Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: Frequency, origin, and diagnostic relevance

Journal of Neuroinflammation

Volumn 7, Issue , 2010, Pages

  Jarius, Sven ^a   Franciotta, Diego ^b   Paul, Friedemann ^c   Ruprecht, Klemens ^c   Bergamaschi, Roberto ^b   Rommer, Paulus S ^d   Reuss, Reinhard ^e   Probst, Christian ^f   Kristoferitsch, Wolfgang ^g   Wandinger, Klaus P ^f,h   Wildemann, Brigitte ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF PAVIA   (Italy)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e Hospital Hohe Warte   (Germany)

^f Institute of Experimental Immunology   (Germany)

^g DANUBE HOSPITAL   (Austria)

^h UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 4; IMMUNOGLOBULIN G; PROTEIN ANTIBODY; RECOMBINANT PROTEIN; AUTOANTIBODY;

ADOLESCENT; ADULT; AGED; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; BLOOD SAMPLING; CELL ASSAY; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE DURATION; FEMALE; HUMAN; IMMUNOGLOBULIN PRODUCTION; MAJOR CLINICAL STUDY; MALE; MYELOOPTIC NEUROPATHY; PREDICTION; RELAPSE; CEREBROSPINAL FLUID; IMMUNOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; AGED; AQUAPORIN 4; AUTOANTIBODIES; FEMALE; HUMANS; MIDDLE AGED; NEUROMYELITIS OPTICA; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC;

EID: 77956469610     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-7-52     Document Type: Article

References (40)

