Usefulness of rat skin as a substitute for human skin in the in vitro skin permeation study

Experimental Animals

Volumn 60, Issue 4, 2011, Pages 374-384

  Takeuchi, Hiroyuki ^a   Mano, Yoko ^a   Terasaka, Shuichi ^a   Sakurai, Takanobu ^a   Furuya, Atsushi ^a   Urano, Hidetoshi ^a   Sugibayashi, Kenji ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b JOSAI UNIVERSITY   (Japan)

Author keywords

Human skin; Inter individual; Rat skin; Skin permeability; Variation

Indexed keywords

FLURBIPROFEN; ISOSORBIDE DINITRATE; NICORANDIL;

ADULT; ANIMAL TISSUE; ARTICLE; CELL; CONTROLLED STUDY; DRUG PENETRATION; FEMALE; FRANZ TYPE DIFFUSION CELL; FREEZING; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MALE; NONHUMAN; PREDICTION; SKIN PERMEABILITY; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT;

RATTUS;

EID: 84856096700     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.60.373     Document Type: Article

References (36)

1. Akomeah, F.K., Martin, G.P., and Brown, M.B. 2007. Variability in human skin permeability in vitro: comparing penetrants with different physicochemical properties. J. Pharm. Sci. 96: 824-834.
2. Babu, R.J., Kanikkannan, N., Kikwai, L., Ortega, C., Andega, S., Ball, K., and Yim, S. 2003. The influence of various methods of cold storage of skin on the permeation of melatonin and nimesulide. J. Control. Release 86: 49-57.
3. Barbero, A.M. and Frasch, H.F. 2009. Pig and guinea pig skin as surrogates for human in vitro penetration studies: a quantitative review. Toxicol. In Vitro 23: 1-13.
4. Bronaugh, R.L., Stewart, R.F., and Congdon, E.R. 1982. Methods for in vitro percutaneous absorption studies II. Animal models for human skin. Toxicol. Appl. Pharmacol. 62: 481-488.
5. Bronaugh, R.L., Stewart, R.F., and Simon, M. 1986. Methods for in vitro percutaneous absorption studies VII: use of excised human skin. J. Pharm. Sci. 75: 1094-1097.
6. EI Maghraby, G.M., Barry, B.W., and Williams, A.C. 2008. Liposomes and skin: from drug delivery to model membranes. Eur. J. Pharm. Sci. 34: 203-222.
7. Franz, T.J. 1975. Percutaneous absorption. On the relevance of in vitro data. J. Invest. Dermatol. 64: 190-195.
8. Fujii, M., Yamanouchi, S., Hori, N., Iwanaga, N., Kawaguchi, N., and Matsumoto, M. 1997. Evaluation of Yucatan micropig skin for use as an in vitro model for skin permeation study. Biol. Pharm. Bull. 20: 249-254.
9. Godin, B. and Touitou, E. 2007. Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models. Adv. Drug Deliv. Rev. 59: 1152-1161.
10. Harison, S.M., Barry, B.W., and Dugard, P.H. 1984. Effects of freezing on human-skin permeability. J. Pharm. Pharmacol. 36: 261-262.
11. Hatanaka, T., Inuma, M., Sugibayashi, K., and Morimoto, Y. 1990. Prediction of skin permeability of drugs. I. Comparison with artificial membrane. Chem. Pharm. Bull. 38: 3452-3459.
12. Hatanaka, T., Inuma, M., Sugibayashi, K., and Morimoto, Y. 1992. Prediction of skin permeability of drugs. II. Development of composite membrane as a skin alternative. Int. J. Pharm. 79: 21-28.
13. Hikima, T., Yamada, K., Kimura, T., Maibach, H.I., and Tojo, K. 2002. Comparison of skin distribution of hydrolytic activity for bioconversion of β-estradiol 17-acetate between man and several animals in vitro. Eur. J. Pharm. Biopharm. 54: 155-160.
14. Kim, M.K., Lee, C.H., and Kim, D.D. 2000. Skin permeation of testosterone and its esterderivatives in rats. J. Pharm. Pharmacol. 52: 369-375.
15. Krishnaiah, Y.S.R., Satyanarayana, V., and Karthikeyan, R.S. 2002. Effect of the solvent system on the in vitro permeability of nicardipine hydrochloride through excised rat epidermis. J. Pharm. Pharmaceut. Sci. 5: 124-130.
16. Morimoto, Y., Hatanaka, T., Sugibayashi, K., and Omiya, H. 1992. Prediction of skin permeability of drugs: comparison of human and hairless rat skin. J. Pharm. Pharmacol. 44: 634-639.
