Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge

Archives of Pharmacal Research

Volumn 31, Issue 6, 2008, Pages 758-763

  Jeon, Su Jin ^c   Son, Kun Ho ^c   Kim, Yeong Shik ^a   Choi, Yong Hwan ^b   Kim, Hyun Pyo ^b  

^a Seoul National University   (South Korea)

^b Kangwon National University   (South Korea)

^c Andong National University   (South Korea)

Author keywords

15,16 Dihydrotanshinone; Anti inflammation; Cryptotanshinone; Cyclooxygenase; Inducible nitric oxide synthase; Salvia miltiorrhiza Bunge; Tanshinone

Indexed keywords

15,16 DIHYDROTANSHINONE I; 15,16-DIHYDROTANSHINONE I; CARRAGEENAN; CRYPTOTANSHINONE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; NOS2 PROTEIN, MOUSE; PHENANTHRENE DERIVATIVE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS2 PROTEIN, MOUSE; TANSHINONE;

ANIMAL; ARTICLE; CELL LINE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; EDEMA; ENZYMOLOGY; GEL MOBILITY SHIFT ASSAY; ISOLATION AND PURIFICATION; MACROPHAGE; MALE; METABOLISM; MOUSE; PLANT ROOT; RAT; SALVIA MILTIORRHIZA; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EDEMA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHENANTHRENES; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA;

EID: 45749101298     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-001-1223-4     Document Type: Article

References (21)

1. Bae, K., In Bae, K. (Ed.). The medicinal plants of Korea, Kyo-Hak Pub. Co., Seoul, pp. 444, (2000).
2. Chi, Y. S., Cheon, B. S., and Kim, H. P., Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. Biochem. Pharmacol., 61, 1195-1203 (2001).
3. Choi, H.-S., Cho, D.-I., Choi, H.-K., Im, S. Y., Ryu, S.-Y., and Kim, K.-M., Molecular mechanisms of inhibitory activity of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells. Arch. Pharm. Res., 27, 1233-1237 (2004).
4. γ 2 and MAPK. Planta Med., 70, 178-180 (2004).
5. Duke, J. A. and Ayensu, E. S., In Duke, J. A. and Ayensu, E. S. (Eds.). Medicinal plants of China. Reference Publications, Inc., Algonquin, Michigan, Vol. 2, pp. 381, (1985).
6. Gallin, J. I. and Snyderman, R., Overview, In Gallin, J. I. and Snyderman, R. (Eds.). Inflammation: Basic principles and clinical correlates 3rd ed. Lippincott Williams & Wilkins, Philadelphia, pp. 1-4, (1999).
7. Hsu, Y.-W., Chi, K.-H., Huang, W.-C., and Lin, W.-W., Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: Effects on protein kinases and transcription factors. J. Immunol., 166, 5388-5397 (2001).
8. Jang, S. I., Jeong, S. I., Kim, K. J., Kim, H. J., Yu, H. H., Park, R., Kim, H. M., and You, Y. O., Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-α, IL-1β and IL-6 in activated RAW 264.7 cells. Planta Med., 69, 1057-1059 (2003).
9. Jin, D. Z., Yin, L. L., Ji, X. Q., and Zhu, X. Z., Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression. Eur. J. Pharmacol., 549, 166-172 (2006).
10. Kang, B. Y., Chung, S. W., Kim, S. H., Ryu, S. Y., and Kim, T. S., Inhibition of interleukin-12 and interferone-γ production in immune cells by tanshinones from Salvia miltiorrhiza. Immunopharmacol., 49, 355-361 (2000).
11. Kang, H. S., Chung, H. Y., Jung, J. H., Kang, S. S., and Choi, J. S., Antioxidant effect of Salvia miltiorrhiza. Arch. Pharm. Res., 20, 496-500 (1997).
12. Kim, H., Lee, H. S., Chang, K. T., Ko, T. H., Baek, K. J., and Kwon, N. S., Chloromethyl ketones block induction of nitric oxide synthase in murine macrophages by preventing activation of nuclear factor-κB. J. Immunol., 154, 4741-4748 (1995).
13. Kim, S. Y., Moon, T. C., Chang, H. W., Son, K. H., Kang, S. S., and Kim, H. P., Effects of tanshinone I isolated from Salvia miltiorrhiza on arachidonic acid metabolism and in vivo inflammatory responses. Phytotherapy Res., 16, 616-620(2002).
14. Dweck, A. C., The folklore and cosmetic use of various Salvia species, In Kintzios, S. E. (Ed.). SAGE The genus Salvia, Overseas Publishers Association, New York, pp. 9-18, (2000).
15. Lee, P., Hur, J., Lee, J., Kim, J., Jeong, J., Kang, I., Kim, S. Y., and Kim, H., 15,16-Dihydrotanshinone I suppresses the activation of BV-2 cell, a murine microglia cell line, by lipopolysaccharide. Neurochem. Int., 48, 60-66 (2006).
16. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic assays. J. Immunol. Methods, 65, 55-63 (1983).
17. Ryu, S. Y., No, Z., Kim, S. H., and Ahn, J. W., Two novel abietane diterpenes from Salvia miltiorrhiza. Planta Med., 63, 44-46 (1997).
18. Ryu, S. Y., Oak, M. H., and Kim, K. M., Inhibition of mast cell degranulation by tanshinones from the roots of Salvia miltiorrhiza. Planta Med., 65, 654-655 (1999).
19. Suh, N., Honda, T., Finlay, H. J., Barchowsky, A., Williams, C., Benoit, N. E., Xie, Q., Nathan, C., Gribble, G. W., and Sporn, M. B., Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer Res., 58, 712-723 (1998).
20. Suh, S. J., Jin, U. H., Choi, H. J., Chang, H. W., Son, J. K., Lee, S. H., Jeon, S. J., Son, K. H., Chang, Y. C., Lee, Y. C., and Kim, C. H., Cryptotanshinone from Salvia miltiorrhiza Bunge has an inhibitory effect on TNF-α-induced matrix metalloproteinase-9 production and HASMC migration via downregulated NF-κB and AP-1. Biochem. Pharmacol., 72, 1680-1689 (2006).
21. Winter, C. A., Risley, E. A., and Nuss, G. W., Carrageenaninduced edema in the hindpaw of the rat as an assay for antiinflammatory drugs. Proc. Soc. Exp. Biol. Med., 111, 544-547(1962).