Basic pathogenic mechanisms operating in experimental models of acute anterior uveitis

Immunology and Cell Biology

Volumn 76, Issue 6, 1998, Pages 497-512

  Smith, Justine R ^a   Hart, Prue H ^a   Williams, Keryn A ^a,b  

^a FLINDERS UNIVERSITY   (Australia)

^b FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Acute anterior uveitis; Endotoxin induced uveitis; Experimental melanin induced uveitis

Indexed keywords

CELL ADHESION MOLECULE; CYTOKINE; ENDOTOXIN; FAS LIGAND; ICOSANOID; MATRIX METALLOPROTEINASE; MELANIN; NITRIC OXIDE; SUBSTANCE P;

ANIMAL MODEL; AUTOIMMUNITY; CLINICAL FEATURE; COMPARATIVE STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DENDRITIC CELL; EXPERIMENTAL MODEL; IRIDOCYCLITIS; LYMPHOCYTE; MACROPHAGE; NEUTROPHIL; NONHUMAN; REVIEW;

ACUTE DISEASE; ANIMALS; CATTLE; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; ENDOTOXINS; HAPLORHINI; IMMUNITY, CELLULAR; INFLAMMATION MEDIATORS; MACROPHAGES; MAST CELLS; MELANINS; MICE; NEUTROPHILS; RABBITS; RATS; UVEITIS, ANTERIOR;

ANIMALIA; BACTERIA (MICROORGANISMS); BOVINAE;

EID: 0032408878     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.1998.00783.x     Document Type: Review

References (138)

1. Bloch-Michel E, Nussenblatt RB. International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease. Am. J. Ophthalmol. 1987; 103: 234-5.
2. Linssen A, Rothova A, Valkenburg HA et al. The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27. Invest. Ophthalmol. Vis. Sci. 1991; 32: 2568-78.
3. Rothova A, Van Veenendaal WG, Linssen A, Glasius E, Kijlstra A, De Jong PTVM. Clinical features of acute anterior uveitis. Am. J. Ophthalmol. 1987; 103: 137-45.
4. Kaplan HJ. Immunologic insights into the eye and uveitis. In: Kraus-Mackiw E, O'Connor GR (eds) Uveitis. Pathophysiology and Therapy. Stuttgart: Thieme, 1986; 227-44.
5. Khan MA. HLA-B27 and its subtypes in world populations. Curr. Opin. Rheumatol. 1995; 7: 263-9.
6. Wakefield D, Montanaro A, McCluskey P. Acute anterior uveitis and HLA-B27. Surv. Ophthalmol. 1991; 36: 223-32.
7. Feltkamp TEW, Muhammad AK, Lopez de Castro JA. The pathogenetic role of HLA-B27. Immunol. Today 1996; 17: 5-7.
8. Wacker WB. Experimental allergic uveitis. Investigations of retinal autoimmunity and the immunopathologic responses evoked. Invest. Ophthalmol. Vis. Sci. 1991; 32: 3119-28.
9. Rosenbaum JT, McDevitt HO, Guss RB, Egbert PR. Endotoxin-induced uveitis in rats as a model for human disease. Nature 1980; 286: 611-13.
10. Kogiso M, Tanouchi Y, Mimura Y, Nagasawa H, Himeno K. Endotoxin-induced uveitis in mice 1. Induction of uveitis and role of T lymphocytes. Jpn J. Ophthalmol. 1992; 36: 281-90.
11. Broekhuyse RM, Kuhlmann ED. Experimental autoimmune anterior uveitis. The preparation of uveitogenic melanin. Invest. Ophthalmol. Vis. Sci. 1993; 34: 698-700.
12. Wacker WB, Lipton MM. Experimental allergic uveitis: Homologous retina as uveitogenic antigen. Nature 1965; 206: 253-4.
13. Wacker WB, Lipton MM. Experimental allergic uveitis. I. Production in the guinea pig and rabbit by immunization with retina in adjuvant. J. Immunol. 1968; 101: 151-6.
