Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism

Molecular Autism

Volumn 2, Issue 1, 2011, Pages

  Wills, Sharifia ^a   Rossi, Christy C ^b,d   Bennett, Jeffrey ^b,d   Martinez Cerdẽo, Veronica ^b,d   Ashwood, Paul ^a,c,d   Amaral, David G ^b,d   Van De Water, Judy ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; AUTOANTIBODY; CALBINDIN; CALCIUM BINDING PROTEIN; CALRETININ; PARVALBUMIN;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTISM; BRAIN; CELL SPECIFICITY; CENTRAL NERVOUS SYSTEM; CHILD; CONTROLLED STUDY; GOLGI COMPLEX; HUMAN; IMMUNOREACTIVITY; INTERNEURON; MACACA; MOUSE; NEOCORTEX; NONHUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SUBCORTEX;

MUS; PRIMATES;

EID: 84855922674     PISSN: None     EISSN: 20402392     Source Type: Journal    
DOI: 10.1186/2040-2392-2-5     Document Type: Article

References (80)

1. Diagnosing autism: analyses of data from the Autism Diagnostic Interview. Lord C, Pickles A, McLennan J, Rutter M, Bregman J, Folstein S, Fombonne E, Leboyer M, Minshew N, J Autism Dev Disord 1997 27 501 517 10.1023/A: 1025873925661 9403369 (Pubitemid 27513149)
2. Autism and the immune system. van Gent T, Heijnen CJ, Treffers PD, J Child Psychol Psychiatry 1997 38 337 349 10.1111/j.1469-7610.1997.tb01518.x 9232480 (Pubitemid 27373343)
3. Reduced natural killer cell activity in autism. Warren RP, Foster A, Margaretten NC, J Am Acad Child Adolesc Psychiatry 1987 26 333 335 10.1097/00004583-198705000-00008 3597287 (Pubitemid 17116696)
4. Immunogenetic studies in autism and related disorders. Warren RP, Singh VK, Averett RE, Odell JD, Maciulis A, Burger RA, Daniels WW, Warren WL, Mol Chem Neuropathol 1996 28 77 81 10.1007/BF02815207 8871944 (Pubitemid 26275053)
5. A review of autism and the immune response. Ashwood P, Van de Water J, Clin Dev Immunol 2004 11 165 174 10.1080/10446670410001722096 15330453 (Pubitemid 38955074)
6. Increased serum albumin, globulin, immunoglobulin IgG, and IgG2 and IgG4 in autism. Croonenberghs J, Wauters A, Devreese K, Verkerk R, Scharpe S, Bosmans E, Egyed B, Deboutte D, Maes M, Psychol Med 2002 32 1457 1463 12455944 (Pubitemid 35385656)
7. The immune response in autism: a new frontier for autism research. Ashwood P, Wills S, Van de Water J, J Leukoc Biol 2006 80 1 15 10.1189/jlb.1205707 16698940 (Pubitemid 44841805)
8. Activation of the inflammatory response system in autism. Croonenberghs J, Bosmans E, Deboutte D, Kenis G, Maes M, Neuropsychobiology 2002 45 1 6 11803234 (Pubitemid 34117721)
9. Neuroglial activation and neuroinflammation in the brain of patients with autism. Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA, Ann Neurol 2005 57 67 81 10.1002/ana.20315 15546155 (Pubitemid 40053317)
10. Is autism an autoimmune disease? Ashwood P, Van de Water J, Autoimmun Rev 2004 3 557 562 10.1016/j.autrev.2004.07.036 15546805 (Pubitemid 39531249)
11. The immunology of multiple sclerosis. Bar-Or A, Semin Neurol 2008 28 29 45 10.1055/s-2007-1019124 18256985 (Pubitemid 351273082)
12. Resistance is futile: antineuronal autoimmunity in multiple sclerosis. Huizinga R, Linington C, Amor S, Trends Immunol 2008 29 54 60 10.1016/j.it.2007.11.002 18182323
13. Sydenham's chorea. Cardoso F, Curr Treat Options Neurol 2008 10 230 235 10.1007/s11940-008-0025-x 18579027
14. Pediatric movement disorders: an update. Wolf DS, Singer HS, Curr Opin Neurol 2008 21 491 496 18607212
15. Circulating autoantibodies to neuronal and glial filament proteins in autism. Singh VK, Warren R, Averett R, Ghaziuddin M, Pediatr Neurol 1997 17 88 90 10.1016/S0887-8994(97)00045-3 9308986 (Pubitemid 27387929)
