Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex

Biochemical and Biophysical Research Communications

Volumn 415, Issue 4, 2011, Pages 720-726

  Kim, Bogyou ^a   Nam, Hye Jin ^a   Pyo, Ki Eun ^a   Jang, Min Jung ^b   Kim, Ik Soo ^a   Kim, Dongha ^a   Boo, Kyungjin ^a   Lee, Seung Hoon ^c   Yoon, Jong Bok ^c   Baek, Sung Hee ^a   Kim, Jung Hwa ^b  

^a Seoul National University   (South Korea)

^b Inha University   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

Breast cancer cells; BRMS1; Cul3; SPOP; Ubiquitination

Indexed keywords

ADAPTOR PROTEIN; BREAST CANCER METASTASIS SUPPRESSOR 1 PROTEIN; CULLIN; CULLIN 3; PROTEIN SPOP; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME SUBSTRATE; GENE REPRESSION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; UBIQUITINATION;

BREAST NEOPLASMS; CELL LINE, TUMOR; CULLIN PROTEINS; FEMALE; HEK293 CELLS; HUMANS; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTEIN STABILITY; REPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84855889543     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.10.154     Document Type: Article

References (39)

1. Seraj M.J., Samant R.S., Verderame M.F., Welch D.R. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. Cancer Res. 2000, 60:2764-2769.
2. Phadke P.A., Vaidya K.S., Nash K.T., Hurst D.R., Welch D.R. BRMS1 suppresses breast cancer experimental metastasis to multiple organs by inhibiting several steps of the metastatic process. Am. J. Pathol. 2008, 172:809-817.
3. Saunders M.M., Seraj M.J., Li Z., Zhou Z., Winter C.R., Welch D.R., Donahue H.J. Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication. Cancer Res. 2001, 61:1765-1767.
4. Hurst D.R., Mehta A., Moore B.P., Phadke P.A., Meehan W.J., Accavitti M.A., Shevde L.A., Hopper J.E., Xie Y., Welch D.R., Samant R.S. Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. Biochem. Biophys. Res. Commun. 2006, 348:1429-1435.
5. Samant R.S., Clark D.W., Fillmore R.A., Cicek M., Metge B.J., Chandramouli K.H., Chambers A.F., Casey G., Welch D.R., Shevde L.A. Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation. Mol. Cancer 2007, 6:6.
6. Cicek M., Fukuyama R., Cicek M.S., Sizemore S., Welch D.R., Sizemore N., Casey G. BRMS1 contributes to the negative regulation of uPA gene expression through recruitment of HDAC1 to the NF-kappaB binding site of the uPA promoter. Clin. Exp. Metastasis 2009, 26:229-237.
7. Edmonds M.D., Hurst D.R., Vaidya K.S., Stafford L.J., Chen D., Welch D.R. Breast cancer metastasis suppressor 1 coordinately regulates metastasis-associated microRNA expression. Int. J. Cancer 2009, 125:1778-1785.
8. Hurst D.R., Edmonds M.D., Scott G.K., Benz C.C., Vaidya K.S., Welch D.R. Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis. Cancer Res. 2009, 69:1279-1283.
9. Hershko A., Ciechanover A. The ubiquitin system. Annu. Rev. Biochem. 1998, 67:425-479.
10. Glickman M.H., Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 2002, 82:373-428.
11. Ardley H.C., Robinson P.A. E3 ubiquitin ligases. Essays Biochem. 2005, 41:15-30.
12. Petroski M.D., Deshaies R.J. Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 2005, 6:9-20.
13. Jackson P.K., Eldridge A.G. The SCF ubiquitin ligase: an extended look. Mol. Cell 2002, 9:923-925.
14. Bosu D.R., Kipreos E.T. Cullin-RING ubiquitin ligases: global regulation and activation cycles. Cell Div. 2008, 3:7.
15. Cardozo T., Pagano M. The SCF ubiquitin ligase: insights into a molecular machine. Nat. Rev. Mol. Cell Biol. 2004, 5:739-751.
16. Deshaies R.J., Joazeiro C.A. RING domain E3 ubiquitin ligases. Annu. Rev. Biochem. 2009, 78:399-434.
17. Stogios P.J., Downs G.S., Jauhal J.J., Nandra S.K., Prive G.G. Sequence and structural analysis of BTB domain proteins. Genome Biol. 2005, 6:R82.
18. Hernandez-Munoz I., Lund A.H., van der Stoop P., Boutsma E., Muijrers I., Verhoeven E., Nusinow D.A., Panning B., Marahrens Y., van Lohuizen M. Stable X chromosome inactivation involves the PRC1 polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. Proc. Natl. Acad. Sci. USA 2005, 102:7635-7640.