14. Rao NA, Wacker WB, Marak GE. Experimental allergic uveitis. Clinicopathologic features associated with varying doses of S antigen. Arch. Ophthalmol. 1979; 97: 1954-8.
15. Wacker WB, Donoso LA, Kalsow CM, Yankeelov JA, Organisciak DT. Experimental allergic uveitis. Isolation, characterization, and localization of a soluble uveitopathogenic antigen from bovine retina. J. Immunol. 1977; 119: 1949-58.
16. Pfister C, Chabre M, Plouet J et al. Retinal S antigen identified as the 48K protein regulating light-dependent phosphodiesterase in rods. Science 1985; 228: 891-3.
17. Nussenblatt RB, Rodrigues MM, Wacker WB et al. Inhibition of experimental autoimmune uveitis in Lewis rats. J. Clin. Invest. 1981; 67: 1228-31.
18. Hanashiro RK, Fujino Y, Gugunfu Samura M, Takahashi T, Masuda K. Synthetic lipid A-induced uveitis and endotoxin-induced uveitis: A comparative study. Jpn J. Ophthalmol. 1997; 41: 355-61.
19. Bhattacherjee P, Williams RN, Eakins KE. An evaluation of ocular inflammation following the injection of bacterial endotoxin into the rat foot pad. Invest. Ophthalmol. Vis. Sci. 1983; 24: 196-202.
20. Cousins SW, Guss RB, Howes EL, Rosenbaum JT. Endotoxin-induced uveitis in the rat: Observations on altered vascular permeability, clinical findings, and histology. Exp. Eye Res. 1984; 39: 665-76.
21. Okumura A, Mochizuki M. Endotoxin-induced uveitis in rats: Morphological and biochemical study. Jpn J. Ophthalmol. 1988; 32: 457-65.
22. Ruiz-Moreno JM, Thillaye B, De Kozak Y. Retino-choroidal changes in endotoxin-induced uveitis in the rat. Ophthalmic Res. 1992; 24: 162-8.
23. Whitcup SM, DeBarge LR, Rosen H, Nussenblatt RB, Chan C-C. Monoclonal antibody against CD11b/CD18 inhibits endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 1993; 34: 673-81.
24. Herbort CP, Chan CC, Nussenblatt RB. Endotoxin-induced uveitis in the rat: A hypothesis for preferential involvement of the anterior uvea. Curr. Eye Res. 1990; 9S: 119-24.
25. Hoekzema R, Verhagen C, Van Haren M, Kijlstra A. Endotoxin-induced uveitis in the rat. The significance of intraocular interleukin-6. Invest. Ophthalmol. Vis. Sci. 1992; 33: 532-9.
26. Broekhuyse RM, Kuhlmann ED, Winkens HJ, Van Vugt AHM. Experimental autoimmune anterior uveitis (EAAU). a new form of experimental uveitis. I. Induction by a detergent-insoluble, intrinsic protein fraction of the retinal pigment epithelium. Exp. Eye Res. 1991; 52: 465-74.
27. Broekhuyse RM, Kuhlman ED, Winkens HJ. Experimental autoimmune anterior uveitis (EAAU). II. Dose-dependent induction and adoptive transfer using a melanin-bound antigen of the retinal pigment epithelium. Exp. Eve Res. 1992; 55: 401-11.
28. Broekhuyse RM, Kuhlmann ED, Winkens HJ. Experimental autoimmune anterior uveitis (EAAU). III. Induction by immunisation with purified uveal and skin melanins. Exp. Eye Res. 1993; 56: 575-83.
29. Nordlund JJ, Abdel-Malek ZA, Boissy RE, Rheins LA. Pigment cell biology: An historical review. J. Invest. Dermatol. 1989; 92: 53S-60.
30. Simpson SC, Kaplan HJ, Bora NS. Uveitogenic proteins isolated from bovine iris and ciliary body. Eye 1997; 11: 206-8.
