Dry powder inhaler device influence on carrier particle performance

Journal of Pharmaceutical Sciences

Volumn 101, Issue 3, 2012, Pages 1097-1107

  Donovan, Martin J ^a   Kim, Sin Hyen ^b   Raman, Venkatramanan ^b   Smyth, Hugh D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b The University of Texas at Austin   (United States)

Author keywords

Excipients; Formulation; Morphology; Particle size; Physical characterization; Pulmonary drug delivery

Indexed keywords

BUDESONIDE; DRUG CARRIER; LACTOSE;

AEROSOL; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG GRANULE; GEOMETRY; IN VITRO STUDY; PARTICLE SIZE; POWDER INHALER; SIMULATION;

EID: 84855892066     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22824     Document Type: Article

References (34)

1. Hickey AJ Ed. 2004. Pharmaceutical inhalation aerosol technology. 2nd ed. New York City, New York: Marcel Dekker, Inc.
2. Finlay WH. 2001. The Mechanics of inhaled pharmaceutical aerosols. London, UK: Academic Press.
3. de Boer A, Hagedoorn P, Gjaltema D, Goede J, Frijlink H. 2003. Air classifier technology (ACT) in dry powder inhalation Part 1. Introduction of a novel force distribution concept (FDC) explaining the performance of a basic air classifier on adhesive mixtures. Int J Pharm 260(2):187-200.
4. Frijlink HW, De Boer AH. 2004. Dry powder inhalers for pulmonary drug delivery. Expert Opin Drug Deliv 1(1):67-86.
5. Islam N, Gladki E. 2008. Dry powder inhalers (DPIs)-a review of device reliability and innovation. Int J Pharm 360(1-2):1-11.
6. Coates MS, Fletcher DF, Chan H-K, Raper JA. 2004. Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: Grid structure and mouthpiece length. J Pharm Sci 93(11):2863-2876.
7. Coates MS, Fletcher DF, Chan H-K, Raper JA. 2005. The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses. Pharm Res 22(6):923-932.
8. Coates MS, Chan H-K, Fletcher DF, Raper JA. 2005. Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses. Pharm Res 22(9):1445-1453.
9. Coates MS, Chan H-K, Fletcher DF, Raper JA. 2006. Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size. J Pharm Sci 95(6):1382-1392.
10. Coates MS, Chan H-K, Fletcher DF, Chiou H. 2007. Influence of mouthpiece geometry on the aerosol delivery performance of a dry powder inhaler. Pharm Res 24(8):1450-1456.
11. Wachtel H, Ertunc O, Koksoy C, Delgado A. 2008. Aerodynamic optimization of Handihaler and respimat: The roles of computational fluid dynamics and flow visualization. Respir Drug Deliv 1:165-174.
12. Voss A, Finlay WH. 2002. Deagglomeration of dry powder pharmaceutical aerosols. Int J Pharm 248:39-50.
13. Nichols SC, Wynn E. 2008. New approaches to optimizing dispersion in dry powder inhalers-Dispersion force mapping and adhesion measurements. Respir Drug Deliv 1:175-184.
14. Wong W, Fletcher DF, Traini D, Chan H-K, Crapper J, Young PM. 2010. Particle aerosolisation and break-up in dry powder inhalers 1: Evaluation and modelling of Venturi effects for agglomerated systems. Pharm Res 27(7):1367-1376.
15. de Boer A, Hagedoorn P, Gjaltema D, Goede J, Kussendrager K, Frijlink H. 2003. Air classifier technology (ACT) in dry powder inhalation Part 2. The effect of lactose carrier surface properties on the drug-to-carrier interaction in adhesive mixtures for inhalation. Int J Pharm 260(2):201-216.
16. Donovan MJ, Smyth HDC. 2010. Influence of size and surface roughness of large lactose carrier particles in dry powder inhaler formulations. Int J Pharm 402(1-2):1-9.
17. Pope SB. 2000. Turbulent flows. Cambridge University Press New York, NY, USA.
18. Kawashima Y, Serigano T, Hino T, Yamamoto H, Takeuchi H. 1998. Effect of surface morphology of carrier lactose on dry powder inhalation property of pranlukast hydrate. Int J Pharm 172:179-188.
19. Larhrib H, Zeng XM, Martin GP, Marriott C, Pritchard J. 1999. The use of different grades of lactose as a carrier for aerosolised salbutamol sulphate. Int J Pharm 191:1-14.
20. Pitchayajittipong C, Price R, Shur J, Kaerger JS, Edge S. 2010. Characterisation and functionality of inhalation anhydrous lactose. Int J Pharm 390(2):134-141.
21. Gupta V, Gupta SK. 1984. Fluid mechanics and its applications. New Delhi, India: New Age International.
22. Begat P, Morton DAV, Staniforth JN, Price R. 2004. Dry powder inhaler formulations I: Direct quantification by atomic force microscopy. Pharm Res 21(9):1591-1597.
23. Saleem I, Smyth H, Telko M. 2008. Prediction of dry powder inhaler formulation performance from surface energetics and blending dynamics. Drug Dev Ind Pharm 34(9):1002-1010.
24. Alshowair R, Tarsin W, Assi K, Pearson S, Chrystyn H. 2007. Can all patients with COPD use the correct inhalation flow with all inhalers and does training help? Respir Med 101(11):2395-2401.
25. Chodosh S, Flanders JS, Kesten S, Serby CW, Hochrainer D, Witek TJ. 2001. Effective delivery of particles with the HandiHaler® dry powder inhalation system over a range of chronic obstructive pulmonary disease severity. J Aerosol Med 14(3):309-315.
26. Bronsky EA, Grossman J, Henis MJ, Gallo PP, Yegen Ü, Cioppa GD, Kottakis J, Mehra S. 2004. Inspiratory flow rates and volumes with the Aerolizer dry powder inhaler in asthmatic children and adults. Curr Med Res Opin 20(2):131-137.
27. Clark AR, Hollingworth AM. 1993. The relationship between powder inhaler resistance and peak inspiratory conditions in healthy volunteers-implications for in vitro testing. J Aerosol Med 6(2):99-110.
28. Mendes P, Pinto J, Sousa J. 2007. A non-dimensional functional relationship for the fine particle fraction produced by dry powder inhalers. J Aerosol Sci 38(6):612-624.
29. Srichana T, Martin GP, Marriott C. 1998. Dry powder inhalers: The influence of device resistance and powder formulation on drug and lactose deposition in vitro. Eur J Pharm Sci 7(1):73-80.
30. Louey M, Vanoort M, Hickey A. 2006. Standardized entrainment tubes for the evaluation of pharmaceutical dry powder dispersion. J Aerosol Sci 37(11):1520-1531.
31. Chew NYK, Chan HK, Bagster DF, Mukhraiya J. 2002. Characterization of pharmaceutical powder inhalers: Estimation of energy input for powder dispersion and effect of capsule device configuration. Aerosol Sci 33:999-1008.
32. Tuley R, Shrimpton J, Jones M, Price R, Palmer M, Prime D. 2008. Experimental observations of dry powder inhaler dose fluidisation. Int J Pharm 358(1-2):238-247.
33. Watling CP, Elliott JA, Cameron RE. 2010. Entrainment of lactose inhalation powders: A study using laser diffraction. Eur J Pharm Sci 40(4):352-358.
34. Shur J, Harris H, Jones MD, Kaerger JS, Price R. 2008. The role of fines in the modification of the fluidization and dispersion mechanism within dry powder inhaler formulations. Pharm Res 25(7):1631-1640.