Anti-tumour effects of xanthone derivatives and the possible mechanisms of action

Investigational New Drugs

Volumn 29, Issue 6, 2011, Pages 1230-1240

  Su, Quan Guan ^a   Liu, Yan ^b   Cai, Yu Chen ^a   Sun, Yue Li ^a   Wang, Bo ^b   Xian, Li Jian ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Anti tumour; Mcl 1 down regulation; Topoisomerase II inhibition; Xanthone derivatives

Indexed keywords

1 HYDROXY 3 (2 OXIRANYLMETHOXY)XANTHONE; 1,3 DIHYDROXYXANTHONE; 1,3,7 TRIHYDROXY 12H BENZO[B]XANTHEN 12 ONE; 26 HYDROXYLXANTHONE; BENZOXANTHONE; CASPASE 3; CASPASE 9; CYTOTOXIC AGENT; DIACETOXYXANTHONE; DIHYDROXYXANTHONE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; HYDROXYL BENZOXANTHONE; HYDROXYLXANTHONE; MESSENGER RNA; MONOACETOXYXANTHONE; MONOHYDROXYXANTHONE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; TETRAACETOXYXANTHONE; TETRAHYDROXYL XANTHONE; TRIACETOXYXANTHONE; TRIHYDROXYL XANTHONE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE; ANTINEOPLASTIC AGENT; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SIGNALING; LIVER CELL CULTURE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; TOPOISOMERASE II GENE; TOPOISOMERASE IIALPHA GENE; CELL STRAIN HEPG2; CHEMISTRY; LIVER TUMOR; METABOLISM; NEOPLASM; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE II; DOWN-REGULATION; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHONES;

EID: 84856046536     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9468-5     Document Type: Article

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