31. Chan C-C, Hikita N, Dastgheib K, Whitcup SM, Gery I, Nussenblatt RB. Experimental melanin-protein-induced uveitis in the Lewis rat. Immunopathologic processes. Ophthalmology 1994; 101: 1275-80.
32. Bora NS, Kim MC, Kabeer NH et al. Experimental autoimmune anterior uveitis. Induction with melanin-associated antigen from the iris and ciliary body. Invent. Ophthalmol. Vis. Sci. 1995; 36: 1056-66.
33. Baer JC, Morris SM. Anterior chamber inflammation in endotoxin induced uveitis is greater in male Lewis rats than in females. ARVO abstracts. Invest. Ophthalmol. Vis. Sci. 1993; 34: 1475.
34. Wakefield D, McCluskey P, Palladinetti P. Distribution of lymphocytes and cell adhesion molecules in iris biopsy specimens from patients with uveitis. Arch. Ophthalmol. 1992; 110: 121-5.
35. Hogan MJ, Wood IS, Godfrey WA. Aqueous humor cytology in uveitis. Arch. Ophthalmol. 1973; 89: 217-20.
36. McMenamin PG, Crewe J. Endotoxin-induced uveitis. Kinetics and phenotype of the inflammatory cell infiltrate and the response of the resident tissue macrophages and dendritic cells in the iris and ciliary body. Invest. Ophthalmol. Vis. Sci. 1995; 36: 1949-59.
37. Hikita N, Chan C-C, Whitcup SM, Nussenblatt RB, Mochizuki M. Effects of topical FK506 on endotoxin-induced uveitis (EIU) in the Lewis rat. Curr. Eye Res. 1995; 14: 209-14.
38. McMenamin PG, Crewe J, Morrison S, Holt PG. Immunomorphologic studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat. mouse and human eye. Invest. Ophthalmol. Vis. Sci. 1994; 35: 3234-50.
39. Kim MC, Kabeer NH, Tandhasetti MT, Kaplan HJ, Bora NS. Immunohistochemical studies on melanin associated antigen (MAA) induced experimental autoimmune anterior uveitis. Curr. Eye Res. 1995; 14: 703-10.
40. De Kozak Y, Saint-Laudy J, Benveniste J, Faure J-P. Evidence for immediate hypersensitivity phenomena in experimental autoimmune uveoretinitis. Eur. J. Immunol. 1981; 11: 612-17.
41. Steptoe RJ, McMenamin C, McMenamin PG. Choroidal mast cell dynamics during experimental autoimmune uveoretinitis in rat strains of differing susceptibility. Ocular Immunol. Inflamm. 1994; 2: 7-22.
42. Li Q, Fujino Y, Caspi RR, Najafian F, Nussenblatt RB, Chan C-C. Association between mast cells and the development of experimental autoimmune uveitis in different rat strains. Clin. Immunol. Immunopathol. 1992; 65: 294-9.
43. Mochizuki M, Kuwabara T, Chan C-C, Nussenblatt RB, Metcalfe DD, Gery I. An association between susceptibility to experimental autoimmune uveitis and choroidal mast cell numbers. J. Immunol. 1984; 133: 1699-701.
44. Smith JR, Hart PH, Coster DJ, Williams KA. Uveal mast cells are not required for rodent uveitis. Ophthalmic Res. 1998; 30: 388-93.
45. McMenamin PG. The distribution of immune cells in the uveal tract of the normal eye. Eye 1997; 11: 183-93.
46. Cheung MK, Dastgheib K, Chan CC, Roberge FG. Inhibition of PMN leucocyte recruitment by NPC 15669 prevents endotoxin-indueed uveitis. ARVO Abstracts. Invest. Opthalmol. Vis. Sci. 1994; 35: 1684.
47. McColl SR, Showell HJ. Neutrophil-derived inflammatory mediators. In: Hellewell PG, Williams TJ (eds) Immunopathology of Neutrophils. London: Academic Press, 1994; 95-114.
