Cobratoxin inhibits pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats: Involvement of cholinergic and serotonergic systems

Toxicon

Volumn 54, Issue 3, 2009, Pages 224-232

  Cheng, Bo Chao ^a   Zhou, Xi Ping ^a   Zhu, Qi ^a   Gong, Shan ^a   Qin, Zheng Hong ^a   Reid, Paul F ^b   Raymond, Laurence N ^b   Yin, Qi Zhang ^a   Jiang, Xing Hong ^a  

^a SOOCHOW UNIVERSITY   (China)

^b ReceptoPharm Inc   (United States)

Author keywords

Antinociception; Cobratoxin (CTX); Muscarinic receptors; Pain evoked discharge; Serotonergic system; Thalamic parafascicular nucleus (Pf)

Indexed keywords

ATROPINE; FENCLONINE; MORPHINE; NALOXONE; SNAKE VENOM;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CHOLINERGIC ACTIVITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG POTENTIATION; EVOKED RESPONSE; MALE; NERVE CELL INHIBITION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM; THALAMUS PARAFASCICULAR NUCLEUS; WISTAR RAT;

ANIMALS; ATROPINE; COBRA NEUROTOXIN PROTEINS; EVOKED POTENTIALS; MALE; NALOXONE; NEURONS; PAIN; RATS; RATS, WISTAR; RECEPTORS, CHOLINERGIC; RECEPTORS, SEROTONIN; THALAMIC NUCLEI;

RATTUS;

EID: 67649401709     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.04.007     Document Type: Article

References (51)

