Chemical inhibition of alpha-toxin, a key corneal virulence factor of staphylococcus aureus

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 6, 2009, Pages 2848-2854

  McCormick, Clare C ^a   Caballero, Armando R ^a   Balzli, Charles L ^a   Tang, Aihua ^a   O'Callaghan, Richard J ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CYCLODEXTRIN; METHYL BETA CYCLODEXTRIN; PHOSPHATE BUFFERED SALINE; STAPHYLOCOCCUS ALPHA TOXIN; BACTERIAL TOXIN; BETA CYCLODEXTRIN DERIVATIVE; EXOTOXIN; HEMOLYSIN; METHYL-BETA-CYCLODEXTRIN; SODIUM CHLORIDE; STAPHYLOCOCCAL ALPHA-TOXIN; STAPHYLOCOCCUS TOXOID; VIRULENCE FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL VIRULENCE; COLONY FORMING UNIT; CONTROLLED STUDY; HEMOLYSIS; HISTOPATHOLOGY; IN VITRO STUDY; INHIBITION KINETICS; KERATITIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; SCORING SYSTEM; SLIT LAMP; STAPHYLOCOCCUS AUREUS; TREATMENT OUTCOME; ANIMAL; BACTERIAL EYE INFECTION; CORNEA; CORNEA ULCER; DISEASE MODEL; DRUG ANTAGONISM; DRUG COMBINATION; DRUG EFFECT; ERYTHROCYTE; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; STAPHYLOCOCCUS INFECTION; VIRULENCE;

ANIMALS; BACTERIAL TOXINS; BETA-CYCLODEXTRINS; CHOLESTEROL; CORNEA; CORNEAL ULCER; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; ERYTHROCYTES; EXOTOXINS; EYE INFECTIONS, BACTERIAL; HEMOLYSIN PROTEINS; HEMOLYSIS; RABBITS; SODIUM CHLORIDE; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCAL TOXOID; STAPHYLOCOCCUS AUREUS; VIRULENCE; VIRULENCE FACTORS;

EID: 66849111209     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-3157     Document Type: Article

References (40)