48. Hikita N, Dastgheib K, Mochizuki M, Nussenblatt RB, Chan C-C. Effect of topical FK506 on experimental melanin-protein induced uveitis (EMIU) in rats. ARVO Abstracts. Invest. Ophthalmol. Vis. Sci. 1994; 35: 1540.
49. Smith JR, Hart PH, Standfield SD, Coster DJ, Williams KA. Experimental melanin-induced uveitis may be prevented by non-depleting anti-CD4 (but not anti-CD8) antibody. Exp. Eye Res. 1998; 67: S71.
50. Steptoe RJ, Holt PG, McMenamin PG. Functional studies of major histocompatibility class II-positive dendritic cells and resident tissue macrophages isolated from the rat iris. Immunology 1995; 85: 630-7.
51. Steptoe RJ, Holt PG, McMenamin PG. Origin and steady-state turnover of major histocompatibility class II-positive dendritic cells and resident-tissue macrophages in the iris of the rat eye. J. Neuroimmunol. 1996; 68: 67-76.
52. Welle M. Development, significance and heterogeneity of mast cells with particular regard to mast cell-specific proteases chymase and tryptase. J. Leukoc. Biol. 1997; 61: 233-45.
53. Smelser GK, Silver S. The distribution of mast cells in the normal eye. A method of study. Exp. Eye Res. 1963; 2: 134-40.
54. Godfrey WA. Characterization of the choroidal mast cell. Trans. Am. Ophthalmol. Soc. 1987; 85: 557-99.
55. Steptoe RJ. McMenamin PG, McMenamin C. Distribution and characterisation of rat choroidal mast cells. Br. J. Ophthalmol. 1994; 78: 211-18.
56. Suzuma K, Mandai M, Kogishi J, Tojo SJ, Honda Y, Yoshimura N. Role of P-selectin in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 1997; 38: 1610-18.
57. Whitcup SM, Wakefield D, Li Q, Nussenblatt RB, Chan C-C. Endothelial leukocyte adhesion molecule-1 in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 1992; 33: 2626-30.
58. Whitcup SM, Kozhich AT, Lobanoff M, Wolitzky BA, Chan C-C. Blocking both E-selectin and P-selectin inhibits endotoxin-induced leukocyte infiltration into the eye. Clin. Immunol. Immunopathol. 1997; 83: 45-52.
59. Whitcup SM, Hikita N, Shirao M et al. Monoclonal antibodies against CD54 (ICAM-1) and CD11a (LFA-1) prevent and inhibit endotoxin-induced uveitis. Exp. Eye Res. 1995; 60: 597-601.
60. Kanagawa T, Matsuda S, Mikawa Y et al. Role of ICAM-1 and LFA-1 in endotoxin-induced uveitis in mice. Jpn J. Ophthalmol. 1996; 40; 174-80.
61. Yoshida M, Yoshimura N, Hangai M, Tanihara H, Honda Y. Interleukin-1α, inlerleukin-1β, and tumor necrosis factor gene expression in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 1994; 35: 1107-13.
62. Planck SR, Huang X-N, Robertson JE, Rosenbaum JT. Cytokine mRNA levels in rat tissues after systemic endotoxin treatment. Invest. Ophthalmol. Vis. Sci. 1994; 35: 924-30.
63. De Vos AF, Klaren VNA, Kijlstra A. Expression of multiple cytokines and IL-1RA in the uvea and retina during endotoxin-induced uveitis in the rat. Invest. Ophthalmol. Vis. Sci. 1994; 35: 3873-83.
64. De Vos AF, Klaren VNA, Kijlstra A. Simultaneous induction of cytokine mRNA expression in the anterior uvea during endoloxin-induced uveitis in the rat. Exp. Eye Res. 1996; 62: 581-4.
65. De Vos AF, Van Haren MAC, Verhagen C, Hoekzema R, Kijlstra A. Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat. Invest. Ophthalmol. Vis. Sci. 1994; 35: 1100-6.
