메뉴 건너뛰기




Volumn 55, Issue 2, 2012, Pages 479-488

Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2A RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRITE; POLYDEOXYRIBONUCLEOTIDE; SODIUM CHLORIDE; VASCULOTROPIN;

EID: 84856101576     PISSN: 07415214     EISSN: 10976809     Source Type: Journal    
DOI: 10.1016/j.jvs.2011.07.083     Document Type: Article
Times cited : (49)

References (52)
  • 1
    • 0026388078 scopus 로고
    • Angiogenesis in wound healing
    • F. Arnold, D.C. West Angiogenesis in wound healing Pharmacol Ther 52 1991 407 422
    • (1991) Pharmacol Ther , vol.52 , pp. 407-422
    • Arnold, F.1    West, D.C.2
  • 3
    • 0034089949 scopus 로고    scopus 로고
    • Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: A new paradigm in wound healing
    • H. Brem, J. Balledux, T. Bloom, M.D. Kerstein, L. Hollier Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: a new paradigm in wound healing Arch Surg 135 2000 627 634 (Pubitemid 30350278)
    • (2000) Archives of Surgery , vol.135 , Issue.6 , pp. 627-634
    • Brem, H.1    Balledux, J.2    Bloom, T.3    Kerstein, M.D.4    Hollier, L.5
  • 4
    • 0001391877 scopus 로고
    • Principles and physiology of skin flap surgery
    • J.G. McCarthy, Saunders Philadelphia
    • R.K. Daniel, C.L. Kerrigan Principles and physiology of skin flap surgery J.G. McCarthy, Plastic surgery 1990 Saunders Philadelphia 225 378
    • (1990) Plastic Surgery , pp. 225-378
    • Daniel, R.K.1    Kerrigan, C.L.2
  • 5
    • 0006095476 scopus 로고
    • Basic techniques of plastic surgery
    • W.C. Grabb, J.W. Smith, Little, Brown Boston
    • W.C. Grabb Basic techniques of plastic surgery W.C. Grabb, J.W. Smith, Plastic surgery 1986 Little, Brown Boston 3 74
    • (1986) Plastic Surgery , pp. 3-74
    • Grabb, W.C.1
  • 6
    • 0141724629 scopus 로고    scopus 로고
    • Revisiting the essential role of oxygen in wound healing
    • DOI 10.1016/S0002-9610(03)00211-3, PII S0002961003002113
    • G.M. Gordillo, C.K. Sen Revisiting the essential role of oxygen in wound healing Am J Surg 2003 2003 259 263 (Pubitemid 38368626)
    • (2003) American Journal of Surgery , vol.186 , Issue.3 , pp. 259-263
    • Gordillo, G.M.1    Sen, C.K.2
  • 7
    • 58649103319 scopus 로고    scopus 로고
    • Wound healing essentials: Let there be oxygen
    • C.K. Sen Wound healing essentials: let there be oxygen Wound Repair Regen 17 2010 1 18
    • (2010) Wound Repair Regen , vol.17 , pp. 1-18
    • Sen, C.K.1
  • 10
    • 0033742818 scopus 로고    scopus 로고
    • Hypoxic conditions decrease the mRNA expression of proalpha1(I) and (III) collagens and increase matrix metalloproteinases-1 of dermal fibroblasts in three-dimensional cultures
    • M. Yamanaka, O. Ishikawa Hypoxic conditions decrease the mRNA expression of proalpha1(I) and (III) collagens and increase matrix metalloproteinases-1 of dermal fibroblasts in three-dimensional cultures J Dermatol Sci 24 2000 99 104
    • (2000) J Dermatol Sci , vol.24 , pp. 99-104
    • Yamanaka, M.1    Ishikawa, O.2
  • 11
    • 34247529500 scopus 로고    scopus 로고
    • Hypoxia-induced lactate dehydrogenase expression and tumor angiogenesis
    • S.M. Colgan, S. Mukherjee, P. Major Hypoxia-induced lactate dehydrogenase expression and tumor angiogenesis Clin Colorectal Cancer 6 2007 442 446 (Pubitemid 46658519)
    • (2007) Clinical Colorectal Cancer , vol.6 , Issue.6 , pp. 442-446
    • Colgan, S.M.1    Mukherjee, S.2    Major, P.3