17. Morimoto, Y., Kokubo, T., and Sugibayashi, K. 1992. Diffusion of drugs in acrylic-type pressure-sensitive adhesive matrix. II. Influence of interaction. J. Control. Release 18: 113-122.
18. Ngawhirunpat, T., Panomsuk, S., Opanasopit, P., Rojanarata, T., and Hatanaka, T. 2006. Comparison of the percutaneous absorption of hydrophilic and lipophilic compounds in shed snake skin and human skin. Pharmazie 61: 331-335.
19. Obata, Y., Sato, H., Li, C.J., Takayama, K., Higashiyama, K., Nagai, T., and Isowa, K. 2000. Effect of synthesized cyclohexanol derivatives using l-menthol as a lead compound on the precutaneous absorption of ketoprofen. Int. J. Pharm. 198: 191-200.
20. OECD. 2004. Test Guideline 428. Skin Absorption: In Vitro Method, OECD, Paris.
21. Oesch, F., Fabian, E., Bartlomowicz, B.O., Werner, C., and Landsiedel, R. 2007. Drug-metabolizing enzymes in the skin of man, rat, and pig. Drug Metab. Rev. 39: 659-698.
22. Okumura, M., Sugibayashi, K., Ogawa, K., and Morimoto, Y. 1989. Skin permeability of water-soluble drugs. Chem. Pharm. Bull. 37: 1404-1406.
23. Panchagnula, R., Stemmer, K., and Ritschel, W.A. 1997. Animal models for transdermal drug delivery. Methods Find. Exp. Clin. Pharmacol. 19: 335-341.
24. Přǐborskŷ, J. and Mühlbachovǎ, E. 1990. Evaluation of in-vitro percutaneous absorption across human skin and in animal models. J. Pharm. Pharmacol. 42: 468-472.
25. Qvist, M.H., Hoeck, U., Kreilgaard, B., Madsen, F., and Frokjaer, S. 2000. Evaluation of Gottingen minipig skin for transdermal in vitro permeation studies. Eur. J. Pharm. Sci. 11: 59-68.
26. Sato, K., Sugibayashi, K., Morimoto, Y., Omiya, H., and Enomoto, N. 1989. Prediction of the in-vitro human skin permeability of nicorandil from animal data. J. Pharm. Pharmacol. 41: 379-383.
27. Sato, K., Sugibayashi, K., and Morimoto, Y. 1991. Species differences in percutaneous absorption of nicorandil. J. Pharm. Sci. 80: 104-107.
28. Schäfer-Koring, M., Bock, U., Diembeck, W., and Weimer, M. 2008. The use of reconstructed human epidermis for skin absorption testing: results of the validation study. Altern. Lab. Anim. 36: 161-187.
29. Schmook, F.P., Meingassner, J.G., and Billich, A. 2001. Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption. Int. J. Pharm. 215: 51-56.
30. Singh, S., Zhao, K., and Singh, J. 2002. In vitro permeability and binding of hydrocarbons in pig ear and human abdominal skin. Drug Chem. Toxicol. 25: 83-92.
31. Sowthwell, D., Barry, B. W., and Woodford, R. 1984. Variations in permeability of human skin within and between specimens. Int. J. Pharm. 18: 299-309.
32. Wang, A., Seki, T., Yuan, D., Saso, Y., Hosoya, O., Chono, S., and Morimoto, K. 2004. Effect of camellia on the permeation of flurubiprofen and diclofenac sodium through rat and pig skin. Biol. Pharm. Bull. 27: 1476-1479.
33. Watanabe, T., Hasegawa, T., Takahashi, H., Ishibashi, T., Takayama, K., and Sugibayashi, K. 2001. Utility of three-dimensional cultured human skin model as a tool to evaluate skin permeation of drugs. Altern. Animal Test. Experiment. 8: 1-14.
34. Yamaguchi, K., Mitsui, T., Aso, Y., and Sugibayashi, K. 2008. Structure-permeability relationship analysis of the permeation barrier properties of the stratum corneum and viable epidermis/dermis of rat skin. J. Pharm. Sci. 97: 4391-4403.
35. Yamashita, N., Takeuchi, H., and Kawashima, K. 1992. Metabolic fate of 4-biphenylylacetic acid (Felbinac) in rats. Absorption, distribution and excretion in rats after topical application of felbinac patch (Seltouch ®). Jpn. Pharmacol. Ther. 20: 3957-3971.
36. Zorin, S., Kuylenstierna, F., and Thulin, H. 1999. In vitro test of nicotine's permeability through human skin. Risk evaluation and safety aspects. Ann. Occup. Hyg. 43: 405-413.