Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients

Journal of Neuroinflammation

Volumn 9, Issue , 2012, Pages

  Jarius, Sven ^a   Ruprecht, Klemens ^b   Wildemann, Brigitte ^a   Kuempfel, Tania ^c   Ringelstein, Marius ^d   Geis, Christian ^e   Kleiter, Ingo ^f,g   Kleinschnitz, Christoph ^e   Berthele, Achim ^h   Brettschneider, Johannes ⁱ   Hellwig, Kerstin ^g   Hemmer, Bernhard ^h   Linker, Ralf A ^g,j   Lauda, Florian ⁱ   Mayer, Christoph A ^k   Tumani, Hayrettin ⁱ   Melms, Arthur ^l   Trebst, Corinna ^m   Stangel, Martin ^m   Marziniak, Martin ⁿ   Hoffmann, Frank ^o   Schippling, Sven ^p   Faiss, Jürgen H ^q   Neuhaus, Oliver ^r   Ettrich, Barbara ^s   Zentner, Christian ^o   Guthke, Kersten ^t   Hofstadt van Oy, Ulrich ^u   Reuss, Reinhard ^u   Pellkofer, Hannah ^c   Ziemann, Ulf ^k   Kern, Peter ^q   Wandinger, Klaus P ^p,v   Bergh, Florian T ^s   Boettcher, Tobias ^w   Langel, Stefan ^x   Liebetrau, Martin ^y   Rommer, Paulus S ^z   Niehaus, Sabine ^aa   Münch, Christoph ^b   Winkelmann, Alexander ^z   Zettl, U Uwe K ^z   Metz, Imke ^ab   Veauthier, Christian ^ac   Sieb, Jörn P ^ac   Wilke, Christian ^ad   Hartung, Hans P ^d   Aktas, Orhan ^d   Paul, Friedemann ^b   more..

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f UNIVERSITY OF REGENSBURG   (Germany)

^g ST JOSEF HOSPITAL   (Germany)

^h TECHNICAL UNIVERSITY OF MUNICH   (Germany)

ⁱ UNIVERSITY OF ULM   (Germany)

^j UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^k GOETHE UNIVERSITY   (Germany)

^l UNIVERSITY OF TÜBINGEN   (Germany)

^m HANNOVER MEDICAL SCHOOL   (Germany)

ⁿ UNIVERSITY OF MÜNSTER   (Germany)

^o Martha Maria Hospital Halle/Saale   (Germany)

^p UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^q Department of Neurology   (Germany)

^r Kliniken Landkreis Sigmaringen GmbH   (Germany)

^s UNIVERSITY OF LEIPZIG   (Germany)

^t Stadtisches Klinikum Gorlitz gGmbH   (Germany)

^u INSTITUTE OF PATHOLOGY   (Germany)

^v Institute of Experimental Immunology   (Germany)

^w Dietrich Bonhoeffer Klinikum   (Germany)

^x Rheinhessen Fachklinik Alzey   (Germany)

^y DR HORST SCHMIDT KLINIKEN   (Germany)

^z UNIVERSITY OF ROSTOCK   (Germany)

^aa KLINIKUM DORTMUND   (Germany)

^ab UNIVERSITY OF GÖTTINGEN   (Germany)

^ac Hanse Klinikum Stralsund   (Germany)

^ad Childrens Hospital   (Germany)

more..

Author keywords

Aquaporin 4 (aqp4) antibody; Cerebrospinal fluid; Clinical features; Devic disease; Devic syndrome; Epidemiology; Longitudinally extensive transverse myelitis; Magnetic resonance imaging; Neuromyelitis optica; Nmo igg; Recurrent optic neuritis

Indexed keywords

AQUAPORIN 4 ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; ANTIBODY; AQP4 PROTEIN, HUMAN; AQUAPORIN 4; METHYLPREDNISOLONE; OLIGOCLONAL BAND;