  • 12
    • 34547124062 scopus 로고    scopus 로고
    • Hypoxia: A key regulator of angiogenesis in cancer
    • DOI 10.1007/s10555-007-9066-y, Special issue on Hypoxia and Cancer, Guest Editor: Gregg L. Semenza
    • D. Liao, R.S. Johnson Hypoxia: a key regulator of angiogenesis in cancer Cancer Metastasis Rev 26 2007 281 290 (Pubitemid 47101669)
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.2 , pp. 281-290
    • Liao, D.1    Johnson, R.S.2
  • 13
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • G. Melillo, T. Musso, A. Sica, L.S. Taylor, G.W. Cox, L. Varesio A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter J Exp Med 182 1995 1683 1693
    • (1995) J Exp Med , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.S.4    Cox, G.W.5    Varesio, L.6
  • 14
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • D. Shweiki, A. Itin, D. Soffer, E. Keshet Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis Nature 359 1992 843 845
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 15
    • 0042889191 scopus 로고    scopus 로고
    • Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis
    • H. Kimura, H. Esumi Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis Acta Biochim Pol 50 2003 49 59 (Pubitemid 37034227)
    • (2003) Acta Biochimica Polonica , vol.50 , Issue.1 , pp. 49-59
    • Kimura, H.1    Esumi, H.2
  • 16
    • 61449150724 scopus 로고    scopus 로고
    • Activated protein C improves ischemic flap survival and modulates proangiogenic and antiinflammatory gene expression
    • M. Bezuhly, S.F. Morris, R. Juskevicius, R.W. Currie, K.A. West, R.S. Liwski Activated protein C improves ischemic flap survival and modulates proangiogenic and antiinflammatory gene expression Plast Reconstr Surg 123 2009 502 515
    • (2009) Plast Reconstr Surg , vol.123 , pp. 502-515
    • Bezuhly, M.1    Morris, S.F.2    Juskevicius, R.3    Currie, R.W.4    West, K.A.5    Liwski, R.S.6
  • 17
    • 23244444179 scopus 로고    scopus 로고
    • Gene therapy with adenovirus-mediated VEGF enhances skin flap prefabrication
    • DOI 10.1002/micr.20142
    • R. Gurunluoglu, R. Meirer, M. Shafighi, G.M. Huemer, B. Yilmaz, H. Piza-Katzer Gene therapy with adenovirus-mediated VEGF enhances skin flap prefabrication Microsurgery 25 2005 433 441 (Pubitemid 41098674)
    • (2005) Microsurgery , vol.25 , Issue.5 , pp. 433-441
    • Gurunluoglu, R.1    Meirer, R.2    Shafighi, M.3    Huemer, G.M.4    Yilmaz, B.5    Piza-Katzer, H.6
  • 18
    • 67650922086 scopus 로고    scopus 로고
    • Effect of application site of low-level laser therapy in random cutaneous flap viability in rats
    • R.P. Prado, C.E. Pinfildi, R.E. Liebano, B.S. Hochman, L.M. Ferreira Effect of application site of low-level laser therapy in random cutaneous flap viability in rats Photomed Laser Surg 27 2009 411 416
    • (2009) Photomed Laser Surg , vol.27 , pp. 411-416
    • Prado, R.P.1    Pinfildi, C.E.2    Liebano, R.E.3    Hochman, B.S.4    Ferreira, L.M.5
  • 19
    • 70349573343 scopus 로고    scopus 로고
    • The effect of transcutaneous electrical nerve stimulation on postmastectomy skin flap necrosis
    • C. Atalay, K.B. Yilmaz The effect of transcutaneous electrical nerve stimulation on postmastectomy skin flap necrosis Breast Cancer Res Treat 117 2009 611 614
    • (2009) Breast Cancer Res Treat , vol.117 , pp. 611-614
    • Atalay, C.1    Yilmaz, K.B.2
  • 22
    • 0141923779 scopus 로고    scopus 로고
    • Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells
    • D.K. Nguyen, M.C. Montesinos, A.J. Williams, M. Kelly, B.N. Cronstein Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells J Immunol 171 2003 3991 3998 (Pubitemid 37238673)
    • (2003) Journal of Immunology , vol.171 , Issue.8 , pp. 3991-3998
    • Khoa, N.D.1    Montesinos, M.C.2    Williams, A.J.3    Kelly, M.4    Cronstein, B.N.5
  • 23
    • 33645100368 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha prevents desensitization of Galphas-coupled receptors by regulating GRK2 association with the plasma membrane
    • N.D. Khoa, M. Postow, J. Danielsson, B.N. Cronstein Tumor necrosis factor-alpha prevents desensitization of Galphas-coupled receptors by regulating GRK2 association with the plasma membrane Mol Pharmacol 69 2006 1311 1319
    • (2006) Mol Pharmacol , vol.69 , pp. 1311-1319
    • Khoa, N.D.1    Postow, M.2    Danielsson, J.3    Cronstein, B.N.4
  • 26
    • 2442689337 scopus 로고    scopus 로고
    • 2A receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis
    • M.C. Montesinos, J.P. Shaw, H. Yee, P. Shamamian, B.N. Cronstein Adenosine A(2A) receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis Am J Pathol 164 2004 1887 1892 (Pubitemid 38669338)
    • (2004) American Journal of Pathology , vol.164 , Issue.6 , pp. 1887-1892
    • Montesinos, M.C.1    Shaw, J.P.2    Yee, H.3    Shamamian, P.4    Cronstein, B.N.5
  • 29
    • 55049118817 scopus 로고    scopus 로고
    • Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease
    • A. Bitto, F. Polito, D. Altavilla, L. Minutoli, A. Migliorato, F. Squadrito Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease J Vasc Surg 48 2008 1292 1300
    • (2008) J Vasc Surg , vol.48 , pp. 1292-1300
    • Bitto, A.1    Polito, F.2    Altavilla, D.3    Minutoli, L.4    Migliorato, A.5    Squadrito, F.6
  • 30
    • 0030219678 scopus 로고    scopus 로고
    • Characterization and quantitation of the active polynucleotide fraction (PDRN) from human placenta, a tissue repair stimulating agent
    • DOI 10.1016/0731-7085(96)01788-8
    • G. Tonello, M. Daglio, N. Zaccarelli, E. Sottofattori, M. Mazzei, A. Balbi Characterization and quantitation of the active polynucleotide fraction (PDRN) from human placenta, a tissue repair stimulating agent J Pharm Biomed Anal 14 1996 1555 1560 (Pubitemid 26279302)
    • (1996) Journal of Pharmaceutical and Biomedical Analysis , vol.14 , Issue.11 , pp. 1555-1560
    • Tonello, G.1    Daglio, M.2    Zaccarelli, N.3    Sottofattori, E.4    Mazzei, M.5    Balbi, A.6
  • 32
    • 0033006710 scopus 로고    scopus 로고
    • Effect of polydeoxyribonucleotides on human fibroblasts in primary culture
    • DOI 10.1002/(SICI)1099-0844(199906)17:2<107::AID-CBF815>3.0.CO;2-#
    • P. Sini, A. Denti, G. Cattarini, M. Daglio, M.E. Tira, C. Balduini Effect of polydeoxyribonucleotides on human fibroblasts in primary culture Cell Biochem Funct 17 1999 107 114 (Pubitemid 29250285)
    • (1999) Cell Biochemistry and Function , vol.17 , Issue.2 , pp. 107-114
    • Sini, P.1    Denti, A.2    Cattarini, G.3    Daglio, M.4    Tira, M.E.5    Balduini, C.6
  • 33
    • 0042704999 scopus 로고    scopus 로고
    • Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: A new proposal for bone tissue repair
    • DOI 10.1016/S0024-3205(03)00547-2