1. Shetty AK, Kumar A. Osteomyelitis in adolescents. Adolesc Med State Art Rev. 2007;18(1):79-94.
2. Popovich KJ, Hota B, Weinstein RA. Treatment of communityassociated methicillin-resistant Staphylococcus aureus. Curr Infect Dis Rep. 2008;10(5):411-420.
3. Fowler VG Jr, Miro JM, Hoen B, et al. Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA. 2005; 293(24):3012-3021.
4. Kielian T, Syed MM, Liu S, et al. The synthetic peroxisome proliferators-activated receptor gamma agonist ciglitazone attenuates neuroinflammation and accelerates encapsulation in bacterial brain abscesses. J Immunol. 2008;180(7):5004-5016.
5. Kuehnert MJ, Hill HA, Kupronis BA, Tokars JI, Solomon SL, Jernigan DB. Methicillin-resistant-Staphylococcus aureus hospitalizations, United States. Emerg Infect Dis. 2005;11(6):868-872.
6. Klevens RM, Morrison MA, Nadle J, et al. Invasive methicillinresistant Staphylococcus aureus infections in the United States. JAMA. 2007;298(15):1763-1771.
7. Kuehnert MJ, Kruszon-Moran D, Hill HA, et al. Prevalence of Staphylococcus aureus nasal colonization in the United States. 2001-2002. J Infect Dis. 2006;193(2):172-179.
8. Klevens RM, Edwards JR, Tenover FC, et al. Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992-2003. Clin Infect Dis. 2006; 42(3):389-391.
9. Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med. 2006;355(7):666-674.
10. Liesegang TJ. Bacterial and fungal keratitis. In: Kaufman HE, Barron BA, McDonald MB, Waltman SR, eds. The Cornea. Boston, MA: Butterworth-Heineman; 1998:219-269.
11. Kattan HM, Flynn HW Jr, Pflugfelder SC, Robertson C, Forster RK. Nosocomial endophthalmitis survey. Current incidence of infection after intraocular surgery. Ophthalmology. 1991;98(2):227-238.
12. McCulley JP, Shine WE. Changing concepts in the diagnosis and management of blepharitis. Cornea. 2000;19(5):650-658.
13. O'Callaghan RJ. Role of exoproteins in bacterial keratitis: the Fourth Annual Thygeson Lecture, presented at the Ocular Microbiology and Immunology Group Meeting, November 7, 1998. Cornea. 1999;18(5):532-537.
14. Callegan MC, Engel LS, Hill JM, O'Callaghan RJ. Corneal virulence of Staphylococcus aureus: roles of alpha-toxin and protein A in pathogenesis. Infect Immun. 1994;62(6):2478-2482.
15. O'Callaghan RJ, Callegan MC, Moreau JM, et al. Specific roles of alpha-toxin during Staphylococcus aureus corneal infection. Infect Immun. 1997;65(5):1571-1578.
16. Moreau JM, Sloop GD, Engel LS, Hill JM, O'Callaghan RJ. Histopathological studies of staphylococcal alpha-toxin: effects on rabbit corneas. Curr Eye Res. 1997;16(12):1221-1228.
17. Kielian T, Cheung A, Hickey WF. Diminished virulence of an alpha-toxin mutant of Staphylococcus aureus in experimental brain abscesses. Infect Immun. 2001;69(11):6902-6911.
18. DeLeo FR, Otto M. An antidote for Staphylococcus aureus pneumonia? J Exp Med. 2008;205(2):271-274.
19. Phillips JR, Tripp TJ, Regelmann WE, Schlievert PM, Wangensteen OD. Staphylococcal alpha-toxin causes increased tracheal epithelial permeability. Pediatr Pulmonol. 2006;41(12):1146-1152.
20. Bubeck Wardenburg J, Schneewind O. Vaccine protection against Staphylococcus aureus pneumonia. J Exp Med. 2008;205(2):287-294.
21. Valeva A, Weisser A, Walker B, et al. Molecular architecture of a toxin pore: a 15 residue sequence lines the transmembrane channel of staphylococcal _-toxin. EMBO J. 1996;15(8):1857-1864.
22. Liang X, Ji Y. Involvement of _5_1-integrin and TNF-_ in Staphylococcus aureus alpha-toxin-induced death of epithelial cells. Cell Microbiol. 2007;9(7):1809-1821.
23. Hasliner B, Strangfeld K, Peters G, Schulze-Osthoff K, Sinha B. Staphylococcus aureus alpha-toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumor necrosis factor-alpha and the mitochondrial death pathway. Cell Microbiol. 2003;5(10):729-741.
24. Haslinger-Löffler B, Kahl BC, Grundmeier M, et al. Multiple virulence factors are required for Staphylococcus aureus-induced apoptosis in endothelial cells. Cell Microbiol. 2005;7(8):1087-1097.
25. Haslinger-Löffler B, Wagner B, Brück M, et al. Staphylococcus aureus induces caspase-independent cell death in human peritoneal mesothelial cells. Kidney Int. 2006;70(6):1089-1098.
26. Eichstaedt S, Gäbler K, Below S, et al. Effects of Staphylococcus aureus-hemolysin A on calcium signaling in immortalized human airway epithelial cells. Cell Calcium. 2008;doi:10. 1016/ j. ceca. 2008. 09. 001[Epub ahead of print].
27. Johansson D, Johansson A, Behnam-Motlagh P. Alpha-toxin of Staphylococcus aureus overcomes acquired cisplatin-resistance in malignant mesothelioma cells. Cancer Lett. 2008;265(1):67-75.
28. Girgis DO, Sloop GD, Reed JM, et al. A new topical model of Staphylococcus corneal infection in the mouse. Invest Ophthalmol Vis Sci. 2003;44(4):1591-1597.
29. Girgis DO, Sloop GD, Reed JM, O'Callaghan RJ. Effects of toxin production in a murine model of Staphylococcus aureus keratitis. Invest Ophthalmol Vis Sci. 2005;46(6):2064-2070.
30. Yotis WW, Savov ZT. Reduction of the cytolytic action of staphylococcal alpha-toxin by progesterone. Yale J Biol Med. 1970;42(6): 411-419.
31. Raff MJ, Barnwell P, Werner AS. Detoxification of staphylococcal alpha-toxin by hydrocortisone and methylprednisolone. J Med Microbiol. 1978;11(1):67-73.
32. Pany S, Vijayvargia R, Krishnasastry MV. Caveolin-1 binding motif of alpha-hemolysin: its role in stability and pore formation. Biochem Biophys Res Commun. 2004;322(1):29-36.
33. Vijayvargia R, Kaur S, Sangha N, et al. Assembly of alpha-hemolysin on A431 cells leads to clustering of Caveolin-1. Biochem Biophys Res Commun. 2004;324(3):1124-1129.
34. Gu LQ, Bayley H. Interaction of the non-covalent molecular adapter, beta-cyclodextrin, with the staphylococcal alpha-hemolysin pore. Biophys J. 2000;79(4):1967-1975.
35. Vijayvargia R, Suresh CG, Krishnasastry MV. Functional form of Caveolin-1 is necessary for the assembly of alpha-hemolysin. Biochem Biophys Res Commun. 2004;324(3):1130-1136.
36. Karginov VA, Nestorovich EM, Schmidtmann F, et al. Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by betacyclodextrin derivatives. Bioorg Med Chem. 2007;15(16):5424-5431.
37. Dajcs JJ, Austin MS, Sloop GD, et al. Corneal pathogenesis of Staphylococcus aureus strain Newman. Invest Ophthalmol Vis Sci. 2002;43(4):1109-1115.
38. Dajcs JJ, Thibodeaux BA, Girgis DO, O'Callaghan RJ. Corneal virulence of Staphylococcus aureus in an experimental model of keratitis. DNA Cell Biol. 2002;21(5-6):375-382.
39. Hume EB, Dajcs JJ, Moreau JM, O'Callaghan RJ. Immunization with alpha-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis. Infect Immun. 2000;68(10):6052-6055.
40. Matthews L, Berry A, Ohanian V, et al. Caveolin mediates rapid glucocorticoid effects and couples glucocorticoid action to the antiproliferative program. Mol Endocrinol. 2008;22(6):1320-1330.