Simulation of cell motility that reproduces the force-velocity relationship

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 20, 2010, Pages 9141-9146

  Schreiber, Christian H ^a,b   Stewart, Murray ^c   Duke, Thomas ^d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MAX PLANCK INSTITUT FÜR PHYSIK KOMPLEXER SYSTEME   (Germany)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Arp2 3; Cell movement; Force generation; Retrograde flow

Indexed keywords

ACTIN;

ACTIN POLYMERIZATION; ARTICLE; CAPPING PHENOMENON; CELL ADHESION; CELL GROWTH; CELL MOTILITY; CELL SWELLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSKELETON; FORCE; INTERMEDIATE FILAMENT; LAMELLIPODIUM; PRIORITY JOURNAL; SIMULATION; VELOCITY;

CELL MOVEMENT; COMPUTER SIMULATION; KINETICS; MICROFILAMENTS; MODELS, BIOLOGICAL; POLYMERS; PSEUDOPODIA; STOCHASTIC PROCESSES;

PSEUDOPODA;

EID: 77952730351     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1002538107     Document Type: Article

References (41)

1. Rafelski SM, Theriot JA (2004) Crawling toward a unified model of cell motility: Spatial and temporal regulation of actin dynamics. Annu Rev Biochem 73:209-239.
2. Pollard TD, Berro J (2008) Mathematical models and simulations of cellular processes based on actin filaments. J Biol Chem 284:5433-5437.
3. Svitkina TM, Borisy GG (1999) Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia. J Cell Biol 145:1009-1026.
4. Watanabe N, Mitchison TJ (2002) Single-molecule speckle analysis of actin filament turnover in lamellipodia. Science 295:1083-1086. (Pubitemid 34132240)
5. Mogilner A, Oster G (2003) Force generation by actin polymerization II: The elastic ratchet and tethered filaments. Biophys J 84:1591-1605. (Pubitemid 36322924)
6. Mogilner A, Oster G (1996) Cell motility driven by actin polymerization. Biophys J 71:3030-3045. (Pubitemid 26422346)
7. Prass M, Jacobson K, Mogilner A, Radmacher M (2006) Direct measurement of the lamellipodial protrusive force in a migrating cell. J Cell Biol 174:767-772. (Pubitemid 44373726)
8. Mogilner A (2009) Mathematics of cell motility: Have we got its number?. J Math Biol 58:105-134.
9. Carlsson AE,Wear MA, Cooper JA (2004) End versus side branching by Arp2/3 complex. Biophys J 86:1074-1081.
10. Carlsson AE (2003) Growth velocities of branched actin networks. Biophys J 84:2907-2918.
11. Joanny JF, Jülicher F, Prost J (2003) Motion of an adhesive gel in a swelling gradient: A mechanism for cell locomotion. Phys Rev Lett 90:168102.
12. Huber F, Käs J, Stuhrmann B (2008) Growing actin networks from lamellipodium and lamellum by self-assembly. Biophys J 95:5508-5523.
13. Schaus TE, Taylor EW, Borisy GG (2007) Self-organization of actin filament orientation in the dendritic-nucleation/array-treadmilling model. Proc Natl Acad Sci USA 104:7086-7091.
14. Lee KC, Liu AJ (2009) Force-velocity relation for actin-polymerization- driven motility from Brownian dynamics simulations. Biophys J 97:1295-1304.
15. Gittes F, Mickey B, Nettleton J, Howard J (1993) Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape. J Cell Biol 120:923-934. (Pubitemid 23056298)
16. Isambert H, et al. (1995) Flexibility of actin filaments derived from thermal fluctuations. Effect of bound nucleotide, phalloidin, and muscle regulatory proteins. J Biol Chem 270:11437-11444.
17. Doi M, Edwards SF (1986) The Theory of Polymer Dynamics (Oxford Univ Press, Oxford, UK), pp 324-380.
18. Fletcher DA, Mullins RD (2010) Cell mechanics and the cytoskeleton. Nature 463:485-492.
19. Philipse AP (1996) The Random contact equation and its implications for (colloidal) rods in packings, suspensions, and anisotropic powders. Langmuir 12:1127-1133.
20. Williams SR, Philipse AP (2003) Random packings of spheres and spherocylinders simulated by mechanical contraction. Phys Rev E 67:051301.
21. Rodney D, Fivel M, Dendievel R (2005) Discrete modelling of entangled materials. Phys Rev Lett 95:108004.
22. Miao L, et al. (2008) The role of filament-packing dynamics in powering amoeboid cell motility. Proc Natl Acad Sci USA 105:5390-5395. (Pubitemid 351753873)
23. Laurent VM, et al. (2005) Gradient of rigidity in the lamellipodia of migrating cells revealed by atomic force microscopy. Biophys J 89:667-675.
24. Carlier MF (1991) Actin: Protein structure and filament dynamics. J Biol Chem 266:1-4.
25. Carlier MF, et al. (1997) Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: Implication in actin-based motility. J Cell Biol 136:1307-1323.
26. Bamburg JR, McGough A, Ono S (1999) Putting a new twist on actin: ADF/cofilins modulate actin dynamics. Trends Cell Biol 9:364-370. (Pubitemid 29447718)
27. Schafer DA, Jennings PB, Cooper CA (1996) Dynamics of capping protein and actin assembly in vitro: Uncapping barbed ends by polyphosphoinositides. J Cell Biol 135:169-179.
28. Machesky LM, et al. (1999) Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc Natl Acad Sci USA 96:3739-3744.
29. Mullins RD, Heuser JA, Pollard TD (1998) The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc Natl Acad Sci USA 95:6181-6186.
30. Rouiller I, et al. (2008) The structural basis of actin filament branching by the Arp2/3 complex. J Cell Biol 180:887-895. (Pubitemid 351398416)
31. Takenawa T, Suetsugu S (2007) The WASP-WAVE protein network: Connecting the membrane to the cytoskeleton. Nat Rev Mol Cell Bio 8:37-48. (Pubitemid 46012013)
32. Zamir E, Geiger B (2001) Molecular complexity and dynamics of cell-matrix adhesions. J Cell Sci 114:3583-3590. (Pubitemid 33041040)
33. Bell GI (1978) Models for specific adhesion of cells to cells. Science 200:618-627.
34. Pollard TD (1986) Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments. J Cell Biol 103:2747-2754. (Pubitemid 17008020)
35. Pollard TD, Blanchoin L, Mullins RD (2000) Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct 29:545-576. (Pubitemid 30599604)
36. Schaub S, Meister JJ, Verkhosvky AB (2007) Analysis of actin filament network organization in lamellipodia by comparing experimental and simulated images. J Cell Sci 120:1491-1500. (Pubitemid 46780041)
37. Oliver T, Dembo M, Jacobson K (1999) Separation of Propulsive and Adhesive Traction Stresses in Locomoting Keratocytes. J Cell Biol 145:589-604. (Pubitemid 29215722)
38. Matthews BD, et al. (2004) Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochem Biophys Res Commun 313:758-764.
39. Luby-Phelps K, Taylor DL, Lanni F (1986) Probing the structure of cytoplasm. J Cell Biol 102:2015-2022.
40. Bershadsky AD, Balaban NQ, Geiger B (2003) Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol 19:677-695.
41. Vallotton P, Danuser G, Bohnet S, Meister JJ, Verkhovsky AB (2005) Tracking retrograde flow in keratocytes: News from the leading edge. Mol Biol Cell 16:1223-1231. (Pubitemid 40349559)