Modeling morphodynamic phenotypes and dynamic regimes of cell motion

Advances in Experimental Medicine and Biology

Volumn 736, Issue , 2012, Pages 337-358

  Enculescu, Mihaela ^a   Falcke, Martin ^b  

^a TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CELL MEMBRANE PROTEIN; COFILIN; EZRIN; F ACTIN; GERSOLIN; MOESIN; MYRISTOYLATED ALANINE RICH C KINASE SUBSTRATE PROTEIN; RADIXIN; THYMOSIN BETA4; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ARTICLE; CELL ADHESION; CELL MOTILITY; CELL MOTION; CELL SHAPE; CELL SPREADING; CELL STRUCTURE; CELL TYPE; EXPERIMENTAL STUDY; LAMELLIPODIUM; MEMBRANE BINDING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; BACTERIAL PHYSIOLOGICAL PHENOMENA; CELL MOVEMENT; CELL SHAPE; CYTOSKELETON; HUMANS; MODELS, BIOLOGICAL; MOVEMENT; SIGNAL TRANSDUCTION;

EID: 84855949230     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-7210-1_20     Document Type: Article

References (147)

1. Abraham V, Krishnamurthi D, Taylor D, Lanni F (1999) The actin-based nanomachine at the leading edge of migrating cells. Biophys J 77:1721-1732 (Pubitemid 29407343)
2. Alt W, Dembo M (1999) Cytoplasm dynamics and cell motion: two phase flow models. MathBiosci 156:207-228 (Pubitemid 29157692)
3. Ananthakrishnan R, Ehrlicher A (2007) The forces behind cell movement. Int J Biol Sci 3(5):303-317 (Pubitemid 46889238)
4. Atilgan E,Wirtz D, Sun S (2005) Morphology of the lamellipodium and organization of actin filaments at the leading edge of crawling cells. Biophys J 89:3589-3602 (Pubitemid 41636111)
5. Atilgan E, Wirtz D, Sun S (2006) Mechanics and dynamics of actin-driven thin membrane protrusions. Biophys J 90:65-76
6. Bamburg J (1999) Proteins of the adf/cofilin family: essential regulators of actin dynamics. Ann Rev Cell Dev Biol 15:185-230 (Pubitemid 32250375)
7. Baumgartner M, Sillman A, Blackwood E, Srivastava J, Madson N, Schilling J, Wright J, Barber D (2006) The nck-interacting kinase phosphorylates erm proteins for formation of lamellipodium by growth factors. PNAS 103:13391-13396 (Pubitemid 44380118)
8. Bear JE, Svitkina TM, Krause M, Schafer DA, Loureiro JJ, Strasser GA, Maly IV, Chaga OY, Cooper JA, Borisy GG, Gertler FB (2002) Antagonism between ena/vasp proteins and actin filament capping regulates fibroblast motility. Cell 109(4):509-521 (Pubitemid 34564477)
9. Bernheim-Groswasser A, Prost J, Sykes C (2005) Mechanism of actin-based motility: a dynamic state diagram. Biophys J 89:1411-1419 (Pubitemid 41099022)
10. Bindschadler M, McGrath J (2007) Relationships betwenn actin regulatory mechanisms and measurable state variables. Annals Biomed Eng 35:995-1011 (Pubitemid 46828709)
11. Bindschadler M, Osborn E, Dewey C, McGrath J (2004) A mechanistic model of the actin cycle. Biophys J 86:2720-2739 (Pubitemid 38552679)
12. Boukellal H, Campas O, Joanny J, Prost J, Sykes C (2004) Soft listeria: actin-based propulsion of liquid drops. Phys Rev E 69:061906
13. Bugyi B, Didry D, Carlier M (2010) How tropomyosin regulates lamellipodial actin-based motility: a combined biochemical and reconstituted motility approach. EMBO J 29:14-26
14. Carlier M, Pantaloni D (2007) Control of actin assembly dynamics in cell motility. J Biol Chem 282(32):23005-23009 (Pubitemid 47311896)
15. Carlier M, Ressad F, Pantaloni D (1999) Control of actin dynamics in cell motility - role of adf/cofilin. J Biol Chem 274:33827-33830 (Pubitemid 129511702)
16. Carlsson A (2001) Growth of branched actin networks against obstacles. Biophys J 81: 1907-1923 (Pubitemid 32917143)
17. Carlsson A (2003) Growth velocities of branched actin networks. Biophys J 84:2907-2918 (Pubitemid 36531744)
