CS, Kittas C: 'High risk' HPV types are frequently detected in potentially malignant and malignant oral lesions, but not in normal oral mucosa. Mod Pathol 2000; 13: 644-653. (Pubitemid 30436801)
53. Hall GL, Shaw RJ, Field EA, Rogers SN, Sutton DN, Woolgar JA, Lowe D, Liloglou T, Field JK, Risk JM: P16 promoter methylation is a potential predictor of malignant transformation in oral epithelial dysplasia. Cancer Epidemiol Biomarkers Prev 2008; 17: 2174-2179.
54. Guimaraes AL, Correia-Silva Jde F, Diniz MG, Xavier GM, Horta MC, Gomez RS: Investigation of functional gene polymorphisms: Il-1b, Il-6 and TNFA in benign migratory glossitis in Brazilian individuals. J Oral Pathol Med 2007; 36: 533-537. (Pubitemid 47393532)
55. Perdigao PF, Guimaraes AL, Victoria JM, Xavier GM, Romano-Silva MA, Gomez RS: Serotonin transporter gene polymorphism (5-HTTLPR) in patients with oral lichen planus. Arch Oral Biol 2007; 52: 889-893. (Pubitemid 47125836)
56. Xavier GM, de Sa AR, Guimaraes AL, da Silva TA, Gomez RS: Investigation of functional gene polymorphisms interleukin-1beta, interleukin-6, interleukin-10 and tumor necrosis factor in individuals with oral lichen planus. J Oral Pathol Med 2007; 36: 476-481. (Pubitemid 47222103)
57. Cuschieri K, Wentzensen N: Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia. Cancer Epidemiol Biomarkers Prev 2008; 17: 2536-2545.
58. Munger K, Basile JR, Duensing S, Eichten A, Gonzalez SL, Grace M, Zacny VL: Biological activities and molecular targets of the human papillomavirus E7 oncoprotein. Oncogene 2001; 20: 7888-7898. (Pubitemid 33135315)
59. Nehls K, Vinokurova S, Schmidt D, Kommoss F, Reuschenbach M, Kisseljov F, Einenkel J, von Knebel Doeberitz M, Wentzensen N: P16 methylation does not affect protein expression in cervical carcinogenesis. Eur J Cancer 2008; 44: 2496-2505.
60. Nemes JA, Deli L, Nemes Z, Marton IJ: Expression of p16(INK4A), p53, and Rb proteins are independent from the presence of human papillomavirus genes in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102: 344-352. (Pubitemid 44233357)
61. Zhang H, Jin Y, Chen X, Jin C, Law S, Tsao SW, Kwong YL: Papillomavirus type 16 E6/ E7 and human telomerase reverse transcriptase in esophageal cell immortalization and early transformation. Cancer Lett 2007; 245: 184-194. (Pubitemid 44970513)
62. Perez-Ordonez B, Beauchemin M, Jordan RC: Molecular biology of squamous cell carcinoma of the head and neck. J Clin Pathol 2006; 59: 445-453.