Effects of instillation of eyedrops containing disulfiram and hydroxypropyl-β-cyclodextrin inclusion complex on endotoxin-induced uveitis in rats

Current Eye Research

Volumn 37, Issue 2, 2012, Pages 124-131

  Kanai, Kazutaka ^a   Ito, Yoshimasa ^b   Nagai, Noriaki ^b   Itoh, Naoyuki ^a   Hori, Yasutomo ^a   Chikazawa, Seishirou ^a   Hoshi, Fumio ^a   Higuchi, Seiichi ^a  

^a KITASATO UNIVERSITY   (Japan)

^b KINKI UNIVERSITY   (Japan)

Author keywords

Anti inflammatory effects; Diethyldithiocarbamate; Disulfiram; Endotoxin induced uveitis; Eyedrops

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CYCLOOXYGENASE 2; DEXAMETHASONE; DISULFIRAM; EYE DROPS; HYDROXYPROPYLMETHYLCELLULOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; AQUEOUS HUMOR; ARTICLE; CELL INFILTRATION; CILIARY BODY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG SOLUBILITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UVEITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AQUEOUS HUMOR; BETA-CYCLODEXTRINS; DEXAMETHASONE; DINOPROSTONE; DISEASE MODELS, ANIMAL; DISULFIRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; LIPOPOLYSACCHARIDES; MALE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OPHTHALMIC SOLUTIONS; RATS; RATS, INBRED LEW; TUMOR NECROSIS FACTOR-ALPHA; UVEITIS;

EID: 84856120089     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2011.622853     Document Type: Article

References (40)

