Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle

Journal of Biological Chemistry

Volumn 287, Issue 4, 2012, Pages 2863-2876

  Barrientos, Genaro C ^a   Feng, Wei ^a   Truong, Kim ^a   Matthaei, Klaus I ^b   Yang, Tianzhong ^c   Allen, Paul D ^c   Lopez, José R ^c   Pessah, Isaac N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Australian National University   (Australia)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ANALYSIS; CALCIUM CHANNELS; CALPAINS; ELECTRICAL STIMULI; EXCITATION-CONTRACTION COUPLING; IN-VIVO; MALIGNANT HYPERTHERMIAS; MYOTUBES; OXYGEN CONSUMPTION RATE; RANK ORDER; RYANODINE; RYANODINE RECEPTOR TYPE 1; SARCOPLASMIC RETICULUM; SINGLE CHANNELS; SINGLE-CHANNEL ANALYSIS;

ANESTHETICS; GENES; INSECTICIDES; MAMMALS; MICROELECTRODES; MUSCLE; OXYGEN; PHOSPHORYLATION;

CALCIUM;

CALCIUM CHANNEL; CALCIUM ION; CALPAIN; HALOTHANE; MAGNESIUM ION; RYANODINE RECEPTOR 1; SERINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; CYTOPLASM; ELECTROSTIMULATION; ENZYME ACTIVITY; EXCITATION CONTRACTION COUPLING; FLEXOR DIGITORUM BREVIS; FLEXOR MUSCLE; GENE DOSAGE; GENE MUTATION; GENE TARGETING; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; IN VIVO STUDY; ION SELECTIVE ELECTRODE; MALIGNANT HYPERTHERMIA; MITOCHONDRION; MOUSE; MUSCLE FIBER MEMBRANE; MUSCLE FUNCTION; MYOTUBE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SARCOPLASMIC RETICULUM; THERMOREGULATION; VASTUS LATERALIS MUSCLE; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; CALCIUM; GENE DOSAGE; HETEROZYGOTE; HOMOZYGOTE; MALIGNANT HYPERTHERMIA; MICE; MICE, TRANSGENIC; MUSCLE FIBERS, SKELETAL; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM;

MUS;

EID: 84856074222     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.307926     Document Type: Article

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