Predominance of G to A codon 12 mutation K-ras gene in Dukes' B colorectal cancer

Singapore Medical Journal

Volumn 53, Issue 1, 2012, Pages 26-31

  Zulhabri, O ^a   Rahman, J ^a   Ismail, S ^a   Isa, M R ^a   Wan Zurinah, W N ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

Author keywords

Codon 12; Colorectal cancer; Dukes' B; K ras gene; Mutation

Indexed keywords

ADENOMA; ADULT; AGED; ARTICLE; CANCER LOCALIZATION; CANCER SIZE; CANCER STAGING; CLINICAL FEATURE; CODON; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA SEQUENCE; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MUTATION RATE; ONCOGENE K RAS; POINT MUTATION; POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM;

ADENINE; ADENOMA; ADULT; AGED; AGED, 80 AND OVER; ASPARTIC ACID; CARCINOMA; CODON; COLORECTAL NEOPLASMS; EXONS; FEMALE; GENES, RAS; GLYCINE; GUANINE; HUMANS; MALE; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 84855826061     PISSN: 00375675     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Sung JJ, Lau JY, Goh KL, Leung WK. Asia Pacific Working Group on Colorectal Cancer. Increasing incidence of colorectal cancer in asia: implications for screening. Lancet Oncol 2005; 6:871-6.
2. Parkin DM, Bray FI, Devesa SS. Cancer Burdens in the Year 2000. The global picture. Eur J Cancer 2001; 37 Suppl 8: S4-66.
3. Hardy RG, Meltzer SJ, Jankowski JA. ABC of Colorectal Cancer. Molecular basis for risk factors. BMJ 2000; 321:886-9.
4. Feng LA. The many roads that lead to ras. Science 1993; 260:767-8.
5. Leslie A, Carey FA, Pratt NR, Steele RJ. The colorectal adenoma-carcinoma sequence. Br J Surg 2002; 89:845-60.
6. Bos JL. ras oncogene in human cancer: a review. Cancer Res 1989; 49:4682-9.
7. Kiaris H, Spandidos D. Mutations of ras genes in human tumors (review). Int J Oncol 1995; 7:413-21.
8. Ronai Z. ras oncogene detection in pre-neoplastic lesions: possible applications for diagnosis and prevention. Oncol Res 1992; 4:45-8.
9. Minamoto T, Ronai Z. Gene mutation as a target for early detection in cancer diagnosis. Crit Rev Oncol Hematol 2001; 40:195-213.
10. Smith G, Carey FA, Beattie J, et al. Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci USA 2002; 99: 9433-8.
11. Gervaz P, Bühler L, Scheiwiller A, Morel P. A tale of two colons and two cancers. Distinct carcinogenesis and clinical outcome according to location proximal or distal to the splenic flexure. Swiss Surg 2003; 9:3-7.
12. Tortola S, Marcuello E, Ritchi B, et al. p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer. J Clin Oncol 1999; 17:1375-81.
13. Einspahr JG, Martinez ME, Jiang R, et al. Associations of Ki-ras protooncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics. Cancer Epidemiol Biomarkers Prev 2006; 15:1443-50.
14. Samowitz WS, Holden JA, Curtin K, et al. Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer. Am J Pathol 2001; 158:1517-24.
15. Oliveira C, Westra JL, Arango D, et al. Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status. Hum Mol Genet 2004; 13:2303-11.
16. Nishikawa T, Maemura K, Hirata I, et al. A simple method of detecting K-ras point mutations in stool samples for colorectal cancer screening using onestep polymerase chain reaction/restriction fragment length polymorphism analysis. Clin Chim Acta 2002; 318:107-12.
17. Wang JY, Lian ST, Chen YF, et al. Unique K-ras mutational pattern in pancreatic adenocarcinoma from Taiwanese patients. Cancer Lett 2002; 180:153-8.
18. Doolittle BR, Emanuel J, Tuttle C, Costa J. Detection of mutated K-ras biomarker in colorectal carcinoma. Exp Mol Pathol 2001; 70:289-301.
19. Bleeker WA, Hayes VM, Karrenbeld A, et al. Impact of KRAS and TP53 mutations on survival in patients with left-and right-sided dukes' C colon cancer. Am J Gastroenterol 2000; 95:2953-7.
20. Thebo JS, Senagore AJ, Reinhold DS, Stapleton SR. Molecular staging of colorectal cancer: K-ras mutation analysis of lymph nodes upstages Dukes B patients. Dis Colon Rectum 2000; 43:155-62.
21. Tórtola S, Steinert R, Hantschick M, et al. Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer. J Clin Oncol 2001; 19:2837-43.
22. Brink M, de Goeij AFPM, Weijenberg MP, et al. K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study. Carcinogenesis 2003; 24:703-10.
23. Conlin A, Smith G, Carey FA, Wolf CR, Steele RJ. The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma. Gut 2005; 54:1283-6.
24. Chang YS, Yeh KT, Chang TJ, et al. Fast simultaneous detection of K-RAS mutations in colorectal cancer. BMC Cancer 2009; 9:179.
25. Nusko G, Sasche R, Mansmann U, Wittekind C, Hahn EG. K-RAS-2 gene mutations as predictors of metachronous colorectal adenomas. Scand J Gastroenterol 1997; 32:1035-41.
26. Rashid A, Zahurak M, Goodman SN, Hamilton SR. Genetic epidemiology of mutated K-ras proto-oncogen, altered suppressor genes, and microsatelite instability in colorectal adenomas. Gut 1999; 44:826-33.
27. Jen J, Powell SM, Papadopoulos N, et al. Molecular determinants of dysplasia in colorectal lesions. Cancer Res 1994; 54:5523-6.
28. Guerrero S, Casanova I, Farre L, et al. K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to archorage-independent growth than codon 13 mutation or proto-oncogene overexpression. Cancer Res 2000; 60:6750-6.
29. Bufill JA. Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med 1990; 15:779-88.
30. Li FY, Lai MD. Colorectal cancer, one entity or three. J Zhejiang Univ Sci B 2009; 10:219-29.
31. Bazan V, Migliavaca M, Zanna I, et al. Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype. Ann Oncol 2002; 13:1438-46.
32. Andreyev HJ, Norman AR, Cuningham D, Oates JR, Clarke PA. Kirsten ras mutations in patients with colorectal cancer: the multicentre "RASCAL" study. J Natl Cancer Inst 1998; 90:675-84.
33. Bouzourene H, Garvaz P, Cerottini JP, et al. p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer. Eur J Cancer 2000; 36:1008-15.
34. Lim GCC, Halimah Y. Second Report of the National Cancer Registry: Cancer Incidence in Malaysia 2003. Kuala Lumpur. National Cancer Registry 2004.