A long-form α-neurotoxin from cobra venom produces potent opioid-independent analgesia

Acta Pharmacologica Sinica

Volumn 27, Issue 4, 2006, Pages 402-408

  Chen, Zhi Xin ^a   Zhang, Hui Ling ^a   Gu, Zhen Lun ^a   Chen, Bo Wen ^a   Han, Rong ^a   Reid, Paul F ^b   Raymond, Laurence N ^b   Qin, Zheng Hong ^a  

^a SOOCHOW UNIVERSITY   (China)

^b ReceptoPharm   (United States)

Author keywords

Analgesia; Atropine; Cobratoxin; Naloxone; Periaqueductal gray matter

Indexed keywords

ACETIC ACID; ACETYLSALICYLIC ACID; ALPHA NEUROTOXIN; ATROPINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; COBROTOXIN; NALOXONE; NEUROTOXIN; OPIATE RECEPTOR; SNAKE VENOM; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMEX TEST; ANTINOCICEPTION; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FEMALE; FUNCTION TEST; HOT PLATE TEST; MALE; MOTOR ACTIVITY; MOUSE; NONHUMAN; OPIOID INDEPENDENT ANALGESIA; PAIN; PERIAQUEDUCTAL GRAY MATTER; WRITHING TEST;

ANALGESIA; ANALGESICS; ANIMALS; ATROPINE; COBRA NEUROTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICROINJECTIONS; NALOXONE; PAIN MEASUREMENT; PERIAQUEDUCTAL GRAY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33645236560     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00293.x     Document Type: Article

References (26)

1. Yang CC. Cobrotoxin: structure and function. J Nat Toxins 1999 8 221 33.
2. Grasset E. The cobra neurotoxin; pharmacology and clinical applications in the treatment of pain. Med Hyg (Geneve) 1952 10 55 8.
3. Chen R Robinson SE. Effect of cholinergic manipulations on the analgesic response to cobrotoxin in mice. Life Sci 1990 47 1949 54.
4. Shiraishi M Minami K Uezono Y Yanagihara N Shigematsu A Shibuya I. Inhibitory effects of Tramadol on nicotinic acetyl-choline receptors in adrenal chromaffin cells and in Xenopus oocytes expressing alpha7 receptors. Br J Pharmacol 2002 136 207 16.
5. Irnaten M Wang J Venkatesan P Evans CK Chang KS Andresen MC et al. Ketamine inhibits presynaptic and postsynaptic nicotinic excitation of identified cardiac parasympathetic neurons in nucleus ambiguus. Anesthesiology 2002 96 667 74.
6. Lukas RJ. Diversity and patterns of regulation of nicotinic receptor subtypes. Ann NY Acad Sci 1955 757 153 8.
7. Servent D Anti-Delbeke S Gaillard C Corringer PJ Changeux JP Menenz A. Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors. Eur J Pharmacol 2000 393 197 204.
8. Dajas-Bailador F Costa G Dajas F Emmett S. Effects of α-bungarotoxin, α-cobratoxin and fasciculin on the nicotine-evoked release of dopamine in the rat striatum in vivo. Neurochem Intl 1998 33 307 12.
9. 2+ ions in nicotinic facilitation of GABA release in mouse thalamus. J Neurosci 1997 17 576 85.
10. Pu XC Wong PT Gopalakrishnakone P. A novel analgesic toxin (hannalgesin) from the venom of king cobra (Ophiophagus hannah). Toxicon 1995 33 1425 31.
11. Adriana CM Andreimar MS Silvia HAE Vitor MF Lewis G Sergio Z et al. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon 1998 36 1927 37.
12. Rudd CJ Viskatis LJ Vidal JC Etcheverry MA. In vitro comparison of cytotoxic effects of crotoxin against three human tumors and normal human epidermal keratinocyte cell line. In vest New Drugs 1994 12 183 4.
13. Corin RE Viskatis LJ Vidal JC Etcheverry MA. Cytotoxicity of Crotoxin on murine erythroleukemia cells in vitro. Invest New Drugs 1993 11 11 5.
14. Cura JE Blanzaco DP Brisson C Cura MA Cabrol R Larrateguy L et al. Phase I and pharmacokinetics study of crotoxin (cytotoxin PLA2, NSC-624244) in patients with advanced cancer. Clin Cancer Res 2002 8 1033 41.
15. Pedigo NW Dewey Wl Harris LS. Determination and characterization of the antinociceptive activity of intraventricularly administered acetylcholine in mice. J Pharmacol Exp Ther 1975 193 845 52.
16. Paxinos G Watson C. The rat brain in stereotaxic coordinates. 2nd ed. New York Academic Press 1986.
17. Yaksh TL Yeung JC Rudy TA. Systematic examination in the rat of brain sites sensitive to the direct application effects with the periaqueductal gray. Brain Res 1976 114 1183 8.
18. Karlsson E. Chemistry of protein toxins in snake venoms. In Lee CY editor. Handbook of experimental pharmacology. New York Springer-Verlag 1979. p 159 83.
19. Jensen TS Yaksh TL. Comparison of antinococeptive action of morphine in the periaqueductal gray, medial and puramedial medulla in rat. Brain Res 1986 363 99 113.
20. Harris LS Dewey WL. Role of cholinergic systems in the central action of narcotic agonists and antagonists. In Kosterlitz HW Collier HOJ Villareal JE Agonist and antagonist actions of narcotic analgesic drugs. London Macmillan 1972. p 198 206.
21. Xiong Y Wand W Pu X Song J. Preliminary study on the mechanism of using snake venoms to substitute for morphine. Toxicon 1992 30 567.
22. Tseng LF Chiu TH Lee CY. Absorption and distribution of I-labeled cobra venom and its purified toxins. Toxicol Appl Pharmacol 1968 12 526 35.
23. Decker MW Meyer MD Sullivan JP. The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control. Expert Opin Investig Drugs 2001 10 1819 30.
24. Damaj MI Meyer EM Martin BR. The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model. Neurophar-macology 2000 39 2785 91.
25. Mundy HR Jones SJ Hobart JC Hanna MG Lee PJ. A randomized controlled study of modified cobratoxin in adrenomyelo-neuropathy. Neurology 2003 61 528 30.
26. Smith MT Cabot PJ Ross FB Robertson AD Lewis RJ. The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices. Pain 2002 96 119 27.