Identification and potency of cyclodextrin-lipid inhibitors of staphylococcus aureus α-Toxin

Current Eye Research

Volumn 37, Issue 2, 2012, Pages 87-93

  Weeks, Anastasia C ^a   Balzli, Charles L ^a   Caballero, Armando ^a   Tang, Aihua ^a   O'Callaghan, Richard ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Hemolysin; Toxin; Cholesterol; Cyclodextrin; Inhibitor; Lanosterol; Lipid; Staphylococcus aureus

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CYCLODEXTRIN DERIVATIVE; DESMOSTEROL; LANOSTEROL; LIPID; METHYL BETA CYCLODEXTRIN; SQUALENE; STAPHYLOCOCCUS ALPHA TOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORNEA EROSION; DRUG POTENCY; HEMOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INHIBITION KINETICS; KERATITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RABBIT; STAPHYLOCOCCUS AUREUS; STATISTICAL SIGNIFICANCE;

ANIMALS; BACTERIAL TOXINS; BETA-CYCLODEXTRINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; COMPLEMENT HEMOLYTIC ACTIVITY ASSAY; CORNEA; HEMOLYSIN PROTEINS; LIPIDS; RABBITS; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 84856078415     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2011.624669     Document Type: Article

References (27)

1. Girgis DO, Sloop GD, Reed JM, O'Callaghan RJ. Effects of toxin production in a murine model of Staphylococcus aureus keratitis. Invest Ophthalmol Vis Sci. 2005;46:2064-2070.
2. Callegan MC, Engel LS, Hill JM, O'Callaghan RJ. Corneal virulence of Staphylococcus aureus: Roles of α-toxin and protein A in pathogenesis. Infect Immun. 1994;62:2478-2482. (Pubitemid 24157079)
3. O'Callaghan RJ, Callegan MC, Moreau JM et al. Specific roles of α-toxin and β-toxin during Staphylococcus aureus corneal infection. Infect Immun. 1997;65:1571-1578. (Pubitemid 27193571)
4. Moreau JM, Sloop GD, Engel LS, Hill JM, O'Callaghan RJ. Histopathological studies of staphylococcal α-toxin: Effects on rabbit corneas. Curr Eye Res. 1997;16:1221-1228. (Pubitemid 27515677)
5. Hume EB, Dajcs JJ, Moreau JM, O'Callaghan RJ. Immunization with α-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis. Infect Immun. 2000;68:6052-6055.
6. McCormick CC, Caballero AR, Balzli CL, Tang A, O'Callaghan RJ. Chemical inhibition of α-toxin, a key corneal virulence factor of Staphylococcus aureus. Invest Ophthalmol Vis Sci. 2009;50:2848-2854.
7. Bubeck Wardenburg J, Bae T, Otto M, Deleo FR, Schneewind O. Poring over pores: α-Hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med. 2007;13:1405-1406. (Pubitemid 350224232)
8. Vijayvargia R, Suresh CG, Krishnasastry MV. Functional form of Caveolin-1 is necessary for the assembly of α-hemolysin. Biochem Biophys Res Commun. 2004;324:1130-1136. (Pubitemid 39361626)
9. Pany S, Vijayvargia R, Krishnasastry MV. Caveolin-1 binding motif of α-hemolysin: Its role in stability and pore formation. Biochem Biophys Res Commun. 2004;322:29-36. (Pubitemid 39093837)
10. Wardenburg J. Staphylococcus aureus infections: New insights on α-hemolysin-mediated injury. International Symposium on Staphylococcus and Staphylococcal Infections. 2010. Bath, England.
11. Wilke GA, Bubeck Wardenburg J. Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus α-hemolysinmediated cellular injury. Proc Natl Acad Sci USA.2010;107:13473-13478.
12. Ragle BE, Karginov VA, Bubeck Wardenburg J. Prevention and treatment of Staphylococcus aureus pneumonia with a β-cyclodextrin derivative. Antimicrob Agents Chemother. 2010;54:298-304.
13. Jonas D, Walev I, Berger T, Liebetrau M, Palmer M, Bhakdi S. Novel path to apoptosis: Small transmembrane pores created by staphylococcal α-toxin in T lymphocytes evoke internucleosomal DNA degradation. Infect Immun. 1994;62:1304-1312. (Pubitemid 24110824)
14. Karginov VA, Nestorovich EM, Schmidtmann F et al. Inhibition of S. aureus α-hemolysin and B. anthracis lethal toxin by β-cyclodextrin derivatives. Bioorg Med Chem. 2007; 15:5424-5431. (Pubitemid 46963000)
15. Szejtli, J, Cyclodextrin Technology. Dordrecht, Netherlands: Kluwer Academic Publisher. 1988:1-6,87
16. Loftsson T, Brewster ME. Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. J Pharm Sci. 1996;85:1017-1025. (Pubitemid 26338912)
17. Pitha J, Milecki J, Fales H, Pannell L, Uekama K. Hydroxypropyl-β- Cyclodextrin: Preparation and characterization; effects on solubility of drugs. Int J Pharm. 1986;29,73-82. (Pubitemid 16162498)
18. Kaur IP, Chhabra S, Aggarwal D. Role of cyclodextrins in ophthalmics. Curr Drug Deliv. 2004;1:351-360
19. O'Callaghan RJ. Role of exoproteins in bacterial keratitis: The Fourth Annual Thygeson Lecture, presented at the Ocular Microbiology and Immunology Group Meeting, November 7, 1998. Cornea. 1999;18:532-537.
20. Howard JG, Wallace KR, Wright GP. The inhibitory effects of cholesterol and related sterols on haemolysis by streptolysin O. Br J Exp Pathol. 1953;34:174-180.
21. Nollmann M, Gilbert R, Mitchell T, Sferrazza M, Byron O. The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin. Biophys J. 2004;86:3141-3151. (Pubitemid 38552714)
22. Marquart ME, Monds KS, McCormick CC et al. Cholesterol as treatment for pneumococcal keratitis: Cholesterol-specific inhibition of pneumolysin in the cornea. Invest Ophthalmol Vis Sci. 2007;48:2661-2666. (Pubitemid 351261218)
23. Johnson MK, Hobden JA, Hagenah M, O'Callaghan RJ, Hill JM, Chen S. The role of pneumolysin in ocular infections with Streptococcus pneumoniae. Curr Eye Res. 1990; 9:1107-1114.
24. Johnson MK, Hobden JA, O'Callaghan RJ, Hill JM. Confirmation of the role of pneumolysin in ocular infections with Streptococcus pneumoniae. Curr Eye Res. 1992;11: 1221-1225. (Pubitemid 23057731)
25. G reen SN, Sanders M, Moore QC 3rd et al. Protection from Streptococcus pneumoniae keratitis by passive immunization with pneumolysin antiserum. Invest Ophthalmol Vis Sci. 2008;49:290-294.
26. Bhave P, Chamie G. Streptococcus pneumoniae keratitis. J Hosp Med. 2008;3:353.
27. Jhanji V, Constantinou M, Taylor HR, Vajpayee RB. Microbiological and clinical profiles of patients with microbial keratitis residing in nursing homes. Br J Ophthalmol. 2009;93:1639-1642.