18. Carlsson A (2004) Structure of autocatalitically branched actin solutions. Phys Rev Lett 92(23):239102
19. Carlsson A (2005) The effect of branching on the critical concentration and average filament length of actin. Biophys J 89(1):130-140 (Pubitemid 41098270)
20. Carlsson A (2006) Contractile stress generation by actomyosin gels. Phys Rev E 74:051912
21. Carlsson A (2006) Stimulation of actin polymerization by filament severing. Biophys J 90:413-422
22. Carlsson A (2010) Dendritic actin filament nucleation causes traveling waves and patches. Phys Rev Lett 104:228102
23. Carlsson A, Sept D (2008) Mathematical modeling of cell migration. Biophys Tools Biol: Vol 1 In Vitro Techniques 84:911
24. Carlsson A,Wear M, Cooper J (2004) End versus side branching by arp2/3 complex. Biophys J 86:1074-1081 (Pubitemid 38209551)
25. Casteo L, Jay D (1999) Radixin is involved in lamellipodial stability during nerve growth cone motility. Mol Biol Cell 5:1511-1520 (Pubitemid 29230905)
26. Chauvière A, Preziosi L, Verdier C (eds) (2010) Cell mechanics. From single scale-based models to multiscalemodeling. Taylor & Francis Group, Chapman & Hall/CRC Mathematical and Computational Biology Series, Boca Raton
27. Co C,Wong D, Gierke S, Chang V, Taunton J (2007) Mechanism of actin network attachment to moving membranes: barbed end capture by n-wasp wh2 domains. Cell 128:901-913 (Pubitemid 46341410)
28. Cooper JA, Sept D (2008) New insights into mechanism and regulation of actin capping protein. Int Rev Cell Mol Biol, 267:183-206
29. Danuser G (2005) Coupling the dynamics of two actin networks - new views on the mechanics of cell protrusion. Biochem Soc Trans 33:1250-1253 (Pubitemid 41779659)
30. Danuser G (2009) Testing the lamella hypothesis: the next steps on the agenda. J Cell Sci 122:1950-1962
31. Dawes A, Ermentrout G, Cytrynbaum E, Edelstein-Keshet L (2006) Actin filament branching and protrusion velocity in a simple 1d model of a motile cell. J Theor Biol 242:265-279 (Pubitemid 44232809)
32. Dayel M, Akin O, Landeryou M, Risca V, Mogilner A, Mullins R (2009) In silico reconstitution of actin-based symmetry breaking and motility. PLoS Biol 7:e1000201
33. Delatour V, Shekhar S, Reymann AC, Didry D, Lê KHD, Romet-Lemonne G, Helfer E, Carlier MF (2008) Actin-based propulsion of functionalized hard versus fluid spherical objects. New J Phys 10(2):025001
34. Delorme V, Machacek M, DerMardirossian C, Anderson K, Wittmann T, Hanein D, Waterman-Storer C, Danuser G, Bokoch G (2007) Cofilin activity downstream of pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks. Dev Cell 13:646-662 (Pubitemid 350011982)
35. Denker S, Barber D (2002) Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J Cell Biol 159:1087-1096 (Pubitemid 36055762)
36. Denker S, Huang D, Orlowski J, Furthmayr H, Barber D (2000) Direct Binding of the Na H Exchanger NHE1 to ERM Proteins Regulates the Cortical Cytoskeleton and Cell Shape Independently of HC Translocation. Mol Cell 6:1425-1436 (Pubitemid 32045934)
37. DiMilla PA, Barbee K, Lauffenburger DA (1991) Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophys J 60:15-37
38. DiNubile MJ, Huang S (1997) High concentrations of phosphatidylinositol- 4,5-bisphosphate may promote actin filament growth by three potential mechanisms: inhibiting capping by neutrophil lysates, severing actin filaments and removing capping protein-[beta]2 from barbed ends. Biochim Biophys Acta (BBA) - Mol Cell Res 1358(3):261-278 (Pubitemid 27462652)
39. Doebereiner HG, Dubin-Thaler B, Giannone G, Xenias H, Sheetz M (2004) Dynamic phase transitions in cell spreading. Phys Rev Lett 93(10):108105
