Metchnikoff's policemen: Macrophages in development, homeostasis and regeneration

Trends in Molecular Medicine

Volumn 17, Issue 12, 2011, Pages 743-752

  Stefater, James A ^a,b   Ren, Shuyu ^c   Lang, Richard A ^a,b   Duffield, Jeremy S ^c  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR; FIBROBLAST GROWTH FACTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; NEUROTROPHIN RECEPTOR P75; PLATELET DERIVED GROWTH FACTOR; SCATTER FACTOR; SCAVENGER RECEPTOR; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR; VASCULOTROPIN C; WNT PROTEIN; WNT7B PROTEIN;

APOPTOSIS; AUTOIMMUNITY; BLOOD PRESSURE; BONE MARROW CELL; BRAIN DEVELOPMENT; CELL FUNCTION; CELL SURVIVAL; CHRONIC INFLAMMATION; EYE DEVELOPMENT; GENE EXPRESSION; HEMATOPOIETIC CELL; HOMEOSTASIS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INNATE IMMUNITY; LIPID METABOLISM; MACROPHAGE; MACROPHAGE ACTIVATION; MICROGLIA; NONHUMAN; OBESITY; PHAGOCYTE; PHAGOCYTOSIS; PHENOTYPE; REGENERATION; REVIEW; TISSUE REPAIR;

ANIMALS; CELL COMMUNICATION; CELL PROLIFERATION; CELL SURVIVAL; GENETIC FITNESS; HEMATOPOIESIS; HOMEOSTASIS; HUMANS; IMMUNITY, INNATE; LIPID METABOLISM; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, TRANSGENIC; MORPHOGENESIS; REGENERATION; WOUND HEALING;

EID: 84855942903     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2011.07.009     Document Type: Review

References (105)