66. Herbort CP, Okumura A, Mochizuki M. Endotoxin-induced uveitis in the rat: A study of the role of inflammation mediators. Graefes Arch. Clin. Exp. Ophthalmol. 1988; 226: 553-8.
67. Okumura A, Mochizuki M, Nishi M, Herbort CP. Endotoxin-induced uveitis (EIU) in the rat: A study of inflammatory and immunological mechanisms. Int. Ophthalmol. 1990; 14: 31-6.
68. Parks DJ, Cheung MK, Chan C-C, Roberge FG. The role of nitric oxide in uveitis. Arch. Ophthalmol. 1994; 112: 544-6.
69. Goureau O, Bellot J, Thillaye B, Courtois Y, de Kozak Y. Increased nitric oxide production in endotoxin-induced uveitis. Reduction of uveitis by an inhibitor of nitric oxide synthase. J. Immunol. 1995; 154: 6518-23.
70. Tilton RG, Chang K, Corbett JA et al. Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production. Invest. Ophthalmol. Vis. Sci. 1994; 35: 3278-88.
71. Mandai M, Mittag TW, Kogishi J, Iwaki M, Hangai M, Yoshimura N. Role of nitric oxide synthase isozymes in endotoxin-indueed uveitis. Invest. Ophthalmol. Vis. Sci. 1996; 37: 826-32.
72. Jacquemin E, De Kozak Y, Thillaye B, Courtois Y, Goureau O. Expression of inducible nitric oxide synthase in the eye from endotoxin-induced uveitis rats. Invest. Ophthalmol. Vis. Sci. 1996; 37: 1187-96.
73. McMenamin PJ, Crewe JM. Cellular localisation and dynamics of nitric oxide synthase expression in the rat anterior segment during endotoxin-induced uveitis. Exp. Eye Res. 1997; 65: 157-64.
74. Di Girolamo N, Verma MJ, McCluskey PJ, Lloyd A, Wakefield D. Increased matrix metalloproteinases in the aqueous humor of patients and experimental animals with uveitis. Curr. Eye Res. 1996; 15: 1060-8.
75. Rosenbaum JT, Rosenbaum SO, Waldman M, Toth C, Mohler K. Do interleukin-1, tumor necrosis factor, or complement contribute to endotoxin-induced uveitis? ARVO Abstracts. Invest. Ophthalmol. Vis. Sci. 1993; 34: 1143.
76. Bora NS, Woon M-D, Unal SH, Kaplan HJ. TNF-α is the major cytokine associated with experimental autoimmune anterior uveitis (EAAU). ARVO Abstracts. Invest. Ophthalmol. Vis. Sci. 1997; 38: S1160.
77. Smith JR, Hart PH, Standfield SD, Coster DJ, Williams KA. Apoptosis of infiltrating inflammatory cells is a prominent feature of acute anterior uveitis in the Fischer 344 rat. International Symposium on Ocular Immunology and Inflammation [Abstract]. Ocular Immunol. Immunopathol. 1998; 6: S45.
78. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994; 84: 2068-101.
79. Baatz H, Pleyer U, Thiel H-J, Hammer C. In vivo study of leucocyte-endothelium interaction in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 1995; 36: 1960-7.
80. Han YB, Gutierrez-Ramos J, Park JM, O'Rourke L, Planck SR, Rosenbaum JT. Importance of beta-2 integrins in endotoxin-induced uveitis as determined in genetically altered mice. ARVO Abstracts. Invest. Ophthalmol Vis. Sci. 1996; 37: S543.
81. Cohen MC, Cohen S. Cytokine function. A study in biologic diversity. Am. J. Clin. Pathol. 1996; 105: 598.
82. Rosenbaum JT, Angell E. Paradoxical effects of IL-10 in endotoxin-induced uveitis. J. Immunol. 1995; 155: 4090-4.
83. Hayashi S, Guex-Crosier Y, Delaux A, Velu T, Roberge FG. Interleukin 10 inhibits inflammatory cells infiltration in endotoxin-mduced uveitis. Graefes Arch. Clin. Exp. Ophthalmol. 1996; 234: 633-6.
