Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen

Journal of the Neurological Sciences

Volumn 291, Issue 1-2, 2010, Pages 52-56

  Jarius, S ^a   Probst, C ^b   Borowski, K ^b   Franciotta, D ^c   Wildemann, B ^a   Stoecker, W ^b   Wandinger, K P ^b,d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Institute of Experimental Immunology   (Germany)

^c UNIVERSITY OF PAVIA   (Italy)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Antibody to aquaporin 4; Diagnosis; Immunofluorescence assay; Longitudinally extensive transverse myelitis; Multiple sclerosis; Neuromyelitis optica (Devic syndrome); NMO IgG; Optic neuritis; Recombinant antigen

Indexed keywords

ANTIBODY; AQUAPORIN 4; AQUAPORIN 4 ANTIBODY; IMMUNOGLOBULIN G; RECOMBINANT ANTIGEN; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; MYELOOPTIC NEUROPATHY; OPTIC NEURITIS; PRIORITY JOURNAL; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; AGED; ANIMALS; AQUAPORIN 4; AUTOANTIBODIES; CELL LINE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MIDDLE AGED; MYELITIS, TRANSVERSE; NEUROMYELITIS OPTICA; OPTIC NEURITIS; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 77649180422     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2010.01.002     Document Type: Article

References (22)

1. Wingerchuk D.M., Hogancamp W.F., O'Brien P.C., and Weinshenker B.G. The clinical course of neuromyelitis optica (Devic's syndrome). Neurology 53 (1999) 1107-1114
2. Wingerchuk D.M., Lennon V.A., Pittock S.J., Lucchinetti C.F., and Weinshenker B.G. Revised diagnostic criteria for neuromyelitis optica. Neurology 66 (2006) 1485-1489
3. Lennon V.A., Wingerchuk D.M., Kryzer T.J., Pittock S.J., Lucchinetti C.F., Fujihara K., et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 364 (2004) 2106-2112
4. Jarius S., Franciotta D., Bergamaschi R., Wright H., Littleton E., Palace J., et al. NMO-IgG in the diagnosis of neuromyelitis optica. Neurology 68 (2007) 1076-1077
5. Matiello M., Lennon V.A., Jacob A., Pittock S.J., Lucchinetti C.F., Wingerchuk D.M., et al. NMO-IgG predicts the outcome of recurrent optic neuritis. Neurology 70 (2008) 2197-2200
6. Weinshenker B.G., Wingerchuk D.M., Vukusic S., Linbo L., Pittock S.J., Lucchinetti C.F., et al. Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis. Ann Neurol 59 (2006) 566-569
7. Lennon V.A., Kryzer T.J., Pittock S.J., Verkman A.S., and Hinson S.R. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 202 (2005) 473-477
8. Waters P., Jarius S., Littleton E., Leite M.I., Jacob S., Gray B., et al. Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis. Arch Neurol 65 (2008) 913-919
9. Takahashi T., Fujihara K., Nakashima I., Misu T., Miyazawa I., Nakamura M., et al. Establishment of a new sensitive assay for anti-human aquaporin-4 antibody in neuromyelitis optica. Tohoku J Exp Med 210 (2006) 307-313
10. Paul F., Jarius S., Aktas O., Bluthner M., Bauer O., Appelhans H., et al. Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica. PLoS Med 4 (2007) e133
11. Takahashi T., Fujihara K., Nakashima I., Misu T., Miyazawa I., Nakamura M., et al. Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain 130 (2007) 1235-1243
12. Hayakawa S., Mori M., Okuta A., Kamegawa A., Fujiyoshi Y., Yoshiyama Y., et al. Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay. J Neuroimmunol 196 (2008) 181-187
13. Matsushita T., Isobe N., Matsuoka T., Shi N., Kawano Y., Wu X., et al. Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese. Mult Scler 15 (2009) 834-847
14. Wingerchuk D.M., Lennon V.A., Lucchinetti C.F., Pittock S.J., and Weinshenker B.G. The spectrum of neuromyelitis optica. Lancet Neurol 6 (2007) 805-815
15. McDonald W.I., Compston A., Edan G., Goodkin D., Hartung H.P., Lublin F.D., et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 50 (2001) 121-127
16. Amiry-Moghaddam M., Frydenlund D.S., and Ottersen O.P. Anchoring of aquaporin-4 in brain: molecular mechanisms and implications for the physiology and pathophysiology of water transport. Neuroscience 129 (2004) 999-1010
17. Tani T., Sakimura K., Tsujita M., Nakada T., Tanaka M., Nishizawa M., et al. Identification of binding sites for anti-aquaporin 4 antibodies in patients with neuromyelitis optica. J Neuroimmunol 211 (2009) 110-113
18. Hinson S.R., Pittock S.J., Lucchinetti C.F., Roemer S.F., Fryer J.P., Kryzer T.J., et al. Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica. Neurology 69 (2007) 2221-2231
19. Jarius S., Aboul-Enein F., Waters P., Kuenz B., Hauser A., Berger T., et al. Antibody to aquaporin-4 in the long-term course of neuromyelitis optica. Brain 131 (2008) 3072-3080
20. Marnetto F., Hellias B., Granieri L., Frau J., Patanella A.K., Nytrova P., et al. Western blot analysis for the detection of serum antibodies recognizing linear aquaporin-4 epitopes in patients with Neuromyelitis Optica. J Neuroimmunol 217 (2009) 74-79
21. Cree B.A., Lamb S., Morgan K., Chen A., Waubant E., and Genain C. An open label study of the effects of rituximab in neuromyelitis optica. Neurology 64 (2005) 1270-1272
22. Jacob A., Weinshenker B.G., Violich I., McLinskey N., Krupp L., Fox R.J., et al. Treatment of neuromyelitis optica with rituximab: retrospective analysis of 25 patients. Arch Neurol 65 (2008) 1443-1448