40. Doebereiner HG, Dubin-Thaler B, Hofman J, Xenias H, Sims T, Giannone G, Dustin M, Wiggins C, Sheetz M (2006) Lateral membrane waves constitute a universal dynamic pattern of motile cells. Phys Rev Lett 97(3):038102
41. Eden S, Rohatgi R, Pdtelejnikov A, Mann M, Kirschner M (2002) Mechaniscm of regulation of wave1-induced actin nucleation by rac1 and nck. Nature 418:790-793
42. Enculescu M, Falcke M (2011) Actin-based propusion of spatially extended objects. New J Phys 13:053040
43. Enculescu M, Gholami A, Falcke M (2008) Dynamic regimes and bifurcation in a model of actin-based motility. Phys Rev E 78:031915
44. Enculescu M, Sabouri-Ghomi M, Danuser G, Falcke M (2010) Modeling of protrusion phenotypes driven by the actin-membrane interaction. Biophys J 98:1-11
45. Faber, M, Enculescu, M, Falcke, M (2010) Filament capping and nucleation in actin-based motility. Eur Phys J Special Topics 191:147-158, DOI 10.1140/epjst/e2010-01347-3, URL http://dx.doi.org/10.1140/epjst/e2010-01347-3
46. Fievet B, Gautreau A, Roy C, Del Maestro L, Mangeat P, Louvard D, Arpin M (2004) Phosphoionositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol 164:653-659 (Pubitemid 38282949)
47. Fievet B, Louvard D, Arpin M (2007) Erm proteins in epithelial cell organization and functions. BBA - Mol Cell Res 1773:653-660 (Pubitemid 46660175)
48. Friedel P, Hegerfeld Y, Tusch M (2004) Collective cell migration in morphogenesis and cancer. Int J Dev Biol 48:441-449 (Pubitemid 39360394)
49. Fuhrmann J, Ks J, Stevens A (2007) Initiation of cytoskeletal asymmetry for cell polymerization and movement. J Theor Biol 249:278-288 (Pubitemid 47632657)
50. Gautreau A, Louvard D, Arpin M (2000) Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane. J Cell Biol 150:193-203 (Pubitemid 30480237)
51. Gerbal F, Chaikin P, Rabin Y, Prost J (2000) An elastic analysis of listeria monocytogenes propulsion. Biophys J 79:2259-2275
52. Gerbal F, Laurent V, Ott A, CarlierM, Chaikin P, Prost J (2000) Measurement of the elasticity of the actin tail of listeria monocytogenes. Eur Biophys J with Biophys Lett 29:134-140
53. Gholami A, Wilhelm J, Frey E (2006) Entropic forces generated by grafted semiflexible polymers. Phys Rev E 74(4):041803
54. Gholami A, Falcke M, Frey E (2008) Velocity oscillations in actin-based motility. New J of Phys 10:033022
55. Ghosh M, Sonx X, Mouneimne G, Sidani M, Lawrence D, Condeelis J (2004) Cofilin promotes actin polymerization and defines the direction of cell motility. Science 304: 743-746 (Pubitemid 38560882)
56. Giannone G, Dubin-Thaler J, Doebereiner HG, Kieffer N, Bresnick A, Sheetz M (2004) Periodic lamellipodial contractions correlate with rearward actin waves. Cell 116: 431-443 (Pubitemid 38366319)
57. Giannone G, Dubin-Thaler B, Rossier O, Cai Y, Chaga O, Jiang G, Beaver W, Dobereiner H, Freund Y, Borisy G, Sheetz M (2007) Lamellipodial actin mechanically links myosin activity with adhesion-site formation. Cell 128:561-575 (Pubitemid 46198897)
58. Gracheva MA, Othmer HG (2004) A continuum model of motility in ameboid cells. Bull Math Biol 66:167-193 (Pubitemid 38178965)
59. Grimm H, Verkhovsky A, Mogilner A, Meister JJ (2003) Analysis of actin dynamics at the leading edge of crawling cells: implications for the shape of keratocyte lamellipodia. Eur Biophys J 32:563-577 (Pubitemid 37408660)
60. Grinstien S,Woodside M,Waddell T, Downey G, Orlowski J, Pouyssegur J,Wong D, Foskett J (1993) Focal localozation of the nhe-1 isoform of the na1/h1 antiport: assesment of effects on intracellular ph. EMBO J 12:5209-5218 (Pubitemid 23358511)