84. Smith JR, Hart PH, Coster DJ, Williams KA. Mice deficient in TNFR p55 and p75, IL-4 or iNOS are susceptible to endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 1998; 39: 658-61.
85. Whitcup SM, Rizzo LV, Lai JC, Hayashi S, Gazzinelli R, Chan C-C. IL-12 inhibits endotoxin-induced inflammation in the eye. Eur. J. Immunol. 1996; 26: 995-9.
86. Guex-Crosier Y, Wittwer AJ, Roberge FG. Intraocular production of a cytokine (CINC) responsible for neutrophil infiltration in endotoxin induced uveitis. Br. J. Ophthalmol. 1996; 80: 649-53.
87. Planck SR, Lee VM, Park JM, Han YB, Rosenbaum JT. Gamma interferon knock-out mice show a reduction in endotoxin-induced uveitis. ARVO Abstracts. Invest. Ophthalmol. Vis. Sci. 1996; 37: S543.
88. Planck SR, Han YB, Park JM et al. Endotoxin-induced uveitis (EIU) in mice with IL-1 receptor and TNF receptor genes deleted. ARVO Abstracts. Invest. Ophthalmol. Vis. Sci. 1997; 38: S188.
89. Rosenbaum JT, Kievit P, Young BH, Park JM, Planck SR. Interleukin-6 does not mediate endotoxin-induced uveitis in mice: Studies in gene deletion mice. Invest. Ophthalmol. Vis. Sci. 1998; 39: 64-9.
90. Yoshida M, Yoshimura N, Ishida K, Honda Y. Increased production of transforming growth factor beta in endotoxin induced uveitis. ARVO Abstracts. Invest. Ophthalmol. Vis. Sci. 1995; 36: S545.
91. Verma MJ, Lloyd A, Rager H et al. Chemokines in acute anterior uveitis. Curr. Eye Res. 1997; 16: 1202-8.
92. De Vos AF, Van Haren MAC, Verhagen C, Hoekzema R, Kijlstra A. Tumour necrosis factor-induced uveitis in the Lewis rat is associated with intraocular interleukin 6 production. Exp. Eye Res. 1995; 60: 199-207.
93. Akira S, Hirano T, Taga T, Kishimoto T. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J. 1990; 4: 2860-7.
94. Barbara JAJ, Van Ostade X, Lopez AF. Tumour necrosis factor-alpha (TNF-α): The good, the bad and potentially very effective. Immunol. Cell Biol. 1996; 74: 434-43.
95. Rosenbaum JT, Boney RS. Failure to inhibit endotoxin-induced uveitis with antibodies that neutralize tumor necrosis factor. Reg. Immunol. 1993; 5: 299-303.
96. Kasner L, Chan C-C, Whitcup SM, Gery I. The paradoxical effect of tumor necrosis factor alpha (TNF-α) in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 1993; 34: 2911-17.
97. De Vos AF, Van Haren MAC, Verhagen C, Hoekzema R, Kijlstra A. Systemic anti-tumor necrosis factor antibody treatment exacerbates endotoxin-induced uveitis in the rat. Exp. Eye Res. 1995; 61: 667-75.
98. Rosenbaum JT, Rosenbaum SO, Waldman ML et al. Failure to inhibit endotoxin-induced uveitis with soluble TNF receptors. Reg. Immunol. 1994; 6: 73-5.
99. Ferrick MR, Thurau SR, Oppenheim MH et al. Ocular inflammation stimulated by intravitreal interleukin-8 and interleukin-1. Invest. Ophthalmol. Vis. Sci. 1991; 32: 1534-9.