1. Andersen E., and Dafny N. An ascending serotonergic pain modulation pathway from the dorsal raphe nucleus to the parafascicularis nucleus of the thalamus. Brain Res. 269 1 (1983) 57-67
2. Andersen E., and Dafny N. Dorsal raphe stimulation reduces responses of parafascicular neurons to noxious stimulation. Pain 15 4 (1983) 323-331
3. Bartolini A., Ghelardini C., Fantetti L., Malcangio M., Malmberg-Aiello P., and Giotti A. Role of muscarinic receptor subtypes in central antinociception. Br. J. Pharmacol. 105 1 (1992) 77-82
4. Benabid A.L., Henriksen S.J., McGinty J.F., and Bloom F.E. Thalamic nucleus ventro-postero-lateralis inhibits nucleus parafascicularis response to noxious stimuli through a non-opioid pathway. Brain Res. 280 2 (1983) 217-231
5. Brodie M.S., and Proudfit H.K. Antinociception induced by local injections of carbachol into the nucleus raphe magnus in rats: alteration by intrathecal injection of monoaminergic antagonists. Brain Res. 371 1 (1986) 70-79
6. Chau T.T., and Dewey W.L. Evidence of existence of peptide and nonpeptide morphine-like materials in mouse brain: effect of on an analgesic intracerebroventricular dose of acetylcholine on their levels. J. Pharmacol. Exp. Ther. 222 3 (1982) 612-616
7. Chen R., and Robinson S.E. Effect of cholinergic manipulations on the analgesic response to cobrotoxin in mice. Life Sci. 47 21 (1990) 1949-1954
8. Chen Z.X., Zhang H.L., Gu Z.L., Chen B.W., Han R., Reid P.F., Raymond L.N., and Qin Z.H. A long-form α-neurotoxin from cobra venom produce potent opioid-independent analgesia. Acta Pharmacol. Sin. 27 4 (2006) 402-408
9. Cury Y., and Picolo G. Animal toxins as analgesics - an overview. Drug News Perspect 19 7 (2006) 381-392
10. Giorgi R., Bernardi M.M., and Cury Y. Analgesic effect evoked by low molecular weight substances extracted from Crotalus durissus terrificus venom. Toxicon 31 10 (1993) 1257-1365
11. Gutierrez V.P., Konno K., Chacur M., Sampaio S.C., Picolo G., Brigatte P., Zambelli V.O., and Cury Y. Crotalphine induces potent antinociception in neuropathic pain by acting at peripheral opioid receptors. Eur. J. Pharmacol. 594 1-3 (2008) 84-92
12. Harte S.E., Hoot M.R., and Borszcz G.S. Involvement of the intralaminar parafascicular nucleus in muscarinic-induced antinociception in rats. Brain Res. 1019 1-2 (2004) 152-161
13. 7 receptors in the parafascicular nucleus suppresses the affective reaction of rats to noxious stimulation. Pain 133 3 (2005) 405-415
14. Hodgson W.C., and Wickramaratna J.C. In vitro neuromuscular activity of snake venoms. Clin. Exp. Pharmacol. Physiol. 29 9 (2002) 807-814
15. Huang G.J., and Herbert J. Serotonin modulates the suppressive effects of corticosterone on proliferating progenitor cells in the dentate gyrus of the hippocampus in the adult rat. Neuropsychopharmacology 30 2 (2005) 231-241
16. Katayama Y., Watkins L.R., Becker D.P., and Hayes R.L. Non-opiate analgesia induced by carbachol microinjection into the pontine parabrachial region of the cat. Brain Res. 296 2 (1984) 263-283
17. Kender R.G., Harte S.E., Munn E.M., and Borszcz G.S. Affective analgesia following muscarinic activation of the ventral tegmental area in rats. J. Pain 9 7 (2008) 597-605
18. Koe B.K., and Weissman A. p-Chlorophenylalanine: a specific depletor of brain serotonin. J. Pharmacol. Exp. Ther. 154 3 (1966) 499-516
19. Konno K., Picolo G., Gutierrez V.P., Brigatte P., Zambelli V.O., Camargo A.C.M., and Cury Y. Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus. Peptides 29 8 (2008) 1293-1304
20. Li B.Y., and Xu T. Influence of morphine microinjection into head of caudate nucleus on electric activities of nociceptive neurons in parafascicular nucleus of rat thalamus. Zhongguo Yao Li Xue Bao 11 2 (1990) 103-107
21. Li Y.R., Sun M.Z., Zhang J.Y., and Xu T. The simultaneous discharges of two neurons in N. Pf and RF and the influence on them by stimulating central grey matter. Sci. Sin. [B] 27 12 (1984) 1273-1281
22. Liu F.Y., Qiao J.T., and Dafny N. Cerebellar stimulation modulates thalamic noxious-evoked responses. Brain Res. Bull. 30 5-6 (1993) 529-534
23. Liu Y.L., Lin H.M., Zou R., Wu J.C., Han R., Raymond L.N., Reid P.F., and Qin Z.H. Suppression of complete Freund's adjuvant-induced adjuvant arthritis by Cobratoxin. Acta Pharmacol. Sin 30 2 (2009) 219-227
24. Macht D.I. Experimental and clinical study of cobra venom as an analgesic. Proc. Natl. Acad. Sci. USA 22 1 (1936) 61-71
25. Mancin A.C., Soares A.M., Andriao-Escarso S.H., Faca V.M., Greene L.J., Zuccolotto S., Pela I.R., and Giglio J.R. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon 36 12 (1998) 1927-1937
26. Mash D.C., and Potter L.T. Autoradiographic localization of M1 and M2 muscarine receptors in the rat brain. Neuroscience 19 2 (1986) 551-564
