Characterisation and functionality of inhalation anhydrous lactose

International Journal of Pharmaceutics

Volumn 390, Issue 2, 2010, Pages 134-141

  Pitchayajittipong, Chonladda ^a   Price, Robert ^a   Shur, Jagdeep ^a   Kaerger, J Sebastian ^b   Edge, Stephen ^c  

^a University of Bath   (United Kingdom)

^b Aeropharm GmbH   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Anhydrous lactose; Dry powder inhaler; Powder fluidisation

Indexed keywords

BUDESONIDE; EXCIPIENT; LACTOHALE; LACTOPRESS; LACTOSE; RESPITOSE; SUPERTAB; UNCLASSIFIED DRUG;

ABSORPTION; AEROSOL; ARTICLE; CONTROLLED STUDY; DENSITY; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRY POWDER; FLOW MEASUREMENT; FLUIDIZATION; IN VITRO STUDY; MOISTURE; PARTICLE SIZE; PHYSICAL CHEMISTRY; POWDER INHALER; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; WATER CONTENT;

ADMINISTRATION, INHALATION; AEROSOLS; BUDESONIDE; DRUG COMPOUNDING; EXCIPIENTS; LACTOSE; PARTICLE SIZE; PHYSICOCHEMICAL PROCESSES; POWDERS; RHEOLOGY; SURFACE PROPERTIES; WATER;

EID: 77951499720     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.01.028     Document Type: Article

References (24)

1. Carr R.L. Evaluating the flow properties of solids-classifying flow properties of solids. Chem. Eng. 1965, 72:163-168.
2. Castellanos A. The relationship between attractive interparticle forces and bulk behaviour in dry and uncharged fine powders. Adv. Phys. 2005, 54:263-376.
3. Castellanos A., Valverde J.M., Quintanilla M.A.S. Fine cohesive powders in rotating drums: transition from rigid-plastic flow to gas-fluidized regime. Phys. Rev. E: Stat. Nonlin. Soft Matter Phys. 2002, 65.
4. Crowder T.M., Sethuraman V., Fields T.B., Hickey A.J. Signal processing and analysis applied to powder behavior in a rotating drum. Part. Part. Syst. Char. 1999, 16:191-196.
5. Edge S., Mueller S., Price R., Shur J. Factors affecting defining the quality and functionality of excipients used in the manufacture of dry powder inhaler products. Drug Dev. Ind. Pharm. 2008, 34:966-973.
6. Edge S., Kibbe A., Shur J. Lactose monohydrate. Handbook of Pharmaceutical Excipients 2009, 364-369. Pharmaceutical Press, London. 6th ed. R.C. Rowe, P.J. Sheskey, S.C. Owen (Eds.).
7. Freeman R. Measuring the flow properties of consolidated, conditioned and aerated powders-a comparative study using a powder rheometer and a rotational shear cell. Powder Technol. 2007, 174:25-33.
8. Hickey A.J., Mansour H.M., Telko M.J., Xu Z., Smyth H.D.C., Mulder T., McLean R., Langridge J., Papadopoulos D. Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics. J. Pharm. Sci. 2007, 96:1282-1301.
9. Hickey A.J., Mansour H.M., Telko M.J., Xu Z., Smyth H.D.C., Mulder T., McLean R., Langridge J., Papadopoulos D. Physical characterization of component particles included in dry powder inhalers. II. Dynamic characteristics. J. Pharm. Sci. 2007, 96:1302-1319.
10. Hooton J.C., Jones M.D., Price R. Predicting the behaviour of novel sugar carriers for dry powder inhaler formulations via the use of a cohesive-adhesive force balance approach. J. Pharm. Sci. 2006, 95:1288-1297.
11. Jackson R. The Dynamics of Fluidized Particles 2000, Cambridge University Press, Cambridge.
12. Jones M.D., Harris H., Hooton J.C., Shur J., King G.S., Mathoulin C.A., Nichol K., Smith T.L., Dawson M.L., Ferrie A.R., Price R. An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive-adhesive force balances. Eur. J. Pharm. Biopharm. 2008, 69:496-507.
13. Jones M.D., Price R. The effect of fines on the performance of DPI formulations. Pharm. Res. 2006, 23:1665-1673.
14. Larhrib H., Zeng X.M., Martin G.P., Marriott C., Pritchard J. The use of different grades of lactose as a carrier for aerosolised salbutamol sulphate. Int. J. Pharm. 1999, 191:1-14.
15. Lerk C.F., Andreae A.C., de Boer A.H., de Hoog P., Kussindrager K., van Leverink J. Alterations of α-lactose during differential scanning calorimetry. J. Pharm. Sci. 1984, 73:856-857.
16. Lucas P., Anderson K., Potter U.J., Staniforth J.N. Enhancement of small particle size dry powder aerosol formulations using an ultra low density additive. Pharm. Res. 1998, 16:1643-1716.
17. Price R., Young P.M., Edge S., Staniforth J.N. The influence of relative humidity on particulate interactions in carrier-based dry powder inhaler formulations. Int. J. Pharm. 2002, 246:47-59.
18. Shah K.R., Hussain M.A., Hubert M., Badawy S.I.F. Form conversion of anhydrous lactose during wet granulation and its effect on compactibility. Int. J. Pharm. 2008, 357:228-234.
19. Shur J., Harris H., Jones M.D., Kaerger J.S., Price R. The role of fines in the modification of the fluidization and dispersion mechanism within dry powder inhaler formulations. Pharm. Res. 2008, 25:1931-1940.
20. Steckel H., Bolzen N. Alternative sugars as potential carriers for dry powder inhalations. Int. J. Pharm 2004, 270:297-306.
21. Tee S.K., Marriott C., Zeng X.M., Martin G.P. The use of different sugars as fine and coarse carriers for aerosolised sulbutamol sulphate. Int. J. Pharm. 2000, 208:111-123.
22. Telko M., Hickey A.J. Dry powder inhaler formulations. Respir. Care 2005, 50:1209-1227.
23. United States Pharmacopoeia XXXII, 2009. Rockville, MD, USA. Powder flow (1174).
24. Valverde J.M., Rasenack N., Castellanos A., Waston P.K. The tensile strength of cohesive powders and its relationship to consolidation, free volume and cohesivity. Powder Technol. 1998, 97:237-245.