16. How relevant are GFAP autoantibodies in autism and Tourette syndrome? Kirkman NJ, Libbey JE, Sweeten TL, Coon HH, Miller JN, Stevenson EK, Lainhart JE, McMahon WM, Fujinami RS, J Autism Dev Disord 2008 38 333 341 10.1007/s10803-007-0398-9 17578659 (Pubitemid 351161424)
17. Antibodies to myelin basic protein in children with autistic behavior. Singh VK, Warren RP, Odell JD, Warren WL, Cole P, Brain Behav Immun 1993 7 97 103 10.1006/brbi.1993.1010 7682457 (Pubitemid 23227066)
18. Are there enhanced MBP autoantibodies in autism? Libbey JE, Coon HH, Kirkman NJ, Sweeten TL, Miller JN, Stevenson EK, Lainhart JE, McMahon WM, Fujinami RS, J Autism Dev Disord 2008 38 324 332 10.1007/s10803-007-0400-6 17588145 (Pubitemid 351161426)
19. Antibrain antibodies in infantile autism. Todd RD, Hickok JM, Anderson GM, Cohen DJ, Biol Psychiatry 1988 23 644 647 10.1016/0006-3223(88)90012-1 3355880 (Pubitemid 18064916)
20. [Nerve growth factor auto-antibodies in children with various forms of mental dysontogenesis and in schizophrenia high risk group] [in Russian]. Kozlovskaia GV, Kliushnik TP, Goriunova AV, Turkova IL, Kalinina MA, Sergienko NS, Zh Nevrol Psikhiatr Im S S Korsakova 2000 100 50 52 11247189
21. Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease. Vojdani A, Bazargan M, Vojdani E, Samadi J, Nourian AA, Eghbalieh N, Cooper EL, Clin Diagn Lab Immunol 2004 11 515 524 15138176 (Pubitemid 38661417)
22. Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy. Connolly AM, Chez M, Streif EM, Keeling RM, Golumbek PT, Kwon JM, Riviello JJ, Robinson RG, Neuman RJ, Deuel RM, Biol Psychiatry 2006 59 354 363 10.1016/j.biopsych.2005.07.004 16181614 (Pubitemid 43238361)
23. Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders. Connolly AM, Chez MG, Pestronk A, Arnold ST, Mehta S, Deuel RK, J Pediatr 1999 134 607 613 10.1016/S0022-3476(99)70248-9 10228297 (Pubitemid 30180601)
24. Prevalence of serum antibodies to caudate nucleus in autistic children. Singh VK, Rivas WH, Neurosci Lett 2004 355 53 56 10.1016/j.neulet.2003.10.026 14729233 (Pubitemid 38077183)
25. Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Cabanlit M, Wills S, Goines P, Ashwood P, Van de Water J, Ann N Y Acad Sci 2007 1107 92 103 10.1196/annals.1381.010 17804536 (Pubitemid 47528785)
26. Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral DG, Van de Water J, Brain Behav Immun 2009 23 64 74 10.1016/j.bbi.2008.07.007 18706993
27. Neuroanatomy of autism. Amaral DG, Schumann CM, Nordahl CW, Trends Neurosci 2008 31 137 145 10.1016/j.tins.2007.12.005 18258309
28. Measles MMR and autism: the confusion continues [Editorial]. Lancet 2000 355 1379 10.1016/S0140-6736(00)02129-2 10791514
29. The pre-linguistic autism diagnostic observation schedule. DiLavore PC, Lord C, Rutter M, J Autism Dev Disord 1995 25 355 379 10.1007/BF02179373 7592249
30. Quantifying the phenotype in autism spectrum disorders. Lord C, Leventhal BL, Cook EH Jr, Am J Med Genet 2001 105 36 38 10.1002/1096-8628(20010108)105: 1<36::AID-AJMG1053>3.0.CO;2-4 11424991
31. Cognitive profiles and social-communicative functioning in children with autism spectrum disorder. Joseph RM, Tager-Flusberg H, Lord C, J Child Psychol Psychiatry 2002 43 807 821 10.1111/1469-7610.00092 12236615 (Pubitemid 36939261)
32. Autism screening questionnaire: diagnostic validity. Berument SK, Rutter M, Lord C, Pickles A, Bailey A, Br J Psychiatry 1999 175 444 451 10.1192/bjp.175.5.444 10789276