61. Hartwig JH, Chambers KA, Stossel TP (1989) Association of gelsolin with actin filaments and cell membranes of macrophages and platelets. J Cell Biol 108(2):467-479 (Pubitemid 19065847)
62. Hartwig JH, Bokoch GM, Carpenter CL, Janmey PA, Taylor LA, Toker A, Stossel TP (1995) Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82(4):643-653
63. Heinemann F, Doschke H, Radmacher M (2011) Keratocyte lamellipodial protrusion is characterized by a concave force-velocity relation. Biophys J 100(6):1420-1427
64. Higgs H, Pollard T (2001) Regulation of actin filament network formation through arp2/3 complex: activation by a diverse array of proteins. Ann Rev Biochem 70:649-676 (Pubitemid 32662221)
65. Huang T, DerMardirossian C, Bokoch G (2006) Cofilin phosphytases and regulation of actin dynamics. Curr Op Cell Biol 18:26-31 (Pubitemid 43107604)
66. Ichetovkin I, GrantW, Condeelis J (2002) Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the arp2/3 complex. Curr Biol 12:79-84 (Pubitemid 34063358)
67. Ikenoya M, Hidaka H, Hosoya T, Suzuki M, Yamamoto N, Sasaki Y (2002) Inhibition of rhokinase-induced myristoylated alanine-rich c kinase substrate (marcks) phosphorylation in human neuronal cells by h-1152, a novel and specific rho-kinase inhibitor. J Neurochem 81: 9-16 (Pubitemid 34808850)
68. Janmey PA, Stossel TPS (1987) Modulation of gelsolin function by phosphatidylinositol 4,5- bisphosphate. Nature 325:362-364 (Pubitemid 17053178)
69. Ji L, Lim J, Danuser G (2008) Fluctuations of intracellular forces during cell protrusion. Nat Cell Biol 10(12):1393-1400
70. John K, Peyla P, Kassner K, Prost J, Misbah C (2008) Nonlinear study of symmetry breaking in actin gels: implications for cellular motility. Phys Rev Lett 100(6):068101
71. Kahsai A, Zhu S, Fenteany G (2010) G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells. BBA - Mol Cell Res 1803:300-310
72. Keren K, Theriot J (2008) Biophysical Aspects of actin-based cell motility in fish epithelial keratocytes. In: Cell motility, Springer New York, pp 31-58
73. Keren K, Pincus Z, Allen G, Barnhart E, Marriott G, Mogilner A, Theriot A (2008) Mechanism of shape determination in motile cells. Nature 453:485-U1
74. 3 exchangers in migrating renal epithelial cells. J Gen Physiol 115:599-608
75. Koester S, Auinger S, Vinzenz M, Rottner K, Small J (2008) Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front. Nat Cell Biol 10:306-313 (Pubitemid 351331017)
76. Kruse K, Joanny J, Jlicher F, Prost J, Sekimoto K (2004) Asters, vortices, and rotating spirals in actove gels of polar filaments. Phys Rev Lett 92(7):078101
77. Kruse K, Joanny J, Jlicher F, Prost J, Sekimoto K (2005) Generic theory of active polar gels: a paradigm for cytoskeletal dynamics. Eur Phys J E 16:5-16 (Pubitemid 40226343)
78. Kruse K, Joanny J, Jlicher F, Prost J (2006) Contractility and retrograde flow in lamellipodium motion. Phys Biol 3:130-137 (Pubitemid 44043093)
79. Kuhn JR, Pollard TD (2007) Single molecule kinetic analysis of actin filament capping. J Biol Chem 282(38):28014-28024
80. Kuo S, McGrath J (2000) Steps and fluctuations of listeria monocytogenes during actin-based motility. Nature 407:1026-1029
81. Kuusela E, Alt W (2009) Continuum model of cell adhesion and migration. J Math Biol 58:135-161
82. Lacayo C, Pincus Z, VanDujin M, Wilson C, Fletcher D, Gertler F, Mogilner A, Theriot J (2007) Emergence of large-scale cell morphology and movement from local actin filament growth dynamics. PLoS Biol 5(9):2035-2052 (Pubitemid 47416600)
83. Lagana A, Vadnais J, Le P, Nguyen T, Laprade R, Nabi I, Noel J (2000) Regulation of the formation of tumor cell pseudopodia by the NaC/HC exchanger NHE1. J Cell Sci 113: 3649-3662