1. Rall TW. In: Gilma AG, Rall TW, Nies AS, Taylor P eds. The Pharmacological Basis of Therapeutics. 8th ed. New York: Pergamon Press; 1990:378-379.
2. Liu J, Shigenaga MK, Yan LJ, Mori A, Ames BN. Antioxidant activity of diethyldithiocarbamate. Free Radic Res. 1996;24: 461-472. (Pubitemid 26188964)
3. Voll RE, Mikulowska A, Kalden JR, Holmdahl R. Amelioration of type II collagen induced arthritis in rats by treatment with sodium diethyldithiocarbamate. J Rheumatol. 1999;26:1352-1358. (Pubitemid 29268090)
4. Ito Y, Cai H, Koizumi Y, Nakao M, Terao M. Correlation between prevention of cataract development by disulfiram and fates of selenium in selenite-treated rats. Curr Eye Res. 1999;18:292-299. (Pubitemid 29237889)
5. Brar SS, Grigg C, Wilson KS et al. Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metaldependent manner in vitro, in mice and in a patient with metastatic disease. Mol Cancer Ther. 2004;3:1049-1060. (Pubitemid 39295002)
6. Schreck R, Meier B, Männel DN, Dröge W, Baeuerle PA. Dithiocarbamates as potent inhibitors of nuclear factor ?B activation in intact cells. J Exp Med. 1992;175: 1181-1194.
7. Bucolo C, Cuzzocrea S, Mazzon E, Caputi AP. Effects of cloricromene, a coumarin derivative, on endotoxin-induced uveitis in Lewis rats. Invest Ophthalmol Vis Sci. 2003;44:1178-1184. (Pubitemid 36297838)
8. Ilieva I, Ohgami K, Jin XH et al. Captopril suppresses inflammation in endotoxin-induced uveitis in rats. Exp Eye Res. 2006;83:651-657. (Pubitemid 43902786)
9. Ohgami K, Ilieva I, Shiratori K et al. Anti-inflammatory effects of aronia extract on rat endotoxin-induced uveitis. Invest Ophthalmol Vis Sci. 2005;46:275-281. (Pubitemid 40041207)
10. Yadav UC, Srivastava SK, Ramana KV. Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2007;48:4634-4642. (Pubitemid 351260981)
11. Li Q, Peng B, Whitcup SM, Jang SU, Chan CC. Endotoxin induced uveitis in the mouse: Susceptibility and genetic control. Exp Eye Res. 1995;61:629-632.
12. Chan CC, Tuaillon N, Li Q, Shen DF. Therapeutic applications of antiflammin peptides in experimental ocular inflammation. Ann N Y Acad Sci. 2000;923:141-146. (Pubitemid 32050211)
13. Kasner L, Chan CC, Whitcup SM, Gery I. The paradoxical effect of tumor necrosis factor α (TNF-α) in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci. 1993;34:2911-2917. (Pubitemid 23269145)
14. Rosenbaum J.T.Boney R.S. Failure to inhibit endotoxin-induced uveitis with antibodies that neutralize tumor necrosis factor Regul. Immunol. 1994 5 299-303
15. Rosenbaum JT, Howes EL Jr, Rubin RM, Samples JR. Ocular inflammatory effects of intravitreally-injected tumor necrosis factor. Am J Pathol. 1988;133:47-53.
16. de Vos AF, van Haren MA, Verhagen C, Hoekzema R, Kijlstra A. Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat. Invest Ophthalmol Vis Sci. 1994;35:1100-1106. (Pubitemid 24079844)
17. Planck SR, Huang XN, Robertson JE, Rosenbaum JT. Cytokine mRNA levels in rat ocular tissues after systemic endotoxin treatment. Invest Ophthalmol Vis Sci. 1994;35:924-930. (Pubitemid 24079823)
18. Jacquemin E, de Kozak Y, Thillaye B, Courtois Y, Goureau O. Expression of inducible nitric oxide synthase in the eye from endotoxin-induced uveitis rats. Invest Ophthalmol Vis Sci. 1996;37:1187-1196.
19. Bellot JL, Palmero M, García-Cabanes C, Espí R, Hariton C, Orts A. Additive effect of nitric oxide and prostaglandin-E2 synthesis inhibitors in endotoxin-induced uveitis in the rabbit. Inflamm Res. 1996;45:203-208. (Pubitemid 26135076)
20. Yadav UC, Subramanyam S, Ramana KV. Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Invest Ophthalmol Vis Sci. 2009;50:2276-2282.
21. Ohta K, Nakayama K, Kurokawa T, Kikuchi T, Yoshimura N. Inhibitory effects of pyrrolidine dithiocarbamate on endotoxin- induced uveitis in Lewis rats. Invest Ophthalmol Vis Sci. 2002;43:744-750. (Pubitemid 34184492)
22. Suzuki Y, Ohgami K, Shiratori K et al. Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-?B signaling pathway. Exp Eye Res. 2006;82:275-281. (Pubitemid 43122113)
23. Kanai K, Itoh N, Yoshioka K et al. Inhibitory effects of oral disulfiram on endotoxin-induced uveitis in rats. Curr Eye Res. 2010;35:892-899.
24. Irie T, Uekama K. Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation. J Pharm Sci. 1997;86:147-162. (Pubitemid 27078377)
25. Müller BW, Brauns U. Solubilization of drugs by modified β-cyclodextrins. Int J Pharm. 1985;26:77-88.
26. Kristinsson JK, Fridriksdóttir H, Thórisdóttir S, Sigurdardóttir AM, Stefánsson E, Loftsson T. Dexamethasone- cyclodextrinpolymer co-complexes in aqueous eye drops. Aqueous humor pharmacokinetics in humans. Invest Ophthalmol Vis Sci. 1996;37:1199-1203. (Pubitemid 26164250)
27. Wang S, Li D, Ito Y, Liu X, Zhang J, Wu C. An ocular drug delivery system containing zinc diethyldithiocarbamate and HPβCD inclusion complex-corneal permeability, anticataract effects and mechanism studies. J Pharm Pharmacol. 2004;56:1251-1257. (Pubitemid 39368995)
28. Wang S, Li D, Ito Y et al. Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-β-cyclodextrin on selenitetreated rats. Curr Eye Res. 2004;29:51-58. (Pubitemid 39389441)
29. Nagai N, Inomata M, Ito Y. Contribution of aldehyde dehydrogenase 3A1 to disulfiram penetration through monolayers consisting of cultured human corneal epithelial cells. Biol Pharm Bull. 2008;31:1444-1448. (Pubitemid 351930666)
30. Nagai N, Takeda M, Ito Y, Takeuchi N, Kamei A. Delay in ICR/f rat lens opacification by the instillation of eye drops containing disulfiram and hydroxypropyl-β-cyclodextrin inclusion complex. Biol Pharm Bull. 2007;30:1529-1534. (Pubitemid 47282211)
31. Smith JR, Hart PH, Williams KA. Basic pathogenic mechanisms operating in experimental models of acute anterior uveitis. Immunol Cell Biol. 1998;76:497-512. (Pubitemid 29003052)
32. Jin XH, Ohgami K, Shiratori K et al. Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis rats. Invest Ophthalmol Vis Sci. 2006;47:2562-2568. (Pubitemid 351639842)
33. Tilton RG, Chang K, Corbett JA et al. Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production. Invest Ophthalmol Vis Sci. 1994;35:3278-3288. (Pubitemid 24241366)
34. Cuzzocrea S, Chatterjee PK, Mazzon E et al. Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation. Br J Pharmacol. 2002;135:496-510. (Pubitemid 34151183)
35. Mandai M, Yoshimura N, Yoshida M, Iwaki M, Honda Y. The role of nitric oxide synthase in endotoxin-induced uveitis: Effects of NG-nitro L-arginine. Invest Ophthalmol Vis Sci. 1994; 35:3673-3680. (Pubitemid 24337980)
36. Masferrer JL, Zweifel BS, Manning PT et al. Selective inhibition of inducible cyclooxygenase 2 in vivo is anti-inflammatory and nonulcerogenic. Proc Natl Acad Sci USA. 1994;91:3228-3232. (Pubitemid 24130209)
37. Seibert K, Zhang Y, Leahy K et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci USA. 1994;91:12013-12017. (Pubitemid 24368594)
38. Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci USA. 1993;90:7240-7244. (Pubitemid 23222425)
39. Nakamura S, Ohno S. Anti-tumor necrosis factor α antibody in the treatment of Behçet's disease. Int Ophthalmol Clin. 2005;45:179-189. (Pubitemid 40570760)
40. Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: The control of NF-[?]B activity. Annu Rev Immunol. 2000;18:621-663. (Pubitemid 30365393)