Elevated CCN2 expression in scleroderma: A putative role for the TGFβ accessory receptors TGFβRIII and endoglin

Journal of Cell Communication and Signaling

Volumn 5, Issue 3, 2011, Pages 173-177

  Holmes, Alan M ^a   Ponticos, Markella ^a   Shi Wen, Xu ^a   Denton, Christopher P ^a   Abraham, David J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

CCN2; Endoglin; TGF ; TGF RIII

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; ENDOGLIN; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3;

ARTICLE; AUTOCRINE EFFECT; CELL SURFACE; CONTROLLED STUDY; EXPRESSION VECTOR; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SCLERODERMA;

EID: 80055020582     PISSN: 18739601     EISSN: 1873961X     Source Type: Journal    
DOI: 10.1007/s12079-011-0140-4     Document Type: Article

References (14)

1. Bilandzic M, Stenvers KL (2011) Betaglycan: a multifunctional accessory. Mol Cell Endocrinol
2. Burton VJ, Ciuclan LI, Holmes AM, Rodman DM, Walker C, Budd DC (2011) Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function. Blood 117:333-341
3. Denton CP, Zheng B, Evans LA, Shi-Wen X, Ong VH, Fisher I, Lazaridis K, Abraham DJ, Black CM, de Crombrugghe B (2003) Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice. J Biol Chem 278:25109-25119 (Pubitemid 37548675)
4. Hermida N, Lopez B, Gonzalez A, Dotor J, Lasarte JJ, Sarobe P, Borras-Cuesta F, Diez J (2009) A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats. Cardiovasc Res 81:601-609
5. Holmes A, Abraham DJ, Sa S, Shiwen X, Black CM, Leask A (2001) CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J Biol Chem 276:10594-10601 (Pubitemid 38089227)
6. Leask A, Abraham DJ (2004) TGF-beta signaling and the fibrotic response. FASEB J 18:816-827
7. Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-Wen X, Chen Y, Venstrom K, Dou X, Ponticos M, Black C, Bernabeu C, Jackman JK, Findell PR, Connolly MK (2002) Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts. Arthritis Rheum 46:1857-1865 (Pubitemid 34774518)
8. Leroy EC (1972) Connective tissue synthesis by scleroderma skin fibroblasts in cell culture. J Exp Med 135:1351-1362
9. Liu M, Suga M, Maclean AA, St George JA, Souza DW, Keshavjee S (2002) Soluble transforming growth factor-beta type III receptor gene transfection inhibits fibrous airway obliteration in a rat model of Bronchiolitis obliterans. Am J Respir Crit Care Med 165:419-423 (Pubitemid 34118519)
10. Morris E, Chrobak I, Bujor A, Hant F, Mummery C, Ten DP, Trojanowska M (2011) Endoglin promotes TGF-beta/Smad1 signaling in scleroderma fibroblasts. J Cell Physiol
11. Pannu J, Nakerakanti S, Smith E, Ten DP, Trojanowska M (2007) Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways. J Biol Chem 282:10405-10413 (Pubitemid 47093454)
12. Perez-Gomez E, Del CG, Juan FS, Lopez-Novoa JM, Bernabeu C, Quintanilla M (2010) The role of the TGF-beta coreceptor endoglin in cancer. ScientificWorldJournal 10:2367-2384
13. Ten DP, Arthur HM (2007) Extracellular control of TGFbeta signalling in vascular development and disease. Nat Rev Mol Cell Biol 8:857-869 (Pubitemid 47622560)
14. Xu SW, Howat SL, Renzoni EA, Holmes A, Pearson JD, Dashwood MR, Bou-Gharios G, Denton CP, du Bois RM, Black CM, Leask A, Abraham DJ (2004) Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem 279:23098-23103 (Pubitemid 38685614)