AGED; ARTICLE; AUTOIMMUNITY; BRAIN DAMAGE; CARCINOMA; CAUCASIAN; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MORTALITY; MYELOOPTIC NEUROPATHY; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIC NEURITIS; OUTCOME ASSESSMENT; PLEOCYTOSIS; PREDICTIVE VALUE; QUADRIPLEGIA; RELAPSE; RETROSPECTIVE STUDY; SCHOOL CHILD; SERODIAGNOSIS; SPINAL CORD LESION; TIME OF DEATH; VISUAL ACUITY; ADOLESCENT; ADULT; BLOOD; BRAIN STEM; CEREBROSPINAL FLUID; CLINICAL TRIAL; COHORT ANALYSIS; DISABILITY; IMMUNOLOGY; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; RECURRENT DISEASE; STATISTICS; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; AQUAPORIN 4; BRAIN STEM; COHORT STUDIES; DISABILITY EVALUATION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; METHYLPREDNISOLONE; MIDDLE AGED; NEUROMYELITIS OPTICA; OLIGOCLONAL BANDS; RECURRENCE; RETROSPECTIVE STUDIES; STATISTICS AS TOPIC; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84855864768     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-14     Document Type: Article

References (80)

1. Wingerchuk DM, Hogancamp WF, O'Brien PC, Weinshenker BG. The clinical course of neuromyelitis optica (Devic's syndrome). Neurology 1999, 53:1107-1114.
2. Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K, Nakashima I, Weinshenker BG. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004, 364:2106-2112. 10.1016/S0140-6736(04)17551-X, 15589308.
3. Jarius S, Franciotta D, Bergamaschi R, Wright H, Littleton E, Palace J, Hohlfeld R, Vincent A. NMO-IgG in the diagnosis of neuromyelitis optica. Neurology 2007, 68:1076-1077. 10.1212/01.wnl.0000256822.01222.bd, 17287449.
4. Waters P, Jarius S, Littleton E, Leite MI, Jacob S, Gray B, Geraldes R, Vale T, Jacob A, Palace J, Maxwell S, Beeson D, Vincent A. Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis. Arch Neurol 2008, 65:913-919. 10.1001/archneur.65.7.913, 18625857.
5. Takahashi T, Fujihara K, Nakashima I, Misu T, Miyazawa I, Nakamura M, Watanabe S, Shiga Y, Kanaoka C, Fujimori J, Sato S, Itoyama Y. Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain 2007, 130:1235-1243. 10.1093/brain/awm062, 17449477.
6. Kalluri SR, Illes Z, Srivastava R, Cree B, Menge T, Bennett JL, Berthele A, Hemmer B. Quantification and functional characterization of antibodies to native aquaporin 4 in neuromyelitis optica. Arch Neurol 2010, 67:1201-1208. 10.1001/archneurol.2010.269, 20937947.
7. Paul F, Jarius S, Aktas O, Bluthner M, Bauer O, Appelhans H, Franciotta D, Bergamaschi R, Littleton E, Palace J, Seelig HP, Hohlfeld R, Vincent A, Zipp F. Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica. PLoS Med 2007, 4:e133. 10.1371/journal.pmed.0040133, 1852124, 17439296.
8. Jarius S, Aboul-Enein F, Waters P, Kuenz B, Hauser A, Berger T, Lang W, Reindl M, Vincent A, Kristoferitsch W. Antibody to aquaporin-4 in the long-term course of neuromyelitis optica. Brain 2008, 131:3072-3080. 10.1093/brain/awn240, 2577801, 18945724.
9. Kinoshita M, Nakatsuji Y, Kimura T, Moriya M, Takata K, Okuno T, Kumanogoh A, Kajiyama K, Yoshikawa H, Sakoda S. Neuromyelitis optica: Passive transfer to rats by human immunoglobulin. Biochem Biophys Res Commun 2009, 386:623-627. 10.1016/j.bbrc.2009.06.085, 19545538.
10. Bradl M, Misu T, Takahashi T, Watanabe M, Mader S, Reindl M, Adzemovic M, Bauer J, Berger T, Fujihara K, Itoyama Y, Lassmann H. Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo. Ann Neurol 2009, 66:630-643. 10.1002/ana.21837, 19937948.
