-
1
-
-
0029862973
-
Hyperinsulinemia as an independent risk factor for ischemic heart disease
-
Despres J.P., Lamarche B., Mauriege P., Cantin B., Dagenais G.R., Moorjani S., Lupien P.J. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N. Engl. J. Med. 1996, 334:952-957.
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 952-957
-
-
Despres, J.P.1
Lamarche, B.2
Mauriege, P.3
Cantin, B.4
Dagenais, G.R.5
Moorjani, S.6
Lupien, P.J.7
-
2
-
-
33646501931
-
Insulin resistance and atherosclerosis
-
Nigro J., Osman N., Dart A.M., Little P.J. Insulin resistance and atherosclerosis. Endocr. Rev. 2006, 27:242-259.
-
(2006)
Endocr. Rev.
, vol.27
, pp. 242-259
-
-
Nigro, J.1
Osman, N.2
Dart, A.M.3
Little, P.J.4
-
3
-
-
0038665339
-
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance
-
Vicent D., Ilany J., Kondo T., Naruse K., Fisher S.J., Kisanuki Y.Y., Bursell S., Yanagisawa M., King G.L., Kahn C.R. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J. Clin. Invest. 2003, 111:1373-1380.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1373-1380
-
-
Vicent, D.1
Ilany, J.2
Kondo, T.3
Naruse, K.4
Fisher, S.J.5
Kisanuki, Y.Y.6
Bursell, S.7
Yanagisawa, M.8
King, G.L.9
Kahn, C.R.10
-
4
-
-
58149328550
-
Effect of endothelium-specific insulin resistance on endothelial function in vivo
-
Duncan E.R., Crossey P.A., Walker S., Anilkumar N., Poston L., Douglas G., Ezzat V.A., Wheatcroft S.B., Shah A.M., Kearney M.T. Effect of endothelium-specific insulin resistance on endothelial function in vivo. Diabetes 2008, 57:3307-3314.
-
(2008)
Diabetes
, vol.57
, pp. 3307-3314
-
-
Duncan, E.R.1
Crossey, P.A.2
Walker, S.3
Anilkumar, N.4
Poston, L.5
Douglas, G.6
Ezzat, V.A.7
Wheatcroft, S.B.8
Shah, A.M.9
Kearney, M.T.10
-
5
-
-
0037662849
-
Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury
-
Kubota T., Kubota N., Moroi M., Terauchi Y., Kobayashi T., Kamata K., Suzuki R., Tobe K., Namiki A., Aizawa S., Nagai R., Kadowaki T., Yamaguchi T. Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury. Circulation 2003, 107:3073-3080.
-
(2003)
Circulation
, vol.107
, pp. 3073-3080
-
-
Kubota, T.1
Kubota, N.2
Moroi, M.3
Terauchi, Y.4
Kobayashi, T.5
Kamata, K.6
Suzuki, R.7
Tobe, K.8
Namiki, A.9
Aizawa, S.10
Nagai, R.11
Kadowaki, T.12
Yamaguchi, T.13
-
6
-
-
34250214950
-
The macrophage at the crossroads of insulin resistance and atherosclerosis
-
Liang C.P., Han S., Senokuchi T., Tall A.R. The macrophage at the crossroads of insulin resistance and atherosclerosis. Circ. Res. 2007, 100:1546-1555.
-
(2007)
Circ. Res.
, vol.100
, pp. 1546-1555
-
-
Liang, C.P.1
Han, S.2
Senokuchi, T.3
Tall, A.R.4
-
7
-
-
77952100841
-
Impact of insulin resistance on enhanced monocyte adhesion to endothelial cells and atherosclerogenesis independent of LDL cholesterol level
-
Mita T., Goto H., Azuma K., Jin W.L., Nomiyama T., Fujitani Y., Hirose T., Kawamori R., Watada H. Impact of insulin resistance on enhanced monocyte adhesion to endothelial cells and atherosclerogenesis independent of LDL cholesterol level. Biochem. Biophys. Res. Commun. 2010, 395:477-483.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.395
, pp. 477-483
-
-
Mita, T.1
Goto, H.2
Azuma, K.3
Jin, W.L.4
Nomiyama, T.5
Fujitani, Y.6
Hirose, T.7
Kawamori, R.8
Watada, H.9
-
8
-
-
85047690709
-
Increased CD36 protein as a response to defective insulin signaling in macrophages
-
Liang C.P., Han S., Okamoto H., Carnemolla R., Tabas I., Accili D., Tall A.R. Increased CD36 protein as a response to defective insulin signaling in macrophages. J. Clin. Invest. 2004, 113:764-773.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 764-773
-
-
Liang, C.P.1
Han, S.2
Okamoto, H.3
Carnemolla, R.4
Tabas, I.5
Accili, D.6
Tall, A.R.7
-
9
-
-
33645567816
-
Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions
-
Han S., Liang C.P., DeVries-Seimon T., Ranalletta M., Welch C.L., Collins-Fletcher K., Accili D., Tabas I., Tall A.R. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell. Metab. 2006, 3:257-266.
