The role of fines in the modification of the fluidization and dispersion mechanism within dry powder inhaler formulations

Pharmaceutical Research

Volumn 25, Issue 7, 2008, Pages 1631-1640

  Shur, Jagdeep ^a   Harris, Haggis ^a   Jones, Matthew D ^a,b   Kaerger, J Sebastian ^c   Price, Robert ^a  

^a University of Bath   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Dry powder inhaler; Fluidization; Particle re suspension; Powder flow; Ternary agents

Indexed keywords

ALPHA LACTOSE; BUDESONIDE; EXCIPIENT;

AEROSOL; ARTICLE; DRUG FORMULATION; DRY POWDER; EXCIPIENT COMPATIBILITY; FLOW MEASUREMENT; FLUIDIZATION; PARTICLE SIZE; PHYSICAL CHEMISTRY; POWDER INHALER; PRIORITY JOURNAL; SHEAR FLOW;

ADMINISTRATION, INHALATION; BRONCHODILATOR AGENTS; BUDESONIDE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG COMPOUNDING; EXCIPIENTS; IMAGE PROCESSING, COMPUTER-ASSISTED; LACTOSE; MICROSCOPY, ELECTRON, SCANNING; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; POWDERS; SURFACE PROPERTIES;

EID: 44749086930     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9538-y     Document Type: Article

References (41)

