Characterization of the DNA copy-number genome in the blood of cutaneous T-Cell lymphoma patients

Journal of Investigative Dermatology

Volumn 132, Issue 1, 2012, Pages 188-197

  Lin, William M ^a   Lewis, Julia M ^a   Filler, Renata B ^a   Modi, Badri G ^a   Carlson, Kacie R ^a   Reddy, Swapna ^a   Thornberg, Adam ^b   Saksena, Gordon ^c   Umlauf, Sheila ^b   Oberholzer, Patrick A ^c,d   Karpova, Maria ^e   Getz, Gad ^c   Mane, Shrikant ^b   Garraway, Levi A ^c,d   Dummer, Reinhard ^e   Berger, Carole L ^a   Edelson, Richard L ^a   Girardi, Michael ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Microarray Facility   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BEXAROTENE; DNA; MESSENGER RNA; METHOTREXATE; VORINOSTAT;

ADULT; AGED; ARTICLE; CHROMOSOME 10; CHROMOSOME 17Q; CHROMOSOME 8Q; CHROMOSOME DELETION; CLINICAL ARTICLE; CUTANEOUS T CELL LYMPHOMA; FEMALE; GENE EXPRESSION; GENOME; HUMAN; HUMAN CELL; MALE; NONHODGKIN LYMPHOMA; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SKIN LYMPHOMA;

EID: 84856087480     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.254     Document Type: Article

References (35)

1. Berger CL, Edelson RL (2003) Current concepts of the immunobiology and immunotherapy of cutaneous T cell lymphoma: insights gained through cross-talk between the clinic and the bench. Leuk Lymphoma 44:1697-703 (Pubitemid 37221043)
2. Berger CL, Tigelaar R, Cohen J et al. (2005) Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells. Blood 105:1640-7 (Pubitemid 40223685)
3. Bernengo MG, Novelli M, Quaglino P et al. (2001) The relevance of the CD4+ CD26-subset in the identification of circulating Sézary cells. Br J Dermatol 144:125-35
4. Beroukhim R, Getz G, Nghiemphu L et al. (2007) Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci USA 104:20007-12
5. Beroukhim R, Mermel CH, Porter D et al. (2010) The landscape of somatic copy-number alteration across human cancers. Nature 463:899-905
6. Bocanegra M, Bergamaschi A, Kim YH et al. (2010) Focal amplification and oncogene dependency of GAB2 in breast cancer. Oncogene 29:774-9
7. Caprini E, Cristofoletti C, Arcelli D et al. (2009) Identification of key regions and genes important in the pathogenesis of Sézary syndrome by combining genomic and expression microarrays. Cancer Res 69: 8438-46
8. Demetri GD, von Mehren M, Blanke CD et al. (2002) Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 347:472-80 (Pubitemid 34879334)
9. Elliott MR, Shanks RA, Khan IU et al. (2004) Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIb. J Immunol 172:7804-12 (Pubitemid 38747648)
10. Fischer TC, Gellrich S, Muche JM et al. (2004) Genomic aberrations and survival in cutaneous T cell lymphomas. J Invest Dermatol 122:579-86 (Pubitemid 38471321)
11. Girardi M, Knobler R, Edelson R (2003) Selective immmunotherapy through extracorporeal photochemotherapy: yesterday, today, and tomorrow. Hematol Oncol Clin North Am 17:1391-403 (Pubitemid 37523676)
12. Heinonen H, Nieminen A, Saarela M et al. (2008) Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer. BMC Genomics 9:348
13. Ho IC, Tai TS, Pai SY (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol 9:125-35
14. Kantarjian H, Sawyers C, Hochhaus A et al. (2002) Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 346:645-52 (Pubitemid 34815868)
15. Kari L, Loboda A, Nebozhyn M et al. (2003) Classification and prediction of survival in patients with the leukemic phase of cutaneous T cell lymphoma. J Exp Med 197:1477-88 (Pubitemid 36682545)
16. Klemke CD, Brade J, Weckesser S et al. (2008) The diagnosis of Sézary syndrome on peripheral blood by flow cytometry requires the use of multiple markers. Br J Dermatol 159:871-80
17. Klemke CD, Mansmann U, Poenitz N et al. (2005) Prognostic factors and prediction of prognosis by the CTCL Severity Index in mycosis fungoides and Sézary syndrome. Br J Dermatol 153:118-24 (Pubitemid 41044537)
18. Laharanne E, Oumouhou N, Bonnet F et al. (2010) Genome-wide analysis of cutaneous T-cell lymphomas identifies three clinically relevant classes. J Invest Dermatol 130:1707-18
19. Lin WM, Baker AC, Beroukhim R et al. (2008) Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res 68:664-73 (Pubitemid 351206741)
20. Manoukian G, Hagemeister F (2009) Denileukin diftitox: a novel immunotoxin. Expert Opin Biol Ther 9:1445-51
21. Mao X, Lillington D, Scarisbrick JJ et al. (2002) Molecular cytogenetic analysis of cutaneous T-cell lymphomas: identification of common genetic alterations in Sézary syndrome and mycosis fungoides. Br J Dermatol 147:464-75 (Pubitemid 35015279)
22. Mao X, Lillington DM, Czepulkowski B et al. (2003) Molecular cytogenetic characterization of Sézary syndrome. Genes Chromosomes Cancer 36:250-60 (Pubitemid 36158198)
23. Olsen EA (2003) Interferon in the treatment of cutaneous T-cell lymphoma. Dermatol Ther 16:311-21 (Pubitemid 38044675)
24. Paez JG, Jänne PA, Lee JC et al. (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304:1497-500 (Pubitemid 38720929)
25. Rappl G, Muche JM, Abken H et al. (2001) CD4(+)CD7(-) T cells compose the dominant T-cell clone in the peripheral blood of patients with Sézary syndrome. J Am Acad Dermatol 44:456-61 (Pubitemid 32199965)
26. Reich M, Liefeld T, Gould J et al. (2006) GenePattern 2.0. Nat Genet 38:500-1
27. Schechter GP, Sausville EA, Fischmann AB et al. (1987) Evaluation of circulating malignant cells provides prognostic information in cutaneous T cell lymphoma. Blood 69:841-9 (Pubitemid 17057466)
28. Skapenko A, Leipe J, Niesner U et al. (2004) GATA-3 in human T cell helper type 2 development. J Exp Med 199:423-8 (Pubitemid 38252054)
29. Vermeer MH, van Doorn R, Dijkman R et al. (2008) Novel and highly recurrent chromosomal alterations in Sézary syndrome. Cancer Res 68:2689-98 (Pubitemid 351556266)
30. Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10:789-99 (Pubitemid 39070849)
31. Vonderheid EC, Pena J, Nowell P (2006) Sézary cell counts in erythrodermic cutaneous T-cell lymphoma: implications for prognosis and staging. Leuk Lymphoma 47:1841-56 (Pubitemid 44649769)
32. Weber BL (2002) Cancer genomics. Cancer Cell 1:37-47 (Pubitemid 41039174)
33. Weir BA, Woo MS, Getz G et al. (2007) Characterizing the cancer genome in lung adenocarcinoma. Nature 450:893-8 (Pubitemid 350231325)
34. Willemze R, Meijer CJ (2006) Classification of cutaneous T-cell lymphoma: from Alibert to WHO-EORTC. J Cutan Pathol 33(Suppl 1):18-26
35. Yawalkar N, Ferenczi K, Jones DA et al. (2003) Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. Blood 102:4059-66 (Pubitemid 37486989)