11. Jarius S, Paul F, Franciotta D, Waters P, Zipp F, Hohlfeld R, Vincent A, Wildemann B. Mechanisms of Disease: aquaporin-4 antibodies in neuromyelitis optica. Nat Clin Pract Neurol 2008, 4:202-214.
12. Jarius S, Wildemann B. AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance. Nat Rev Neurol 2010, 6:383-392. 10.1038/nrneurol.2010.72, 20639914.
13. Bennett JL, Lam C, Kalluri SR, Saikali P, Bautista K, Dupree C, Glogowska M, Case D, Antel JP, Owens GP, Gilden D, Nessler S, Stadelmann C, Hemmer B. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol 2009, 66:617-629. 10.1002/ana.21802, 3180961, 19938104.
14. Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain 2010, 133:349-361. 10.1093/brain/awp309, 2822632, 20047900.
15. Marignier R, Nicolle A, Watrin C, Touret M, Cavagna S, Varrin-Doyer M, Cavillon G, Rogemond V, Confavreux C, Honnorat J, Giraudon P. Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury. Brain 2010, 133:2578-2591. 10.1093/brain/awq177, 20688809.
16. Sabater L, Giralt A, Boronat A, Hankiewicz K, Blanco Y, Llufriu S, Alberch J, Graus F, Saiz A. Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study. J Neuroimmunol 2009, 215:31-35. 10.1016/j.jneuroim.2009.07.014, 19695715.
17. Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurol 2007, 6:805-815. 10.1016/S1474-4422(07)70216-8, 17706564.
18. Weinshenker BG, Wingerchuk DM, Vukusic S, Linbo L, Pittock SJ, Lucchinetti CF, Lennon VA. Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis. Ann Neurol 2006, 59:566-569. 10.1002/ana.20770, 16453327.
19. Matiello M, Lennon VA, Jacob A, Pittock SJ, Lucchinetti CF, Wingerchuk DM, Weinshenker BG. NMO-IgG predicts the outcome of recurrent optic neuritis. Neurology 2008, 70:2197-2200. 10.1212/01.wnl.0000303817.82134.da, 18434643.
20. Jarius S, Frederikson J, Waters P, Paul F, Akman-Demir G, Marignier R, Franciotta D, Ruprecht K, Kuenz B, Rommer P, Kristoferitsch W, Wildemann B, Vincent A. Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis. J Neurol Sci 2010, 298:158-162. 10.1016/j.jns.2010.07.011, 20850793.
21. Petzold A, Pittock S, Lennon V, Maggiore C, Weinshenker BG, Plant GT. Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritis. J Neurol Neurosurg Psychiatry 2010, 81:109-111. 10.1136/jnnp.2008.146894, 20019228.
22. Baba T, Nakashima I, Kanbayashi T, Konno M, Takahashi T, Fujihara K, Misu T, Takeda A, Shiga Y, Ogawa H, Itoyama Y. Narcolepsy as an initial manifestation of neuromyelitis optica with anti-aquaporin-4 antibody. J Neurol 2009, 256:287-288. 10.1007/s00415-009-0139-4, 19266146.
23. Popescu BF, Lennon VA, Parisi JE, Howe CL, Weigand SD, Cabrera-Gomez JA, Newell K, Mandler RN, Pittock SJ, Weinshenker BG, Lucchinetti CF. Neuromyelitis optica unique area postrema lesions: Nausea, vomiting, and pathogenic implications. Neurology 2011, 76:1229-1237. 10.1212/WNL.0b013e318214332c, 21368286.
24. Akman-Demir G, Tuzun E, Waters P, Icoz S, Kurtuncu M, Jarius S, Yapici Z, Mutlu M, Yesilot N, Vincent A, Eraksoy M. Prognostic implications of aquaporin-4 antibody status in neuromyelitis optica patients. J Neurol 2011, 258:464-470. 10.1007/s00415-010-5780-4, 20953960.