33. Mechanisms of postnatal neurobiological development: implications for human development. Webb SJ, Monk CS, Nelson CA, Dev Neuropsychol 2001 19 147 171 10.1207/S15326942DN1902-2 11530973 (Pubitemid 32845926)
34. The distribution of GABAergic cells, fibers, and terminals in the monkey amygdaloid complex: an immunohistochemical and in situ hybridization study. Pitkänen A, Amaral DG, J Neurosci 1994 14 2200 2224 8158266
35. A cryoprotection method that facilitates cutting frozen sections of whole monkey brains for histological and histochemical processing without freezing artifact. Rosene DL, Roy NJ, Davis BJ, J Histochem Cytochem 1986 34 1301 1315 10.1177/34.10.3745909 3745909 (Pubitemid 16015742)
36. Distribution of GABAergic cells and fibers in the hippocampal formation of the macaque monkey: an immunohistochemical and in situ hybridization study. Jongen-Rêlo AL, Pitkänen A, Amaral DG, J Comp Neurol 1999 408 237 271 10.1002/(SICI)1096-9861(19990531)408:2<237::AID-CNE7>3.0.CO;2-1 10333273 (Pubitemid 29211200)
37. Distribution of parvalbumin-immunoreactive cells and fibers in the monkey temporal lobe: the hippocampal formation. Pitkänen A, Amaral DG, J Comp Neurol 1993 331 37 74 10.1002/cne.903310104 8320348 (Pubitemid 23115578)
38. Macaque monkey retrosplenial cortex: I. three-dimensional and cytoarchitectonic organization. Kobayashi Y, Amaral DG, J Comp Neurol 2000 426 339 365 10.1002/1096-9861(20001023)426:3<339::AID-CNE1>3.0.CO;2-8 10992242
39. Microglia can be induced by IFN- or IL-4 to express neural or dendritic-like markers. Butovsky O, Bukshpan S, Kunis G, Jung S, Schwartz M, Mol Cell Neurosci 2007 35 490 500 10.1016/j.mcn.2007.04.009 17560122 (Pubitemid 46990939)
40. Breceptors to modulate interleukin release. Kuhn SA, van Landeghem FK, Zacharias R, Farber K, Rappert A, Pavlovic S, Hoffmann A, Nolte C, Kettenmann H, Mol Cell Neurosci 2004 25 312 322 10.1016/j.mcn.2003.10.023 15019947 (Pubitemid 38338642)
41. Numbers and proportions of GABA-immunoreactive neurons in different areas of monkey cerebral cortex. Hendry SH, Schwark HD, Jones EG, Yan J, J Neurosci 1987 7 1503 1519 3033170
42. Distribution of GABAergic neurons and axon terminals in the macaque striate cortex. Fitzpatrick D, Lund JS, Schmechel DE, Towles AC, J Comp Neurol 1987 264 73 91 10.1002/cne.902640107 3680625 (Pubitemid 17147828)
43. Distribution of GABA and neuropeptides in the human cerebral cortex: a light and electron microscopic study. Ong WY, Garey LJ, Anat Embryol (Berl) 1991 183 397 413
44. Distribution and patterns of connectivity of interneurons containing calbindin, calretinin, and parvalbumin in visual areas of the occipital and temporal lobes of the macaque monkey. DeFelipe J, González-Albo MC, Del Río MR, Elston GN, J Comp Neurol 1999 412 515 526 10.1002/(SICI)1096- 9861(19990927)412:3<515::AID-CNE10>3.0.CO;2-1 10441237 (Pubitemid 29398707)
45. Parvalbumin-, calbindin-, and calretinin-immunoreactive neurons in the prefrontal cortex of the owl monkey (Aotus trivirgatus): a standardized quantitative comparison with sensory and motor areas. Elston GN, González-Albo MC, Brain Behav Evol 2003 62 19 30 10.1159/000071957 12907857 (Pubitemid 36980710)
46. The distribution of calcium-binding proteins in the lateral geniculate nucleus and visual cortex of a New World monkey, the marmoset, Callithrix jacchus. Goodchild AK, Martin PR, Vis Neurosci 1998 15 625 642 9682866 (Pubitemid 28358379)