27. Nogueira-Neto F.S., Amorim R.L., Brigatte P., Picolo G., Ferreira W.J., Gutierrez V.P., Conceição I.M., Della-Casa M.S., Takahira R.K., Nicoletti J.L., and Cury Y. The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators. Pharmacol. Biochem. Behav. 91 2 (2008) 252-260
28. In: Paxinos G., and Watson C. (Eds). The Rat Brain in Stereotaxic Coordinates. fifth ed (2005), Elsevier Academic Press, San Diego, CA
29. Pedigo N.W., Dewey W.L., and Harris L.S. Determination and characterization of the antinociceptive activity of intraventricularly administered acetylcholine in mice. J. Pharmacol. Exp. Ther. 193 3 (1975) 845-852
30. Petkov V.D., Belcheva S., Konstantinova E., and Kehayov R. Participation of different 5-HT receptors in the memory process in rats and its modulation by the serotonin depletor p-chlorophenylalanine. Acta Neurobiol. Exp.(Wars.) 55 4 (1995) 243-252
31. Pu X.C., Wong P.T., and Gopalakrishnakone P. A novel analgesic toxin (hannalgesin) from the venom of king cobra (Ophiophagus hannah). Toxicon 33 11 (1995) 1425-1431
32. Qiao J.T., and Dafny N. Dorsal raphe stimulation modulates nociceptive responses in thalamic parafascicular neurons via an ascending pathway: further studies on ascending pain modulation pathways. Pain 34 1 (1988) 65-74
33. Rajendra W., Armugam A., and Jeyaseelan K. Toxins in anti-nociception and anti-inflammation. Toxicon 44 1 (2004) 1-17
34. Reyes-Vazquez C., and Dafny N. Microiontophoretically applied morphine and naloxone on single cell activity in the parafascicularis nucleus of naïve and morphine-dependent rats. J. Pharmacol. Exp. Ther. 229 2 (1984) 583-588
35. Sawynok J. The 1988 Merck Frosst Award. The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies. Can. J. Physiol. Pharmacol. 67 9 (1989) 975-988
36. Servent D., Anti-Delbeke S., Gaillard C., Corringer P.J., Changeux J.P., and Menenz A. Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors. Eur. J. Pharmacol. 393 1-3 (2000) 197-204
37. Weigel R., and Krauss J.K. Center median-parafascicular complex and pain control. Review from a neurosurgical perspective. Stereotact. Funct. Neurosurg. 82 2-3 (2004) 115-126
38. Wess J., Duttaroy A., Gomeza J., Zhang W., Yamada M., Felder C.C., Bernardini N., and Reeh P.W. Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review. Life Sci. 72 18-19 (2003) 2047-2054
39. Xu M.Y., Sun M.Z., Yang L.Z., Zhang L.M., and Han J.S. Simultaneous electric activities of pain-excitation and pain-inhibition neurons in nucleus parafascicularis of thalamus in rats during acute morphine tolerance. Zhongguo Yao Li Xue Bao 11 3 (1990) 200-203
40. Xu G.Y., Duanmu Z.X., and Yin Q.Z. Reversal of the inhibitory effect of electroacupuncture on the nociceptive response of neurons in parafascicular nucleus by naloxone and atropine in acute arthritic rats. Acta Physiol. Sin. 46 5 (1994) 427-434
41. Yoshimura M., and Furue H. Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord. J. Pharmacol. Sci. 101 2 (2006) 107-117
42. Yu G.D., Liu S.Y., Gao A.L., Ge Z.S., Yin Q.Z., Qian Z.N., Jiang M.H., Wang Y.Q., He B.R., Yin W.P., Guo Y.Y., and Deng H.Z. Relationship between lip-acupuncture analgesia and serotonergic neuronal system in the brain. Chin. Med. J. 59 9 (1979) 534-538
43. Yu F.S., Gong S., Yin W.P., and Yin Q.Z. Effects of microinjection of kainic acid into nucleus raphe dorsalis on electro-acupuncture, morphine and stress analgesia. Acta Pharmacol. Sin. 4 4 (1983) 232-235
44. Zhang X.T. Integrative action of thalamus in the process of acupuncture for analgesia. Sci. Sin. 16 1 (1973) 28-52
45. Zhang W.H., Gong S., Yin W.P., and Yin Q.Z. The role of locus coeruleus-noradrenergic and dorsal raphe nucleus-serotonergic systems in analgesic effect of hypothalamic arcuate nucleus stimulation. Kexue Tongbao 32 11 (1987) 773-777
46. Zhang C., Guo Y.Q., Qiao J.T., and Dafny N. Locus coeruleus modulates thalamic nociceptive responses via adrenoceptors. Brain Res. 784 1-2 (1998) 116-122
47. Zhang H.L., Han R., Chen Z.X., Chen B.W., Gu Z.L., Reid P.F., Raymond L.N., and Qin Z.H. Opiate and acetylcholine-independent analgesic actions of crotoxin isolated from Crotalus durissus terrificus venom. Toxicon 48 2 (2006) 175-182
48. Zhang H.L., Han R., Chen Z.X., Gu Z.L., Reid P.F., Raymond L.N., and Qin Z.H. Analgesic effects of receptin, a chemically modified cobratoxin from Thailand cobra venom. Neurosci. Bull. 22 5 (2006) 267-273
49. Zhao D.C., Xu T., and Sun M.Z. The effects of acetylcholine on the electric activities of pain reaction neurons in nucleus parafascicularis of thalamus and midbrain reticular formation in rats. Acta Physiol. Sin. 40 4 (1988) 326-334
50. Zhu Q., Wu D.C., Zhou X.P., Gong S., Cheng B.C., Qin Z.H., Reid P.F., Yin Q.Z., and Jiang X.H. Inhibitory effect of crotoxin on the pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats. Toxicon 51 1 (2008) 102-111
51. Zimmermann M. Ethical guidelines for investigation of experimental pain in conscious animals. Pain 16 2 (1983) 109-110