25. Nakashima I, Fujihara K, Miyazawa I, Misu T, Narikawa K, Nakamura M, Watanabe S, Takahashi T, Nishiyama S, Shiga Y, Sato S, Weinshenker BG, Itoyama Y. Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMO-IgG. J Neurol Neurosurg Psychiatry 2006, 77:1073-1075. 10.1136/jnnp.2005.080390, 2077753, 16505005.
26. Ghezzi A, Bergamaschi R, Martinelli V, Trojano M, Tola MR, Merelli E, Mancardi L, Gallo P, Filippi M, Zaffaroni M, Comi G. Clinical characteristics, course and prognosis of relapsing Devic's Neuromyelitis Optica. J Neurol 2004, 251:47-52. 10.1007/s00415-004-0271-0, 14999489.
27. Collongues N, Marignier R, Zephir H, Papeix C, Blanc F, Ritleng C, Tchikviladze M, Outteryck O, Vukusic S, Fleury M, Fontaine B, Brassat D, Clanet M, Milh M, Pelletier J, Audoin B, Ruet A, Lebrun-Frenay C, Thouvenot E, Camu W, Debouverie M, Creange A, Moreau T, Labauge P, Castelnovo G, Edan G, Le Page E, Defer G, Barroso B, Heinzlef O, et al. Neuromyelitis optica in France: a multicenter study of 125 patients. Neurology 2010, 74:736-742. 10.1212/WNL.0b013e3181d31e35, 20194912.
28. Asgari N, Lillevang ST, Skejoe HP, Falah M, Stenager E, Kyvik KO. A population-based study of neuromyelitis optica in Caucasians. Neurology 2011, 76:1589-1595. 10.1212/WNL.0b013e3182190f74, 21536639.
29. O'Riordan JI, Gallagher HL, Thompson AJ, Howard RS, Kingsley DP, Thompson EJ, McDonald WI, Miller DH. Clinical, CSF, and MRI findings in Devic's neuromyelitis optica. J Neurol Neurosurg Psychiatry 1996, 60:382-387. 10.1136/jnnp.60.4.382, 1073888, 8774400.
30. de Seze J, Stojkovic T, Ferriby D, Gauvrit JY, Montagne C, Mounier-Vehier F, Verier A, Pruvo JP, Hache JC, Vermersch P. Devic's neuromyelitis optica: clinical, laboratory, MRI and outcome profile. J Neurol Sci 2002, 197:57-61. 10.1016/S0022-510X(02)00043-6, 11997067.
31. Tanaka M, Tanaka K, Komori M, Saida T. Anti-aquaporin 4 antibody in Japanese multiple sclerosis: the presence of optic spinal multiple sclerosis without long spinal cord lesions and anti-aquaporin 4 antibody. J Neurol Neurosurg Psychiatry 2007, 78:990-992. 10.1136/jnnp.2006.114165, 2117855, 17702782.
32. Tanaka K, Kujuro Y, Suzuki S, Tanahashi N, Hamada J, Nogawa S, Suzuki N. Clinical and laboratory features of in-patients with multiple sclerosis in a University Hospital in Tokyo from 1988-2002. Intern Med 2005, 44:560-566. 10.2169/internalmedicine.44.560, 16020880.
33. Bichuetti DB, Oliveira EM, Souza NA, Rivero RL, Gabbai AA. Neuromyelitis optica in Brazil: a study on clinical and prognostic factors. Mult Scler 2009, 15:613-619. 10.1177/1352458508101935, 19299436.
34. Papeix C, De Seze J, Pierrot-Deseilligny C, Tourbah A, Lebrun C, Moreau T, Vermersch P, Gout O. French therapeutic experience of Devic's disease: a retrospective study of 33 cases. Neurology 2005, 64:A323.
35. Tanaka K, Tani T, Tanaka M, Saida T, Idezuka J, Yamazaki M, Tsujita M, Nakada T, Sakimura K, Nishizawa M. Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with long spinal cord lesions. Mult Scler 2007,
36. Wingerchuk DM, Lennon VA, Pittock SJ, Lucchinetti CF, Weinshenker BG. Revised diagnostic criteria for neuromyelitis optica. Neurology 2006, 66:1485-1489. 10.1212/01.wnl.0000216139.44259.74, 16717206.
37. Trebst C, Berthele A, Jarius S, Kumpfel T, Schippling S, Wildemann B, Wilke C. [Diagnosis and treatment of neuromyelitis optica: Consensus recommendations of the Neuromyelitis Optica Study Group.]. Nervenarzt 2011, 82:768-777. 10.1007/s00115-010-3192-4, 21174070.