1. Wingerchuk DM, Hogancamp WF, O'Brien PC, Weinshenker BG. The clinical course of neuromyelitis optica (Devic's syndrome). Neurology 1999, 53:1107-1114.
2. Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K, Nakashima I, Weinshenker BG. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004, 364:2106-2112. 10.1016/S0140-6736(04)17551-X, 15589308.
3. Jarius S, Paul F, Franciotta D, Waters P, Zipp F, Hohlfeld R, Vincent A, Wildemann B. Mechanisms of Disease: aquaporin-4 antibodies in neuromyelitis optica. Nat Clin Pract Neurol 2008, 4:202-214.
4. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 2005, 202:473-477. 10.1084/jem.20050304, 2212860, 16087714.
5. Jarius S, Franciotta D, Bergamaschi R, Wright H, Littleton E, Palace J, Hohlfeld R, Vincent A. NMO-IgG in the diagnosis of neuromyelitis optica. Neurology 2007, 68:1076-1077. 10.1212/01.wnl.0000256822.01222.bd, 17287449.
6. Bradl M, Misu T, Takahashi T, Watanabe M, Mader S, Reindl M, Adzemovic M, Bauer J, Berger T, Fujihara K, et al. Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo. Ann Neurol 2009, 66:630-643. 10.1002/ana.21837, 19937948.
7. Jarius S, Wildemann B. AQP4 antibodies in neuromyelitis optica: pathogenic and diagnostic relevance. Nature Reviews Neurology 2010, 6:383-392. 10.1038/nrneurol.2010.72, 20639914.
8. Bennett JL, Lam C, Kalluri SR, Saikali P, Bautista K, Dupree C, Glogowska M, Case D, Antel JP, Owens GP, et al. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol 2009, 66:617-629. 10.1002/ana.21802, 19938104.
9. Waters P, Jarius S, Littleton E, Leite MI, Jacob S, Gray B, Geraldes R, Vale T, Jacob A, Palace J, et al. Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis. Arch Neurol 2008, 65:913-919. 10.1001/archneur.65.7.913, 18625857.
10. Paul F, Jarius S, Aktas O, Bluthner M, Bauer O, Appelhans H, Franciotta D, Bergamaschi R, Littleton E, Palace J, et al. Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica. PLoS Med 2007, 4:e133. 10.1371/journal.pmed.0040133, 1852124,1852124, 17439296.
11. Hayakawa S, Mori M, Okuta A, Kamegawa A, Fujiyoshi Y, Yoshiyama Y, Mitsuoka K, Ishibashi K, Sasaki S, Hattori T, Kuwabara S. Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay. J Neuroimmunol 2008, 196:181-187. 10.1016/j.jneuroim.2008.03.009, 18462810.
12. Klawiter EC, Alvarez E, Xu J, Paciorkowski AR, Zhu L, Parks BJ, Cross AH, Naismith RT. NMO-IgG detected in CSF in seronegative neuromyelitis optica. Neurology 2009, 72:1101-1103. 10.1212/01.wnl.0000345066.57745.50, 2677472, 19307546.
13. Takahashi T, Fujihara K, Nakashima I, Misu T, Miyazawa I, Nakamura M, Watanabe S, Shiga Y, Kanaoka C, Fujimori J, et al. Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain 2007, 130:1235-1243. 10.1093/brain/awm062, 17449477.
14. Jarius S, Probst C, Borowski K, Franciotta D, Wildemann B, Stoecker W, Wandinger KP. Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen. J Neurol Sci 2010, 291:52-56. 10.1016/j.jns.2010.01.002, 20117794.
15. Reiber H, Ungefehr S, Jacobi C. The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Mult Scler 1998, 4:111-117.
16. Reiber H. Cerebrospinal fluid--physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases. Mult Scler 1998, 4:99-107.
17. Reiber H, Lange P. Quantification of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain. Clin Chem 1991, 37:1153-1160.
18. Reiber H, Peter JB. Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs. J Neurol Sci 2001, 184:101-122. 10.1016/S0022-510X(00)00501-3, 11239944.
19. Reiber H. Flow rate of cerebrospinal fluid (CSF)--a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases. J Neurol Sci 1994, 122:189-203. 10.1016/0022-510X(94)90298-4, 8021703.
20. Jarius S, Aboul-Enein F, Waters P, Kuenz B, Hauser A, Berger T, Lang W, Reindl M, Vincent A, Kristoferitsch W. Antibody to aquaporin-4 in the long-term course of neuromyelitis optica. Brain 2008, 131:3072-3080. 10.1093/brain/awn240, 2577801, 18945724.
21. Bergamaschi R. Importance of cerebrospinal fluid examination in differential diagnosis of Devic's neuromyelitis optica by multiple sclerosis. Neurol Sci 2003, 24:95-96. 10.1007/s10072-003-0092-4, 14600818.
22. Ghezzi A, Bergamaschi R, Martinelli V, Trojano M, Tola MR, Merelli E, Mancardi L, Gallo P, Filippi M, Zaffaroni M, Comi G. Clinical characteristics, course and prognosis of relapsing Devic's Neuromyelitis Optica. J Neurol 2004, 251:47-52. 10.1007/s00415-004-0271-0, 14999489.
23. Zaffaroni M. Cerebrospinal fluid findings in Devic's neuromyelitis optica. Neurol Sci 2004, 25(Suppl 4):S368-370. 10.1007/s10072-004-0343-z, 15727236.
24. Melamud L, Madalena L, Facio ML, A PM, Garcea O, VA M. Cerebrospinal fluid findings in Devic's neuromyelitis optica. Multiple Sclerosis 2006, 12:P246.
25. O'Riordan JI, Gallagher HL, Thompson AJ, Howard RS, Kingsley DP, Thompson EJ, McDonald WI, Miller DH. Clinical, CSF, and MRI findings in Devic's neuromyelitis optica. J Neurol Neurosurg Psychiatry 1996, 60:382-387. 10.1136/jnnp.60.4.382, 1073888, 8774400.
26. Matiello M, Lennon VA, Jacob A, Pittock SJ, Lucchinetti CF, Wingerchuk DM, Weinshenker BG. NMO-IgG predicts the outcome of recurrent optic neuritis. Neurology 2008, 70:2197-2200. 10.1212/01.wnl.0000303817.82134.da, 18434643.
27. Weinshenker BG, Wingerchuk DM, Vukusic S, Linbo L, Pittock SJ, Lucchinetti CF, Lennon VA. Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis. Ann Neurol 2006, 59:566-569. 10.1002/ana.20770, 16453327.
28. Kinoshita M, Nakatsuji Y, Kimura T, Moriya M, Takata K, Okuno T, Kumanogoh A, Kajiyama K, Yoshikawa H, Sakoda S. Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells. Biochem Biophys Res Commun 2010, 394:205-210. 10.1016/j.bbrc.2010.02.157, 20188706.
29. Zhang ET, Inman CB, Weller RO. Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum. J Anat 1990, 170:111-123. 1257067, 2254158.
30. Broadwell RD, Sofroniew MV. Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system. Exp Neurol 1993, 120:245-263. 10.1006/exnr.1993.1059, 8491281.
31. Esiri MM, Gay D. Immunological and neuropathological significance of the Virchow-Robin space. J Neurol Sci 1990, 100:3-8. 10.1016/0022-510X(90)90004-7, 2089138.
32. Poduslo JF, Curran GL, Berg CT. Macromolecular permeability across the blood-nerve and blood-brain barriers. Proc Natl Acad Sci USA 1994, 91:5705-5709. 10.1073/pnas.91.12.5705, 44065, 8202551.
33. Brimijoin S, Balm M, Hammond P, Lennon VA. Selective complexing of acetylcholinesterase in brain by intravenously administered monoclonal antibody. J Neurochem 1990, 54:236-241. 10.1111/j.1471-4159.1990.tb13306.x, 2293614.
34. Saadoun S, Waters P, Bell BA, Vincent A, Verkman AS, Papadopoulos MC. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain 2010, 133:349-361. 10.1093/brain/awp309, 20047900.
35. Vincent T, Saikali P, Cayrol R, Roth AD, Bar-Or A, Prat A, Antel JP. Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment. J Immunol 2008, 181:5730-5737.
36. Hinson SR, Pittock SJ, Lucchinetti CF, Roemer SF, Fryer JP, Kryzer TJ, Lennon VA. Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica. Neurology 2007, 69:2221-2231. 10.1212/01.WNL.0000289761.64862.ce, 17928579.
37. Hinson SR, Roemer SF, Lucchinetti CF, Fryer JP, Kryzer TJ, Chamberlain JL, Howe CL, Pittock SJ, Lennon VA. Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2. J Exp Med 2008, 205:2473-2481. 10.1084/jem.20081241, 2571922, 18838545.
38. Zhou J, Kong H, Hua X, Xiao M, Ding J, Hu G. Altered blood-brain barrier integrity in adult aquaporin-4 knockout mice. Neuroreport 2008, 19:1-5. 10.1097/WNR.0b013e3282f2b4eb, 18281883.
39. Wingerchuk DM, Lennon VA, Pittock SJ, Lucchinetti CF, Weinshenker BG. Revised diagnostic criteria for neuromyelitis optica. Neurology 2006, 66:1485-1489. 10.1212/01.wnl.0000216139.44259.74, 16717206.
40. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001, 50:121-127. 10.1002/ana.1032, 11456302.