Dicer-substrate siRNA inhibits tumor necrosis factor alpha secretion in Kupffer cells in vitro: In vivo targeting of Kupffer cells by siRNA-liposomes

Pharmacological Research

Volumn 65, Issue 1, 2012, Pages 48-55

  Pichu, Sivakamasundari ^a   Krishnamoorthy, Swapna ^a   Zhang, Bi ^a   Jing, Yawu ^a   Shishkov, Andrei ^a   Ponnappa, Biddanda C ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Kupffer cells; Lipopolysaccharide; Liposomes; siRNA; TNF alpha

Indexed keywords

DICER; LIPOSOME; MESSENGER RNA; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DOWN REGULATION; DRUG EFFICACY; DRUG FORMULATION; DRUG POTENCY; ENCAPSULATION; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SUBSTRATE; GENE SILENCING; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; KUPFFER CELL; LIPOSOMAL DELIVERY; MALE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; TARGET CELL;

ANIMALS; CELLS, CULTURED; DOWN-REGULATION; GENE THERAPY; INJECTIONS, INTRAVENOUS; KUPFFER CELLS; LIPOPOLYSACCHARIDES; LIPOSOMES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RIBONUCLEASE III; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SUBSTRATE SPECIFICITY; TIME FACTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84856020342     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.09.001     Document Type: Article

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