38. Jarius S, Probst C, Borowski K, Franciotta D, Wildemann B, Stoecker W, Wandinger KP. Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen. J Neurol Sci 2010, 291:52-56. 10.1016/j.jns.2010.01.002, 20117794.
39. Reiber H, Ungefehr S, Jacobi C. The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Mult Scler 1998, 4:111-117.
40. Jarius S, Franciotta D, Bergamaschi R, Rauer S, Wandinger KP, Petereit HF, Maurer M, Tumani H, Vincent A, Eichhorn P, Wildemann B, Wick M, Voltz R. Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica. J Neurol Neurosurg Psychiatry 2008, 79:1134-1136. 10.1136/jnnp.2007.133330, 18270237.
41. Heerlein K, Jarius S, Jacobi C, Rohde S, Storch-Hagenlocher B, Wildemann B. Aquaporin-4 antibody positive longitudinally extensive transverse myelitis following varicella zoster infection. J Neurol Sci 2009, 276:184-186. 10.1016/j.jns.2008.08.015, 18805556.
42. Bates D. Treatment effects of immunomodulatory therapies at different stages of multiple sclerosis in short-term trials. Neurology 2011, 76:S14-25.
43. Confavreux C, Vukusic S. Natural history of multiple sclerosis: a unifying concept. Brain 2006, 129:606-616. 10.1093/brain/awl007, 16415308.
44. Lucchinetti CF, Bruck W, Lassmann H. Evidence for pathogenic heterogeneity in multiple sclerosis. Ann Neurol 2004, 56:308. 10.1002/ana.20182, 15293289.
45. Palace J, Leite MI, Nairne A, Vincent A. Interferon beta treatment in neuromyelitis optica: increase in relapses and aquaporin 4 antibody titers. Arch Neurol 2010, 67:1016-1017. 10.1001/archneurol.2010.188, 20697055.
46. Shimizu Y, Yokoyama K, Misu T, Takahashi T, Fujihara K, Kikuchi S, Itoyama Y, Iwata M. Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis. J Neurol 2008, 255:305-307. 10.1007/s00415-007-0730-5, 18004636.
47. Tanaka M, Tanaka K, Komori M. Interferon-beta(1b) treatment in neuromyelitis optica. Eur Neurol 2009, 62:167-170. 10.1159/000227277, 19590215.
48. Uzawa A, Mori M, Hayakawa S, Masuda S, Kuwabara S. Different responses to interferon beta-1b treatment in patients with neuromyelitis optica and multiple sclerosis. Eur J Neurol 2010, 17:672-676. 10.1111/j.1468-1331.2009.02897.x, 20039942.
49. Warabi Y, Matsumoto Y, Hayashi H. Interferon beta-1b exacerbates multiple sclerosis with severe optic nerve and spinal cord demyelination. J Neurol Sci 2007, 252:57-61. 10.1016/j.jns.2006.10.008, 17125797.
50. Shimizu J, Hatanaka Y, Hasegawa M, Iwata A, Sugimoto I, Date H, Goto J, Shimizu T, Takatsu M, Sakurai Y, Nakase H, Uesaka Y, Hashida H, Hashimoto K, Komiya T, Tsuji S. IFNbeta-1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum. Neurology 2010, 75:1423-1427. 10.1212/WNL.0b013e3181f8832e, 20826711.
51. Pittock SJ, Lennon VA, Krecke K, Wingerchuk DM, Lucchinetti CF, Weinshenker BG. Brain abnormalities in neuromyelitis optica. Arch Neurol 2006, 63:390-396. 10.1001/archneur.63.3.390, 16533966.
52. Nakamura M, Misu T, Fujihara K, Miyazawa I, Nakashima I, Takahashi T, Watanabe S, Itoyama Y. Occurrence of acute large and edematous callosal lesions in neuromyelitis optica. Mult Scler 2009, 15:695-700. 10.1177/1352458509103301, 19435750.
53. Pittock SJ, Rodriguez M. Benign multiple sclerosis: a distinct clinical entity with therapeutic implications. Curr Top Microbiol Immunol 2008, 318:1-17. 10.1007/978-3-540-73677-6_1, 18219812.
