An automated screening assay for determination of aqueous equilibrium solubility enabling SPR study during drug lead optimization

JALA - Journal of the Association for Laboratory Automation

Volumn 10, Issue 6, 2005, Pages 364-373

  Tan, Helming ^a   Semin, David ^a   Wacker, Maggie ^a   Cheetham, Janet ^a  

^a AMGEN INC   (United States)

Author keywords

Aqueous equilibrium solubility; High throughput; HPLC UV; Physicochemical properties; Structure property relationship

Indexed keywords

ASSAYS; CENTRIFUGATION; CENTRIFUGES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROCHLORIC ACID; PHOSPHATES; PHYSICAL PROPERTIES; ROBOTICS; THERMODYNAMICS;

AQUEOUS EQUILIBRIUM SOLUBILITY; CENTRIFUGAL SEPARATION; PHOSPHATE BUFFER SALINE (PBS); PHYSICOCHEMICAL PROPERTIES; ROBOTIC LIQUID HANDLING; SIMULATED INTESTINAL FLUID (SIF); STRUCTURE PROPERTY RELATIONSHIOP;

SOLUBILITY;

CHEMICAL COMPOUND; FUROSEMIDE; HYDROCHLORIC ACID; HYDROCORTISONE; INDOMETACIN; KETOCONAZOLE; NITROFURANTOIN; PHENYLBUTAZONE; PHOSPHATE BUFFERED SALINE; PIROXICAM; SOLVENT; TERFENADINE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; DRUG DETERMINATION; DRUG SCREENING; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LABORATORY AUTOMATION; PROCESS OPTIMIZATION; REPRODUCIBILITY; ROBOTICS; SEPARATION TECHNIQUE; SIMULATION; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

EID: 30344483643     PISSN: 15355535     EISSN: 15402452     Source Type: Journal    
DOI: 10.1016/j.jala.2005.06.003     Document Type: Article

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