100. Hamel CP, Detrick B, Hooks JJ. Evaluation of Ia expression in rat ocular tissues following inoculation with interferon-gamma. Exp. Eye Res. 1990; 50: 173-82.
101. Murray PI, Hoekzema R, Van Haren MAC, De Han FD, Kijlstra A. Aqueous humor interleukin-6 levels in uveitis. Invest. Ophthalmol. Vis. Sci. 1990; 31: 917-20.
102. Abi-Hanna D, McCluskey P, Wakefield D. HLA antigens in the iris and aqueous humor gamma interferon levels in anterior uveitis. Invest. Ophthalmol. Vis. Sci. 1989; 30: 990-4.
103. Young HA, Hardy KJ. Role of interferon-gamma in immune cell regulation. J. Leukoc. Biol. 1995; 58: 373-81.
104. Brown MA, Hural J. Functions of IL-4 and control of its expression. Crit. Rev. Immunol. 1997; 17: 1-32.
105. Ramanathan S, de Kozak Y, Saoudi A et al. Recombinant IL-4 aggravates experimental autoimmune uveoretinitis in rats. J. Immunol. 1996; 157: 2209-15.
106. D'Andrea A, Ma X, Aste-Amezaga M, Paganin C, Trinchieri G. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor α production. J. Exp. Med. 1995; 181: 537-46.
107. Kambayashi T, Jacob CO, Strassmann G. IL-4 and IL-13 modulate IL-10 release in endotoxin-stimulaled murine peritoneal mononuclear phagocytes. Cell. Immunol. 1996; 171: 153-8.
108. Masinovsky B, Urdal D, Gallatin M. IL-4 acts synergistically with II-1β to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1. J. Immunol. 1990; 145: 2886-95.
109. Van den Berg TK, van Die I, de Renardel Lavalette C et al. Regulation of sialoadhesin expression on rat macrophages. Induction by glueocorticoids and enhancement by IFN-β, IFN-γ, IL-4, and lipopolysaccharide. J. Immunol. 1996; 157: 3130-8.
110. Zlotnik A, Fischer M, Roehm N, Zipori D. Evidence for effects of Interleukin 4 (B cell stimulatory factor 1) on macrophages: Enhancement of antigen presenting ability of bone marrow-derived macrophages. J. Immunol. 1987; 138: 4275-9.
111. Te Velde AA, Klomp JPG, Yard BA, de Vries JE, Figdor CG. Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4. J. Immunol. 1988; 140: 1548-54.
112. De Waal-Malefyt R, Yssel H, Roncarolo MG, Spits H, De Vreis JE. Interleukin-10. Curr. Opin. Immunol. 1992; 4: 314-20.
113. Balish MJ, Planck SR, Balish E, Rosenbaum JT, Hopkins S. Interleukin-10 knockout mice show increased inflammation in endotoxin-induced uveitis model. ARVO Abstracts. Invest. Ophthalmol. Vis. Sci. 1997; 38: S188.
114. Germann T, Rude E. Interleukin-12. Int. Arch. Allergy Immunol. 1995; 108: 103-12.
115. Pasquale LR, Dorman-Pease ME, Lutty GA, Quigley HA, Jampel HD. Immunolocalization of TGF-β1, TGF-β2, and TGF-β3 in the anterior segment of the human eye. Invest. Ophthalmol. Vis. Sci. 1993; 34: 23-30.
116. Cousins SW, McCabe MM, Danielpour D, Streilein JW. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest. Ophthalmol. Vis. Sci. 1991; 32: 2201-11.
117. De Boer JH, Limpens J, Orengo-Nania S, De Jong PTVM, La Heij E, Kijlstra A. Low mature TGF-β2 levels in aqueous humor during uveitis. Invest. Ophthalmol. Vis. Sci. 1994; 35: 3702-10.
118. Li Q, Dastgheib K, Luyo D, Egwuaga C, Nussenblatt RB, Chan C-C. Expression of transforming growth factor β1 (TGFβ1) in experimental melanin protein induced uveitis and experimental autoimmune uveitis. In: Nussenblatt RB, Whitcup SM, Caspi RR, Gery I (eds) Advances in Ocular Immunology. Amsterdam: Elsevier Science BV, 1994; 9-102.