    • S. Guizzardi, C. Galli, P. Govoni, R. Boratto, G. Cattarini, D. Martini Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: a new proposal for bone tissue repair Life Sci 73 2003 1973 1983 (Pubitemid 36930048)
    • (2003) Life Sciences , vol.73 , Issue.15 , pp. 1973-1983
    • Guizzardi, S.1    Galli, C.2    Govoni, P.3    Boratto, R.4    Cattarini, G.5    Martini, D.6    Belletti, S.7    Scandroglio, R.8
  • 34
    • 0034798156 scopus 로고    scopus 로고
    • Clinical evaluation of the trophic effect of polydeoxyribonucleotide (PDRN) in patients undergoing skin explants. A pilot study
    • DOI 10.1185/030079901317010793
    • P. Rubegni, G. De Aloe, C. Mazzatenta, L. Cattarini, M. Fimiani A pilot study Clinical evaluation of the trophic effect of polydeoxyribonucleotide (PDRN) in patients undergoing skin explants Curr Med Res Opin 17 2001 128 131 (Pubitemid 32964006)
    • (2001) Current Medical Research and Opinion , vol.17 , Issue.2 , pp. 128-131
    • Rubegni, P.1    De Aloe, G.2    Mazzatenta, C.3    Cattarini, L.4    Fimiani, M.5
  • 35
    • 1542406154 scopus 로고    scopus 로고
    • Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: A pilot study
    • L. Valdatta, A. Thione, C. Mortarino, M. Buoro, S. Tuinder Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: a pilot study Curr Med Res Opin 20 2004 403 404
    • (2004) Curr Med Res Opin , vol.20 , pp. 403-404
    • Valdatta, L.1    Thione, A.2    Mortarino, C.3    Buoro, M.4    Tuinder, S.5
  • 36
    • 4143058035 scopus 로고    scopus 로고
    • Clinical evaluation of corneal epithelialization after photorefractive keratectomy in patients treated with polydeoxyribonucleotide (PDRN) eye drops: A randomized, double-blind, placebo-controlled trial
    • M. Lazzarotto, E.M. Tomasello, A. Caporossi Clinical evaluation of corneal epithelialization after photorefractive keratectomy in patients treated with polydeoxyribonucleotide (PDRN) eye drops: a randomized, double-blind, placebo-controlled trial Eur J Ophthalmol 14 2004 284 289 (Pubitemid 39094806)
    • (2004) European Journal of Ophthalmology , vol.14 , Issue.4 , pp. 284-289
    • Lazzarotto, M.1    Tomasello, E.M.2    Caporossi, A.3
  • 37
    • 0033605832 scopus 로고    scopus 로고
    • 2 purinergic receptor subtypes
    • DOI 10.1016/S0024-3205(99)00104-6, PII S0024320599001046
    • S. Thellung, T. Florio, A. Maragliano, G. Cattarini, G. Schettini Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2 purinergic receptor subtypes Life Sci 64 1999 1661 1674 (Pubitemid 29185347)
    • (1999) Life Sciences , vol.64 , Issue.18 , pp. 1661-1674
    • Thellung, S.1    Florio, T.2    Maragliano, A.3    Cattarini, G.4    Schettini, G.5
  • 39
    • 0026655657 scopus 로고
    • Ischemia in wound healing II: Design of a flap modelbiochemical properties
    • A. Quirinia, A. Viidik Ischemia in wound healing II: design of a flap modelbiochemical properties Scand J Plast Reconstr Surg Hand Surg 26 1992 133 139
    • (1992) Scand J Plast Reconstr Surg Hand Surg , vol.26 , pp. 133-139
    • Quirinia, A.1    Viidik, A.2
  • 41
    • 0348222661 scopus 로고    scopus 로고
    • Adenosine: An endogenous regulator of innate immunity
    • DOI 10.1016/j.it.2003.11.003
    • G. Hask, B.N. Cronstein Adenosine: an endogenous regulator of innate immunity Trends Immunol 25 2004 33 39 (Pubitemid 38032805)
    • (2004) Trends in Immunology , vol.25 , Issue.1 , pp. 33-39
    • Hasko, G.1    Cronstein, B.N.2
  • 42
    • 17844371308 scopus 로고    scopus 로고
    • Adenosine in tissue protection and tissue regeneration