84. Lai F, Bosse T, Szczodrak M, Benesch S, Auinger S, Faix J, Small J, Stradel T, Rottner K (2008) Arp2/3-complex regulation in motility and host-pathogen interaction. FEBS J 275:39
85. Lamb R, Ozanne B, Roy C, McGarry L, Stipp C,Mangeat P, Jay D (1997) Essential functions of ezrin in maintenance of cell shape and lamellipodial extension in normal and transformed fibroblasts. Curr Biol 7:682-688 (Pubitemid 27408866)
86. Larripa K, Mogilner A (2006) Transport of a 1d viscoelastic actin-myosin strip of gel as a model of a crawling cell. Phys A 372:113-123 (Pubitemid 44436777)
87. Le Clainche C, Carlier M (2008) Regulation of actin assembly associated with protrusion and adhesion in cell migration. Physiol Rev 88:89-513
88. Lee KC, Liu AJ (2009) Force-velocity relation for actin-polymerization- driven motility from brownian dynamics simulations. Biophys J 97(5):1295-1304
89. Lim JI, Sabouri-Ghomi M, Machacek M, Waterman CM, Danuser G (2010) Protrusion and actin assembly are coupled to the organization of lamellar contractile structures. Exp Cell Res 316(13):2027-2041
90. Lin Y (2009) Mechanics model for actin-based motility. Phys Rev E 79:021916
91. Machacek M, Danuser G (2006)Morphodynamic profiling of protrusion phenotypes. Biophys J 90:1439-1442
92. Marcy Y, Prost J, CarlierMF, Sykes C (2004) Forces generated during actin-based propulsion: a direct measurement by micromanipulation. PNAS 101(16):5992-5997 (Pubitemid 38520516)
93. Matsui T, Yonemura S, Tsukita S, Tsukita S (1999) Activation of erm proteins in vivo by rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not rock kinases. Curr Biol 9: 1259-1262 (Pubitemid 29527153)
94. Méré J, Chahinian A, Maciver SK, Fattoum A, Bettache N, Benyamin Y, Roustan C (2005) Gelsolin binds to polyphosphoinositide-free lipid vesicles and simultaneously to actin microfilaments. Biochem J 386:47-56 (Pubitemid 40289223)
95. Michalsky P, Carlsson A (2010) The effects of filament aging and annealing on a model lamellipodium undergoing disassembly by severing. Phys Biol 7:026004
96. Mogilner A, Edelstein-Keshet L (2002) Regulation of actin dynamics in rapidly moving cells: a quantitative analysis. Biophys J 83:1237-1258 (Pubitemid 34977700)
97. Mogilner A, Oster G (1996) Cell motility drivern by actin polymerization. Biophys J 71:3030-3045 (Pubitemid 26422346)
98. Mogilner A, Oster G (2003) Force generation by actin polymerization ii: the elastic ratchet and tethered filaments. Biophys J 84:1591-1605 (Pubitemid 36322924)
99. Nagumo H, Ikenoya M, Sakurada K, Furuya K, Ikuhara T, Hiraoka H, Sasaki Y (2001) Rhoassociated kinase phosphorylates marcks in human neuronal cells. Biochem Biophys Res Commun 280:605-609 (Pubitemid 32924471)
100. Nakamura N, Pshiro N, Fukata Y, Amoano M, Fukata M, Kuroda S, Matsuura Y, Leung T, Lim K, Kaibuchi K (2000) Phosphorylation of erm proteins at filopodia induced by cdc42. Genes Cells 5:571-581 (Pubitemid 30602699)
101. Ng T, Parsons M, Hughes W, Monypenny J, Zicha D, Gautreau A, Arpin M, Gschmeissner S, Verveer P, Bastiaens P, Parker P (2001) Ezrin is a downstream effector of trafficking pkcintegrin complexes involved in the control of cell motility. EMBO J 20:2723-2741 (Pubitemid 32938557)
102. Novak I, Slepchenko B, Mogilner A, Loew L (2004) Cooperativity between cell contractility and adhesion. Phys Rev Lett 93:268109
103. Oliver J, King J, Mckinlay K, Brown P, Grant D, Scotchford C, Wood J (2005) Thin-film theories for two-phase reactive flow models of active cell motion. Math Med Biol 22:53-98 (Pubitemid 40521276)