47. Heterogeneity of chandelier neurons in monkey neocortex: corticotropin-releasing factor- and parvalbumin-immunoreactive populations. Lewis DA, Lund JS, J Comp Neurol 1990 293 599 615 10.1002/cne.902930406 2329196 (Pubitemid 20111768)
48. Types of neurons, synaptic connections and chemical characteristics of cells immunoreactive for calbindin-D28K, parvalbumin and calretinin in the neocortex. DeFelipe J, J Chem Neuroanat 1997 14 1 19 10.1016/S0891-0618(97) 10013-8 9498163 (Pubitemid 28051036)
49. Probing the transcriptome of neuronal cell types. Nelson SB, Hempel C, Sugino K, Curr Opin Neurobiol 2006 16 571 576 10.1016/j.conb.2006.08.006 16962313 (Pubitemid 44466396)
50. The organization of the transcriptional network in specific neuronal classes. Winden KD, Oldham MC, Mirnics K, Ebert PJ, Swan CH, Levitt P, Rubenstein JL, Horvath S, Geschwind DH, Mol Syst Biol 2009 5 291 19638972
51. Neurochemical correlates of autistic disorder: a review of the literature. Lam KS, Aman MG, Arnold LE, Res Dev Disabil 2006 27 254 289 10.1016/j.ridd.2005.03.003 16002261
52. Suppressed GABAergic inhibition as a common factor in suspected etiologies of autism. Hussman JP, J Autism Dev Disord 2001 31 247 248 10.1023/A:1010715619091 11450824 (Pubitemid 37490171)
53. 2+ signaling. Krey JF, Dolmetsch RE, Curr Opin Neurobiol 2007 17 112 119 10.1016/j.conb.2007.01.010 17275285 (Pubitemid 46227984)
54. Elevated plasma -aminobutyric acid (GABA) levels in autistic youngsters: stimulus for a GABA hypothesis of autism. Dhossche D, Applegate H, Abraham A, Maertens P, Bland L, Bencsath A, Martinez J, Med Sci Monit 2002 8 R1 6 12165753
55. Model of autism: increased ratio of excitation/inhibition in key neural systems. Rubenstein JL, Merzenich MM, Genes Brain Behav 2003 2 255 267 10.1034/j.1601-183X.2003.00037.x 14606691 (Pubitemid 37345664)
56. Epilepsy in disintegrative psychosis and infantile autism: a long-term validation study. Mouridsen SE, Rich B, Isager T, Dev Med Child Neurol 1999 41 110 114 10.1017/S0012162299000213 10075096 (Pubitemid 29074077)
57. Epilepsy in children with autistic spectrum disorder. Wong V, J Child Neurol 1993 8 316 322 10.1177/088307389300800405 7693796 (Pubitemid 23292462)
58. Epilepsy in autism. Tuchman R, Rapin I, Lancet Neurol 2002 1 352 358 10.1016/S1474-4422(02)00160-6 12849396 (Pubitemid 37159160)
59. The autism-epilepsy connection. Levisohn PM, Epilepsia 2007 48 Suppl 9 33 35 18329993 (Pubitemid 350198226)
60. Epilepsy in young adults with autism: a prospective population-based follow-up study of 120 individuals diagnosed in childhood. Danielsson S, Gillberg IC, Billstedt E, Gillberg C, Olsson I, Epilepsia 2005 46 918 923 10.1111/j.1528-1167.2005.57504.x 15946331 (Pubitemid 40847358)
61. Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices. Fatemi SH, Halt AR, Stary JM, Kanodia R, Schulz SC, Realmuto GR, Biol Psychiatry 2002 52 805 810 10.1016/S0006- 3223(02)01430-0 12372652
62. Areceptor downregulation in brains of subjects with autism. Fatemi SH, Reutiman TJ, Folsom TD, Thuras PD, J Autism Dev Disord 2009 39 223 230 10.1007/s10803-008-0646-7 18821008
63. The hyperglutamatergic hypothesis of autism. Fatemi SH, Prog Neuropsychopharmacol Biol Psychiatry 2008 32 911 913 10.1016/j.pnpbp.2007.11.004 18160196 (Pubitemid 351312357)
64. Increased GAD67 mRNA expression in cerebellar interneurons in autism: implications for Purkinje cell dysfunction. Yip J, Soghomonian JJ, Blatt GJ, J Neurosci Res 2008 86 525 530 10.1002/jnr.21520 17918742 (Pubitemid 351204465)
65. Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications. Yip J, Soghomonian JJ, Blatt GJ, Acta Neuropathol 2007 113 559 568 10.1007/s00401-006-0176-3 17235515 (Pubitemid 46672602)
66. Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study. Blatt GJ, Fitzgerald CM, Guptill JT, Booker AB, Kemper TL, Bauman ML, J Autism Dev Disord 2001 31 537 543 10.1023/A:1013238809666 11814263 (Pubitemid 37490148)
67. Serotonin and amino acid content in platelets of autistic children. Rolf LH, Haarmann FY, Grotemeyer KH, Kehrer H, Acta Psychiatr Scand 1993 87 312 316 10.1111/j.1600-0447.1993.tb03378.x 8517170 (Pubitemid 23134638)
68. Cytokines in inflammatory brain lesions: helpful and harmful. Merrill JE, Benveniste EN, Trends Neurosci 1996 19 331 338 10.1016/0166-2236(96)10047-3 8843602 (Pubitemid 26349062)
69. Corticotropin-releasing hormone and the blood-brain-barrier. Theoharides TC, Konstantinidou AD, Front Biosci 2007 12 1615 1628 10.2741/2174 17127408 (Pubitemid 46846794)
70. Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution. Hawkins BT, Abbruscato TJ, Egleton RD, Brown RC, Huber JD, Campos CR, Davis TP, Brain Res 2004 1027 48 58 10.1016/j.brainres.2004.08.043 15494156 (Pubitemid 39370994)
71. Extravasation of blood-borne immunoglobulin G through blood-brain barrier during adrenaline-induced transient hypertension in the rat. Kuang F, Wang BR, Zhang P, Fei LL, Jia Y, Duan XL, Wang X, Xu Z, Li GL, Jiao XY, Ju G, Int J Neurosci 2004 114 575 591 15204064 (Pubitemid 38679902)
72. Cognition and immunity; antibody impairs memory. Kowal C, DeGiorgio LA, Nakaoka T, Hetherington H, Huerta PT, Diamond B, Volpe BT, Immunity 2004 21 179 188 10.1016/j.immuni.2004.07.011 15308099 (Pubitemid 39094048)
73. Immunity and behavior: antibodies alter emotion. Huerta PT, Kowal C, DeGiorgio LA, Volpe BT, Diamond B, Proc Natl Acad Sci USA 2006 103 678 683 10.1073/pnas.0510055103 16407105 (Pubitemid 43153085)
74. Autoantibodies to glutamate receptors can damage the brain in epilepsy, systemic lupus erythematosus and encephalitis. Levite M, Ganor Y, Expert Rev Neurother 2008 8 1141 1160 10.1586/14737175.8.7.1141 18590483 (Pubitemid 351962080)
75. Autoantibodies to neuronal glutamate receptors in patients with paraneoplastic neurodegenerative syndrome enhance receptor activation. Gahring LC, Twyman RE, Greenlee JE, Rogers SW, Mol Med 1995 1 245 253 8529103
76. Autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel. Levite M, Fleidervish IA, Schwarz A, Pelled D, Futerman AH, J Autoimmun 1999 13 61 72 10.1006/jaut.1999.0301 10441169 (Pubitemid 29367008)
77. Stereological analysis of amygdala neuron number in autism. Schumann CM, Amaral DG, J Neurosci 2006 26 7674 7679 10.1523/JNEUROSCI.1285-06.2006 16855095 (Pubitemid 44315187)
78. Neurons in the fusiform gyrus are fewer and smaller in autism. van Kooten IA, Palmen SJ, von Cappeln P, Steinbusch HW, Korr H, Heinsen H, Hof PR, van Engeland H, Schmitz C, Brain 2008 131 987 999 10.1093/brain/awn033 18332073 (Pubitemid 351499430)
79. The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells. McLachlan SM, Nagayama Y, Pichurin PN, Mizutori Y, Chen CR, Misharin A, Aliesky HA, Rapoport B, Endocrinology 2007 148 5724 5733 10.1210/en.2007-1024 17823263 (Pubitemid 350146191)
80. Analysis of cognitive and psychological deficits in systemic lupus erythematosus patients without overt central nervous system disease. Kozora E, Thompson LL, West SG, Kotzin BL, Arthritis Rheum 1996 39 2035 2045 10.1002/art.1780391213 8961909 (Pubitemid 27009072)