19. Kwon J.E., La M., Oh K.H., Oh Y.M., Kim G.R., Seol J.H., Baek S.H., Chiba T., Tanaka K., Bang O.S., Joe C.O., Chung C.H. BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. J. Biol. Chem. 2006, 281:12664-12672.
20. Zhang Q., Zhang L., Wang B., Ou C.Y., Chien C.T., Jiang J. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev. Cell 2006, 10:719-729.
21. Zhang Q., Shi Q., Chen Y., Yue T., Li S., Wang B., Jiang J. Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. Proc. Natl. Acad. Sci. USA 2009, 106:21191-21196.
22. Liu J., Ghanim M., Xue L., Brown C.D., Iossifov I., Angeletti C., Hua S., Negre N., Ludwig M., Stricker T., Al-Ahmadie H.A., Tretiakova M., Camp R.L., Perera-Alberto M., Rimm D.L., Xu T., Rzhetsky A., White K.P. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Science 2009, 323:1218-1222.
23. Pintard L., Willems A., Peter M. Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J. 2004, 23:1681-1687.
24. Pintard L., Willis J.H., Willems A., Johnson J.L., Srayko M., Kurz T., Glaser S., Mains P.E., Tyers M., Bowerman B., Peter M. The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Nature 2003, 425:311-316.
25. Xu L., Wei Y., Reboul J., Vaglio P., Shin T.H., Vidal M., Elledge S.J., Harper J.W. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature 2003, 425:316-321.
26. Furukawa M., He Y.J., Borchers C., Xiong Y. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Nat. Cell Biol. 2003, 5:1001-1007.
27. Geyer R., Wee S., Anderson S., Yates J., Wolf D.A. BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Mol. Cell 2003, 12:783-790.
28. Lecuyer C., Dacheux J.L., Hermand E., Mazeman E., Rousseaux J., Rousseaux-Prevost R. Actin-binding properties and colocalization with actin during spermiogenesis of mammalian sperm calicin. Biol. Reprod. 2000, 63:1801-1810.
29. Wang X.J., Zhang D.D. Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. PLoS ONE 2009, 4:e5492.
30. Bayon Y., Trinidad A.G., de la Puerta M.L., Del Carmen Rodriguez M., Bogetz J., Rojas A., De Pereda J.M., Rahmouni S., Williams S., Matsuzawa S., Reed J.C., Crespo M.S., Mustelin T., Alonso A. KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases. FEBS J. 2008, 275:3900-3910.
31. Zhuang M., Calabrese M.F., Liu J., Waddell M.B., Nourse A., Hammel M., Miller D.J., Walden H., Duda D.M., Seyedin S.N., Hoggard T., Harper J.W., White K.P., Schulman B.A. Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol. Cell 2009, 36:39-50.
32. Vaidya K.S., Harihar S., Phadke P.A., Stafford L.J., Hurst D.R., Hicks D.G., Casey G., DeWald D.B., Welch D.R. Breast cancer metastasis suppressor-1 differentially modulates growth factor signaling. J. Biol. Chem. 2008, 283:28354-28360.
33. Steeg P.S., Bevilacqua G., Kopper L., Thorgeirsson U.P., Talmadge J.E., Liotta L.A., Sobel M.E. Evidence for a novel gene associated with low tumor metastatic potential. J. Natl Cancer Inst. 1988, 80:200-204.
34. Stafford L.J., Vaidya K.S., Welch D.R. Metastasis suppressors genes in cancer. Int. J. Biochem. Cell Biol. 2008, 40:874-891.
35. Smith S.C., Theodorescu D. Learning therapeutic lessons from metastasis suppressor proteins. Nat. Rev. Cancer 2009, 9:253-264.
36. Tavazoie S.F., Alarcon C., Oskarsson T., Padua D., Wang Q., Bos P.D., Gerald W.L., Massague J. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008, 451:147-152.
37. Tsai Y.C., Mendoza A., Mariano J.M., Zhou M., Kostova Z., Chen B., Veenstra T., Hewitt S.M., Helman L.J., Khanna C., Weissman A.M. The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation. Nat. Med. 2007, 13:1504-1509.
38. Hoeller D., Dikic I. Targeting the ubiquitin system in cancer therapy. Nature 2009, 458:438-444.
39. Cohen P., Tcherpakov M. Will the ubiquitin system furnish as many drug targets as protein kinases?. Cell 2010, 143:686-693.