104. Oshiro N, Fukata Y, Kaibuchi K (1998) Phosphorylation of moesin by rho-associated kinase (rho-kinase) plays a crucial role in the formation of microvilli-like structures. J Biol Chem 273:34663-34666 (Pubitemid 29028150)
105. Paluch E, van der Gucht J, Joanny JF, Sykes C (2006) Deformations in actin comets from rocketing beads. Biophys J 91(8):3113-3122 (Pubitemid 44526500)
106. Papakonstanti E, Ridley A, Vanhaesebroeck B (2007) The p110d isoform of pi 3-kinase negatively controls rhoa and pten. EMBO J 26:3050-3061 (Pubitemid 47057501)
107. Parekh SH, Chaudhuri O, Theriot JA, Fletcher DA (2005) Loading history determines the velocity of actin-network growth. Nat Cell Biol 7(12):1219-1223
108. Paskin C, Odell G, Oster G (1993) Cellular motions and thermal fluctuations: the Brownian ratchet. Biophs J 65:316-324 (Pubitemid 23206064)
109. Pierres A, Benoliel A, Touchard D, Bongard P (2008) How cells tiptoe on adhesive surfaces before sticking. Biophys J 94:4114-4122
110. Pollard T (2003) The cytoskeleton, cellular motility and the reductionist agenda. Nature 422:741-745 (Pubitemid 36514116)
111. Ponti A, Machacek M, Gupton S, Waterman-Storer C, Danuser G (2004) Two distinct actin networks drive the protrusion of migrating cells. Science 207:1782-1786 (Pubitemid 39249647)
112. Prass M, Jacobson K, Mogilner A, Radmacher M (2006) Direct measurement of the lamellipodial protrusive force in a migrating cell. J Cell Biol 174:767-772 (Pubitemid 44373726)
113. Rubinstein B, Jacobson K, Moginer A (2005) Multiscale two-dimensional modelling of a motile simple-shaped cell. Multiscale Model Simul 3(2):413-439 (Pubitemid 40951979)
114. Sardet C, Counillon L, Franchi A, Pouyssegur J (1993) Growth factors induce phosphorylation of the na1/h1 antiporter, glycoprotein of 110 kd. Science 247:723-726
115. Schafer DA, Jennings PB, Cooper JA (1996) Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. J Cell Biol 135(1):169-179 (Pubitemid 26337745)
116. Schreiber CH, Stewart M, Duke T (2010) Simulation of cell motility that reproduces the force-velocity relationship. Proc Natl Acad Sci 107(20):9141-9146
117. Sheetz M, Sable J, Dobereiner HG (2006) Continous membrane-cytoskeleton adhesion requires continous accomodation to lipid and cytoskeleton dynamics. Annu Rev Biophys Biomol Struct 35:417-434 (Pubitemid 43877385)
118. Shiraishi M, Tanabe A, Saito N, Sasaki Y (2006) Unphosphorylated marcks is involved in neurite initiation induced by insulin-like growth factor-l in sh-sy5y cells. J Cell Physiol 209:1029-1038 (Pubitemid 44665726)
119. Shlomovitz R, Gov N (2007) Membrane waves driven by actin and myosin. Phys Rev Lett 98:168103
120. Shlomovitz R, Gov N (2008) Exciting cytoskeleton-membrane waves. Phys Rev E 78:041911
121. Small J, Resch G (2005) The comings and goings of actin: coupling protrusion and retraction in cell motility. Curr Op Cell Biol 17:517-523 (Pubitemid 41267166)
122. Small J, Herzog M, Anderson K (1995) Actin filament organization in the fish keratocyte lamellipodium. J Cell Biol 129(5):1275-1286
123. Small J, Auinger S, Nemethova M, Koestler S, Goldie K, Hoenger A, Resch G (2008) Unravelling the structure of the lamellipodium. J Microsc-Oxford 231:479-485
124. Small JV, Stradal T, Vignal E, Rottner K (2002) The lamellipodium: where motility begins. Trends Cell Biol 12(3):112-120 (Pubitemid 34164650)
125. Smith J, Diez G, Klemm A, Schewkunow V, Goldmann W (2006) Capz-lipid membrane interactions: a computer analysis. Theor Biol Med Model 3(1):30
126. Stolarska M, Y K, Othmer H (2009) Multi-scale models of cell and tissue dynamics. Phyl Trans Roy Soc A 367:3525-3553
