Co-exposure to nickel and cobalt chloride enhances cytotoxicity and oxidative stress in human lung epithelial cells

Toxicology and Applied Pharmacology

Volumn 258, Issue 3, 2012, Pages 367-375

  Patel, Eshan ^a   Lynch, Christine ^a   Ruff, Victoria ^a   Reynolds, Mindy ^a  

^a WASHINGTON COLLEGE   (United States)

Author keywords

Apoptosis; Cobalt; Double strand breaks; Nickel; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE 7; COBALT CHLORIDE; NICKEL CHLORIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOUBLE STRANDED DNA BREAK; HEAVY METAL POISONING; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; OXIDATIVE STRESS; PROTEIN CLEAVAGE;

ACETYLCYSTEINE; APOPTOSIS; CASPASE 3; CASPASE 7; CELL SURVIVAL; CELLS, CULTURED; COBALT; DNA BREAKS, DOUBLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; HUMANS; LUNG; NICKEL; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES;

ANIMALIA;

EID: 84855976097     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.11.019     Document Type: Article

References (37)

1. Albino A.P., Jorgensen E.D., Rainey P., Gillman G., Clark T.J., Gietl D., Zhao H., Traganos F., Darzynkiewicz Z. gammaH2AX: a potential DNA damage response biomarker for assessing toxicological risk of tobacco products. Mutat. Res. 2009, 678:43-52.
2. Beyersmann D., Hartwig A. Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms. Arch. Toxicol. 2008, 82:493-512.
3. Bonner W.M., Redon C.E., Dickey J.S., Nakamura A.J., Sedelnikova O.A., Solier S., Pommier Y. GammaH2AX and cancer. Nat. Rev. Cancer 2008, 8:957-967.
4. Boulares A.H., Yakovlev A.G., Ivanova V., Stoica B.A., Wang G., Iyer S., Smulson M. Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J. Biol. Chem. 1999, 274:22932-22940.
5. Chen C.Y., Wang Y.F., Huang W.R., Huang Y.T. Nickel induces oxidative stress and genotoxicity in human lymphocytes. Toxicol. Appl. Pharmacol. 2003, 189:153-159.
6. Costa M. Molecular mechanisms of nickel carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 1991, 31:321-337.
7. Cross D.P., Ramachandran G., Wattenberg E.V. Mixtures of nickel and cobalt chlorides induce synergistic cytotoxic effects: implications for inhalation exposure modeling. Ann. Occup. Hyg. 2001, 45:409-418.
8. Doll R., Morgan L.G., Speizer F.E. Cancers of the lung and nasal sinuses in nickel workers. Br. J. Cancer 1970, 24:623-632.
9. Harnett P.B., Robison S.H., Swartzendruber D.E., Costa M. Comparison of protein, RNA, and DNA binding and cell-cycle-specific growth inhibitory effects of nickel compounds in cultured cells. Toxicol. Appl. Pharmacol. 1982, 64:20-30.
10. Harris R.M., Williams T.D., Hodges N.J., Waring R.H. Reactive oxygen species and oxidative DNA damage mediate the cytotoxicity of tungsten-nickel-cobalt alloys in vitro. Toxicol. Appl. Pharmacol. 2011, 250:19-28.
11. Jensen A.A., Tuchsen F. Cobalt exposure and cancer risk. Crit. Rev. Toxicol. 1990, 20:427-437.
12. Johansson A., Lundborg M., Wiernik A., Jarstrand C., Camner P. Rabbit alveolar macrophages after long-term inhalation of soluble cobalt. Environ. Res. 1986, 41:488-496.
13. Johansson A., Curstedt T., Robertson B., Camner P. Lung lesions after experimental combined exposure to nickel and trivalent chromium. Environ. Res. 1989, 50:103-119.
14. Johansson A., Curstedt T., Camner P. Lung lesions after combined inhalation of cobalt and nickel. Environ. Res. 1991, 54:24-38.
15. Kasprzak K.S. The role of oxidative damage in metal carcinogenicity. Chem. Res. Toxicol. 1991, 4:604-615.
16. Ke Q., Ellen T.P., Costa M. Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity. Toxicol. Appl. Pharmacol. 2008, 228:190-199.