1. Ginhoux F., et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010, 330:841-845.
2. Jenkins S.J., et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 2011, 332:1284-1288.
3. Dzik J.M. The ancestry and cumulative evolution of immune reactions. Acta Biochim. Pol. 2010, 57:443-466.
4. Tauber A.I. Metchnikoff and the phagocytosis theory. Nat. Rev. Mol. Cell Biol. 2003, 4:897-901.
5. Metchnikoff E. Lectures on the Comparative Pathology of Inflammation (delivered at the Pasteur Institute in 1891) 1968, Dover Publications.
6. Vanfurth R., et al. Mononuclear phagocyte system - new classification of macrophages, monocytes, and their precursor cells. Bull. World Health Organ. 1972, 46:845-852.
7. Mackaness G.B. The immunological basis of acquired cellular resistance. J. Exp. Med. 1964, 120:105-120.
8. Lobov I.B., et al. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 2005, 437:417-421.
9. Van Nguyen A., Pollard J.W. Colony stimulating factor-1 is required to recruit macrophages into the mammary gland to facilitate mammary ductal outgrowth. Dev. Biol. 2002, 247:11-25.
10. Fantin A., et al. Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood 2010, 116:829-840.
11. Reddien P.W., et al. Phagocytosis promotes programmed cell death in C. elegans. Nature 2001, 412:198-202.
12. Hoeppner D.J., et al. Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature 2001, 412:202-206.
13. Marin-Teva J.L., et al. Microglia promote the death of developing Purkinje cells. Neuron 2004, 41:535-547.
14. Frade J.M., Barde Y.A. Microglia-derived nerve growth factor causes cell death in the developing retina. Neuron 1998, 20:35-41.
15. Lang R.A., Bishop M.J. Macrophages are required for cell death and tissue remodeling in the developing mouse eye. Cell 1993, 74:453-462.
16. Diez-Roux G., Lang R.A. Macrophages induce apoptosis in normal cells in vivo. Development 1997, 124:3633-3638.
17. Ravichandran K.S., Lorenz U. Engulfment of apoptotic cells: signals for a good meal. Nat. Rev. Immunol. 2007, 7:964-974.
18. Gordon E.J., et al. Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development 2010, 137:3899-3910.
19. Wiktor-Jedrzejczak W., et al. Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse. Proc. Natl. Acad. Sci. U.S.A. 1990, 87:4828-4832.
20. Kubota Y., et al. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J. Exp. Med. 2009, 206:1089-1102.
21. Sunderkotter C., et al. Macrophages and angiogenesis. J. Leukoc. Biol. 1994, 55:410-422.
22. Folkman J. Angiogenesis. Annu. Rev. Med. 2006, 57:1-18.
23. Stefater J.A., et al. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature 2011, 474:511-515.
24. Van Wesenbeeck L., et al. The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:14303-14308.
25. Pollard J.W., Hennighausen L. Colony stimulating factor 1 is required for mammary gland development during pregnancy. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:9312-9316.
26. Ingman W.V., et al. Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Dev. Dyn. 2006, 235:3222-3229.
27. Gouon-Evans V., et al. Postnatal mammary gland development requires macrophages and eosinophils. Development 2000, 127:2269-2282.
28. Banaei-Bouchareb L., et al. Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice. J. Leukoc. Biol. 2004, 76:359-367.
29. Wynes M.W., et al. IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal. J. Leukoc. Biol. 2004, 76:1019-1027.
30. Rae F., et al. Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter. Dev. Biol. 2007, 308:232-246.
31. Smith S.J., et al. Targeted cell-ablation in Xenopus embryos using the conditional, toxic viral protein M2(H37A). Dev. Dyn. 2007, 236:2159-2171.
32. Banaei-Bouchareb L., et al. A transient microenvironment loaded mainly with macrophages in the early developing human pancreas. J. Endocrinol. 2006, 188:467-480.
33. Geutskens S.B., et al. Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro. J. Leukoc. Biol. 2005, 78:845-852.
34. Michaelson M.D., et al. CSF-1 deficiency in mice results in abnormal brain development. Development 1996, 122:2661-2672.
35. Cohen P.E., et al. Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation. Biol. Reprod. 1997, 56:110-118.
36. Pollard J.W. Trophic macrophages in development and disease. Nat. Rev. Immunol. 2009, 9:259-270.
37. Houlgatte R., et al. Secretion of nerve growth factor in cultures of glial cells and neurons derived from different regions of the mouse brain. J. Neurosci. Res. 1989, 24:143-152.
38. Mallat M., et al. Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro. Dev. Biol. 1989, 133:309-311.
39. Elkabes S., et al. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J. Neurosci. 1996, 16:2508-2521.
40. Paolicelli R.C., et al. Synaptic pruning by microglia is necessary for normal brain development. Science 2011, 10.1126/science.1202529.
41. Weisberg S.P., et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003, 112:1796-1808.
42. Wiktor-Jedrzejczak W., et al. CSF-1 deficiency in the op/op mouse has differential effects on macrophage populations and differentiation stages. Exp. Hematol. 1992, 20:1004-1010.
43. Gouon-Evans V., Pollard J.W. Unexpected deposition of brown fat in mammary gland during postnatal development. Mol. Endocrinol. 2002, 16:2618-2627.
44. Chazaud B., et al. Satellite cells attract monocytes and use macrophages as a support to escape apoptosis and enhance muscle growth. J. Cell Biol. 2003, 163:1133-1143.
45. Kajimura S., et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature 2009, 460:1154-1158.
46. Wyllie A.H., et al. Cell death in the normal neonatal rat adrenal cortex. J. Pathol. 1973, 111:255-261.
47. Gordy C., et al. Regulation of steady-state neutrophil homeostasis by macrophages. Blood 2011, 117:618-629.
48. Chow A., et al. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J. Exp. Med. 2011, 208:261-271.
49. Adrogue H.J., Madias N.E. Sodium and potassium in the pathogenesis of hypertension. N. Engl. J. Med. 2007, 356:1966-1978.
50. Schafflhuber M., et al. Mobilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats. Am. J. Physiol. Renal Physiol. 2007, 292:F1490-F1500.
51. Titze J., et al. Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin. Am. J. Physiol. Heart Circ. Physiol. 2004, 287:H203-H208.
52. Machnik A., et al. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat. Med. 2009, 15:545-552.
53. Jeltsch M., et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 1997, 276:1423-1425.