-
(2006)
Cell. Metab.
, vol.3
, pp. 257-266
-
-
Han, S.1
Liang, C.P.2
DeVries-Seimon, T.3
Ranalletta, M.4
Welch, C.L.5
Collins-Fletcher, K.6
Accili, D.7
Tabas, I.8
Tall, A.R.9
-
10
-
-
33645563765
-
Myeloid lineage cell-restricted insulin resistance protects apolipoprotein E-deficient mice against atherosclerosis
-
Baumgartl J., Baudler S., Scherner M., Babaev V., Makowski L., Suttles J., McDuffie M., Tobe K., Kadowaki T., Fazio S., Kahn C.R., Hotamisligil G.S., Krone W., Linton M., Bruning J.C. Myeloid lineage cell-restricted insulin resistance protects apolipoprotein E-deficient mice against atherosclerosis. Cell Metab. 2006, 3:247-256.
-
(2006)
Cell Metab.
, vol.3
, pp. 247-256
-
-
Baumgartl, J.1
Baudler, S.2
Scherner, M.3
Babaev, V.4
Makowski, L.5
Suttles, J.6
McDuffie, M.7
Tobe, K.8
Kadowaki, T.9
Fazio, S.10
Kahn, C.R.11
Hotamisligil, G.S.12
Krone, W.13
Linton, M.14
Bruning, J.C.15
-
11
-
-
34249823656
-
Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3
-
O'Connor J.C., Sherry C.L., Guest C.B., Freund G.G. Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3. J. Immunol. 2007, 178:6886-6893.
-
(2007)
J. Immunol.
, vol.178
, pp. 6886-6893
-
-
O'Connor, J.C.1
Sherry, C.L.2
Guest, C.B.3
Freund, G.G.4
-
12
-
-
0034746443
-
Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells
-
Aljada A., Ghanim H., Saadeh R., Dandona P. Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells. J. Clin. Endocrinol. Metab. 2001, 86:450-453.
-
(2001)
J. Clin. Endocrinol. Metab.
, vol.86
, pp. 450-453
-
-
Aljada, A.1
Ghanim, H.2
Saadeh, R.3
Dandona, P.4
-
13
-
-
0034915177
-
Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?
-
Dandona P., Aljada A., Mohanty P., Ghanim H., Hamouda W., Assian E., Ahmad S. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?. J. Clin. Endocrinol. Metab. 2001, 86:3257-3265.
-
(2001)
J. Clin. Endocrinol. Metab.
, vol.86
, pp. 3257-3265
-
-
Dandona, P.1
Aljada, A.2
Mohanty, P.3
Ghanim, H.4
Hamouda, W.5
Assian, E.6
Ahmad, S.7
-
14
-
-
42549098517
-
Insulin inhibits LPS-induced signaling pathways in alveolar macrophages
-
Martins J.O., Ferracini M., Ravanelli N., Landgraf R.G., Jancar S. Insulin inhibits LPS-induced signaling pathways in alveolar macrophages. Cell Physiol. Biochem. 2008, 21:297-304.
-
(2008)
Cell Physiol. Biochem.
, vol.21
, pp. 297-304
-
-
Martins, J.O.1
Ferracini, M.2
Ravanelli, N.3
Landgraf, R.G.4
Jancar, S.5
-
15
-
-
70350539525
-
FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages
-
Su D., Coudriet G.M., Hyun Kim D., Lu Y., Perdomo G., Qu S., Slusher S., Tse H.M., Piganelli J., Giannoukakis N., Zhang J., Henry Dong H. FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages. Diabetes 2009, 58:2624-2633.