    • DOI 10.1124/mol.105.011783
    • J. Linden Adenosine in tissue protection and tissue regeneration Mol Pharmacol 67 2005 1385 1387 (Pubitemid 40594134)
    • (2005) Molecular Pharmacology , vol.67 , Issue.5 , pp. 1385-1387
    • Linden, J.1
  • 43
    • 0020322310 scopus 로고
    • Treatment of acute radiodermatitis of first and second degrees with semi-greasy placenta ointment
    • P. Bigliardi Treatment of acute radiodermatitis of first and second degrees with semi-greasy placenta ointment Int J Tissue React 4 1982 153 154 (Pubitemid 12049829)
    • (1982) International Journal of Tissue Reactions , vol.4 , Issue.2 , pp. 153-154
    • Bigliardi, P.1
  • 44
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • DOI 10.1210/er.2003-0027
    • N. Ferrara Vascular endothelial growth factor: basic science and clinical progress Endocr Rev 25 2004 581 611 (Pubitemid 39099316)
    • (2004) Endocrine Reviews , vol.25 , Issue.4 , pp. 581-611
    • Ferrara, N.1
  • 45
    • 33646909636 scopus 로고    scopus 로고
    • Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells
    • DOI 10.1016/j.bcp.2006.03.020, PII S0006295206001912
    • S. Merighi, A. Benini, P. Mirandola, S. Gessi, K. Varani, E. Leung Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells Biochem Pharmacol 72 2006 19 31 (Pubitemid 43795348)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.1 , pp. 19-31
    • Merighi, S.1    Benini, A.2    Mirandola, P.3    Gessi, S.4    Varani, K.5    Leung, E.6    Maclennan, S.7    Borea, P.A.8
  • 46
    • 0034901463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
    • G.L. Semenza Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology Trends Mol Med 2001 2001 45 350
    • (2001) Trends Mol Med , vol.2001 , pp. 45-350
    • Semenza, G.L.1
  • 49
    • 0033233243 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor 1
    • DOI 10.1146/annurev.cellbio.15.1.551
    • G.L. Semenza Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1 Annu Rev Cell Dev Biol 15 1999 551 578 (Pubitemid 32250386)
    • (1999) Annual Review of Cell and Developmental Biology , vol.15 , pp. 551-578
    • Semenza, G.L.1
  • 50
    • 0034900922 scopus 로고    scopus 로고
    • The role of iNOS in wound healing
    • DOI 10.1067/msy.2001.115837
    • H.P. Shi, D. Most, D.T. Efron, U. Tantry, M.H. Fischel, A. Barbul The role of iNOS in wound healing Surgery 130 2001 225 229 (Pubitemid 32721673)
    • (2001) Surgery , vol.130 , Issue.2 , pp. 225-229
    • Shi, H.P.1    Efron, D.T.2    Most, D.3    Barbul, A.4
  • 51
    • 0031925590 scopus 로고    scopus 로고
    • Role of nitric oxide in angiogenesis and microcirculation in tumors
    • DOI 10.1023/A:1005908805527
    • D. Fukumura, R.K. Jain Role of nitric oxide in angiogenesis and microcirculation in tumors Cancer Metastasis Rev 17 1998 77 89 (Pubitemid 28194647)
    • (1998) Cancer and Metastasis Reviews , vol.17 , Issue.1 , pp. 77-89
    • Fukumura, D.1    Jain, R.K.2
  • 52
    • 0032707717 scopus 로고    scopus 로고
    • Nitric oxide as a signaling molecule in the vascular system: An overview
    • L.J. Ignarro, G. Cirino, A. Casini, C. Napoli Nitric oxide as a signaling molecule in the vascular system: an overview J Cardiovasc Pharmacol 34 1999 879 886
    • (1999) J Cardiovasc Pharmacol , vol.34 , pp. 879-886
    • Ignarro, L.J.1    Cirino, G.2    Casini, A.3    Napoli, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.