Simple and efficient HPLC-UV quantitation of etoposide and its cis-isomer in rat micro-volume plasma and tissue samples: Application to pharmacokinetic and biodistribution studies

Journal of Liquid Chromatography and Related Technologies

Volumn 34, Issue 18, 2011, Pages 2130-2148

  Saadati, Roonak ^a   Dadashzadeh, Simin ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Etoposide; HPLC UV; Monolithic column; Pharmacokinetics; Rat plasma; Tissue distribution

Indexed keywords

ETOPOSIDE; HPLC-UV; MONOLITHIC COLUMNS; RAT PLASMA; TISSUE DISTRIBUTION;

ACETONITRILE; HEXANE; ISOMERS; LIQUIDS; METHANOL; ORGANIC SOLVENTS; PHARMACOKINETICS; RATS; SAMPLING; SIGNAL TO NOISE RATIO; SOLVENT EXTRACTION; TISSUE;

PLASMA STABILITY;

ACETONITRILE; CHLOROFORM; ETOPOSIDE; HEXANE; LAMOTRIGINE; METHANOL; PHOSPHATE; TRIETHYLAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STABILITY; DRUG TISSUE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERISM; LIQUID LIQUID EXTRACTION; MALE; MEAN RESIDENCE TIME; NONHUMAN; PH; RAT; ROOM TEMPERATURE; TISSUE DISTRIBUTION; TISSUE HOMOGENATE; ULTRAVIOLET SPECTROSCOPY; VALIDATION STUDY;

RATTUS;

EID: 84855871863     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2011.585483     Document Type: Article

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