Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-beta-cyclodextrin on selenite-treated rats

Current Eye Research

Volumn 29, Issue 1, 2004, Pages 51-58

  Wang, Siling ^a   Li, Dexin ^a   Ito, Yoshimasa ^b   Nabekura, Tomohiro ^b   Wang, Shujun ^a   Zhang, Jinghai ^a   Wu, Chunfu ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b KINKI UNIVERSITY   (Japan)

Author keywords

Bioavailability; Cataract; Disulfiram; Hydroxypropyl cyclodextrin inclusion; Hydroxypropylmethylcellulose; Permeability; Solubility

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 4 BROMOPHENACYL BROMIDE; AGENTS ACTING ON THE EYE; BENZALKONIUM CHLORIDE; DIETHYLTHIOCARBAMATE; DISULFIRAM; EYE DROPS; HYDROXYPROPYLMETHYLCELLULOSE; SELENITE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; CATARACT; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; FEMALE; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SLIT LAMP; X RAY DIFFRACTION;

ADMINISTRATION, TOPICAL; ANIMALS; AQUEOUS HUMOR; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; CATARACT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORNEA; DISULFIRAM; DRUG DELIVERY SYSTEMS; FEMALE; MALE; OPHTHALMIC SOLUTIONS; PERMEABILITY; RABBITS; RATS; RATS, WISTAR; SODIUM SELENITE; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 6344284503     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1080/02713680490513209     Document Type: Article

References (21)

1. Terao M, Ito Y. Method for treatment of cataract with radical scavenger. US Patent. 1997;56:655-770.
2. Ito Y, Cai H, Koizumi Y, Nakao M, Terao M. Correlation between prevention of cataract development by disulfiram and fates of selenium in selenite-treated rats. Cur Eye Res. 1999;18:292-299.
3. Ito Y, Cai H, Koizumi Y, Hori R, Terao M, Kimura T, Takagi S, Tomohiro M. Effects of lipid composition on the transcorneal penetration of liposomes containing disuliram, a potential anticataract agent, in the rabbit. Bio Pharm Bull. 2000;23:327-333.
4. Kristinsson JK, Fridriksdottir H, Thorisdottir S, Sigurdardottir AM, Stefansson E, Loftsson T. Dexamethasone-cyclodextrin-polymer co-complexes in aqueous eye drops. Invest Ophthalmol & Vis Sci. 1996;37:1199-1203.
5. Muller BW, Brauns U. Solubilization of drugs by modified β-cyclodextrins. Int J Pharm. 1985;26:77-88.
6. Castillo JA, Palomo-Canales J, Garcia JJ, Lastres JL, Bolas F, Torrado JJ. Preparation and characterization of albendazole beta-cyclodextrin complexes. Drug Dev Ind Pharm. 1999;25:1241-1248.
7. Loftsson T, Fridriksdottir H, Thorisdottir S, Stefansson E. The effect of hydroxypropyl methylcellulose on the release of dexamethasone from aqueous 2-hydroxypropyl-β-cyclodextrins formulations. Int J Pharmacol. 1994; 104: 181-184.
8. Higuchi T, Lach JL. Investigation of some complexes formed in solution by caffeine: IV Interactions between caffeine and sulfathiazole, sulfadiazine, p-aminobenzoic acid, benzocaine, phenobarbital, and barbital. J Am Pharm Assoc Sci Ed. 1954;43:349-354.
9. Iwata S, Ohtani Y, Osada E, Ogino H. Aspect on corneal permeability of bupranolol. Yakugaku Zasshi. 1980; 100(4):402-406.
10. Meisner D, Pringel J, Mezei M. Liposomal ophthalmic drug delivery. Pharmacodynamic and biodisposition studies of atropine. Int J Pharm. 1989;55:105-113.
11. Yamaoka K, Tanigawara T, Nakagawa T, Uno T. Pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobio-Dyn. 1981;4:879-885.
12. Ogiso T, Ito Y, Iwaki M, Yamamoto Y. Percutaneous absorption of clonazepam in rabbit. Chem Pharm Bull. 1989;37: 442-445.
13. Adamsons I, Taylor KI, Enger C, Taylor HR. A new method for documenting lens opacities. Am J Ophthalmol. 1991;111:65-70.
14. Kojima M, Sasaki K. Application of a new scheimpflug camera (EAS-1000) to animal cataract models. Ophthalmic Res. 1992;24:3-9.
15. Higuchi T, Kristiansen H. Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into two groups according to binding tendencies. J Pharm Sci. 1970;59:1601-1608.
16. Castillo JA, Palomo-Canales J, Garcia JJ. Preparation and characterization of albendazole β-cyclodextrin complexes. Drug Dev Ind Pharm. 1999;25:1241-1248.
17. Vandelli MA, Salvioli G, Mucci A, Panini R. 2-Hydroxypropyl-β- cyclodextrin complexation with ursodeoxycholic acid. M J Pharm. 1995;118:77-83.
18. Giles HG, Au J, Sellers EM. Analysis of plasma diethyldithiocarbmate a metablite of disulfiram. J Liq Chromatogr. 1982;5:945-951.
19. Benny J. Rapid and sensitive on-line precolumn purification and high-performance liquid Chromatographic assay for disulfiram and its metabolites. Jour of Chromato 1986;378:419-429.
20. Paul H. Triethy loxonium tetrefluoroboarate derivation and HPLC analysis of diethydithiocarbamate in plasma. Analyt Lett. 1985;18:57-66.
21. Tomohiro Nabekura, Yoshimasa Ito, Hong Cai, Motome Terao, Ryohei Hori. Preparation and in vivo absorption studies of disulfiram solid dispersion. Biol Pharm Bull. 2000;23(5):616-620.