54. Bergamaschi R, Jarius S, Robotti M, Pichiecchio A, Wildemann B, Meola G. Two cases of benign neuromyelitis optica in patients with celiac disease. J Neurol 2009, 256:2097-2099. 10.1007/s00415-009-5288-y, 21473007.
55. Koller H, Neuen-Jacob E, Saleh A, Kieseier BC, Jander S, Hartung HP. A patient with a benign course of neuromyelitis optica (Devic's syndrome) over 12 years: MRI follow up and histological findings. J Neurol 2006, 253:819-820. 10.1007/s00415-006-0116-0, 16511648.
56. Collongues N, Cabre P, Marignier R, Zephir H, Papeix C, Audoin B, Lebrun-Frenay C, Pelletier J, Fontaine B, Vermersch P, Confavreux C, de Seze J. A benign form of neuromyelitis optica: does it exist?. Arch Neurol 2011, 68:918-924. 10.1001/archneurol.2011.127, 21747032.
57. Takahashi T, Miyazawa I, Misu T, Takano R, Nakashima I, Fujihara K, Tobita M, Itoyama Y. Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations. J Neurol Neurosurg Psychiatry 2008, 79:1075-1078. 10.1136/jnnp.2008.145391, 18420727.
58. Misu T, Fujihara K, Nakashima I, Sato S, Itoyama Y. Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica. Neurology 2005, 65:1479-1482. 10.1212/01.wnl.0000183151.19351.82, 16275842.
59. Pittock SJ, Weinshenker BG, Lucchinetti CF, Wingerchuk DM, Corboy JR, Lennon VA. Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression. Arch Neurol 2006, 63:964-968. 10.1001/archneur.63.7.964, 16831965.
60. Weinshenker BG, Bass B, Rice GP, Noseworthy J, Carriere W, Baskerville J, Ebers GC. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 1989, 112(Pt 1):133-146.
61. Mader S, Lutterotti A, Di Pauli F, Kuenz B, Schanda K, Aboul-Enein F, Khalil M, Storch MK, Jarius S, Kristoferitsch W, Berger T, Reindl M. Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica. PLoS One 2010, 5:e10455. 10.1371/journal.pone.0010455, 2864757, 20463974.
62. Jarius S, Franciotta D, Paul F, Ruprecht K, Bergamaschi R, Rommer PS, Reuss R, Probst C, Kristoferitsch W, Wandinger KP, Wildemann B. Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance. J Neuroinflammation 2010, 7:52. 10.1186/1742-2094-7-52, 2945323, 20825655.
63. Jarius S, Eichhorn P, Jacobi C, Wildemann B, Wick M, Voltz R. The intrathecal, polyspecific antiviral immune response: Specific for MS or a general marker of CNS autoimmunity?. J Neurol Sci 2009, 280:98-100. 10.1016/j.jns.2008.08.002, 19041103.
64. Jarius S, Paul F, Franciotta D, Ruprecht K, Ringelstein M, Bergamaschi R, Rommer P, Kleiter I, Stich O, Reuss R, Rauer S, Zettl UK, Wandinger KP, Melms A, Aktas O, Kristoferitsch W, Wildemann B. Cerebrospinal fluid findings in aquaporin-4 antibody positive neuromyelitis optica: Results from 211 lumbar punctures. J Neurol Sci 2011, 306:82-90. 10.1016/j.jns.2011.03.038, 21550068.
65. Reiber H, Teut M, Pohl D, Rostasy KM, Hanefeld F. Paediatric and adult multiple sclerosis: age-related differences and time course of the neuroimmunological response in cerebrospinal fluid. Mult Scler 2009, 15:1466-1480. 10.1177/1352458509348418, 19995844.
66. Andersson M, Alvarez-Cermeno J, Bernardi G, Cogato I, Fredman P, Frederiksen J, Fredrikson S, Gallo P, Grimaldi LM, Gronning M, et al. Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report. J Neurol Neurosurg Psychiatry 1994, 57:897-902. 10.1136/jnnp.57.8.897, 1073070, 8057110.