-
(2009)
Diabetes
, vol.58
, pp. 2624-2633
-
-
Su, D.1
Coudriet, G.M.2
Hyun Kim, D.3
Lu, Y.4
Perdomo, G.5
Qu, S.6
Slusher, S.7
Tse, H.M.8
Piganelli, J.9
Giannoukakis, N.10
Zhang, J.11
Henry Dong, H.12
-
16
-
-
58149337286
-
Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress
-
Senokuchi T., Liang C.P., Seimon T.A., Han S., Matsumoto M., Banks A.S., Paik J.H., DePinho R.A., Accili D., Tabas I., Tall A.R. Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes 2008, 57:2967-2976.
-
(2008)
Diabetes
, vol.57
, pp. 2967-2976
-
-
Senokuchi, T.1
Liang, C.P.2
Seimon, T.A.3
Han, S.4
Matsumoto, M.5
Banks, A.S.6
Paik, J.H.7
DePinho, R.A.8
Accili, D.9
Tabas, I.10
Tall, A.R.11
-
17
-
-
57549092036
-
Molecular mechanisms of atherosclerosis in metabolic syndrome: role of reduced IRS2-dependent signaling
-
Gonzalez-Navarro H., Vinue A., Vila-Caballer M., Fortuno A., Beloqui O., Zalba G., Burks D., Diez J., Andres V. Molecular mechanisms of atherosclerosis in metabolic syndrome: role of reduced IRS2-dependent signaling. Arterioscler. Thromb. Vasc. Biol. 2008, 28:2187-2194.
-
(2008)
Arterioscler. Thromb. Vasc. Biol.
, vol.28
, pp. 2187-2194
-
-
Gonzalez-Navarro, H.1
Vinue, A.2
Vila-Caballer, M.3
Fortuno, A.4
Beloqui, O.5
Zalba, G.6
Burks, D.7
Diez, J.8
Andres, V.9
-
18
-
-
0033755408
-
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia
-
Kubota N., Tobe K., Terauchi Y., Eto K., Yamauchi T., Suzuki R., Tsubamoto Y., Komeda K., Nakano R., Miki H., Satoh S., Sekihara H., Sciacchitano S., Lesniak M., Aizawa S., Nagai R., Kimura S., Akanuma Y., Taylor S.I., Kadowaki T. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 2000, 49:1880-1889.
-
(2000)
Diabetes
, vol.49
, pp. 1880-1889
-
-
Kubota, N.1
Tobe, K.2
Terauchi, Y.3
Eto, K.4
Yamauchi, T.5
Suzuki, R.6
Tsubamoto, Y.7
Komeda, K.8
Nakano, R.9
Miki, H.10
Satoh, S.11
Sekihara, H.12
Sciacchitano, S.13
Lesniak, M.14
Aizawa, S.15
Nagai, R.16
Kimura, S.17
Akanuma, Y.18
Taylor, S.I.19
Kadowaki, T.20
more..
-
19
-
-
57549112337
-
In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid
-
Yamada H., Yoshida M., Nakano Y., Suganami T., Satoh N., Mita T., Azuma K., Itoh M., Yamamoto Y., Kamei Y., Horie M., Watada H., Ogawa Y. In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid. Arterioscler. Thromb. Vasc. Biol. 2008, 28:2173-2179.
-
(2008)
Arterioscler. Thromb. Vasc. Biol.
, vol.28
, pp. 2173-2179
-
-
Yamada, H.1
Yoshida, M.2
Nakano, Y.3
Suganami, T.4
Satoh, N.5
Mita, T.6
Azuma, K.7
Itoh, M.8
Yamamoto, Y.9
Kamei, Y.10
Horie, M.11
Watada, H.12
Ogawa, Y.13
-
20
-
-
10744233909
-
Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells
-
Choi J.B., Uchino H., Azuma K., Iwashita N., Tanaka Y., Mochizuki H., Migita M., Shimada T., Kawamori R., Watada H. Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 2003, 46:1366-1374.
-
(2003)
Diabetologia
, vol.46
, pp. 1366-1374
-
-
Choi, J.B.1
Uchino, H.2
Azuma, K.3
Iwashita, N.4
Tanaka, Y.5
Mochizuki, H.6
Migita, M.7
Shimada, T.8
Kawamori, R.9
Watada, H.10
-
21
-
-
57249097121
-
Impact of whole body irradiation and vascular endothelial growth factor-A on increased beta cell mass after bone marrow transplantation in a mouse model of diabetes induced by streptozotocin
-
Nakayama S., Uchida T., Choi J.B., Fujitani Y., Ogihara T., Iwashita N., Azuma K., Mochizuki H., Hirose T., Kawamori R., Inoue M., Watada H. Impact of whole body irradiation and vascular endothelial growth factor-A on increased beta cell mass after bone marrow transplantation in a mouse model of diabetes induced by streptozotocin. Diabetologia 2009, 52:115-124.