1. J. A. Hersey. Ordered mixing: A new concept in powder mixing practise. Powder Technol. 11:41-44 (1975).
2. R. J. Malcolmson, and J. K. Embleton. Dry powder formulations for pulmonary delivery. Pharm. Sci. Technol. Today 1:394-398 (1998).
3. S. Edge, A. Kibbe, and K. D. Kussendrager. Lactose monohydrate. In R. C. Rowe, P. J. Sheskey, and S. C. Owen (eds.), Handbook of Pharmaceutical Excipients, Pharmaceutical Press, London, UK, 2005, pp. 389-395.
4. H. W. Frijlink, and A. H. de Boer. Dry powder inhalers for pulmonary drug delivery. Expert Opin. Drug. Del. 1:67-86 (2004).
5. T. Srichana, G. P. Martin, and C. Marriott. Dry powder inhalers: The influence of device resistance and powder formulation on drug and lactose deposition in vitro. Eur J. Pharm. Sci. 7:73-80 (1998).
6. M. D. Louey, M. van Oort, and A. J. Hickey. Standardised entrainment tubes for the evaluation of pharmaceutical dry powder dispersion. J. Aerosol. Sci. 37:1520-1531 (2006).
7. M. D. Louey, and P. J. Stewart. Particle interactions involved in aerosol dispersion of ternary interactive mixtures. Pharm. Res. 19:1524-1531 (2002).
8. S. K. Tee, C. Marriott, X. M. Zeng, and G. P. Martin. The use of different sugars as fine and coarse carriers for aerosolised sulbutamol sulphate. Int. J. Pharm. 208:111-123 (2000).
9. P. Lucas, K. Anderson, and J. N. Staniforth. Protein deposition from dry powder inhalers: Fine particle multiplets as performance modifiers. Pharm. Res. 15:562-569 (1998).
10. N. Islam, P. Stewart, I. Larson, and P. Hartley. Lactose surface modification by decantation: Are drug-fine lactose ratios the key to better dispersion of salmeterol xinafoate from lactose-interactive mixtures? Pharm. Res. 21:492-499 (2004).
11. M. Telko, and A. J. Hickey. Dry powder inhaler formulations. Respir. Care 50:1209-1227 (2005).
12. A. Castellanos, J. M. Valverde, A. T. Perez, A. Ramos, and P. K. Watson. Flow regimes in fine cohesive powders. Phys. Rev. Lett. 82:1156-1159 (1999).
13. A. Castellanos. The relationship between attractive interparticle forces and bulk behaviour in dry and uncharged fine powders. Adv. Phys. 54:263-376 (2005).
14. J. M. Valverde, N. Rasenack, A. Castellanos, and P. K. Watson. The tensile strength of cohesive powders and its relationship to consolidation, free volume and cohesivity. Powder Technol. 97:237-245 (1998).
15. J. R. Howard. Fluidized Bed Technology: Principles & Application, Adam Hilger, Bristol, UK, 1989, pp. 25-32.
16. P. C. Carman. Fluid flow through granular beds. Trans. Inst. Chem. Eng. 15:150 (1937).
17. J. M. Valverde, A. Ramos, A. Castellanos, and P. K. Watson. The tensile strength of cohesive powders and its relationship to consolidation, free volume and cohesivity. Powder Technol. 97:237-245 (1998).
18. P. K. Watson, J. M. Valverde, and A. Castellanos. The tensile strength and free volume of cohesive powders compressed by gas flow. Powder Technol. 115:45-50 (2001).
19. X. M. Zeng, G. P. Martin, and C. Marriott. Particulate Interaction in Dry Powder Formulations for Inhalation, Taylor & Francis, London, UK, 2001, pp. 104-114.
20. A. H. de Boer, P. Hagedoorn, D. Gjaltema, J. Goede, and H. W. Frijlink. Air classifier technology (ACT) in dry powder inhalation: Part 1. Introduction of a novel force distribution concept (FDC) explaining the performance of a basic air classifier on adhesive mixtures. Int. J. Pharm. 260:187-200 (2003).
21. D. Ganderton. General factors influencing drug delivery to the lung. Respir. Med. 91:13-16 (1997).
22. P. L. Stephenson, and W. J. Thiel. The mechanical stability of ordered mixtures when fluidised and their pharmaceutical application. Powder Technol. 26:225-227 (1980).
23. N. M. Concessio, M. van Oort, M. R. Knowles, and A. J. Hickey. Pharmaceutical dry aerosols: Correlation of powder properties with dose delivery and implications for pharmacodynamic effect. Pharm. Res. 16:828-834 (1999).
24. T. Crowder, and A. J. Hickey. Powder specific active dispersion for generation of pharmaceutical aerosols. Int. J. Pharm. 327:65-72 (2006).
25. R. Freeman. Measuring the flow properties of consolidated, conditioned and aerated powders-A comparative study using a powder rheometer and a rotational shear cell. Powder Technol. 174:25-33 (2007).
26. P. M. Young, H. K. Chan, H. Chiou, S. Edge, T. H. S. Tee, and D. Traini. The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance. J. Pharm. Sci. 96:1331-1341 (2007).
27. P. M. Young, S. Edge, D. Traini, M. D. Jones, R. Price, D. El-Sabawi, C. Urry, and C. Smith. The influence of dose on the performance of dry powder inhalation systems. Int. J. Pharm. 296:26-33 (2005).
28. X. M. Zeng, S. K. Tee, G. P. Martin, and C. Marriott. Effects of Mixing Procedure and Particle Size Distribution of Carrier Particles on the Deposition of Salbutamol Sulphate from Dry Powder Inhaler Formulations, Proceedings of Drug Delivery to the Lungs 7, The Aerosol Society, London, UK, 1996, pp. 40-43.
29. X. M. Zeng, G. P. Martin, S. K. Tee, A. A. Ghoush, and C. Marriot. Effects of particle size and adding sequence of fine lactose on the deposition of salbutamol sulphate from dry powder formulations. Int. J. Pharm. 182:133-144 (1999).
30. X. M. Zeng, K. H. Pandhal, and G. P. Martin. The influence of lactose carrier on the content homogeneity and dispersibility of beclomethasone dipropionate from dry powder aerosols. Int. J. Pharm. 197:41-52 (2000).
31. T. Hartmann, and H. Steckel. Influence of Mixer Type and Mixing Conditions on Delivery Efficiency from Flowcaps, a Capsule-Based Dry Powder Inhaler, Proceedings of Drug Delivery to the Lungs 15, The Aerosol Society, London, UK, 2004, pp. 178-181.
32. N. Islam, P. Stewart, I. Larson, and P. Hartley. Surface roughness contribution to the adhesion force distribution of salmeterol xinafoate on lactose carriers by atomic force microscopy. J. Pharm. Sci. 94:1500-1511 (2005).
33. H. Adi, P. J. Stewart, and I. Larson. Influence of Different Sugars on the Dispersion of Salmeterol Xinafoate in Ddry Powder Inhalation Formulations, Proceedings of Fformula IV: Frontiers in Formulation Science, Royal Society of Chemistry, London, UK, 2005, pp. 25-28.
34. J. M. Valverde, and A. Castellanos. Types of gas fluidization of cohesive granular materials. Phys. Rev. E. 75:1-6 (2007).
35. M. D. Jones. An Investigation into the Dispersion Mechanisms of Ternary Dry Powder Inhaler Formulations by the Quantification of Interparticulate Forces, PhD Thesis, University of Bath, Bath, UK, 2006, pp. 110-111.
36. J. M. Valverde, and A. Castellanos. Compaction of fine powders: From fluidized agglomerates to primary particles. Granul. Matter 9:19-24 (2007).
37. A. Castellanos, J. M. Valverde, and M. A. S. Quintanilla. Fine cohesive powders in rotating drums: Transition from rigid-plastic flow to gas-fluidized regime. Phys. Rev. E. 65: Art. No. 061301 (2002).
38. R. Jackson. The Dynamics of Fluidized Particles, Cambridge University Press, Cambridge, UK, 2000, pp. 117-124.
39. J. Shrimpton. The challenge of predicting particle dynamics in dry powder inhalers, Proceedings of Drug Delivery to the Lungs 16, The Aerosol Society, London, UK, 2005, pp. 84-88.
40. W. John, D. N. Fritter, and W. Winklmayr. Re-suspension induced by impacting particles. J. Aerosol. Sci. 22:723-736 (1991).
41. W. Theerachaisupakij, S. Matsusaka, Y. Akashi, and H. Masuda. Re-entrainment of deposited particles by drag and aerosol collision. J. Aerosol. Sci. 34:261-274 (2003).