67. Brettschneider J, Tumani H, Kiechle U, Muche R, Richards G, Lehmensiek V, Ludolph AC, Otto M. IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome. PLoS One 2009, 4:e7638. 10.1371/journal.pone.0007638, 2766627, 19890384.
68. Sellner J, Hemmer B, Muhlau M. The clinical spectrum and immunobiology of parainfectious neuromyelitis optica (Devic) syndromes. J Autoimmun 2010, 34:371-379. 10.1016/j.jaut.2009.09.013, 19853412.
69. Wandinger KP, Stangel M, Witte T, Venables P, Charles P, Jarius S, Wildemann B, Probst C, Iking-Konert C, Schneider M. Autoantibodies against aquaporin-4 in patients with neuropsychiatric systemic lupus erythematosus and primary Sjogren's syndrome. Arthritis Rheum 2010, 62:1198-1200. 10.1002/art.27337, 20131265.
70. Pittock SJ, Lennon VA, de Seze J, Vermersch P, Homburger HA, Wingerchuk DM, Lucchinetti CF, Zephir H, Moder K, Weinshenker BG. Neuromyelitis optica and non organ-specific autoimmunity. Arch Neurol 2008, 65:78-83. 10.1001/archneurol.2007.17, 18195142.
71. Jarius S, Jacob S, Waters P, Jacob A, Littleton E, Vincent A. Neuromyelitis optica in patients with gluten sensitivity associated with antibodies to aquaporin-4. J Neurol Neurosurg Psychiatry 2008, 79:1084. 10.1136/jnnp.2007.143263, 18708571.
72. Uzawa A, Mori M, Iwai Y, Kobayashi M, Hayakawa S, Kawaguchi N, Kuwabara S. Association of anti-aquaporin-4 antibody-positive neuromyelitis optica with myasthenia gravis. J Neurol Sci 2009, 287:105-107. 10.1016/j.jns.2009.08.040, 19729173.
73. Kay CS, Scola RH, Lorenzoni PJ, Jarius S, Arruda WO, Werneck LC. NMO-IgG positive neuromyelitis optica in a patient with myasthenia gravis but no thymectomy. J Neurol Sci 2008, 275:148-150. 10.1016/j.jns.2008.06.038, 18703206.
74. Jarius S, Paul F, Franciotta D, de Seze J, Munch C, Salvetti M, Ruprecht K, Liebetrau M, Wandinger K, Akman-Demir G, Melms A, Kristoferitsch W, Wildemann B. Neuromyelitis optica spectrum disorders in patients with myasthenia gravis: ten new aquaporin-4 antibody positive cases and a review of the literature. Mult Scler 2011,
75. Jarius S, Jacobi C, de Seze J, Zephir H, Paul F, Franciotta D, Rommer P, Mader S, Kleiter I, Reindl M, Akman-Demir G, Seifert-Held T, Kristoferitsch W, Melms A, Wandinger KP, Wildemann B. Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders. Mult Scler 2011, 17:1067-1073. 10.1177/1352458511403958, 21543553.
76. De Keyser J. Autoimmunity in multiple sclerosis. Neurology 1988, 38:371-374.
77. Berglund L, Bjorling E, Oksvold P, Fagerberg L, Asplund A, Szigyarto CA, Persson A, Ottosson J, Wernerus H, Nilsson P, Lundberg E, Sivertsson A, Navani S, Wester K, Kampf C, Hober S, Ponten F, Uhlen M. A genecentric human protein atlas for expression profiles based on antibodies. Mol Cell Proteomics 2008, 7:2019-2027. 10.1074/mcp.R800013-MCP200, 18669619.
78. Pittock SJ, Lennon VA. Aquaporin-4 autoantibodies in a paraneoplastic context. Arch Neurol 2008, 65:629-632. 10.1001/archneur.65.5.629, 18474738.
79. Chan KH, Kwan JS, Ho PW, Ho JW, Chu AC, Ramsden DB. Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays. J Neuroinflammation 2010, 7:50. 10.1186/1742-2094-7-50, 2941752, 20822515.
80. Pellkofer HL, Krumbholz M, Berthele A, Hemmer B, Gerdes LA, Havla J, Bittner R, Canis M, Meinl E, Hohlfeld R, Kuempfel T. Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab. Neurology 2011, 76:1310-1315. 10.1212/WNL.0b013e3182152881, 21482945.