127. Stradal T, Scita G (2006) Protein complexes regulation arp2/3-mediated actin assembly. Curr Op Cell Biol 18:4-10 (Pubitemid 43107601)
128. Stradal T, Rottner K, Disanza A, Confalonieri S, Innocenti M, Scita G (2004) Regulation of actin dynamics by wasp and wave family proteins. Trends Cell Biol 14:303-311 (Pubitemid 38798179)
129. Sun HQ, Yamamoto M, Mejillano M, Yin HL (1999) Gelsolin, a multifunctional actin regulatory protein. J Biol Chem 274(47):33179-33182 (Pubitemid 129511609)
130. Svitkina T (2007) N-wasp generates a buzz at membranes on the move. Cell 128:828-830 (Pubitemid 46341427)
131. Svitkina TM, Verkhovsky AB,McQuade KM, Borisy GG (1997) Analysis of the actin-myosin II system in fish epidermal keratocytes: mechanism of cell body translocation. J Cell Biol 139:397-415 (Pubitemid 27459313)
132. Tatsumi S, Mabuchi T, Katano T, Matsumura S, Abe T, Hidaka H, Suzuki M, Sasaki Y, Minami T, Ito S (2005) Involvement of rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich c-kinase substrate (marcks). Neurosci 131:491-498 (Pubitemid 40222456)
133. Timpson P, Daly R (2005) Distinction at the leading edge of the cell. Bioessays 27:349-352 (Pubitemid 40592590)
134. Trichet L, Campàs O, Sykes C (2007) Vasp governs actin dynamics by modulating filament anchoring. Biophys J 92:1081-1089 (Pubitemid 46203237)
135. Trichet L, Campas O, Sykes C, Palastino J (2007) Vasp governs actin dynamics by modulating filament anchoring. Biophys J 92:1081-1089 (Pubitemid 46203237)
136. Tsukita S, Hieda Y, Tsukita S (1989) A new 82-kd barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization. J Cell Biol 108:2369-2382 (Pubitemid 19168926)
137. Urban W, Jacob S, Nemethova M, Resch G, Small J (2010) Electron tomography reveals unbranched networks of actin filaments in lamellipodia. Nat Cell Biol 12:429-435
138. Vallotton P, Small JV (2009) Shifting views on the leading role of the lamellipodium in cell migration: speckle tracking revisited. J Cell Sci 122(12):1955-1958
139. Verkhovsky A, Chaga O, Schaub S, Svitkina T, J-J M, Borisy G (2003) Orientational order of the lamellipodial actin network as demonstrated in living motile cells. Mol Biol Cell 14: 4667-4675 (Pubitemid 37444664)
140. Watt S, Kular G, Fleming I, Downes C, Lucocq J (2002) Subcellular localozation of phosphytidylinositol 4,5-biphosphate using the pleckstrin homology domain of phospholipase cd1. Biochem J 363:657-666 (Pubitemid 34526386)
141. Wedlich D (ed) (2004) Cell Migration in Development and Disease. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
142. Weichsel J, Schwarz US (2010) Two competing orientation patterns explain experimentally observed anomalies in growing actin networks. Proc Natl Acad Sci 107(14):6304-6309
143. Wolgemuth C (2005) Lamellipodial contractions during crawling and spreading. Biophys J 89:1643-1649 (Pubitemid 41233521)
144. Yamaguchi H, Shiraishi M, Fukami K, Tanabe A, Ikeda-Matsuo Y, Naito Y, Sasaki Y (2009) MARCKS regulates lamellipodia formation induced by IGF-I via association with PIP2 and ?-actin at membrane microdomains. J Cell Physiol 220:748-755
145. Yin HL, Stossel TP (1979) Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein. Nature 281:583-586 (Pubitemid 10242871)
146. Yin HL, Albrecht JH, Fattoum A (1981) Identification of gelsolin, a Ca2C-dependent regulatory protein of actin gel-sol transformation, and its intracellular distribution in a variety of cells and tissues. J Cell Biol 91(3):901-906 (Pubitemid 12211183)
147. Zimmermann J, Enculescu M, Falcke M (2010) Leading edge - gel coupling in lamellipodium motion. Phys Rev E 82(5):051925