119. Peng B, Li Q, Roberge FG, Chan C-C. Effect of transforming growth factor beta-1 in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 1997; 38: 257-60.
120. Li Q, Sun B, Dastgheib K, Chan C-C. Suppressive effect of transforming growth factor β1 on the recurrence of experimental melanin protein-induced uveitis: Upregulation of ocular interleukin-10. Clin. Immunol. Immunopathol. 1996; 81: 55-61.
121. Proost P, Wuyts A, Van Damme J. The role of chemokines in inflammation. Int. J. Clin. Lab. Res. 1996; 26: 211-23.
122. Whitelocke RAF, Fakins KE, Bennett A. Acute anterior uveitis and prostaglandins. Proc. R. Soc. Med. 1973; 66: 429-34.
123. Sand BB, Krogh E. Topical indomethacin, a prostaglandin inhibitor, in acute anterior uveitis. A controlled clinical trial of non-steroid versus steroid anti-inflammatory treatment. Acta Ophthalmol. (Copenh.) 1991; 69: 145-8.
124. Chan C-C, Ni M, Miele L et al. Effects of antiflammins on endotoxin-induced uveitis in rats. Arch. Ophthalmol. 1991; 109: 278-81.
125. Herbort CP, Okumura A, Mochizuki M, Immunopharmacological analysis of endotoxin-induced uveitis in the rat. Exp. Eye Res. 1989; 48: 693-705.
126. Bhattacherjce P, Williams RN, Eakins KE. A comparison of the ocular anti-inflammatory activity of steroidal and nonsteroidal compounds in the rat. Invest. Ophthalmol. Vis. Sci. 1983; 24: 1143-6.
127. Soloway MR, Stjernschantz J, Sears M. The miotic effect of substance P on the isolated rabbit iris. Invest. Ophthalmol. Vis. Sci. 1981; 20: 47-52.
128. Lowenstein CJ, Dinerman JL, Snyder SH. Nitric oxide: A physiologic messenger. Ann. Intern. Med. 1994; 120: 227-37.
129. Allen JB, McGahan MC, Ferrell JB, Adler KB, Fleisher LN. Nitric oxide synthase inhibitors exert differential time-dependent effects on LPS-induced uveitis. Exp. Eye Res. 1996; 62: 21-8.
130. 2 synthesis inhibitors in endotoxin-induced uveitis in the rabbit. Inflamin. Res. 1996; 45: 203-8.
131. Kahari VM, Saariahlo-Kere U. Matrix metalloproteinases in skin. Exp. Dermatol. 1997; 6: 199-213.
132. Ando H, Twining SS, Yue BYJT et al. MMPs and proteinase inhibitors in human aqueous humor. Inrest. Ophthalmol. Vis. Sci. 1993; 34: 3541-8.
133. Nagata S, Golstein P. The Fas death factor. Science 1995; 267: 1449-56.
134. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 1995; 270: 1189-92.
135. Stuart PM, Griffith TS, Usui N, Pepose J, Yu X, Ferguson TA. CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival. J. Clin. Invest. 1997; 99: 396-402.
136. Watson RWG, Rotstein OD, Jimenez M, Parodo J, Marshall JC. Augmented intracellular glutathione inhibits Fas-triggered apoptosis of activated human neutrophils. Blood 1997; 89: 4175-81.
137. McCombs CC, DeShazo RD. Immune system disorders. In: Speight TM, Holford NHG (eds) Avery's Drug Treatment. Auckland: Adis International, 1997; 1295-345.
138. Nussenblatt RB, Gery I, Weiner HL et al. Treatment of uveitis by oral administration of retinal antigens: Results of a phase I/II randomized masked trial. Am. J. Ophthalmol. 1997; 123: 583-92.