17. Leonard S., Gannett P.M., Rojanasakul Y., Schwegler-Berry D., Castranova V., Vallyathan V., Shi X. Cobalt-mediated generation of reactive oxygen species and its possible mechanism. J. Inorg. Biochem. 1998, 70:239-244.
18. Lison D., De Boeck M., Verougstraete V., Kirsch-Volders M. Update on the genotoxicity and carcinogenicity of cobalt compounds. Occup. Environ. Med. 2001, 58:619-625.
19. Lowe S.W., Schmitt E.M., Smith S.W., Osborne B.A., Jacks T. P53 is Required for Radiation-Induced Apoptosis in Mouse Thymocytes. Nature 1993, 362:847-849.
20. Mills K.D., Ferguson D.O., Alt F.W. The role of DNA breaks in genomic instability and tumorigenesis. Immunol. Rev. 2003, 194:77-95.
21. Pietruska J.R., Liu X., Smith A., McNeil K., Weston P., Zhitkovich A., Hurt R., Kane A.B. Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol. Sci. 2011, 124(1):138-148.
22. Ponti J., Sabbioni E., Munaro B., Broggi F., Marmorato P., Franchini F., Colognato R., Rossi F. Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride: an in vitro study in Balb/3T3 mouse fibroblasts. Mutagenesis 2009, 24:439-445.
23. Reynolds M., Zhitkovich A. Cellular vitamin C increases chromate toxicity via a death program requiring mismatch repair but not p53. Carcinogenesis 2007, 28:1613-1620.
24. Reynolds M.F., Peterson-Roth E.C., Bespalov I.A., Johnston T., Gurel V.M., Menard H.L., Zhitkovich A. Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers. Cancer Res. 2009, 69:1071-1079.
25. Rivedal E., Sanner T. Synergistic effect on morphological transformation of hamster embryo cells by nickel sulphate and benz[a]pyrene. Cancer Lett. 1980, 8:203-208.
26. Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 1998, 273:5858-5868.
27. Salnikow K., Zhitkovich A. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem. Res. Toxicol. 2008, 21:28-44.
28. Salnikow K., Gao M., Voitkun V., Huang X., Costa M. Altered oxidative stress responses in nickel-resistant mammalian cells. Cancer Res. 1994, 54:6407-6412.
29. Salnikow K., Blagosklonny M.V., Ryan H., Johnson R., Costa M. Carcinogenic nickel induces genes involved with hypoxic stress. Cancer Res. 2000, 60:38-41.
30. Salnikow K., Su W., Blagosklonny M.V., Costa M. Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism. Cancer Res. 2000, 60:3375-3378.
31. Salnikow K., Donald S.P., Bruick R.K., Zhitkovich A., Phang J.M., Kasprzak K.S. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J. Biol. Chem. 2004, 279:40337-40344.
32. Salnikow K., Li X., Lippmann M. Effect of nickel and iron co-exposure on human lung cells. Toxicol. Appl. Pharmacol. 2004, 196:258-265.
33. Sedelnikova O.A., Rogakou E.P., Panyutin I.G., Bonner W.M. Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat. Res. 2002, 158:486-492.
34. Sunderman F.W., Hopfer S.M., Plowman M.C., Knight J.A. Carcinogenesis bioassays of nickel oxides and nickel-copper oxides by intramuscular administration to Fischer-344 rats. Res. Commun. Chem. Pathol. Pharmacol. 1990, 70:103-113.
35. Tan C.B., Gao M., Xu W.R., Yang X.Y., Zhu X.M., Du G.H. Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride. Biol. Pharm. Bull. 2009, 32:1359-1363.
36. Wang X., Yokoi I., Liu J., Mori A. Cobalt(II) and nickel(II) ions as promoters of free radicals in vivo: detected directly using electron spin resonance spectrometry in circulating blood in rats. Arch. Biochem. Biophys. 1993, 306:402-406.
37. Zhou X., Li Q., Arita A., Sun H., Costa M. Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol. Appl. Pharmacol. 2009, 236:78-84.