-
(2009)
Diabetologia
, vol.52
, pp. 115-124
-
-
Nakayama, S.1
Uchida, T.2
Choi, J.B.3
Fujitani, Y.4
Ogihara, T.5
Iwashita, N.6
Azuma, K.7
Mochizuki, H.8
Hirose, T.9
Kawamori, R.10
Inoue, M.11
Watada, H.12
-
22
-
-
34249063553
-
Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice
-
Mita T., Otsuka A., Azuma K., Uchida T., Ogihara T., Fujitani Y., Hirose T., Mitsumata M., Kawamori R., Watada H. Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice. Biochem. Biophys. Res. Commun. 2007, 358:679-685.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.358
, pp. 679-685
-
-
Mita, T.1
Otsuka, A.2
Azuma, K.3
Uchida, T.4
Ogihara, T.5
Fujitani, Y.6
Hirose, T.7
Mitsumata, M.8
Kawamori, R.9
Watada, H.10
-
23
-
-
77951151612
-
Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
-
Arakawa M., Mita T., Azuma K., Ebato C., Goto H., Nomiyama T., Fujitani Y., Hirose T., Kawamori R., Watada H. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 2010, 59:1030-1037.
-
(2010)
Diabetes
, vol.59
, pp. 1030-1037
-
-
Arakawa, M.1
Mita, T.2
Azuma, K.3
Ebato, C.4
Goto, H.5
Nomiyama, T.6
Fujitani, Y.7
Hirose, T.8
Kawamori, R.9
Watada, H.10
-
24
-
-
0032134003
-
Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
-
Gu L., Okada Y., Clinton S.K., Gerard C., Sukhova G.K., Libby P., Rollins B.J. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol. Cell 1998, 2:275-281.
-
(1998)
Mol. Cell
, vol.2
, pp. 275-281
-
-
Gu, L.1
Okada, Y.2
Clinton, S.K.3
Gerard, C.4
Sukhova, G.K.5
Libby, P.6
Rollins, B.J.7
-
25
-
-
0033022438
-
Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice
-
Aiello R.J., Bourassa P.A., Lindsey S., Weng W., Natoli E., Rollins B.J., Milos P.M. Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 1999, 19:1518-2155.
-
(1999)
Arterioscler. Thromb. Vasc. Biol.
, vol.19
, pp. 1518-2155
-
-
Aiello, R.J.1
Bourassa, P.A.2
Lindsey, S.3
Weng, W.4
Natoli, E.5
Rollins, B.J.6
Milos, P.M.7
-
26
-
-
0035980021
-
Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway
-
Iida K.T., Shimano H., Kawakami Y., Sone H., Toyoshima H., Suzuki S., Asano T., Okuda Y., Yamada N. Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway. J. Biol. Chem. 2001, 276:32531-32537.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32531-32537
-
-
Iida, K.T.1
Shimano, H.2
Kawakami, Y.3
Sone, H.4
Toyoshima, H.5
Suzuki, S.6
Asano, T.7
Okuda, Y.8
Yamada, N.9
-
27
-
-
0030723973
-
Dependence of augmentation of arterial endothelial cell expression of plasminogen activator inhibitor type 1 by insulin on soluble factors released from vascular smooth muscle cells
-
Schneider D.J., Absher P.M., Ricci M.A. Dependence of augmentation of arterial endothelial cell expression of plasminogen activator inhibitor type 1 by insulin on soluble factors released from vascular smooth muscle cells. Circulation 1997, 96:2868-2876.
-
(1997)
Circulation
, vol.96
, pp. 2868-2876
-
-
Schneider, D.J.1
Absher, P.M.2
Ricci, M.A.3
-
28
-
-
0141866848
-
Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways
-
Wang C.C., Gurevich I., Draznin B. Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways. Diabetes 2003, 52:2562-2569.
-
(2003)
Diabetes
, vol.52
, pp. 2562-2569
-
-
Wang, C.C.1
Gurevich, I.2
Draznin, B.3
|