54. Moncada S., et al. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 1991, 43:109-142.
55. Takeda N., et al. Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev. 2010, 24:491-501.
56. Brannstrom M., et al. Localization of leukocyte subsets in the rat ovary during the periovulatory period. Biol. Reprod. 1993, 48:277-286.
57. Niemi M., et al. Macrophages in the interstitial tissue of the rat testis. Cell Tissue Res. 1986, 243:337-344.
58. Giannessi F., et al. Ultrastructure of testicular macrophages in aging mice. J. Morphol. 2005, 263:39-46.
59. Hutson J.C. Development of cytoplasmic digitations between Leydig cells and testicular macrophages of the rat. Cell Tissue Res. 1992, 267:385-389.
60. Cohen P.E., et al. Macrophages: important accessory cells for reproductive function. J. Leukoc. Biol. 1999, 66:765-772.
61. Cohen P.E., et al. Absence of colony-stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice results in male fertility defects. Biol. Reprod. 1996, 55:310-317.
62. Motoyoshi K. Biological activities and clinical application of M-CSF. Int. J. Hematol. 1998, 67:109-122.
63. Babamusta F., et al. Angiotensin II infusion induces site-specific intra-laminar hemorrhage in macrophage colony-stimulating factor-deficient mice. Atherosclerosis 2006, 186:282-290.
64. Linton M.F., et al. A direct role for the macrophage low density lipoprotein receptor in atherosclerotic lesion formation. J. Biol. Chem. 1999, 274:19204-19210.
65. Leibovich S.J., Ross R. A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro. Am. J. Pathol. 1976, 84:501-514.
66. Martin P., et al. Wound healing in the PU.1 null mouse - tissue repair is not dependent on inflammatory cells. Curr. Biol. 2003, 13:1122-1128.
67. Mirza R., et al. Selective and specific macrophage ablation is detrimental to wound healing in mice. Am. J. Pathol. 2009, 175:2454-2462.
68. Goren I., et al. A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. Am. J. Pathol. 2009, 175:132-147.
69. Mori R., et al. Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring. J. Exp. Med. 2008, 205:43-51.
70. Nahrendorf M., et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J. Exp. Med. 2007, 204:3037-3047.
71. Arnold L., et al. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J. Exp. Med. 2007, 204:1057-1069.
72. Lin S.L., et al. Macrophage Wnt7b is critical for kidney repair and regeneration. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:4194-4199.
73. Duffield J.S., et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J. Clin. Invest. 2005, 115:56-65.
74. Glod J., et al. Monocytes form a vascular barrier and participate in vessel repair after brain injury. Blood 2006, 107:940-946.
75. Pull S.L., et al. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:99-104.
76. Seno H., et al. Efficient colonic mucosal wound repair requires Trem2 signaling. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:256-261.
77. Perides G., et al. TNF-alpha-dependent regulation of acute pancreatitis severity by Ly-6C(hi) monocytes in mice. J. Biol. Chem. 2011, 286:13327-13335.
78. Gyorki D.E., et al. Resident macrophages influence stem cell activity in the mammary gland. Breast Cancer Res. 2009, 11:R62.
79. Serhan C.N., Savill J. Resolution of inflammation: the beginning programs the end. Nat. Immunol. 2005, 6:1191-1197.
80. Savill J., et al. Cell biology. Eat me or die. Science 2003, 302:1516-1517.
81. Hanayama R., et al. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002, 417:182-187.
82. Botto M. C1q knock-out mice for the study of complement deficiency in autoimmune disease. Exp. Clin. Immunogenet. 1998, 15:231-234.
83. Hanayama R., et al. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 2004, 304:1147-1150.
84. Ogden C.A., et al. IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo. Autoimmunity 2005, 38:259-264.
85. Castano A.P., et al. Serum amyloid P inhibits fibrosis through Fc γ R-dependent monocyte-macrophage regulation in vivo. Sci. Transl. Med. 2009, 1:5ra13.
86. Lu J., et al. Structural recognition and functional activation of FcγR by innate pentraxins. Nature 2008, 456:989-992.
87. Ogden C.A., Elkon K.B. Role of complement and other innate immune mechanisms in the removal of apoptotic cells. Curr. Dir. Autoimmun. 2006, 9:120-142.
88. Li B., et al. The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair. FASEB J. 2010, 24:4767-4781.
89. Meijer C., et al. Kupffer cell depletion by CI2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy. Liver 2000, 20:66-77.
90. Takeishi T., et al. The role of Kupffer cells in liver regeneration. Arch Histol. Cytol. 1999, 62:413-422.
91. Shimokado K., et al. A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Cell 1985, 43:277-286.
92. Wynn T.A. Cellular and molecular mechanisms of fibrosis. J. Pathol. 2008, 214:199-210.
93. Nusse R. Wnt signaling in disease and in development. Cell Res. 2005, 15:28-32.
94. Rao S., et al. Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development 2007, 134:4449-4458.
95. Li B., et al. Mobilized human hematopoietic stem/progenitor cells promote kidney repair after ischemia/reperfusion injury. Circulation 2010, 121:2211-2220.
96. Hristov M., Weber C. Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance. J. Cell. Mol. Med. 2004, 8:498-508.
97. Zovein A.C., et al. Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell 2008, 3:625-636.
98. Maruyama K., et al. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am. J. Pathol. 2007, 170:1178-1191.
99. Lettre G., Hengartner M.O. Developmental apoptosis in C. elegans: a complex CEDnario. Nat. Rev. Mol. Cell Biol. 2006, 7:97-108.
100. Nishikawa A., et al. Roles of macrophages in programmed cell death and remodeling of tail and body muscle of Xenopus laevis during metamorphosis. Histochem. Cell Biol. 1998, 109:11-17.
101. Wood W., et al. Mesenchymal cells engulf and clear apoptotic footplate cells in macrophageless PU.1 null mouse embryos. Development 2000, 127:5245-5252.
102. Hipfner D.R., Cohen S.M. Connecting proliferation and apoptosis in development and disease. Nat. Rev. Mol. Cell Biol. 2004, 5:805-815.
103. Ichimura T., et al. Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J. Clin. Invest. 2008, 118:1657-1668.
104. McLaren J., et al. Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. J. Clin. Invest. 1996, 98:482-489.
105. Wiktor-Jedrejczak W., et al. Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op-op) mouse. Proc. Natl. Acad. Sci. U.S.A. 1990, 87:4828-4832.